FDG‐PET/CT–guided intensity modulated head and neck radiotherapy: A pilot investigation

2‐deoxy‐2[18F]fluoro‐d‐glucose–positron emission tomography (FDG‐PET) imaging can be registered with CT images and can potentially improve neck staging sensitivity and specificity in patients with head and neck squamous cell cancer. The intent of this study was to examine the use of registered FDG‐PET/CT imaging to guide head and neck intensity modulated radiotherapy (IMRT) planning.

[1]  B. Jeremic,et al.  Hyperfractionated Radiation Therapy With or Without Concurrent Low-Dose Daily Cisplatin in Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Prospective Randomized Trial , 2000 .

[2]  Curtis B Caldwell,et al.  The impact of (18)FDG-PET on target and critical organs in CT-based treatment planning of patients with poorly defined non-small-cell lung carcinoma: a prospective study. , 2002, International journal of radiation oncology, biology, physics.

[3]  S. Dische,et al.  Where exactly does failure occur after radiation in head and neck cancer? , 1995, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[4]  Yoshimi Anzai,et al.  FDG-PET/CT imaging for preradiotherapy staging of head-and-neck squamous cell carcinoma. , 2005, International journal of radiation oncology, biology, physics.

[5]  David R. Haynor,et al.  PET-CT image registration in the chest using free-form deformations , 2003, IEEE Transactions on Medical Imaging.

[6]  Mohamed Allaoua,et al.  Standardized uptake value of 2-[(18)F] fluoro-2-deoxy-D-glucose in predicting outcome in head and neck carcinomas treated by radiotherapy with or without chemotherapy. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[7]  T E Schultheiss,et al.  Dose escalation with 3D conformal treatment: five year outcomes, treatment optimization, and future directions. , 1998, International journal of radiation oncology, biology, physics.

[8]  M K Martel,et al.  Patterns of local-regional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer. , 2000, International journal of radiation oncology, biology, physics.

[9]  Di Yan,et al.  Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer: a comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation. , 2003, International journal of radiation oncology, biology, physics.

[10]  W. Mendenhall,et al.  Quality of life outcomes after primary radiotherapy for squamous cell carcinoma of the base of tongue. , 1996, International journal of radiation oncology, biology, physics.

[11]  R. Hustinx,et al.  18FDG‐PET for the assessment of primary head and neck tumors: Clinical, computed tomography, and histopathological correlation in 38 patients , 1998, The Laryngoscope.

[12]  J. Debatin,et al.  Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology. , 2003, JAMA.

[13]  G. Noël,et al.  [Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma]. , 2000, Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique.

[14]  J. Eary,et al.  Staging of head and neck squamous cell cancer with extended-field FDG-PET. , 2003, Archives of otolaryngology--head & neck surgery.

[15]  A. Garden,et al.  A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. , 2000, International journal of radiation oncology, biology, physics.

[16]  H D Suit,et al.  Impact of improved local control on survival. , 1986, International journal of radiation oncology, biology, physics.

[17]  M. Leblanc,et al.  Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  J L Roodenburg,et al.  Detection of lymph node metastases of squamous-cell cancer of the head and neck with FDG-PET and MRI. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[19]  G. Calais,et al.  Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. , 1999, Journal of the National Cancer Institute.

[20]  G. V. von Schulthess,et al.  Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography. , 2003, The New England journal of medicine.

[21]  O. Hoekstra,et al.  Positron emission tomography using [18F]fluorodeoxyglucose (FDG-PET) in the clinically negative neck: is it likely to be superior? , 2004, European Archives of Oto-Rhino-Laryngology and Head & Neck.

[22]  P. Xia,et al.  Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience. , 2001, International journal of radiation oncology, biology, physics.

[23]  Daniel A Low,et al.  Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer. , 2003, International journal of radiation oncology, biology, physics.

[24]  K. Geisinger,et al.  A comparative diagnostic study of head and neck nodal metastases using positron emission tomography , 1995, The Laryngoscope.

[25]  Tohru Shiga,et al.  Image fusion between 18FDG-PET and MRI/CT for radiotherapy planning of oropharyngeal and nasopharyngeal carcinomas. , 2002, International journal of radiation oncology, biology, physics.

[26]  A. Huang,et al.  Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. , 1998, The New England journal of medicine.

[27]  K. Geisinger,et al.  Positron emission tomography of patients with head and neck carcinoma before and after high dose irradiation , 1994, Cancer.

[28]  C. Ling,et al.  Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer. , 1999, International journal of radiation oncology, biology, physics.

[29]  R Mohan,et al.  The potential for sparing of parotids and escalation of biologically effective dose with intensity-modulated radiation treatments of head and neck cancers: a treatment design study. , 2000, International journal of radiation oncology, biology, physics.

[30]  P. Xia,et al.  Intensity-modulated radiation therapy for head-and-neck cancer: the UCSF experience focusing on target volume delineation. , 2003, International journal of radiation oncology, biology, physics.

[31]  A. Yonkers,et al.  Computed Tomography and Magnetic Resonance Imaging of Cervical Metastasis , 1989, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[32]  C. Silver,et al.  Computed tomography of the clinically negative neck , 1990, Head & neck.

[33]  R K Ten Haken,et al.  Conformal and intensity modulated irradiation of head and neck cancer: the potential for improved target irradiation, salivary gland function, and quality of life. , 1999, Acta oto-rhino-laryngologica Belgica.

[34]  S. Kaasa,et al.  Quality of life in patients treated for head and neck cancer: a follow-up study 7 to 11 years after radiotherapy. , 1994, International journal of radiation oncology, biology, physics.

[35]  Sasa Mutic,et al.  Treatment planning guidelines regarding the use of CT/PET-guided IMRT for cervical carcinoma with positive paraaortic lymph nodes. , 2004, International journal of radiation oncology, biology, physics.

[36]  James F Dempsey,et al.  Determination and delineation of nodal target volumes for head-and-neck cancer based on patterns of failure in patients receiving definitive and postoperative IMRT. , 2002, International journal of radiation oncology, biology, physics.

[37]  M Schwaiger,et al.  Comparison of fluorine-18-fluorodeoxyglucose PET, MRI and endoscopy for staging head and neck squamous-cell carcinomas. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[38]  E Abemayor,et al.  Positron emission tomography: A new, precise imaging modality for detection of primary head and neck tumors and assessment of cervical adenopathy , 1992, The Laryngoscope.

[39]  W N Hanafee,et al.  Extracranial head and neck: PET imaging with 2-[F-18]fluoro-2-deoxy-D-glucose and MR imaging correlation. , 1993, Radiology.

[40]  V Grégoire,et al.  Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience. , 2000, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[41]  M N Maisey,et al.  FDG–PET. A possible prognostic factor in head and neck cancer , 2002, British Journal of Cancer.

[42]  R. Weichselbaum,et al.  Induction Chemotherapy followed by Concomitant TFHX Chemoradiotherapy with Reduced Dose Radiation in Advanced Head and Neck Cancer , 2003 .

[43]  Dean Billheimer,et al.  Prospective feasibility trial of radiotherapy target definition for head and neck cancer using 3-dimensional PET and CT imaging. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[44]  W. Portilla,et al.  Improving diagnostic accuracy of cervical metastases with computed tomography and magnetic resonance imaging. , 1990, Archives of otolaryngology--head & neck surgery.

[45]  D P Dearnaley,et al.  Intensity modulated radiation therapy: a clinical review. , 2000, The British journal of radiology.