Effects of exercise and physical activity on gut microbiota composition and function in older adults: a systematic review

[1]  Z. Barad,et al.  Exercise‐induced modulation of neuroinflammation in ageing , 2022, The Journal of physiology.

[2]  R. Andrade,et al.  Therapeutics That Can Potentially Replicate or Augment the Anti-Aging Effects of Physical Exercise , 2022, International journal of molecular sciences.

[3]  Mark B. Vestergaard,et al.  New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary , 2022, Aging.

[4]  L. Osborne,et al.  A gut‐centric view of aging: Do intestinal epithelial cells contribute to age‐associated microbiota changes, inflammaging, and immunosenescence? , 2022, Aging cell.

[5]  W. Lefferts,et al.  Exercise as an Aging Mimetic: A New Perspective on the Mechanisms Behind Exercise as Preventive Medicine Against Age-Related Chronic Disease , 2022, Frontiers in Physiology.

[6]  Z. Mirzazadeh,et al.  A Systematic Review and Meta-Analysis of Resistance Training on Quality of Life, Depression, Muscle Strength, and Functional Exercise Capacity in Older Adults Aged 60 Years or More , 2022, Biological research for nursing.

[7]  J. Halling,et al.  Impact of Aging and Lifelong Exercise Training on Mitochondrial Function and Network Connectivity in Human Skeletal Muscle. , 2022, The journals of gerontology. Series A, Biological sciences and medical sciences.

[8]  L. Rodríguez-Mañas,et al.  Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging , 2022, International journal of molecular sciences.

[9]  A. Bäumler,et al.  The microbiome and gut homeostasis , 2022, Science.

[10]  A. Lang,et al.  The microbiome–gut–brain axis in Parkinson disease — from basic research to the clinic , 2022, Nature Reviews Neurology.

[11]  Kaelin C. Young,et al.  Exploring the Effects of Six Weeks of Resistance Training on the Fecal Microbiome of Older Adult Males: Secondary Analysis of a Peanut Protein Supplemented Randomized Controlled Trial , 2022, Sports.

[12]  D. Dardevet,et al.  Gut microbes and muscle function: can probiotics make our muscles stronger? , 2022, Journal of cachexia, sarcopenia and muscle.

[13]  M. Agmon,et al.  Increased physical activity improves gut microbiota composition and reduces short-chain fatty acid concentrations in older adults with insomnia , 2022, Scientific Reports.

[14]  Yong Tang,et al.  Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice , 2022, Journal of neuroinflammation.

[15]  D. Magistro,et al.  Systematic Review of the Effects of Exercise and Physical Activity on the Gut Microbiome of Older Adults , 2022, Nutrients.

[16]  H. Vlamakis,et al.  Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease , 2021, Genome medicine.

[17]  H. Keyvani,et al.  Dual role of microbiota-derived short-chain fatty acids on host and pathogen. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[18]  V. Martin,et al.  Effect of Concurrent Training on Body Composition and Gut Microbiota in Postmenopausal Women with Overweight or Obesity , 2021, Medicine and science in sports and exercise.

[19]  Takuji Yamada,et al.  Identification of Faecalibacterium prausnitzii strains for gut microbiome-based intervention in Alzheimer’s-type dementia , 2021, Cell reports. Medicine.

[20]  E. Baranovičová,et al.  Strenuous Physical Training, Physical Fitness, Body Composition and Bacteroides to Prevotella Ratio in the Gut of Elderly Athletes , 2021, Frontiers in Physiology.

[21]  M. Wolters,et al.  The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society , 2021, Nutrients.

[22]  D. Corella,et al.  Effect on gut microbiota of a 1-y lifestyle intervention with Mediterranean diet compared with energy-reduced Mediterranean diet and physical activity promotion: PREDIMED-Plus Study , 2021, The American journal of clinical nutrition.

[23]  P. Carapeto,et al.  Effects of exercise on cellular and tissue aging , 2021, Aging.

[24]  D. Seals,et al.  Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans , 2021, Hypertension.

[25]  A. Donnelly,et al.  The Influence of Different Physical Activity Behaviours on the Gut Microbiota of Older Irish Adults , 2021, The journal of nutrition, health & aging.

[26]  D. Philpott,et al.  Defined gut microbial communities: promising tools to understand and combat disease. , 2021, Microbes and infection.

[27]  J. Ramírez,et al.  Association between physical activity and changes in intestinal microbiota composition: A systematic review , 2021, PloS one.

[28]  J. Cryan,et al.  Unravelling the Microbial Mechanisms Underlying the Psychobiotic Potential of a Bifidobacterium breve Strain. , 2021, Molecular nutrition & food research.

[29]  John C. Earls,et al.  Gut microbiome pattern reflects healthy aging and predicts survival in humans , 2021, Nature Metabolism.

[30]  David A. Drew,et al.  Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals , 2021, Nature Medicine.

[31]  P. O’Toole,et al.  A synthetic consortium of 100 gut commensals modulates the composition and function in a colon model of the microbiome of elderly subjects , 2021, Gut microbes.

[32]  Zhiqiang Wen,et al.  Oscillospira - a candidate for the next-generation probiotics , 2021, Gut microbes.

[33]  R. Nagatomi,et al.  Effect of an 8-week Exercise Training on Gut Microbiota in Physically Inactive Older Women , 2020, International Journal of Sports Medicine.

[34]  S. Peddada,et al.  Analysis of microbial compositions: a review of normalization and differential abundance analysis , 2020, npj Biofilms and Microbiomes.

[35]  M. Yassour,et al.  Delivery Mode Affects Stability of Early Infant Gut Microbiota , 2020, Cell reports. Medicine.

[36]  S. Tagliaferri,et al.  The Gut-Muscle Axis in Older Subjects with Low Muscle Mass and Performance: A Proof of Concept Study Exploring Fecal Microbiota Composition and Function with Shotgun Metagenomics Sequencing , 2020, International journal of molecular sciences.

[37]  E. Prifti,et al.  From correlation to causality: the case of Subdoligranulum , 2020, Gut microbes.

[38]  J. Martiny,et al.  Alpha-, beta-, and gamma-diversity of bacteria varies across habitats , 2020, PloS one.

[39]  O. Pedersen,et al.  Gut microbiota in human metabolic health and disease , 2020, Nature Reviews Microbiology.

[40]  D. Repsilber,et al.  Differences in Gut Microbiome Composition between Senior Orienteering Athletes and Community-Dwelling Older Adults , 2020, Nutrients.

[41]  Yurong Tan,et al.  Extrinsic factors influencing gut microbes, the immediate consequences and restoring eubiosis , 2020, AMB Express.

[42]  S. Peddada,et al.  Analysis of compositions of microbiomes with bias correction , 2020, Nature Communications.

[43]  Guankui Du,et al.  Effects of exercise frequency on the gut microbiota in elderly individuals , 2020, MicrobiologyOpen.

[44]  W. Demark-Wahnefried,et al.  Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial. , 2020, Journal of the Academy of Nutrition and Dietetics.

[45]  L. Rodríguez-Mañas,et al.  Physical activity and exercise: Strategies to manage frailty , 2020, Redox biology.

[46]  J. Gilbert,et al.  Comparative Analysis of Gut Microbiota Following Changes in Training Volume Among Swimmers , 2020, International Journal of Sports Medicine.

[47]  P. O’Toole,et al.  The role of the microbiota in sedentary lifestyle disorders and ageing: lessons from the animal kingdom , 2020, Journal of internal medicine.

[48]  Riley L Hughes,et al.  A Review of the Role of the Gut Microbiome in Personalized Sports Nutrition , 2020, Frontiers in Nutrition.

[49]  Z. Xia,et al.  Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention. , 2019, Cell metabolism.

[50]  R. Fielding,et al.  Muscle strength is increased in mice that are colonized with microbiota from high-functioning older adults , 2019, Experimental Gerontology.

[51]  S. Engelsen,et al.  Physical fitness in community‐dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures , 2019, bioRxiv.

[52]  K. Moreau,et al.  Aerobic exercise training and vascular function with ageing in healthy men and women , 2019, The Journal of physiology.

[53]  M. Izquierdo,et al.  Physical Exercise in the Oldest Old. , 2019, Comprehensive Physiology.

[54]  T. Hansen,et al.  Structured exercise alters the gut microbiota in humans with overweight and obesity—A randomized controlled trial , 2019, International Journal of Obesity.

[55]  Natalie S Blencowe,et al.  RoB 2: a revised tool for assessing risk of bias in randomised trials , 2019, BMJ.

[56]  E. Blaak,et al.  The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity , 2019, Nutrients.

[57]  Chang-liang Zhu,et al.  Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria , 2019, Critical reviews in food science and nutrition.

[58]  K. Maslowski Metabolism at the centre of the host–microbe relationship , 2019, Clinical and experimental immunology.

[59]  Jacob M. Luber,et al.  Meta’omic analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism , 2019, Nature Medicine.

[60]  Byung-Yong Kim,et al.  The combination of sport and sport-specific diet is associated with characteristics of gut microbiota: an observational study , 2019, Journal of the International Society of Sports Nutrition.

[61]  N. Bolter,et al.  Gut Microbiota Composition Is Related to Cardiorespiratory Fitness in Healthy Young Adults. , 2019, International journal of sport nutrition and exercise metabolism.

[62]  Ting Zhang,et al.  Akkermansia muciniphila is a promising probiotic , 2019, Microbial biotechnology.

[63]  Ota,et al.  Aerobic Exercise Training with Brisk Walking Increases Intestinal Bacteroides in Healthy Elderly Women , 2019, Nutrients.

[64]  J. Raes,et al.  The neuroactive potential of the human gut microbiota in quality of life and depression , 2019, Nature Microbiology.

[65]  A. Gasbarrini,et al.  What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases , 2019, Microorganisms.

[66]  Masahito Hosokawa,et al.  Effects of short‐term endurance exercise on gut microbiota in elderly men , 2018, Physiological reports.

[67]  B. Bohannan,et al.  Microbiomes as Metacommunities: Understanding Host-Associated Microbes through Metacommunity Ecology. , 2018, Trends in ecology & evolution.

[68]  R. Krajmalnik-Brown,et al.  Diet, physical activity and screen time but not body mass index are associated with the gut microbiome of a diverse cohort of college students living in university housing: a cross-sectional study , 2018, BMC Microbiology.

[69]  W. Dieterich,et al.  Microbiota in the Gastrointestinal Tract , 2018, Medical sciences.

[70]  Karsten Zengler,et al.  GABA Modulating Bacteria of the Human Gut Microbiota , 2018, Nature Microbiology.

[71]  X. Lv,et al.  Gut dysbiosis is associated with the reduced exercise capacity of elderly patients with hypertension , 2018, Hypertension Research.

[72]  L. Elo,et al.  Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women , 2018, Front. Microbiol..

[73]  Gretchen A Stevens,et al.  Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1·9 million participants. , 2018, The Lancet. Global health.

[74]  T. Moritani,et al.  Effect of combined bifidobacteria supplementation and resistance training on cognitive function, body composition and bowel habits of healthy elderly subjects. , 2018, Beneficial microbes.

[75]  Sammi R. Chekroud,et al.  Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study. , 2018, The lancet. Psychiatry.

[76]  L. Partridge,et al.  Facing up to the global challenges of ageing , 2018, Nature.

[77]  A. Nouvenne,et al.  Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review , 2018, Clinical interventions in aging.

[78]  M. Trenell,et al.  Systematic review assessing the effectiveness of dietary intervention on gut microbiota in adults with type 2 diabetes , 2018, Diabetologia.

[79]  M. Schloter,et al.  Intestinal Metagenomes and Metabolomes in Healthy Young Males: Inactivity and Hypoxia Generated Negative Physiological Symptoms Precede Microbial Dysbiosis , 2018, Front. Physiol..

[80]  Rob Knight,et al.  American Gut: an Open Platform for Citizen Science Microbiome Research , 2018, mSystems.

[81]  Yifeng Du,et al.  Long-term treadmill exercise attenuates Aβ burdens and astrocyte activation in APP/PS1 mouse model of Alzheimer’s disease , 2018, Neuroscience Letters.

[82]  R. Isaacson,et al.  Deciphering Diversity Indices for a Better Understanding of Microbial Communities. , 2017, Journal of microbiology and biotechnology.

[83]  Hannah D. Holscher,et al.  Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans , 2017, Medicine and science in sports and exercise.

[84]  Eddy J. Bautista,et al.  Community characteristics of the gut microbiomes of competitive cyclists , 2017, Microbiome.

[85]  Patrice D Cani,et al.  Microbial Impact on Host Metabolism: Opportunities for Novel Treatments of Nutritional Disorders? , 2017, Microbiology spectrum.

[86]  Elaine Holmes,et al.  The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level , 2017, Gut.

[87]  M. Morrison,et al.  Diet and the Microbiome. , 2017, Gastroenterology clinics of North America.

[88]  Margarita Pérez,et al.  Differences in gut microbiota profile between women with active lifestyle and sedentary women , 2017, PloS one.

[89]  Guofeng Yan,et al.  Treadmill exercise promotes neuroprotection against cerebral ischemia–reperfusion injury via downregulation of pro-inflammatory mediators , 2016, Neuropsychiatric disease and treatment.

[90]  N. Mach,et al.  Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes , 2016, Journal of the International Society of Sports Nutrition.

[91]  M. Hernán,et al.  ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions , 2016, British Medical Journal.

[92]  N. Beerenwinkel,et al.  The Common Gut Microbe Eubacterium hallii also Contributes to Intestinal Propionate Formation , 2016, Front. Microbiol..

[93]  Sanjoy Ghosh,et al.  Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions , 2016, Microbiome.

[94]  Yangkai Wang,et al.  Metabolic factors-triggered inflammatory response drives antidepressant effects of exercise in CUMS rats , 2015, Psychiatry Research.

[95]  M. Joyner,et al.  Exercise attenuates the major hallmarks of aging. , 2015, Rejuvenation research.

[96]  E. Murphy,et al.  Exercise and associated dietary extremes impact on gut microbial diversity , 2014, Gut.

[97]  S. Donovan,et al.  Early Development of the Gut Microbiome and Immune-Mediated Childhood Disorders , 2014, Seminars in Reproductive Medicine.

[98]  Jeffrey S. Spence,et al.  Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging , 2013, Front. Aging Neurosci..

[99]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[100]  L. Partridge,et al.  Genetics of longevity in model organisms: debates and paradigm shifts. , 2013, Annual review of physiology.

[101]  S. Blair,et al.  Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy , 2012, BDJ.

[102]  J. Clemente,et al.  Human gut microbiome viewed across age and geography , 2012, Nature.

[103]  J. Sterne,et al.  The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials , 2011, BMJ : British Medical Journal.

[104]  Patrick D. Schloss,et al.  The Effects of Alignment Quality, Distance Calculation Method, Sequence Filtering, and Region on the Analysis of 16S rRNA Gene-Based Studies , 2010, PLoS Comput. Biol..

[105]  D. Moher,et al.  Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement , 2009, BMJ : British Medical Journal.

[106]  Marti J. Anderson,et al.  Multivariate dispersion as a measure of beta diversity. , 2006, Ecology letters.

[107]  I. García-Pérez,et al.  Distinct microbiome composition and metabolome exists across subgroups of elite Irish athletes. , 2019, Journal of science and medicine in sport.

[108]  A. Nouvenne,et al.  Exercise and immune system as modulators of intestinal microbiome: implications for the gut-muscle axis hypothesis. , 2019, Exercise immunology review.

[109]  J. Cauley,et al.  The Association between Objectively Measured Physical Activity and the Gut Microbiome among Older Community Dwelling Men , 2019, The journal of nutrition, health & aging.

[110]  Jonathan M. Chase,et al.  Navigating the multiple meanings of β diversity: a roadmap for the practicing ecologist. , 2011, Ecology letters.