Mechanisms involved in lung cancer development in COPD.

[1]  G. Giaccone,et al.  Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. , 2010, The Lancet. Oncology.

[2]  S. Heath,et al.  Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. , 2010, International journal of epidemiology.

[3]  M. Karin,et al.  Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation. , 2010, Cancer cell.

[4]  E. Birney,et al.  A small cell lung cancer genome reports complex tobacco exposure signatures , 2009, Nature.

[5]  Tom Royce,et al.  A comprehensive catalogue of somatic mutations from a human cancer genome , 2010, Nature.

[6]  Yingdong Zhao,et al.  MicroRNA Expression Differentiates Histology and Predicts Survival of Lung Cancer , 2010, Clinical Cancer Research.

[7]  Shanling Xu,et al.  The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy , 2010, Expert opinion on therapeutic targets.

[8]  T. Tsuji,et al.  Alveolar Cell Senescence Exacerbates Pulmonary Inflammation in Patients with Chronic Obstructive Pulmonary Disease , 2009, Respiration.

[9]  D. Flieder,et al.  Population-based trends in lung cancer incidence in women. , 2009, Seminars in oncology.

[10]  D. Zeldin,et al.  Hormonal influences on lung function and response to environmental agents: lessons from animal models of respiratory disease. , 2009, Proceedings of the American Thoracic Society.

[11]  M. Karin NF-kappaB as a critical link between inflammation and cancer. , 2009, Cold Spring Harbor perspectives in biology.

[12]  R. Lotan,et al.  Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. , 2009, Carcinogenesis.

[13]  S. De Flora,et al.  Prevention of cigarette smoke–induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N‐acetylcysteine , 2009, International journal of cancer.

[14]  A. Fields,et al.  Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. , 2009, Cancer research.

[15]  J. Mitchell,et al.  Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease , 2009, British journal of pharmacology.

[16]  P. Elliott,et al.  A protein deacetylase SIRT1 is a negative regulator of metalloproteinase‐9 , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[17]  Scott F. Saccone,et al.  The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. , 2009, Cancer research.

[18]  S. Bojesen,et al.  CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50 000 individuals , 2009, Pharmacogenetics and genomics.

[19]  J J Bax,et al.  COPD and cancer mortality: the influence of statins , 2009, Thorax.

[20]  Ying Zheng,et al.  Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. , 2009, Cancer research.

[21]  I. Rahman,et al.  Current concepts on the role of inflammation in COPD and lung cancer. , 2009, Current opinion in pharmacology.

[22]  P. Massion,et al.  High-throughput molecular analysis in lung cancer: insights into biology and potential clinical applications , 2009, European Respiratory Journal.

[23]  J. Mulshine,et al.  Lung cancer and inflammation: interaction of chemokines and hnRNPs. , 2009, Current opinion in pharmacology.

[24]  R. Hopkins,et al.  Potential benefits of statins on morbidity and mortality in chronic obstructive pulmonary disease: a review of the evidence , 2009, Postgraduate Medical Journal.

[25]  Ya‐Wen Cheng,et al.  O6-Methylguanine-DNA Methyltransferase Hypermethylation Modulated by 17β-Estradiol in Lung Cancer Cells , 2009 .

[26]  A. Jemal,et al.  Cancer Statistics, 2009 , 2009, CA: a cancer journal for clinicians.

[27]  Wen Tan,et al.  Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. , 2009, Cancer research.

[28]  Pan‐Chyr Yang,et al.  Genetic Polymorphisms of Cytochrome P450 and Matrix Metalloproteinase in Chronic Obstructive Pulmonary Disease , 2009, Biochemical Genetics.

[29]  R. D'Agostino,et al.  Lung tumor promotion by curcumin. , 2009, Carcinogenesis.

[30]  S. De Flora,et al.  Modulation by Phenethyl Isothiocyanate and Budesonide of Molecular and Histopathologic Alterations Induced by Environmental Cigarette Smoke in Mice , 2009, Cancer Prevention Research.

[31]  Nilanjan Chatterjee,et al.  Phase I Metabolic Genes and Risk of Lung Cancer: Multiple Polymorphisms and mRNA Expression , 2009, PloS one.

[32]  C. Powell,et al.  Update in lung cancer 2008. , 2009, American journal of respiratory and critical care medicine.

[33]  E. Szabo,et al.  Lung cancer and chronic obstructive pulmonary disease: needs and opportunities for integrated research. , 2009, Journal of the National Cancer Institute.

[34]  M. Tucker,et al.  Cause-specific mortality in long-term survivors of retinoblastoma. , 2009, Journal of the National Cancer Institute.

[35]  I. Wistuba,et al.  Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model. , 2009, American journal of respiratory cell and molecular biology.

[36]  K. Syrigos,et al.  Overexpression of hnRNPA2/B1 in bronchoscopic specimens: a potential early detection marker in lung cancer. , 2009, Anticancer research.

[37]  Hongbing Shen,et al.  A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptibility of Lung Cancer in Chinese , 2009, Cancer Epidemiology Biomarkers & Prevention.

[38]  Randall Harris,et al.  Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung , 2009, Inflammopharmacology.

[39]  E. White,et al.  Association of Nonsteroidal Anti-Inflammatory Drugs with Lung Cancer: Results from a Large Cohort Study , 2009, Cancer Epidemiology Biomarkers & Prevention.

[40]  A. Schwartz,et al.  Chronic Obstructive Lung Diseases and Risk of Non-small Cell Lung Cancer in Women , 2009, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[41]  G. Scagliotti,et al.  Nonsmall cell lung cancer in never smokers , 2009, Current opinion in oncology.

[42]  U. Pastorino,et al.  Transcription Deregulation at the 15q25 Locus in Association with Lung Adenocarcinoma Risk , 2009, Clinical Cancer Research.

[43]  B. Stripp,et al.  Prospective Isolation of Bronchiolar Stem Cells Based Upon Immunophenotypic and Autofluorescence Characteristics , 2009, Stem cells.

[44]  S. Henikoff,et al.  DNA demethylation by DNA repair. , 2009, Trends in genetics : TIG.

[45]  M. Lenburg,et al.  Clinical Impact of High-Throughput Gene Expression Studies in Lung Cancer , 2009, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[46]  A. Moll,et al.  Risk of second malignancies in survivors of retinoblastoma: more than 40 years of follow-up. , 2008, Journal of the National Cancer Institute.

[47]  S. Otsuka,et al.  The CXCR4/SDF-1 Chemokine Receptor Axis: A New Target Therapeutic for Non-small Cell Lung Cancer , 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[48]  Y. Nasuhara,et al.  Down-regulated Nf-e2–related Factor 2 in Pulmonary Macrophages of Aged Smokers and Patients with Chronic Obstructive Pulmonary Disease Materials and Methods Collection of Human Alveolar Macrophages , 2022 .

[49]  W. Foulkes,et al.  Inherited susceptibility to common cancers. , 2008, The New England journal of medicine.

[50]  M. Spitz,et al.  The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. , 2008, Journal of the National Cancer Institute.

[51]  D. Deepak,et al.  COX2 and p53 risk-alleles coexist in COPD. , 2008, Clinica chimica acta; international journal of clinical chemistry.

[52]  K. Kubo,et al.  Enhanced levels of prostaglandin E2 and matrix metalloproteinase‐2 correlate with the severity of airflow limitation in stable COPD , 2008, Respirology.

[53]  Marshall W. Anderson,et al.  Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. , 2008, Journal of the National Cancer Institute.

[54]  Deepti Malhotra,et al.  Decline in Nrf2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, Dj-1 , 2022 .

[55]  Tsutomu Ohta,et al.  Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy , 2008, Proceedings of the National Academy of Sciences.

[56]  P. Ran,et al.  Association between polymorphisms of microsomal epoxide hydrolase and COPD: Results from meta‐analyses , 2008, Respirology.

[57]  Yasutaka Nakano,et al.  Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. , 2008, American journal of respiratory and critical care medicine.

[58]  A. Coyle,et al.  Gene-environment interactions in chronic obstructive pulmonary disease , 2008, International journal of chronic obstructive pulmonary disease.

[59]  J. Lees,et al.  Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion , 2008, Proceedings of the National Academy of Sciences.

[60]  Susanna M Cramb,et al.  The International Epidemiology of Lung Cancer: Geographical Distribution and Secular Trends , 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[61]  Hongbing Shen,et al.  Genetic variants of miRNA sequences and non-small cell lung cancer survival. , 2008, The Journal of clinical investigation.

[62]  J. Agúndez Polymorphisms of human N-acetyltransferases and cancer risk. , 2008, Current drug metabolism.

[63]  B. Crestani,et al.  Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema , 2008, Thorax.

[64]  H. Sekhon,et al.  Activated cholinergic signaling provides a target in squamous cell lung carcinoma. , 2008, Cancer research.

[65]  S. Dubinett,et al.  Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment. , 2008, Critical reviews in oncology/hematology.

[66]  Liam Ck A 4-year trial of tiotropium in chronic obstructive pulmonary disease. , 2008 .

[67]  W. Bamlet,et al.  Alpha1-antitrypsin deficiency carriers, tobacco smoke, chronic obstructive pulmonary disease, and lung cancer risk. , 2008, Archives of internal medicine.

[68]  G. Mills,et al.  Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 , 2008, Nature Genetics.

[69]  Ping Yang,et al.  Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. , 2008, Mayo Clinic proceedings.

[70]  C. Powell,et al.  Update in lung cancer 2007. , 2008, American journal of respiratory and critical care medicine.

[71]  R. Tuder,et al.  Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung. , 2008, American journal of respiratory cell and molecular biology.

[72]  I. Rahman,et al.  Sirt1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease at a Glance Commentary , 2022 .

[73]  Ying Zheng,et al.  PPARbeta/delta agonist stimulates human lung carcinoma cell growth through inhibition of PTEN expression: the involvement of PI3K and NF-kappaB signals. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[74]  Paolo Vineis,et al.  A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 , 2008, Nature.

[75]  Daniel F. Gudbjartsson,et al.  A variant associated with nicotine dependence, lung cancer and peripheral arterial disease , 2008, Nature.

[76]  E. Smit,et al.  CT detected indeterminate pulmonary nodules in a chemoprevention trial of fluticasone. , 2008, Lung cancer.

[77]  M. Esteller Epigenetics in cancer. , 2008, The New England journal of medicine.

[78]  Steven Piantadosi,et al.  DNA methylation markers and early recurrence in stage I lung cancer. , 2008, The New England journal of medicine.

[79]  S. Hirohashi,et al.  Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. , 2008, Cancer research.

[80]  J. Soria,et al.  Gene expression profiling of non-small-cell lung cancer , 2008, Expert review of molecular diagnostics.

[81]  Hongwei Yao,et al.  Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice. , 2008, American journal of respiratory cell and molecular biology.

[82]  K. Tsuneyama,et al.  Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study , 2008, Journal of Cancer Research and Clinical Oncology.

[83]  K. Rabe,et al.  COPD and Lung Cancer , 2008 .

[84]  Xueyan Zhong,et al.  High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer , 2008, Proceedings of the National Academy of Sciences.

[85]  Jingwu Z. Zhang,et al.  Cyclophilin A Is Required for CXCR4-mediated Nuclear Export of Heterogeneous Nuclear Ribonucleoprotein A2, Activation and Nuclear Translocation of ERK1/2, and Chemotactic Cell Migration* , 2008, Journal of Biological Chemistry.

[86]  A. Schwartz,et al.  Regular Adult Aspirin Use Decreases the Risk of Non-Small Cell Lung Cancer among Women , 2008, Cancer Epidemiology Biomarkers & Prevention.

[87]  D. Sin,et al.  Understanding the biological differences in susceptibility to chronic obstructive pulmonary disease between men and women. , 2007, Proceedings of the American Thoracic Society.

[88]  R. Dhir,et al.  Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells. , 2007, Pulmonary pharmacology & therapeutics.

[89]  B. Fingleton,et al.  Epithelial NF-κB activation promotes urethane-induced lung carcinogenesis , 2007, Proceedings of the National Academy of Sciences.

[90]  Carla F. Kim,et al.  Paving the road for lung stem cell biology: bronchioalveolar stem cells and other putative distal lung stem cells. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[91]  T. Byers,et al.  Bronchial Epithelial Ki-67 Index Is Related to Histology, Smoking, and Gender, but Not Lung Cancer or Chronic Obstructive Pulmonary Disease , 2007, Cancer Epidemiology Biomarkers & Prevention.

[92]  V. Steele,et al.  Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT). , 2007, Carcinogenesis.

[93]  M. Dohadwala,et al.  Inflammation and lung carcinogenesis: applying findings in prevention and treatment , 2007, Expert review of anticancer therapy.

[94]  A. Papi,et al.  Pathogenic link between chronic obstructive pulmonary disease and squamous cell lung cancer , 2007, Expert review of respiratory medicine.

[95]  F. Martinez,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. , 2007, American journal of respiratory and critical care medicine.

[96]  Zuo-Feng Zhang,et al.  Nicotine Induces Hypoxia-Inducible Factor-1α Expression in Human Lung Cancer Cells via Nicotinic Acetylcholine Receptor–Mediated Signaling Pathways , 2007, Clinical Cancer Research.

[97]  M. Manjili,et al.  Tumor immunoediting and immunosculpting pathways to cancer progression. , 2007, Seminars in cancer biology.

[98]  M. Thun,et al.  Chronic obstructive pulmonary disease is associated with lung cancer mortality in a prospective study of never smokers. , 2007, American journal of respiratory and critical care medicine.

[99]  P. Paré,et al.  The growing burden of chronic obstructive pulmonary disease and lung cancer in women: examining sex differences in cigarette smoke metabolism. , 2007, American journal of respiratory and critical care medicine.

[100]  D. Mannino COPD and lung cancer have come a long way ...baby. , 2007, American journal of respiratory and critical care medicine.

[101]  W. Wąsowicz,et al.  Polymorphism of selected enzymes involved in detoxification and biotransformation in relation to lung cancer. , 2007, Lung cancer.

[102]  J. Park,et al.  Acetylcholine-induced proliferation of fibroblasts and myofibroblasts in vitro is inhibited by tiotropium bromide. , 2007, Life sciences.

[103]  Luc Girard,et al.  Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. , 2007, Cancer research.

[104]  P. Snijders,et al.  The influence of fluticasone inhalation on markers of carcinogenesis in bronchial epithelium. , 2007, American journal of respiratory and critical care medicine.

[105]  M. Decramer,et al.  Increased galectin-3 expression and intra-epithelial neutrophils in small airways in severe COPD , 2007, European Respiratory Journal.

[106]  P. Barnes,et al.  Repression of Inflammatory Gene Expression in Human Pulmonary Epithelial Cells by Small-Molecule IκB Kinase Inhibitors , 2007, Journal of Pharmacology and Experimental Therapeutics.

[107]  H. Sekhon,et al.  M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. , 2007, Cancer research.

[108]  J. Minna,et al.  A Translational View of the Molecular Pathogenesis of Lung Cancer , 2007, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[109]  Stephen T Holgate,et al.  Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease. , 2007, American journal of respiratory and critical care medicine.

[110]  S. Janes,et al.  Lung cancer and lung stem cells: strange bedfellows? , 2007, American journal of respiratory and critical care medicine.

[111]  Kirk R. Smith,et al.  Household Air Pollution from Coal and Biomass Fuels in China: Measurements, Health Impacts, and Interventions , 2007, Environmental health perspectives.

[112]  Bartolome Celli,et al.  Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. , 2007, The New England journal of medicine.

[113]  Ya-ping Zhang,et al.  Relationship between COPD and polymorphisms of HOX-1 and mEPH in a Chinese population. , 2007, Oncology reports.

[114]  R. Salgia,et al.  Lung carcinoma in African Americans , 2007, Nature Clinical Practice Oncology.

[115]  I. Wistuba Genetics of preneoplasia: lessons from lung cancer. , 2007, Current molecular medicine.

[116]  V. Steele,et al.  Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors , 2006, International journal of cancer.

[117]  Bharat B. Aggarwal,et al.  Nuclear factor‐κB (nf‐κB) is frequently expressed in lung cancer and preneoplastic lesions , 2006 .

[118]  C. Prakash,et al.  Xenobiotic-metabolizing enzymes in human lung. , 2006, Current drug metabolism.

[119]  A. Folsom,et al.  Association between Nonsteroidal Anti-inflammatory Drug Use and the Incidence of Lung Cancer in the Iowa Women's Health Study , 2006, Cancer Epidemiology Biomarkers & Prevention.

[120]  T. Tsuji,et al.  Alveolar cell senescence in patients with pulmonary emphysema. , 2006, American journal of respiratory and critical care medicine.

[121]  J. Herman,et al.  Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer , 2006, PLoS medicine.

[122]  I. Adcock,et al.  Gene–environment interactions in the development of chronic obstructive pulmonary disease , 2006, Current opinion in allergy and clinical immunology.

[123]  Sevim Karakaş,et al.  The Association Between Polymorphic Genotypes of Glutathione S-Transferases and COPD in the Turkish Population , 2006, Biochemical Genetics.

[124]  R. Vermeulen,et al.  Impaired lung function and lung cancer incidence in a cohort of Swedish construction workers , 2006, Thorax.

[125]  Avrum Spira,et al.  State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer. , 2006, Proceedings of the American Thoracic Society.

[126]  Alan D. Lopez,et al.  Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data , 2006, The Lancet.

[127]  S. De Flora,et al.  Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: Chemoprevention by budesonide and N-acetylcysteine , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[128]  C. Shih,et al.  Polymorphisms of p53 and p21 genes in chronic obstructive pulmonary disease. , 2006, The Journal of laboratory and clinical medicine.

[129]  Kazuhiro Ito,et al.  Kinase inhibitors and airway inflammation. , 2006, European journal of pharmacology.

[130]  Tsutomu Ohta,et al.  Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. , 2006, Molecular cell.

[131]  F. Ruíz-Espejo,et al.  Cholinesterase activity of human lung tumours varies according to their histological classification. , 2006, Carcinogenesis.

[132]  I. Adcock,et al.  Epigenetics and airways disease , 2006, Respiratory research.

[133]  S. Lam,et al.  The relationship between stage 1 and 2 non-small cell lung cancer and lung function in men and women , 2006, BMC pulmonary medicine.

[134]  Marshall W. Anderson,et al.  Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsies , 2005, BMC Cancer.

[135]  I. Adcock,et al.  Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease , 2005 .

[136]  J. Gills,et al.  Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. , 2005, Carcinogenesis.

[137]  P. Paré,et al.  Relationship between reduced forced expiratory volume in one second and the risk of lung cancer: a systematic review and meta-analysis , 2005, Thorax.

[138]  S. Kardia,et al.  Risk of lung cancer among white and black relatives of individuals with early-onset lung cancer. , 2005, JAMA.

[139]  T. Jacks,et al.  Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer , 2005, Cell.

[140]  M. Brennan,et al.  p53 is a suppressor of inflammatory response in mice , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[141]  N. Papadopoulos,et al.  Oxidants in asthma and in chronic obstructive pulmonary disease (COPD). , 2005, Current pharmaceutical design.

[142]  N. Anthonisen,et al.  The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial , 2005 .

[143]  M. Decramer,et al.  Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial , 2005, The Lancet.

[144]  Hani Doss,et al.  Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). , 2005, Oncology reports.

[145]  J. Califano,et al.  Differential DNA Hypermethylation of Critical Genes Mediates the Stage-Specific Tobacco Smoke-Induced Neoplastic Progression of Lung Cancer , 2005, Clinical Cancer Research.

[146]  K. Nakachi,et al.  Detection of plasma hnRNP B1 mRNA, a new cancer biomarker, in lung cancer patients by quantitative real-time polymerase chain reaction. , 2005, Lung cancer.

[147]  Hiroyuki Aburatani,et al.  Overexpression of the Aldo-Keto Reductase Family Protein AKR1B10 Is Highly Correlated with Smokers' Non–Small Cell Lung Carcinomas , 2005, Clinical Cancer Research.

[148]  J. Ferlay,et al.  Global Cancer Statistics, 2002 , 2005, CA: a cancer journal for clinicians.

[149]  H. Kubo,et al.  Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism , 2005, Human Genetics.

[150]  H. Dienemann,et al.  Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. , 2004, Carcinogenesis.

[151]  Irina Petrache,et al.  Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. , 2004, The Journal of clinical investigation.

[152]  I. Adcock,et al.  Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD. , 2004, Current opinion in investigational drugs.

[153]  S. Lam,et al.  A Randomized Phase IIb Trial of Pulmicort Turbuhaler (Budesonide) in People with Dysplasia of the Bronchial Epithelium , 2004, Clinical Cancer Research.

[154]  J. Roman,et al.  Nicotine and fibronectin expression in lung fibroblasts: implications for tobacco‐related lung tissue remodeling , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[155]  Marshall W. Anderson,et al.  A major lung cancer susceptibility locus maps to chromosome 6q23-25. , 2004, American journal of human genetics.

[156]  R. Doll,et al.  Mortality in relation to alcohol consumption: a prospective study among male British doctors. , 2004, International journal of epidemiology.

[157]  K. Racké,et al.  The airway cholinergic system: physiology and pharmacology. , 2004, Pulmonary pharmacology & therapeutics.

[158]  David R. Jones,et al.  Combined histone deacetylase and NF-kappaB inhibition sensitizes non-small cell lung cancer to cell death. , 2004, Surgery.

[159]  L. Fabbri,et al.  COPD increases the risk of squamous histological subtype in smokers who develop non-small cell lung carcinoma , 2004, Thorax.

[160]  A. Sancar,et al.  Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. , 2004, Annual review of biochemistry.

[161]  Keith M. Kerr,et al.  Gene Expression Profiling in Non-Small Cell Lung Cancer , 2004, Clinical Cancer Research.

[162]  M. Karin,et al.  The IKK/NF-κB activation pathway—a target for prevention and treatment of cancer , 2004 .

[163]  M. Mayo,et al.  Combined proteasome and histone deacetylase inhibition in non-small cell lung cancer. , 2004, The Journal of thoracic and cardiovascular surgery.

[164]  D. Easton,et al.  Lifetime risks of common cancers among retinoblastoma survivors. , 2004, Journal of the National Cancer Institute.

[165]  J. Mullol,et al.  Cyclooxygenase-2 is up-regulated in lung parenchyma of chronic obstructive pulmonary disease and down-regulated in idiopathic pulmonary fibrosis. , 2004, Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG.

[166]  P. Barnes Alveolar Macrophages as Orchestrators of COPD , 2004, COPD.

[167]  M. Spitz,et al.  Risk for smoking-related cancer among relatives of lung cancer patients. , 2003, Cancer research.

[168]  D. Spandidos,et al.  Genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes and lung cancer risk. , 2003, Oncology reports.

[169]  Vidar Skaug,et al.  Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. , 2003, Carcinogenesis.

[170]  A. Sakurada,et al.  hnRNP B1 protein may be a possible prognostic factor in squamous cell carcinoma of the lung. , 2003, Lung cancer.

[171]  Christopher I Amos,et al.  Genetic susceptibility to lung cancer: the role of DNA damage and repair. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[172]  D. Mannino,et al.  Low lung function and incident lung cancer in the United States: data From the First National Health and Nutrition Examination Survey follow-up. , 2003, Archives of internal medicine.

[173]  Christopher I. Amos,et al.  Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk , 2003, Human Genetics.

[174]  C. Berg Who Is at Risk for Lung Cancer , 2003 .

[175]  J. Blusztajn,et al.  Synthesis of acetylcholine by lung cancer. , 2003, Life sciences.

[176]  S. Bozinovski,et al.  Acquired somatic mutations in the molecular pathogenesis of COPD. , 2003, Trends in pharmacological sciences.

[177]  I. Adcock,et al.  Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers. , 2002, American journal of respiratory and critical care medicine.

[178]  I. Adcock,et al.  Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD , 2002, European Respiratory Journal.

[179]  F. Gilliland,et al.  Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. , 2002, Cancer research.

[180]  S. Weitzman,et al.  Chronic inflammation and cancer. , 2002, Oncology.

[181]  Diane D. Liu,et al.  Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers. , 2002, Cancer research.

[182]  D. Carney Lung cancer--time to move on from chemotherapy. , 2002, The New England journal of medicine.

[183]  T B Martonen,et al.  COMPUTER SIMULATIONS OF PARTICLE DEPOSITION IN THE LUNGS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS , 2002, Inhalation toxicology.

[184]  S D Stellman,et al.  Smoking and lung cancer risk in American and Japanese men: an international case-control study. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[185]  M. Serrano,et al.  Tumor susceptibility of p21(Waf1/Cip1)-deficient mice. , 2001, Cancer research.

[186]  D. Kromhout,et al.  Diet and chronic obstructive pulmonary disease: independent beneficial effects of fruits, whole grains, and alcohol (the MORGEN study) , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[187]  J. Coebergh,et al.  Trends in incidence and prognosis of the histological subtypes of lung cancer in North America, Australia, New Zealand and Europe. , 2001, Lung cancer.

[188]  Alberto Mantovani,et al.  Inflammation and cancer: back to Virchow? , 2001, The Lancet.

[189]  M. Spitz,et al.  Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study. , 2000, Journal of the National Cancer Institute.

[190]  J. Herman,et al.  Predicting lung cancer by detecting aberrant promoter methylation in sputum. , 2000, Cancer research.

[191]  J. Minna,et al.  Molecular changes in the bronchial epithelium of patients with small cell lung cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[192]  O. Dalesio,et al.  EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups. , 2000, Journal of the National Cancer Institute.

[193]  V. Steele,et al.  Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol. , 2000, Carcinogenesis.

[194]  J. Minna,et al.  Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer. , 1999, Journal of the National Cancer Institute.

[195]  J. Herman,et al.  In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[196]  J. Minna,et al.  Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma , 1999, Oncogene.

[197]  A. Ristimäki,et al.  Expression of cyclooxygenase-2 in human lung carcinoma. , 1998, Cancer research.

[198]  E Gabrielson,et al.  Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[199]  Y. Yatabe,et al.  Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. , 1998, Cancer research.

[200]  Y. Miller,et al.  Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis. , 1997, The Journal of clinical investigation.

[201]  J. Samet,et al.  Molecular damage in the bronchial epithelium of current and former smokers. , 1997, Journal of the National Cancer Institute.

[202]  I. Wistuba,et al.  Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas. , 1997, Cancer research.

[203]  J. Jett,et al.  Anti-p53 antibodies in sera from patients with chronic obstructive pulmonary disease can predate a diagnosis of cancer. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[204]  S. S. Smith,et al.  DNA adduct 8-hydroxyl-2'-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase. , 1995, Carcinogenesis.

[205]  D. Schottenfeld,et al.  Declining FEV1 and chronic productive cough in cigarette smokers: a 25-year prospective study of lung cancer incidence in Tecumseh, Michigan. , 1994, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[206]  R. Everson,et al.  Aspirin Use and Lung, Colon, and Breast Cancer Incidence in a Prospective Study , 1994, Epidemiology.

[207]  G. Draper,et al.  Non-ocular cancer in relatives of retinoblastoma patients. , 1989, British Journal of Cancer.

[208]  N. Anthonisen,et al.  Airways obstruction and the risk for lung cancer. , 1987, Annals of internal medicine.

[209]  K P Offord,et al.  Higher risk of lung cancer in chronic obstructive pulmonary disease. A prospective, matched, controlled study. , 1986, Annals of internal medicine.

[210]  E. C. Hammond,et al.  Changes in bronchial epithelium in relation to cigarette smoking, 1955-1960 vs. 1970-1977. , 1979, The New England journal of medicine.

[211]  後藤 康洋 Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma , 2010 .

[212]  M. Esteller,et al.  DNA methylomes, histone codes and miRNAs: tying it all together. , 2009, The international journal of biochemistry & cell biology.

[213]  J. Soriano,et al.  Inhaled corticosteroids and risk of lung cancer among COPD patients who quit smoking. , 2009, Respiratory medicine.

[214]  Stephanie Spange,et al.  Acetylation of non-histone proteins modulates cellular signalling at multiple levels. , 2009, The international journal of biochemistry & cell biology.

[215]  Ya-Wen Cheng,et al.  O6-Methylguanine-DNA methyltransferase hypermethylation modulated by 17beta-estradiol in lung cancer cells. , 2009, Anticancer research.

[216]  L. Tanoue Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer , 2009 .

[217]  E. Spindel,et al.  Basic and clinical aspects of non-neuronal acetylcholine: expression of non-neuronal acetylcholine in lung cancer provides a new target for cancer therapy. , 2008, Journal of pharmacological sciences.

[218]  J. Maurer Inhaled Corticosteroids and Risk of Lung Cancer among Patients with Chronic Obstructive Pulmonary Disease , 2008 .

[219]  V. Steele,et al.  Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra MT). , 2007, Carcinogenesis.

[220]  Ajmal Khan,et al.  Lung cancer chemoprevention with inhaled corticosteroids? , 2007, American journal of respiratory and critical care medicine.

[221]  H. Dienemann,et al.  Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms. , 2007, Lung cancer.

[222]  S. Kamholz Wine, spirits and the lung: good, bad or indifferent? , 2006, Transactions of the American Clinical and Climatological Association.

[223]  A. Schwartz,et al.  Familial lung cancer: genetic susceptibility and relationship to chronic obstructive pulmonary disease. , 2006, American journal of respiratory and critical care medicine.

[224]  P Zabel,et al.  [Chronic obstructive pulmonary disease (COPD)]. , 2006, Der Internist.

[225]  M. Karin,et al.  The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. , 2004, Cancer letters.

[226]  A. Bird,et al.  Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). , 2004, Nucleic acids research.

[227]  J. Blusztajn,et al.  Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. , 2003, Cancer research.

[228]  C. Harris,et al.  Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. , 2003, The Journal of clinical investigation.

[229]  L. Allen Stem cells. , 2003, The New England journal of medicine.

[230]  J. Somberg Genetic polymorphisms. , 2002, American journal of therapeutics.

[231]  M. Spitz,et al.  Cytochrome P450 2E1 DraI polymorphisms in lung cancer in minority populations. , 1998, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.