Automatic segmentation of multimodal brain tumor images based on classification of super-voxels

Despite the rapid growth in brain tumor segmentation approaches, there are still many challenges in this field. Automatic segmentation of brain images has a critical role in decreasing the burden of manual labeling and increasing robustness of brain tumor diagnosis. We consider segmentation of glioma tumors, which have a wide variation in size, shape and appearance properties. In this paper images are enhanced and normalized to same scale in a preprocessing step. The enhanced images are then segmented based on their intensities using 3D super-voxels. Usually in images a tumor region can be regarded as a salient object. Inspired by this observation, we propose a new feature which uses a saliency detection algorithm. An edge-aware filtering technique is employed to align edges of the original image to the saliency map which enhances the boundaries of the tumor. Then, for classification of tumors in brain images, a set of robust texture features are extracted from super-voxels. Experimental results indicate that our proposed method outperforms a comparable state-of-the-art algorithm in term of dice score.

[1]  Brian B. Avants,et al.  The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) , 2015, IEEE Transactions on Medical Imaging.

[2]  R. Meier,et al.  A Hybrid Model for Multimodal Brain Tumor Segmentation , 2013 .

[3]  Pascal Fua,et al.  SLIC Superpixels Compared to State-of-the-Art Superpixel Methods , 2012, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[4]  Paulo J. G. Lisboa,et al.  The Use of Artificial Neural Networks in Decision Support in Cancer: a Systematic Review , 2005 .

[5]  FuaPascal,et al.  SLIC Superpixels Compared to State-of-the-Art Superpixel Methods , 2012 .

[6]  Matti Pietikäinen,et al.  A comparative study of texture measures with classification based on featured distributions , 1996, Pattern Recognit..

[7]  Subhashis Banerjee,et al.  A Novel GBM Saliency Detection Model Using Multi-Channel MRI , 2016, PloS one.

[8]  P. Kleihues,et al.  Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. , 2005, Journal of neuropathology and experimental neurology.

[9]  Hoo-Chang Shin,et al.  Hybrid Clustering and Logistic Regression for Multi-Modal Brain Tumor Segmentation , 2012 .

[10]  Dong Hye Ye,et al.  Context-sensitive Classication Forests for Segmentation of Brain Tumor Tissues , 2012 .

[11]  Ashutosh Saxena,et al.  Make3D: Learning 3D Scene Structure from a Single Still Image , 2009, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[12]  Paul A. Yushkevich,et al.  Multi-atlas Segmentation without Registration: A Supervoxel-Based Approach , 2013, MICCAI.

[13]  Ezequiel Geremia,et al.  Spatial Decision Forests for Glioma Segmentation in Multi-Channel MR Images , 2011 .

[14]  Bjoern H Menze,et al.  Patch-based Segmentation of Brain Tissues , 2013 .

[15]  Enhua Wu,et al.  Constant Time Weighted Median Filtering for Stereo Matching and Beyond , 2013, 2013 IEEE International Conference on Computer Vision.

[16]  Sabine Süsstrunk,et al.  Saliency detection using maximum symmetric surround , 2010, 2010 IEEE International Conference on Image Processing.