Effect of Pijusaballi Rasa on Thyroid Hormones in Sprague-Dawley Rats

Pijusaballi Rasa (PJB) is an Ayurvedic preparation used as a traditional medicine in the treatment of constipation in the rural population in Bangladesh. In this study, the effect of PJB on thyroid hormone profile was evaluated after chronic administration of this drug to male Sprague-Dawley rats. The acute pharmacological test of PJB recorded no death or any signs of toxicity even at the highest dose of 4000 mg/kg body weight. For chronic pharmacological evaluation, the animals were divided into two groups. The first group was given PJB preparation at a dose of 400 mg/kg body weight for 28 days while the second group that served as the control received water for the same period. After 28 days of chronic administration of the PJB preparation, the following effects on the thyroid hormone panel were noted. There was a statistically insignificant (p = 0.523; 5.20%) decrease in the serum-circulating total thyroxine (tT4) level of the male rats. There was a statistically insignificant (p = 0.667; 3.35%) decrease in the serum-circulating total triiodothyronine (tT3) level of the male rats. There was a statistically insignificant (p = 0.551; 4.40%) decrease in the serum-circulating free thyroxine (fT4) level of the male rats. There was a statistically highly significant (p = 0.003; 16.36%) increase in the serum-circulating free triiodothyronine (fT3) level of the male rats. There was a statistically insignificant (p = 0.691; 51.03%) increase in the serum-circulating thyroid-stimulating hormone (TSH) level of the male rats. Ratios of other hormone levels with respect to fT3 level showed a more deviating trend.

[1]  A. Hollenberg,et al.  New insights into thyroid hormone action☆ , 2017, Pharmacology & therapeutics.

[2]  A. Lonardo,et al.  Is nonalcoholic steatohepatitis associated with a high-though-normal thyroid stimulating hormone level and lower cholesterol levels? , 2013, Internal and Emergency Medicine.

[3]  G. Brabant,et al.  Thyroid Hormones and the Metabolic Syndrome , 2013, European Thyroid Journal.

[4]  G. Brent,et al.  Mechanisms of thyroid hormone action. , 2012, The Journal of clinical investigation.

[5]  O. Gungor,et al.  The association between thyroid hormones and arterial stiffness in peritoneal dialysis patients , 2012, International Urology and Nephrology.

[6]  J. Carrero,et al.  Associations of triiodothyronine levels with carotid atherosclerosis and arterial stiffness in hemodialysis patients. , 2011, Clinical journal of the American Society of Nephrology : CJASN.

[7]  P. Davis,et al.  Molecular aspects of thyroid hormone actions. , 2010, Endocrine reviews.

[8]  G. Brent,et al.  Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation , 2010, Trends in Endocrinology & Metabolism.

[9]  G. Medeiros-Neto,et al.  Mutations of the thyroglobulin gene and its relevance to thyroid disorders , 2009, Current opinion in endocrinology, diabetes, and obesity.

[10]  Kwang-Huei Lin,et al.  Thyroid hormone dependent regulation of target genes and their physiological significance. , 2008, Chang Gung medical journal.

[11]  J. Murabito,et al.  Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. , 2008, Archives of internal medicine.

[12]  B. Velkeniers,et al.  Thyroid disease and female reproduction , 2007, Clinical endocrinology.

[13]  T. Jørgensen,et al.  Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. , 2005, The Journal of clinical endocrinology and metabolism.

[14]  M. Shelby,et al.  Role of thyroid hormones in human and laboratory animal reproductive health. , 2003, Birth defects research. Part B, Developmental and reproductive toxicology.

[15]  G. Brent,et al.  Mechanisms of thyroid hormone action. Implications for the clinical manifestation of thyrotoxicosis. , 1998, Endocrinology and metabolism clinics of North America.

[16]  T. Slotkin,et al.  Cardiac alpha-adrenergic receptor expression is regulated by thyroid hormone during a critical developmental period. , 1996, Journal of molecular and cellular cardiology.

[17]  E. Jannini,et al.  Thyroid hormone and male gonadal function. , 1995, Endocrine reviews.

[18]  R Bianchi,et al.  Thyroidal and peripheral production of 3,5,3'-triiodothyronine in humans by multicompartmental analysis. , 1990, The American journal of physiology.

[19]  Y. Muto,et al.  Serum thyroid hormone levels in patients with fulminant hepatitis: Usefulness of rT3 and the rT3/T3 ratio as prognostic indices , 1987, Gastroenterologia Japonica.

[20]  R. Caldara,et al.  Thyroid function tests in chronic liver disease: evidence for multiple abnormalities despite clinical euthyroidism. , 1983, Gut.

[21]  J. Feely,et al.  Screening for thyroid dysfunction in diabetics. , 1979, British medical journal.

[22]  H. Wahner,et al.  Interpretation of serum tri-iodothyronine levels measured by the sterling technic. , 1971, The New England journal of medicine.

[23]  M. Zimmermann.  Iodine deficiency. , 2009, Endocrine reviews.

[24]  M. Kaplan,et al.  Hypothyroidism and Thyroiditis , 2002 .

[25]  G. Brent.  Graves’ Disease , 2000, Endocrine Updates.

[26]  J. Oppenheimer,et al.  Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat. , 1991, The Journal of clinical investigation.

[27]  F. Gohs,et al.  Reference range data base for serum chemistry and hematology values in laboratory animals. , 1986, Journal of toxicology and environmental health.

[28]  R. Williams,et al.  Williams Textbook of endocrinology , 1985 .

[29]  S. Shimoda,et al.  [Methods for the measurement of free thyroid hormones (author's transl)]. , 1982, Horumon to rinsho. Clinical endocrinology.