Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Aung Ko Win | M. Kloor | B. Bonanni | P. Møller | L. Rasmussen | E. Hovig | J. Hopper | S. Thibodeau | M. Southey | S. Nakken | G. Capellá | J. Weitz | A. Lindblom | S. Gallinger | J. Dowty | J. Lubiński | P. Newcomb | L. Ricciardiello | M. Jenkins | J. Reece | N. Samadder | J. Guillem | E. Stoffel | P. Peltomäki | J. Mecklin | N. Lindor | C. Engel | V. Heuveline | J. Burn | M. Greenblatt | M. Kohonen-Corish | J. Ngeow | I. Bernstein | D. Buchanan | L. Sunde | H. Okkels | J. Figueiredo | N. Gluck | Tatsuro Yamaguchi | A. Gerdes | M. Mints | J. Sampson | F. Lalloo | P. James | M. Hall | I. Winship | L. Senter | S. Aretz | F. Macrae | R. Sijmons | D. G. Evans | D. Carraro | M. Nielsen | C. Lautrup | K. Wadt | G. Cavestro | H. Hampel | C. Snyder | N. Poplawski | N. Hoogerbrugge | D. Winter | R. Ankathil | E. Crosbie | P. Morrison | A. Backman | M. Aronson | L. Lindberg | D. Vangala | J. Brunet | T. Dębniak | T. Caldés | M. Tibiletti | L. Bertario | J. Plazzer | K. Heinimann | F. Duijkers | N. Rahner | L. Laghi | R. Kennelly | L. Katz | L. Lino-Silva | M. Pineda | G. Torrezan | H. Thomas | A. Latchford | K. Green | T. Seppälä | L. Renkonen-Sinisalo | R. Chen-Shtoyerman | D. Amor | C. Guillén-Ponce | Z. Levi | H. Sheth | M. Loeffler | H. Williams | M. Bohórquez | C. Vaccaro | C. Therkildsen | E. Palmero | O. Thorlacius-Ussing | N. Abu-Freha | K. Horisberger | C. Perne | I. Laish | G. Rosner | M. Dominguez-Valentin | R. Hüneburg | M. N. Zahary | R. Pai | Verena Steinke-Lange | T. John | Saskia Haupt | A. Ahadova | P. Garre | K. Monahan | D. Tjandra | S. Redler | S. Parry | B. Rossi | J. Arnold | Núria Dueñas | Wolff Schmiegel | I. Nascimento | Florencia Neffa | P. Esperón | N. Rossi | Claudia Martin | P. Kalfayan | Verónica Barca-Tierno | R. Kariv | R. Büttner | A. Stakelum | K. Newton | E. Holinski-Feder | A. Zaránd | E. Half | E. Vainer | K. Pylvänäinen | M. Ligtenberg | L. Renkonen‐Sinisalo | Rodney J. Scott | Grant Lee | W. Pavicic | Liselotte P. Hest | A. D. Valle | Carmen Portenkirchner | F. Lopez-Koestner | M. K. Knebel Doeberitz | Karin Alvarez-Valenzuela | Des Winter | Leandro Apolinário Silva | Anna Lepisto | Aı́da Falcón de Vargas | Robyn Ward | T. O. Overeem Hansen | L. Marchand | Sanne W. Broeke | Thiago Bassaneze | G. Moslein | The European Hereditary Tumour Group and the Internati Consortium | V. Steinke-Lange | L. Hest | M. Jenkins | Kirsi Pylvänäinen | W. Schmiegel | S. W. Broeke | Verónica Barca-Tierno

[1]  M. Kloor,et al.  The coding microsatellite mutation profile of PMS2-deficient colorectal cancer. , 2021, Experimental and molecular pathology.

[2]  M. Hegde,et al.  Genetic testing for inherited colorectal cancer and polyposis, 2021 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG) , 2021, Genetics in Medicine.

[3]  Katherine M. Tucker,et al.  Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study. , 2021, The Lancet. Oncology.

[4]  M. Kloor,et al.  European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender , 2020, The British journal of surgery.

[5]  Aung Ko Win,et al.  Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database , 2020, Genetics in Medicine.

[6]  M. Kloor,et al.  The “unnatural” history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance , 2020, International journal of cancer.

[7]  M. Kloor,et al.  A Frameshift Peptide Neoantigen-Based Vaccine for Mismatch Repair-Deficient Cancers: A Phase I/IIa Clinical Trial , 2020, Clinical Cancer Research.

[8]  A. Broeks,et al.  Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers , 2020, Nature Medicine.

[9]  C. Blank,et al.  Learning from clinical trials of neoadjuvant checkpoint blockade , 2020, Nature Medicine.

[10]  P. Møller The Prospective Lynch Syndrome Database reports enable evidence-based personal precision health care , 2020, Hereditary cancer in clinical practice.

[11]  R. Pai,et al.  Detection of DNA mismatch repair deficient crypts in random colonoscopic biopsies identifies Lynch syndrome patients , 2020, Familial Cancer.

[12]  M. Kloor,et al.  Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report , 2019, Hereditary cancer in clinical practice.

[13]  Aung Ko Win,et al.  Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database , 2019, Genetics in Medicine.

[14]  M. von Knebel Doeberitz,et al.  The Apparent Genetic Anticipation in PMS2-Associated Lynch Syndrome Families Is Explained by Birth-cohort Effect , 2019, Cancer Epidemiology, Biomarkers & Prevention.

[15]  M. Kloor,et al.  Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report , 2019, Hereditary Cancer in Clinical Practice.

[16]  M. Kloor,et al.  No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies. , 2018, Gastroenterology.

[17]  Aung Ko Win,et al.  Cancer Risks for PMS2-Associated Lynch Syndrome. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  H. Morreau,et al.  Molecular Background of Colorectal Tumors From Patients With Lynch Syndrome Associated With Germline Variants in PMS2. , 2018, Gastroenterology.

[19]  Aung Ko Win,et al.  Physical activity and the risk of colorectal cancer in Lynch syndrome , 2018, International journal of cancer.

[20]  S. Thibodeau,et al.  DNA mismatch repair protein deficient non-neoplastic colonic crypts: a novel indicator of Lynch syndrome , 2018, Modern Pathology.

[21]  P. Møller,et al.  Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report , 2017, Hereditary cancer in clinical practice.

[22]  P. Møller,et al.  Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database , 2016, Gut.

[23]  M. Kloor,et al.  Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome – Molecular Alterations and Association with Clinical Parameters , 2015, PloS one.

[24]  P. Møller,et al.  Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts , 2013, Gut.

[25]  Axel Benner,et al.  Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study. , 2012, The Lancet. Oncology.

[26]  Laetitia Huiart,et al.  Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome. , 2011, JAMA.

[27]  Aung Ko Win,et al.  Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes , 2011, British Journal of Cancer.

[28]  M. Kloor,et al.  Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers. , 2008, Gastroenterology.

[29]  P. Møller,et al.  Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer) , 2007, Journal of Medical Genetics.

[30]  J. Douglas,et al.  History and molecular genetics of Lynch syndrome in family G: a century later. , 2005, JAMA.

[31]  F. Nagengast,et al.  Interval cancers in hereditary non-polyposis colorectal cancer (Lynch syndrome) , 1995, The Lancet.

[32]  P. Sistonen,et al.  Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer. , 1995, Gastroenterology.

[33]  J. Lubiński,et al.  Hereditary Cancer in Clinical Practice , 2017 .