Aldehyde oxidase 1 activity and protein expression in human, rabbit, and pig ocular tissues.

[1]  T. Lassila,et al.  Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues , 2022, Drug Metabolism and Disposition.

[2]  A. Urtti,et al.  Ocular metabolism and distribution of drugs in the rabbit eye: quantitative assessment after intracameral and intravitreal administrations. , 2021, International journal of pharmaceutics.

[3]  W. Lagrèze,et al.  The Human Eye Transcriptome Atlas: A Searchable Comparative Transcriptome Database for Healthy and Diseased Human Eye Tissue , 2021, bioRxiv.

[4]  T. Lassila,et al.  Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues , 2021, Molecular pharmaceutics.

[5]  Philip C. Smith,et al.  Differential Detergent Fractionation of Membrane Protein From Small Samples of Hepatocytes and Liver Tissue for Quantitative Proteomic Analysis of Drug Metabolizing Enzymes and Transporters. , 2020, Journal of pharmaceutical sciences.

[6]  Jeffrey P. Jones,et al.  Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey , 2020, Drug Metabolism and Disposition.

[7]  H. Yamazaki,et al.  Human Aldehyde Oxidase 1–Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes , 2020, Drug Metabolism and Disposition.

[8]  M. Romão,et al.  Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes , 2020, The Journal of Biological Chemistry.

[9]  C. Beedham.  Aldehyde oxidase; new approaches to old problems , 2020, Xenobiotica; the fate of foreign compounds in biological systems.

[10]  E. Garattini,et al.  Aldehyde oxidase at the crossroad of metabolism and preclinical screening , 2019, Drug metabolism reviews.

[11]  L. Di,et al.  Aldehyde oxidase and its role as a drug metabolizing enzyme. , 2019, Pharmacology & therapeutics.

[12]  Craig R. Lee,et al.  Targeted quantitative proteomic analysis of drug metabolizing enzymes and transporters by nano LC-MS/MS in the sandwich cultured human hepatocyte model. , 2019, Journal of pharmacological and toxicological methods.

[13]  Jeffrey P. Jones,et al.  Time Course of Aldehyde Oxidase and Why It Is Nonlinear , 2019, Drug Metabolism and Disposition.

[14]  A. Urtti,et al.  Esterase activity in porcine and albino rabbit ocular tissues , 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[15]  V. Sasseville,et al.  Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route , 2018, Drug Metabolism and Disposition.

[16]  L. Ferrucci,et al.  The Human Eye Proteome Project: Updates on an Emerging Proteome , 2018, Proteomics.

[17]  M. Hecker,et al.  A rapid and sensitive fluorometric method for determination of aldehyde oxidase activity , 2018, Toxicology and applied pharmacology.

[18]  S. Leimkühler,et al.  Direct comparison of the four aldehyde oxidase enzymes present in mouse gives insight into their substrate specificities , 2018, PloS one.

[19]  S. Gygi,et al.  Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes , 2017, Scientific Reports.

[20]  U. Argikar,et al.  Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet? , 2017, Journal of pharmaceutical sciences.

[21]  S. Leimkühler,et al.  Direct Comparison of the Enzymatic Characteristics and Superoxide Production of the Four Aldehyde Oxidase Enzymes Present in Mouse , 2017, Drug Metabolism and Disposition.

[22]  S. Pinto,et al.  Toward Postgenomics Ophthalmology: A Proteomic Map of the Human Choroid-Retinal Pigment Epithelium Tissue. , 2017, Omics : a journal of integrative biology.

[23]  M. Romão,et al.  Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms , 2016, Drug Metabolism and Disposition.

[24]  Y. Kaneko,et al.  Species differences in metabolism of ripasudil (K-115) are attributed to aldehyde oxidase , 2016, Xenobiotica; the fate of foreign compounds in biological systems.

[25]  Sangya Pundir,et al.  UniProt Tools , 2016, Current protocols in bioinformatics.

[26]  T. Lassila,et al.  Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes. , 2015, Journal of pharmaceutical and biomedical analysis.

[27]  M. Romão,et al.  Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase. , 2015, Nature chemical biology.

[28]  Jeffrey P. Jones,et al.  Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidase. , 2015, Biochemical pharmacology.

[29]  Jeffrey P. Jones,et al.  A Novel Reaction Mediated by Human Aldehyde Oxidase: Amide Hydrolysis of GDC-0834 , 2015, Drug Metabolism and Disposition.

[30]  Natércia F. Brás,et al.  Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases , 2014, JBIC Journal of Biological Inorganic Chemistry.

[31]  H. Mizuo,et al.  Oxidative Metabolic Pathway of Lenvatinib Mediated by Aldehyde Oxidase , 2014, Drug Metabolism and Disposition.

[32]  Edward J Kelly,et al.  Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition , 2014, Drug metabolism reviews.

[33]  G. Gudi,et al.  Effect of commonly used organic solvents on Aldehyde oxidase-mediated Vanillin, Phthalazine and Methotrexate oxidation in human, rat and mouse liver subcellular fractions , 2014, Xenobiotica; the fate of foreign compounds in biological systems.

[34]  R. Nirogi,et al.  Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions , 2014, Xenobiotica; the fate of foreign compounds in biological systems.

[35]  S. Ramanathan,et al.  The pharmacokinetics and safety of idelalisib in subjects with severe renal impairment , 2013, Cancer Chemotherapy and Pharmacology.

[36]  Jeffrey P. Jones,et al.  Evaluation of Rhesus Monkey and Guinea Pig Hepatic Cytosol Fractions as Models for Human Aldehyde Oxidase , 2013, Drug Metabolism and Disposition.

[37]  R. Obach,et al.  Aldehyde Oxidase 1 (AOX1) in Human Liver Cytosols: Quantitative Characterization of AOX1 Expression Level and Activity Relationship , 2013, Drug Metabolism and Disposition.

[38]  L. Pattini,et al.  Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression , 2012, Cellular and Molecular Life Sciences.

[39]  Enrico Garattini,et al.  The role of aldehyde oxidase in drug metabolism , 2012, Expert opinion on drug metabolism & toxicology.

[40]  Jeffrey P. Jones,et al.  Inhibition of Human Liver Aldehyde Oxidase: Implications for Potential Drug-Drug Interactions , 2011, Drug Metabolism and Disposition.

[41]  Deepak Dalvie,et al.  Aldehyde oxidase: an enzyme of emerging importance in drug discovery. , 2010, Journal of medicinal chemistry.

[42]  S. Yamaguchi,et al.  A Single Amino Acid Substitution Confers High Cinchonidine Oxidation Activity Comparable with That of Rabbit to Monkey Aldehyde Oxidase 1 , 2010, Drug Metabolism And Disposition.

[43]  M. Fratelli,et al.  The mammalian aldehyde oxidase gene family , 2009, Human Genomics.

[44]  J. Sahi,et al.  Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human. , 2008, Drug metabolism letters.

[45]  M. Fratelli,et al.  Mammalian aldehyde oxidases: genetics, evolution and biochemistry , 2008, Cellular and Molecular Life Sciences.

[46]  R. Obach,et al.  Human Liver Aldehyde Oxidase: Inhibition by 239 Drugs , 2004, Journal of clinical pharmacology.

[47]  M. Romão,et al.  Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology. , 2003, The Biochemical journal.

[48]  L. Wheeler,et al.  Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes. , 2002, Drug metabolism and disposition: the biological fate of chemicals.

[49]  R. J. Price,et al.  Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase , 2002, Xenobiotica; the fate of foreign compounds in biological systems.

[50]  Y. Moriwaki,et al.  Widespread cellular distribution of aldehyde oxidase in human tissues found by immunohistochemistry staining. , 2001, Histology and histopathology.

[51]  S. Kitamura,et al.  Extremely high drug-reductase activity based on aldehyde oxidase in monkey liver. , 2001, Biological & pharmaceutical bulletin.

[52]  J. Paxton,et al.  Inter-species variation in the metabolism and inhibition of N-[(2'-dimethylamino)ethyl]acridine-4-carboxamide (DACA) by aldehyde oxidase. , 2000, Biochemical pharmacology.

[53]  S. Kitamura,et al.  Variation of Hepatic Methotrexate 7‐Hydroxylase Activity in Animals and Humans , 1999, IUBMB life.

[54]  B. Kirchhof,et al.  Topical application of methotrexate for inhibition of corneal angiogenesis , 1999, Graefe's Archive for Clinical and Experimental Ophthalmology.

[55]  S. Demontis,et al.  Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone. , 1999, The Biochemical journal.

[56]  A. Furukawa,et al.  Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. , 1999, Archives of biochemistry and biophysics.

[57]  J. Brown,et al.  Aldehyde Oxidase‐catalysed Oxidation of Methotrexate in the Liver of Guinea‐pig, Rabbit and Man , 1999, The Journal of pharmacy and pharmacology.

[58]  B. Testa,et al.  Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver. , 1998, Biochemical pharmacology.

[59]  M. Rashidi,et al.  In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver. , 1997, Drug metabolism and disposition: the biological fate of chemicals.

[60]  S. Kitamura,et al.  Involvement of mammalian liver cytosols and aldehyde oxidase in reductive metabolism of zonisamide. , 1996, Drug metabolism and disposition: the biological fate of chemicals.

[61]  C. Beedham,et al.  Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon. , 1995, Archives of biochemistry and biophysics.

[62]  S. Clarke,et al.  Role of aldehyde oxidase in the in vitro conversion of famciclovir to penciclovir in human liver. , 1995, Drug metabolism and disposition: the biological fate of chemicals.

[63]  C. Beedham,et al.  Species variation in hepatic aldehyde oxidase activity , 1987, European Journal of Drug Metabolism and Pharmacokinetics.

[64]  S. Kitamura,et al.  Nicotinamide N-oxide reductase activity in bovine and rabbit eyes. , 1987, Investigative ophthalmology & visual science.

[65]  P. Rissanen,et al.  The Steady-State Pharmacokinetics of Tamoxifen and its Metabolites in Breast Cancer Patients , 1986, The Journal of international medical research.

[66]  J. Stell,et al.  Elevation of molybdenum hydroxylase levels in rabbit liver after ingestion of phthalazine or its hydroxylated metabolite. , 1984, Biochemical pharmacology.

[67]  S. Kitamura,et al.  Reduction of tertiary amine N-oxides by liver preparations: function of aldehyde oxidase as a major N-oxide reductase. , 1984, Biochemical and biophysical research communications.

[68]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[69]  D. Johns.  Human liver aldehyde oxidase: differential inhibition of oxidation of charged and uncharged substrates. , 1967, The Journal of clinical investigation.

[70]  Maurits J. J. Dijkstra,et al.  Multiple Sequence Alignment. , 2017, Methods in molecular biology.

[71]  B. Kearney,et al.  Clinical Pharmacokinetic and Pharmacodynamic Profile of Idelalisib , 2015, Clinical Pharmacokinetics.

[72]  M. Nishimura,et al.  Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes. , 2006, Drug metabolism and pharmacokinetics.

[73]  C. Beedham,et al.  Enzymatic oxidation of phthalazine with guinea pig liver aldehyde oxidase and liver slices: inhibition by isovanillin. , 2004, Acta biochimica Polonica.

[74]  Michael D. Abràmoff,et al.  Image processing with ImageJ , 2004 .

[75]  S. Munk,et al.  Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase. , 1996, Xenobiotica; the fate of foreign compounds in biological systems.

[76]  S. Kitamura,et al.  Purification of aldehyde oxidase from bovine ciliary body. , 1989, Current eye research.

[77]  T. Krenitsky.  Xanthine oxidase and aldehyde oxidase in purine and purine analogue metabolism. , 1973, Advances in experimental medicine and biology.

[78]  T. Terasaki,et al.  Fluids and Barriers of the Cns , 2022 .