The lifelong course of social anxiety disorder: a clinical perspective

 Social anxiety disorder (SAD) is among the most frequently observed psychiatric disorders, with estimates of approximately 10% of people likely to suffer from the disorder during their lifetime. However, despite causing significant impairment of normal functioning, this disorder is often mistaken as shyness and remains under‐recognized and under‐treated. Following onset in adolescence, patients with generalized SAD often experience a lifelong and unremitting mental disorder characterized by severe anxiety and disability. Typical duration of the illness is far in excess of that seen in panic disorder, and prospective, long‐term, naturalistic studies have indicated that only one‐third of individuals attain remission from SAD within 8 years, compared with over two‐thirds of those with panic disorder. Comorbidity of other anxiety disorders, depression and personality disorders are common in SAD and associated with more pronounced impairment and a poorer long‐term outcome. Effective treatment for SAD is available but use is low and may remain suboptimal, despite the development of pharmacotherapeutic agents with anxiolytic and antidepressant properties and the efficacy of psychotherapeutic approaches. Increased knowledge of the course of SAD highlights the need to examine the role of available treatments, administered individually or in combination, as acute, continuation or maintenance therapy to maximize the chances of remission and long‐term benefit for patients.

[1]  K. Merikangas,et al.  Comorbidity and social phobia: evidence from clinical, epidemiologic, and genetic studies , 2005, European Archives of Psychiatry and Clinical Neuroscience.

[2]  J. Angst,et al.  The Zurich study , 1984, European archives of psychiatry and neurological sciences.

[3]  K. Phillips,et al.  Personality disorders and time to remission in generalized anxiety disorder, social phobia, and panic disorder. , 2002, Archives of general psychiatry.

[4]  H. Wittchen,et al.  Epidemiology, patterns of comorbidity, and associated disabilities of social phobia. , 2001, The Psychiatric clinics of North America.

[5]  M. Pollack Comorbidity, neurobiology, and pharmacotherapy of social anxiety disorder. , 2001, The Journal of clinical psychiatry.

[6]  M. Keller,et al.  An eight-year longitudinal comparison of clinical course and characteristics of social phobia among men and women. , 2001, Psychiatric services.

[7]  P. Tibbo,et al.  Toward an integrative understanding of social phobia. , 2001, Journal of psychiatry & neuroscience : JPN.

[8]  K. Phillips,et al.  Patterns of personality pathology in patients with generalized anxiety disorder, panic disorder with and without agoraphobia, and social phobia. , 2001, Journal of personality disorders.

[9]  R. Lydiard Social anxiety disorder: comorbidity and its implications. , 2001, The Journal of clinical psychiatry.

[10]  J. Greist,et al.  Social anxiety disorder: an unrecognized problem in primary care. , 2001, The Journal of clinical psychiatry.

[11]  R. Shrivastava,et al.  Reemergence of sexual dysfunction in patients with major depressive disorder: double-blind comparison of nefazodone and sertraline. , 2001, The Journal of clinical psychiatry.

[12]  J. Markowitz,et al.  A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression. , 2000, The New England journal of medicine.

[13]  F. Schneier,et al.  Social phobia. Epidemiology and cost of illness. , 2000, PharmacoEconomics.

[14]  P. Ninan Use of venlafaxine other psychiatric disorders , 2000, Depression and anxiety.

[15]  Dan J Stein,et al.  Social Anxiety Disorder , 1999, CNS Spectrums.

[16]  J. Ballenger Clinical guidelines for establishing remission in patients with depression and anxiety. , 1999, The Journal of clinical psychiatry.

[17]  P. Tariot Evaluating response to metrifonate. , 1998, The Journal of clinical psychiatry.

[18]  R. Kessler,et al.  Social phobia subtypes in the National Comorbidity Survey. , 1998, The American journal of psychiatry.

[19]  S. Stahl How psychiatrists can build new therapies for impotence. , 1998, The Journal of clinical psychiatry.

[20]  A. Gelenberg Hats Off to the Reviewers!: (Editorial) , 1998 .

[21]  D. Attias,et al.  High association of anticardiolipin antibodies with psychosis. , 1998, The Journal of clinical psychiatry.

[22]  H. Westenberg The nature of social anxiety disorder. , 1998, The Journal of clinical psychiatry.

[23]  M. Stein,et al.  Lifetime patterns of social phobia: A retrospective study of the course of social phobia in a nonclinical population , 1998, Depression and anxiety.

[24]  M. Shear,et al.  Psychotherapy in the overall management strategy for social anxiety disorder. , 1998, Journal of Clinical Psychiatry.

[25]  K. Suthers,et al.  Antidepressant response in late-life depression. , 1998, The Journal of clinical psychiatry.

[26]  M. Stein,et al.  A direct-interview family study of generalized social phobia. , 1998, The American journal of psychiatry.

[27]  D. Nutt,et al.  Brain mechanisms of social anxiety disorder. , 1998, The Journal of clinical psychiatry.

[28]  D. Baldwin,et al.  The side effect burden associated with drug treatment of panic disorder. , 1998, The Journal of clinical psychiatry.

[29]  D. Beidel Social anxiety disorder: etiology and early clinical presentation. , 1998, The Journal of clinical psychiatry.

[30]  Y. Lecrubier Comorbidity in social anxiety disorder: impact on disease burden and management. , 1998, The Journal of clinical psychiatry.

[31]  H. Westenberg,et al.  Consensus statement on social anxiety disorder from the International Consensus Group on Depression and Anxiety. , 1998, The Journal of clinical psychiatry.

[32]  J. Davidson Pharmacotherapy of social anxiety disorder. , 1998, The Journal of clinical psychiatry.

[33]  Y. Lecrubier,et al.  Comorbidities in social phobia , 1997, International clinical psychopharmacology.

[34]  Yves Leerubier S.04.03 Implications of early onset social phobia on outcome , 1997, European Neuropsychopharmacology.

[35]  S. Montgomery,et al.  Social phobia: long‐term treatment outcome and prediction of response - a moclobemide study , 1997, International clinical psychopharmacology.

[36]  C. G. Last,et al.  Anxious children in adulthood: a prospective study of adjustment. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[37]  J. Davidson,et al.  A 2‐Year Follow‐up of Social Phobia: Status After a Brief Medication Trial , 1996, The Journal of nervous and mental disease.

[38]  H. Wittchen,et al.  The impact of social phobia on quality of life , 1996, International clinical psychopharmacology.

[39]  M. Versiani,et al.  The long-term treatment of social phobia with moclobemide , 1996, International clinical psychopharmacology.

[40]  R. Kessler,et al.  Agoraphobia, simple phobia, and social phobia in the National Comorbidity Survey. , 1996, Archives of general psychiatry.

[41]  P. Boyer,et al.  Social Phobia in General Health Care: An Unrecognised Undertreated Disabling Disorder , 1996, British Journal of Psychiatry.

[42]  R. van Dyck Non-drug treatment for social phobia. , 1996, International clinical psychopharmacology.

[43]  R. Heimberg,et al.  Social phobia. Longitudinal course and long-term outcome of cognitive-behavioral treatment. , 1995, The Psychiatric clinics of North America.

[44]  R. Heimberg,et al.  Social phobia subtype and avoidant personality disorder: Effect on severity of social phobia, impairment, and outcome of cognitive behavioral treatment , 1995 .

[45]  R. Kessler,et al.  Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. , 1994, Archives of general psychiatry.

[46]  J. Davidson,et al.  The epidemiology of social phobia: findings from the Duke Epidemiological Catchment Area Study , 1993, Psychological Medicine.

[47]  P. Lavori,et al.  Time to recovery, chronicity, and levels of psychopathology in major depression. A 5-year prospective follow-up of 431 subjects. , 1992, Archives of general psychiatry.

[48]  D. Beidel,et al.  Social phobia: a comparison of specific and generalized subtypes and avoidant personality disorder. , 1992, Journal of abnormal psychology.

[49]  M. Weissman,et al.  Social Phobia: Comorbidity and Morbidity in an Epidemiologic Sample , 1992 .

[50]  D. Beidel,et al.  Somatic complaints in anxious children , 1991, Journal of abnormal child psychology.

[51]  A. Stewart,et al.  The functioning and well-being of depressed patients. Results from the Medical Outcomes Study. , 1989, JAMA.

[52]  K. Larkin,et al.  Situational determinants of social anxiety in clinic and nonclinic samples: physiological and cognitive correlates. , 1986, Journal of consulting and clinical psychology.

[53]  O. Cameron,et al.  Ages of onset of DSM-III anxiety disorders. , 1985, Comprehensive psychiatry.