Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration

Kinesin-5 is traditionally considered a mitotic motor protein. This article presents evidence that kinesin-5 is also critically influential in the process of neuronal migration, wherein terminally postmitotic neurons undergo orderly movement from their sites of birth to their final destinations.

[1]  R. Köster,et al.  The centrosome neither persistently leads migration nor determines the site of axonogenesis in migrating neurons in vivo , 2010, The Journal of cell biology.

[2]  P. Baas,et al.  Kinesin-12, a Mitotic Microtubule-Associated Motor Protein, Impacts Axonal Growth, Navigation, and Branching , 2010, The Journal of Neuroscience.

[3]  D. Xia,et al.  Leading Tip Drives Soma Translocation via Forward F-Actin Flow during Neuronal Migration , 2010, The Journal of Neuroscience.

[4]  M. Valdeolmillos,et al.  Actomyosin Contraction at the Cell Rear Drives Nuclear Translocation in Migrating Cortical Interneurons , 2010, The Journal of Neuroscience.

[5]  Cheng-Hai Zhang,et al.  Trio Is a Key Guanine Nucleotide Exchange Factor Coordinating Regulation of the Migration and Morphogenesis of Granule Cells in the Developing Cerebellum* , 2010, The Journal of Biological Chemistry.

[6]  R. Hindges,et al.  Rac1 Regulates Neuronal Polarization through the WAVE Complex , 2010, The Journal of Neuroscience.

[7]  L. Qiang,et al.  Basic Fibroblast Growth Factor Elicits Formation of Interstitial Axonal Branches via Enhanced Severing of Microtubules , 2010, Molecular biology of the cell.

[8]  J. Chelly,et al.  Tubulin-related cortical dysgeneses: microtubule dysfunction underlying neuronal migration defects. , 2009, Trends in genetics : TIG.

[9]  Shaun S. Gleason,et al.  Myosin II Motors and F-Actin Dynamics Drive the Coordinated Movement of the Centrosome and Soma during CNS Glial-Guided Neuronal Migration , 2009, Neuron.

[10]  R. Vallee,et al.  Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones. , 2009, Trends in cell biology.

[11]  A. Represa,et al.  Mutations in the β-tubulin gene TUBB2B result in asymmetrical polymicrogyria , 2009, Nature Genetics.

[12]  P. Baas,et al.  Kinesin-5 Is Essential for Growth-Cone Turning , 2008, Current Biology.

[13]  Hiroki Umeshima,et al.  Microtubule-based nuclear movement occurs independently of centrosome positioning in migrating neurons , 2007, Proceedings of the National Academy of Sciences.

[14]  P. Baas,et al.  Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array , 2007, The Journal of cell biology.

[15]  R. Vallee,et al.  Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissue , 2007, Nature Neuroscience.

[16]  S. Strome,et al.  Kinesin-5 acts as a brake in anaphase spindle elongation , 2007, Current Biology.

[17]  Li-Huei Tsai,et al.  Trekking across the Brain: The Journey of Neuronal Migration , 2007, Cell.

[18]  Steve D. M. Brown,et al.  Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans , 2007, Cell.

[19]  M. Black,et al.  Antagonistic Forces Generated by Cytoplasmic Dynein and Myosin‐II during Growth Cone Turning and Axonal Retraction , 2006, Traffic.

[20]  A. Musacchio,et al.  Regulation of Cytoplasmic Dynein ATPase by Lis1 , 2006, The Journal of Neuroscience.

[21]  Jared C Cochran,et al.  ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol. , 2005, Biochemistry.

[22]  S. Mcconnell,et al.  Cytoskeletal coordination during neuronal migration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[23]  A. Kriegstein,et al.  LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages , 2005, The Journal of cell biology.

[24]  Michel Bornens,et al.  Nucleokinesis in Tangentially Migrating Neurons Comprises Two Alternating Phases: Forward Migration of the Golgi/Centrosome Associated with Centrosome Splitting and Myosin Contraction at the Rear , 2005, The Journal of Neuroscience.

[25]  Li-Huei Tsai,et al.  Nucleokinesis in Neuronal Migration , 2005, Neuron.

[26]  E. Peterman,et al.  The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks , 2005, Nature.

[27]  J. Huh,et al.  Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures. , 2005, Cell motility and the cytoskeleton.

[28]  M. Black,et al.  Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments , 2005, The Journal of cell biology.

[29]  N. Rusan,et al.  Centrosome fragments and microtubules are transported asymmetrically away from division plane in anaphase , 2005, The Journal of cell biology.

[30]  P. Baas,et al.  Role of Actin Filaments in the Axonal Transport of Microtubules , 2004, The Journal of Neuroscience.

[31]  M. Hatten,et al.  Par6α signaling controls glial-guided neuronal migration , 2004, Nature Neuroscience.

[32]  A. Wynshaw-Boris,et al.  Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration , 2004, The Journal of cell biology.

[33]  P. Baas,et al.  Monastrol, a prototype anti-cancer drug that inhibits a mitotic kinesin, induces rapid bursts of axonal outgrowth from cultured postmitotic neurons. , 2004, Cell motility and the cytoskeleton.

[34]  J. Sibarita,et al.  Microtubule release from the centrosome in migrating cells , 2002, The Journal of cell biology.

[35]  Lei Wang,et al.  Rapid Movement of Microtubules in Axons , 2002, Current Biology.

[36]  N. Nakatsuji,et al.  Efficient gene transfer into the embryonic mouse brain using in vivo electroporation. , 2001, Developmental biology.

[37]  G. C. Rogers,et al.  Microtubule motors in mitosis , 2000, Nature.

[38]  Torsten Wittmann,et al.  Motor proteins regulate force interactions between microtubules and microfilaments in the axon , 2000, Nature Cell Biology.

[39]  G. Lyons,et al.  Expression of the Mitotic Motor Protein Eg5 in Postmitotic Neurons: Implications for Neuronal Development , 1998, The Journal of Neuroscience.

[40]  D. Ledbetter,et al.  Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality , 1998, Nature Genetics.

[41]  G. Bix,et al.  Platelet-Activating Factor Receptor Stimulation Disrupts Neuronal Migration In Vitro , 1998, The Journal of Neuroscience.

[42]  A. Pearlman,et al.  Abnormal reorganization of preplate neurons and their associated extracellular matrix: An early manifestation of altered neocortical development in the reeler mutant mouse , 1997, The Journal of comparative neurology.

[43]  T. Schroer,et al.  Opposing motor activities are required for the organization of the mammalian mitotic spindle pole , 1996, The Journal of cell biology.

[44]  P. Rakic,et al.  Polarity of microtubule assemblies during neuronal cell migration. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[45]  J. Altman,et al.  Development of the Cerebellar System: In Relation to Its Evolution, Structure, and Functions , 1996 .

[46]  F. Ahmad,et al.  Microtubule fragmentation and partitioning in the axon during collateral branch formation , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[47]  M. Miura,et al.  Cell adhesion molecule L1 guides cell migration in primary reaggregation cultures of mouse cerebellar cells , 1992, Neuroscience Letters.

[48]  P. Liesi.  Neuronal migration on laminin involves neuronal contact formation followed by nuclear movement inside a preformed process , 1992, Experimental Neurology.

[49]  M. Hatten,et al.  Mechanisms of glial-guided neuronal migration in vitro and in vivo , 1990, Experientia.

[50]  D. Dahl,et al.  Expression of neurofilament immunoreactivity in developing rat cerebellum in vitro and in vivo , 1989, Neuroscience Letters.

[51]  C. Mason,et al.  Cytology and neuron-glial apposition of migrating cerebellar granule cells in vitro , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[52]  R. Vallee,et al.  Isolated flagellar outer arm dynein translocates brain microtubules in vitro , 1987, Nature.

[53]  P. Liesi.  Do neurons in the vertebrate CNS migrate on laminin? , 1985, The EMBO journal.

[54]  M. Schachner,et al.  L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum , 1983, Nature.

[55]  J. Altman.  Postnatal development of the cerebellar cortex in the rat. IV. Spatial organization of bipolar cells, parallel fibers and glial palisades , 1975, The Journal of comparative neurology.

[56]  P. Rakić,et al.  Neuronal migration, with special reference to developing human brain: a review. , 1973, Brain research.

[57]  J. Altman,et al.  Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layer , 1972, The Journal of comparative neurology.

[58]  J. Altman,et al.  Autoradiographic and histological studies of postnatal neurogenesis. III. Dating the time of production and onset of differentiation of cerebellar microneurons in rats , 1969, The Journal of comparative neurology.

[59]  A. Represa,et al.  Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria , 2011 .

[60]  M. Hatten,et al.  Par6alpha signaling controls glial-guided neuronal migration. , 2004, Nature neuroscience.

[61]  J. Solowska,et al.  Expression of the mitotic kinesin Kif15 in postmitotic neurons: Implications for neuronal migration and development , 2003, Journal of neurocytology.

[62]  G. Moonen,et al.  Laminin promotes cerebellar granule cells migration in vitro and is synthesized by cultured astrocytes. , 1985, Developmental neuroscience.

[63]  J. Altman,et al.  Autoradiographic and histological studies of post-natal neurogenesis IV , 1966 .