Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator

[1]  A. Jolma,et al.  A protein activity assay to measure global transcription factor activity reveals determinants of chromatin accessibility , 2018, Nature Biotechnology.

[2]  Justin K. Huang,et al.  A global transcriptional network connecting noncoding mutations to changes in tumor gene expression , 2018, Nature Genetics.

[3]  R. Kingston,et al.  Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription. , 2017, Molecular cell.

[4]  Aaron T. L. Lun,et al.  A non‐canonical function of Ezh2 preserves immune homeostasis , 2017, EMBO reports.

[5]  Henry W. Long,et al.  Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance , 2017, Science.

[6]  Kaitlyn M. Gayvert,et al.  N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer. , 2016, Cancer cell.

[7]  K. Lam,et al.  ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer , 2016, Nature Medicine.

[8]  Thomas P. Howard,et al.  SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 , 2015, Nature Medicine.

[9]  R. Margueron,et al.  Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation , 2015, Molecular cell.

[10]  M. Loda,et al.  EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent , 2012, Science.

[11]  D. Noh,et al.  EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. , 2012, Molecular cell.

[12]  S. Armstrong,et al.  Polycomb repressive complex 2 is required for MLL-AF9 leukemia , 2012, Proceedings of the National Academy of Sciences.

[13]  Jun Liu,et al.  Cooperation between Polycomb and androgen receptor during oncogenic transformation. , 2012, Genome research.

[14]  V. Sartorelli,et al.  Polycomb protein Ezh1 promotes RNA polymerase II elongation. , 2012, Molecular cell.

[15]  A. Ventura,et al.  Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer. , 2011, Cancer research.

[16]  Zhaohui S. Qin,et al.  An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. , 2010, Cancer cell.

[17]  Guo-Cheng Yuan,et al.  EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. , 2008, Molecular cell.

[18]  Kristian Helin,et al.  Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity , 2004, The EMBO journal.

[19]  S. Dhanasekaran,et al.  The polycomb group protein EZH2 is involved in progression of prostate cancer , 2002, Nature.

[20]  W. Schaffner,et al.  Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated. , 1988, Genes & development.

[21]  A. Jemal,et al.  Cancer statistics, 2015 , 2015, CA: a cancer journal for clinicians.

[22]  S. Orkin,et al.  PRC2 directly methylates GATA4 and represses its transcriptional activity. , 2012, Genes & development.