Abnormal cortical voice processing in autism

Impairments in social interaction are a key feature of autism and are associated with atypical social information processing. Here we report functional magnetic resonance imaging (fMRI) results showing that individuals with autism failed to activate superior temporal sulcus (STS) voice-selective regions in response to vocal sounds, whereas they showed a normal activation pattern in response to nonvocal sounds. These findings suggest abnormal cortical processing of socially relevant auditory information in autism.

[1]  S. Baron-Cohen,et al.  Reading the Mind in the Voice: A Study with Normal Adults and Adults with Asperger Syndrome and High Functioning Autism , 2002, Journal of autism and developmental disorders.

[2]  H. Critchley,et al.  The functional neuroanatomy of social behaviour: changes in cerebral blood flow when people with autistic disorder process facial expressions. , 2000, Brain : a journal of neurology.

[3]  C. Frith,et al.  Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. , 2002, Brain : a journal of neurology.

[4]  L. Kanner Autistic disturbances of affective contact. , 1968, Acta paedopsychiatrica.

[5]  Alan C. Evans,et al.  Event-Related fMRI of the Auditory Cortex , 1998, NeuroImage.

[6]  U. Frith,et al.  Autism: beyond “theory of mind” , 1994, Cognition.

[7]  T. Allison,et al.  Social perception from visual cues: role of the STS region , 2000, Trends in Cognitive Sciences.

[8]  Ami Klin,et al.  Young autistic children's listening preferences in regard to speech: A possible characterization of the symptom of social withdrawal , 1991, Journal of autism and developmental disorders.

[9]  R. Näätänen,et al.  Speech–sound-selective auditory impairment in children with autism: They can perceive but do not attend , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[10]  E. Courchesne,et al.  Face processing occurs outside the fusiform 'face area' in autism: evidence from functional MRI. , 2001, Brain : a journal of neurology.

[11]  F. Volkmar,et al.  Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. , 2000, Archives of general psychiatry.

[12]  D. Rosielle,et al.  Psychiatry , 1905, NeuroImage.

[13]  J. Winn,et al.  Brain , 1878, The Lancet.

[14]  R. Zatorre,et al.  Voice-selective areas in human auditory cortex , 2000, Nature.

[15]  R. Knoepfli [THE NERVOUS CHILD]. , 1964, Therapeutische Umschau. Revue therapeutique.

[16]  J. Boucher,et al.  Unfamiliar face recognition in relatively able autistic children. , 1992, Journal of child psychology and psychiatry, and allied disciplines.

[17]  I. Peretz,et al.  Enhanced Pitch Sensitivity in Individuals with Autism: A Signal Detection Analysis , 2003, Journal of Cognitive Neuroscience.