Terminal Hematuria Associated with Oral Isotretinoin Treatment in a Patient with Acne Vulgaris

Abstract:  Hematuria is defined as the abnormal presence of red blood cells in the urine and is commonly divided into gross and microscopic hematuria. Terminal hematuria occurs at the end of the urine stream and may have a prostatic, bladder, or trigonal cause. Here, we present a 16‐year‐old boy who developed terminal hematuria after 1 month of treatment with isotretinoin for acne vulgaris. This side effect of isotretinoin is not reported in the literature. This is the first case report.

[1]  M. Rademaker.  Adverse effects of isotretinoin: A retrospective review of 1743 patients started on isotretinoin , 2010, The Australasian journal of dermatology.

[2]  A. Kolivras,et al.  Gianotti‐Crosti Syndrome Following Hepatitis A Vaccination , 2008, Pediatric dermatology.

[3]  R. Quigley.  Evaluation of hematuria and proteinuria: how should a pediatrician proceed? , 2008, Current opinion in pediatrics.

[4]  C. Pan.  Evaluation of gross hematuria. , 2006, Pediatric clinics of North America.

[5]  M. Lacour,et al.  Gianotti-Crosti syndrome as a result of vaccination and Epstein-Barr virus infection , 1995, European Journal of Pediatrics.

[6]  C. Oh,et al.  Gianotti-Crosti syndrome following Japanese encephalitis vaccination. , 2003, Journal of Korean medical science.

[7]  Y. Chang.  Asymptomatic urinary abnormalities. , 2003 .

[8]  H. Chan,et al.  A Prospective Case Control Study of the Association of Gianotti–Crosti Syndrome with Human Herpesvirus 6 and Human Herpesvirus 7 Infections , 2002, Pediatric dermatology.

[9]  N. Andıran,et al.  Combined Vaccination by Measles and Hepatitis B Vaccines: A New Cause of Gianotti-Crosti Syndrome , 2002, Dermatology.

[10]  Tidman,et al.  Gianotti–Crosti syndrome after measles, mumps and rubella vaccination , 1998, The British journal of dermatology.

[11]  P. Carroll,et al.  Evaluation of asymptomatic microscopic hematuria. , 1998, The Urologic clinics of North America.

[12]  Z. Ahmed,et al.  Asymptomatic urinary abnormalities. Hematuria and proteinuria. , 1997, The Medical clinics of North America.

[13]  U. Baldari,et al.  Infantile acrodermatitis of Gianotti-Crosti and Lyme borreliosis. , 1996, Acta dermato-venereologica.

[14]  G. Pistritto,et al.  Gianotti-Crosti syndrome in an adult after influenza virus vaccination. , 1995, Dermatology.

[15]  M. Turner,et al.  Gianotti-Crosti syndrome and human immunodeficiency virus infection. , 1994, Archives of dermatology.

[16]  U. Baldari,et al.  An epidemic of infantile papular acrodermatitis (Gianotti-Crosti syndrome) due to Epstein-Barr virus. , 1994, Dermatology.

[17]  E. Giannì,et al.  Gianotti-Crosti syndrome: a retrospective analysis of 308 cases. , 1992, Journal of the American Academy of Dermatology.

[18]  D. Lask,et al.  Sports hematuria. , 1990, The Journal of urology.

[19]  W. James,et al.  Gianotti-Crosti syndrome associated with infections other than hepatitis B. , 1986, JAMA.

[20]  P. Pasquier,et al.  Gianotti‐Crosti syndrome: a study of 26 cases , 1986, The British journal of dermatology.

[21]  R. Winkelmann,et al.  Gianotti-Crosti syndrome. A review of ten cases not associated with hepatitis B. , 1984, Archives of dermatology.