Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease.
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Guojun Bu | David M Holtzman | Joachim Herz | D. Holtzman | G. Bu | J. Herz
[1] L. Mucke,et al. Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. , 2012, Cold Spring Harbor perspectives in medicine.
[2] M. Leissring,et al. Proteolytic degradation of amyloid β-protein. , 2012, Cold Spring Harbor perspectives in medicine.
[3] C. Haass,et al. Trafficking and proteolytic processing of APP. , 2012, Cold Spring Harbor perspectives in medicine.
[4] K. Reymann,et al. Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors , 2011, Neurobiology of Aging.
[5] David M Holtzman,et al. Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance , 2011, Science Translational Medicine.
[6] Rudi D'Hooge,et al. Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant , 2011, The Journal of Neuroscience.
[7] L. Mucke,et al. Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease , 2011, The Journal of Neuroscience.
[8] K. Ashe,et al. Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration , 2010, Neuron.
[9] J. Herz,et al. Lipoprotein receptors – an evolutionarily ancient multifunctional receptor family , 2010, Biological chemistry.
[10] Prema Subbarayal,et al. Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain. , 2010, The Biochemical journal.
[11] M. Frotscher. Role for Reelin in stabilizing cortical architecture , 2010, Trends in Neurosciences.
[12] Jürgen Götz,et al. Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models , 2010, Cell.
[13] R. Nitsch,et al. Reduced Reelin Expression Accelerates Amyloid-β Plaque Formation and Tau Pathology in Transgenic Alzheimer's Disease Mice , 2010, The Journal of Neuroscience.
[14] L. Mucke,et al. Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks , 2010, Nature Neuroscience.
[15] J. Herz,et al. ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling , 2010, Proceedings of the National Academy of Sciences.
[16] W. Klein,et al. Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5 , 2010, Neuron.
[17] M. Giustetto,et al. Learning, AMPA receptor mobility and synaptic plasticity depend on n‐cofilin‐mediated actin dynamics , 2010, The EMBO journal.
[18] M. Götz,et al. LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche , 2010, Journal of Cell Science.
[19] S. Strittmatter,et al. Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein , 2010, The Journal of Neuroscience.
[20] M. Frotscher,et al. Emerging topics in Reelin function , 2010, The European journal of neuroscience.
[21] Courtney M. Karner,et al. Lrp4 Regulates Initiation of Ureteric Budding and Is Crucial for Kidney Formation – A Mouse Model for Cenani-Lenz Syndrome , 2010, PloS one.
[22] A. Bradley,et al. Ectodomains of the LDL Receptor-Related Proteins LRP1b and LRP4 Have Anchorage Independent Functions In Vivo , 2010, PloS one.
[23] Eduardo Soriano,et al. Reelin Regulates Postnatal Neurogenesis and Enhances Spine Hypertrophy and Long-Term Potentiation , 2010, The Journal of Neuroscience.
[24] A. Fagan,et al. APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging , 2010, Annals of neurology.
[25] D. Holtzman,et al. Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance , 2009, Neuron.
[26] E. Weeber,et al. ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo , 2009, The Journal of Neuroscience.
[27] Jin-Moo Lee,et al. Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide , 2009, Proceedings of the National Academy of Sciences.
[28] S. Strittmatter,et al. Cellular prion protein mediates the toxicity of beta-amyloid oligomers: implications for Alzheimer disease. , 2009, Archives of neurology.
[29] G. Bu,et al. Receptor-associated Protein Interacts with Amyloid-β Peptide and Promotes Its Cellular Uptake* , 2009, The Journal of Biological Chemistry.
[30] Joachim Herz,et al. Reelin signaling antagonizes β-amyloid at the synapse , 2009, Proceedings of the National Academy of Sciences.
[31] Nick C Fox,et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes , 2009, Nature Genetics.
[32] P. Bosco,et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease , 2009, Nature Genetics.
[33] O. Combarros,et al. Genetic Interaction between Tau and the Apolipoprotein E Receptor LRP1 Increases Alzheimer’s Disease Risk , 2009, Dementia and Geriatric Cognitive Disorders.
[34] D. Holtzman,et al. The Role of Apolipoprotein E in Alzheimer's Disease , 2009, Neuron.
[35] M. Frotscher,et al. Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge , 2009, Communicative & integrative biology.
[36] Joachim Herz,et al. Apolipoprotein E receptors in the nervous system , 2009, Current opinion in lipidology.
[37] E. Weeber,et al. ApoE isoform-dependent changes in hippocampal synaptic function , 2009, Molecular Neurodegeneration.
[38] O. Manzoni,et al. Reelin Secreted by GABAergic Neurons Regulates Glutamate Receptor Homeostasis , 2009, PloS one.
[39] Guojun Bu,et al. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy , 2009, Nature Reviews Neuroscience.
[40] Wytse J. Wadman,et al. The N-terminal region of reelin regulates postnatal dendritic maturation of cortical pyramidal neurons , 2009, Proceedings of the National Academy of Sciences.
[41] G. Alexander,et al. Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease , 2009, Proceedings of the National Academy of Sciences.
[42] D. Holtzman,et al. Microglia Mediate the Clearance of Soluble Aβ through Fluid Phase Macropinocytosis , 2009, The Journal of Neuroscience.
[43] K. Boycott,et al. Mutations in VLDLR as a Cause for Autosomal Recessive Cerebellar Ataxia With Mental Retardation (Dysequilibrium Syndrome) , 2009, Journal of child neurology.
[44] M. Ehlers,et al. The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity* , 2009, Journal of Biological Chemistry.
[45] J. Auwerx,et al. LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling* , 2009, Journal of Biological Chemistry.
[46] A. Palmeri,et al. Picomolar Amyloid-β Positively Modulates Synaptic Plasticity and Memory in Hippocampus , 2008, The Journal of Neuroscience.
[47] Katie Hamm,et al. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. , 2008, The Journal of clinical investigation.
[48] H. Bock,et al. γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1 , 2008, Science Signaling.
[49] G. D’Arcangelo,et al. The Reelin Signaling Pathway Promotes Dendritic Spine Development in Hippocampal Neurons , 2008, The Journal of Neuroscience.
[50] Shaomin Li,et al. Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory , 2008, Nature Medicine.
[51] D. Strickland,et al. LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. , 2008, Physiological reviews.
[52] D. Holtzman,et al. ApoE Promotes the Proteolytic Degradation of Aβ , 2008, Neuron.
[53] A. Pramatarova,et al. Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis , 2008, Journal of Cell Science.
[54] V. Narayanaswami,et al. Interaction with amyloid beta peptide compromises the lipid binding function of apolipoprotein E. , 2008, Biochemistry.
[55] D. Berman,et al. Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism , 2008, Nature Neuroscience.
[56] D. Holtzman,et al. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. , 2008, The Journal of clinical investigation.
[57] B. Zlokovic. The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders , 2008, Neuron.
[58] T. Terasaki,et al. Cerebral clearance of human amyloid‐β peptide (1–40) across the blood–brain barrier is reduced by self‐aggregation and formation of low‐density lipoprotein receptor‐related protein‐1 ligand complexes , 2007, Journal of neurochemistry.
[59] R. Vassar,et al. Molecular Neurodegeneration BioMed Central Review The Alzheimer's disease β-secretase enzyme, BACE1 , 2007 .
[60] Xianlin Han. Potential mechanisms contributing to sulfatide depletion at the earliest clinically recognizable stage of Alzheimer’s disease: a tale of shotgun lipidomics , 2007, Journal of neurochemistry.
[61] L. Muglia,et al. Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1 , 2007, Neuron.
[62] Jonathan A. Cooper,et al. Reelin and mDab1 regulate the development of hippocampal connections , 2007, Molecular and Cellular Neuroscience.
[63] Daniel Choquet,et al. NMDA Receptor Surface Trafficking and Synaptic Subunit Composition Are Developmentally Regulated by the Extracellular Matrix Protein Reelin , 2007, The Journal of Neuroscience.
[64] Anatol C. Kreitzer,et al. Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease , 2007, Neuron.
[65] A. Goate,et al. Clearance of amyloid-β by circulating lipoprotein receptors , 2007, Nature Medicine.
[66] N. Inestrosa,et al. ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity , 2007, Molecular Neurodegeneration.
[67] E. Weeber,et al. Deletion of Apolipoprotein E Receptor-2 in Mice Lowers Brain Selenium and Causes Severe Neurological Dysfunction and Death When a Low-Selenium Diet Is Fed , 2007, The Journal of Neuroscience.
[68] A. Myers,et al. Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease , 2007, Proceedings of the National Academy of Sciences.
[69] L. Mucke,et al. Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model , 2007, Science.
[70] D. Holtzman,et al. Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[71] Bernardo L Sabatini,et al. Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway , 2007, The Journal of Neuroscience.
[72] L. Mucke,et al. Reelin Depletion in the Entorhinal Cortex of Human Amyloid Precursor Protein Transgenic Mice and Humans with Alzheimer's Disease , 2007, The Journal of Neuroscience.
[73] K. Lunetta,et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease , 2007, Nature Genetics.
[74] D. Selkoe,et al. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide , 2007, Nature Reviews Molecular Cell Biology.
[75] R. Hammer,et al. ApoE Receptor 2 Controls Neuronal Survival in the Adult Brain , 2006, Current Biology.
[76] G. Rebeck,et al. Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons , 2006, Molecular Neurodegeneration.
[77] E. Weeber,et al. Differential Reelin-Induced Enhancement of NMDA and AMPA Receptor Activity in the Adult Hippocampus , 2006, The Journal of Neuroscience.
[78] D. Quartermain,et al. Blocking the apolipoprotein E/amyloid-β interaction as a potential therapeutic approach for Alzheimer's disease , 2006, Proceedings of the National Academy of Sciences.
[79] D. Holtzman,et al. Apolipoprotein E and Low Density Lipoprotein Receptor-related Protein Facilitate Intraneuronal Aβ42 Accumulation in Amyloid Model Mice* , 2006, Journal of Biological Chemistry.
[80] J. Herz,et al. Reelin, lipoprotein receptors and synaptic plasticity , 2006, Nature Reviews Neuroscience.
[81] K. Fukuchi,et al. Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice , 2006, Neurobiology of Aging.
[82] E. Weeber,et al. Altered hippocampus synaptic function in selenoprotein P deficient mice , 2006, Molecular Neurodegeneration.
[83] David Walker,et al. Profile and Regulation of Apolipoprotein E (ApoE) Expression in the CNS in Mice with Targeting of Green Fluorescent Protein Gene to the ApoE Locus , 2006, The Journal of Neuroscience.
[84] B. Gmeiner,et al. Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes. , 2006, Biochimie.
[85] R. Mahley,et al. Putting cholesterol in its place: apoE and reverse cholesterol transport. , 2006, The Journal of clinical investigation.
[86] D. Selkoe,et al. Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers , 2006, The Journal of physiology.
[87] M. Gallagher,et al. A specific amyloid-β protein assembly in the brain impairs memory , 2006, Nature.
[88] R. Hammer,et al. Functional Dissection of Reelin Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic Plasticity , 2006, The Journal of Neuroscience.
[89] M. Ehlers,et al. Apolipoprotein E Receptor 2 Interactions with the N-Methyl-D-aspartate Receptor* , 2006, Journal of Biological Chemistry.
[90] D. Holtzman,et al. Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease* , 2005, Journal of Biological Chemistry.
[91] M. Staufenbiel,et al. Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice* , 2005, Journal of Biological Chemistry.
[92] M. Hayden,et al. The Absence of ABCA1 Decreases Soluble ApoE Levels but Does Not Diminish Amyloid Deposition in Two Murine Models of Alzheimer Disease* , 2005, Journal of Biological Chemistry.
[93] R. Hammer,et al. Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. , 2005, Human molecular genetics.
[94] A. Fagan,et al. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. , 2005, The Journal of clinical investigation.
[95] Y. Matsuoka,et al. F-Spondin Interaction with the Apolipoprotein E Receptor ApoEr2 Affects Processing of Amyloid Precursor Protein , 2005, Molecular and Cellular Biology.
[96] B. Hyman,et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[97] I. Bezprozvanny,et al. Reelin Modulates NMDA Receptor Activity in Cortical Neurons , 2005, The Journal of Neuroscience.
[98] E. Wirrell,et al. Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification. , 2005, American journal of human genetics.
[99] M. Frotscher,et al. Modulation of Synaptic Plasticity and Memory by Reelin Involves Differential Splicing of the Lipoprotein Receptor Apoer2 , 2005, Neuron.
[100] G. D’Arcangelo. Apoer2: A Reelin Receptor to Remember , 2005, Neuron.
[101] P. Greengard,et al. Regulation of NMDA receptor trafficking by amyloid-β , 2005, Nature Neuroscience.
[102] Y. Goda,et al. The actin cytoskeleton: integrating form and function at the synapse. , 2005, Annual review of neuroscience.
[103] D. Holtzman,et al. The Low Density Lipoprotein Receptor Regulates the Level of Central Nervous System Human and Murine Apolipoprotein E but Does Not Modify Amyloid Plaque Pathology in PDAPP Mice* , 2005, Journal of Biological Chemistry.
[104] E. Weeber,et al. Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation In Vitro , 2005, The Journal of Neuroscience.
[105] Yonghe Li,et al. Rapid Endocytosis of the Low Density Lipoprotein Receptor-related Protein Modulates Cell Surface Distribution and Processing of the β-Amyloid Precursor Protein* , 2005, Journal of Biological Chemistry.
[106] D. Holtzman,et al. Human Apolipoprotein E4 Alters the Amyloid-β 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model , 2005, The Journal of Neuroscience.
[107] S. Blacklow,et al. Phosphoinositide Binding by the Disabled-1 PTB Domain Is Necessary for Membrane Localization and Reelin Signal Transduction* , 2005, Journal of Biological Chemistry.
[108] J. D. McGaugh,et al. Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice , 2005, Neuron.
[109] M. Roth,et al. The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease* , 2004, Journal of Biological Chemistry.
[110] C. Finch,et al. Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers , 2004, The Journal of Neuroscience.
[111] Holly Soares,et al. Cerebrospinal fluid β-amyloid1–42 and tau in control subjects at risk for Alzheimer’s disease: The effect of APOE ε4 allele , 2004, Biological Psychiatry.
[112] L. Tsai,et al. Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning , 2004, Neuron.
[113] Edwin J. Weeber,et al. Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice , 2004, Molecular and Cellular Biology.
[114] L. Bernier,et al. Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain* , 2004, Journal of Biological Chemistry.
[115] Peter J. Lenting,et al. LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms , 2004, Neuron.
[116] A. Levey,et al. Loss of apolipoprotein E receptor LR11 in Alzheimer disease. , 2004, Archives of neurology.
[117] S. Lovestone,et al. GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila , 2004, Molecular Psychiatry.
[118] Yonghe Li,et al. The Low Density Lipoprotein Receptor-related Protein 1B Retains β-Amyloid Precursor Protein at the Cell Surface and Reduces Amyloid-β Peptide Production* , 2004, Journal of Biological Chemistry.
[119] S. Paul,et al. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides , 2004, Nature Medicine.
[120] L. Thal,et al. Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease , 2004, Neurology.
[121] Sascha Weggen,et al. FE65 Constitutes the Functional Link between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein , 2004, The Journal of Neuroscience.
[122] Michael W. Salter,et al. Src kinases: a hub for NMDA receptor regulation , 2004, Nature Reviews Neuroscience.
[123] J. Sweatt,et al. Receptor Clustering Is Involved in Reelin Signaling , 2004, Molecular and Cellular Biology.
[124] D. Holtzman,et al. Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[125] Bruce J Aronow,et al. ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition Evidence that ApoE Regulates Extracellular Aβ Metabolism In Vivo , 2004, Neuron.
[126] C. Quattrocchi,et al. Reelin Promotes Hippocampal Dendrite Development through the VLDLR/ApoER2-Dab1 Pathway , 2004, Neuron.
[127] Amir H Assadi,et al. Interaction of reelin signaling and Lis1 in brain development , 2003, Nature Genetics.
[128] F. Tang,et al. Cellular growth inhibition by IGFBP‐3 and TGF‐β1 requires LRP‐1 , 2003 .
[129] D. Holtzman,et al. Apolipoprotein E Markedly Facilitates Age-Dependent Cerebral Amyloid Angiopathy and Spontaneous Hemorrhage in Amyloid Precursor Protein Transgenic Mice , 2003, The Journal of Neuroscience.
[130] A. Goffinet,et al. Reelin and brain development , 2003, Nature Reviews Neuroscience.
[131] F. Pfrieger,et al. Cholesterol homeostasis and function in neurons of the central nervous system , 2003, Cellular and Molecular Life Sciences CMLS.
[132] J. Poirier. Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease. , 2003, Trends in molecular medicine.
[133] M. Vitek,et al. Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an Apolipoprotein E receptor/disabled‐1/glycogen synthase kinase‐3β cascade , 2003 .
[134] Lionel Arnaud,et al. Fyn Tyrosine Kinase Is a Critical Regulator of Disabled-1 during Brain Development , 2003, Current Biology.
[135] Joachim Herz,et al. Reelin Activates Src Family Tyrosine Kinases in Neurons , 2003, Current Biology.
[136] Joachim Herz,et al. Genetic Modulation of Tau Phosphorylation in the Mouse , 2003, The Journal of Neuroscience.
[137] H. Bock,et al. Reelin-mediated Signaling Locally Regulates Protein Kinase B/Akt and Glycogen Synthase Kinase 3β* , 2002, The Journal of Biological Chemistry.
[138] E. Masliah,et al. Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein , 2002, The Journal of Neuroscience.
[139] Xianlin Han,et al. Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein. , 2002, Journal of biochemistry.
[140] J. Sweatt,et al. Reelin and ApoE Receptors Cooperate to Enhance Hippocampal Synaptic Plasticity and Learning* , 2002, The Journal of Biological Chemistry.
[141] K. Zou,et al. Apolipoprotein E (ApoE) Isoform-dependent Lipid Release from Astrocytes Prepared from Human ApoE3 and ApoE4 Knock-in Mice* , 2002, The Journal of Biological Chemistry.
[142] Bruce J Aronow,et al. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[143] Richard G. W. Anderson,et al. Platelet-derived Growth Factor Mediates Tyrosine Phosphorylation of the Cytoplasmic Domain of the Low Density Lipoprotein Receptor-related Protein in Caveolae* , 2002, The Journal of Biological Chemistry.
[144] Sripriya Ranganathan,et al. Platelet-derived Growth Factor (PDGF)-induced Tyrosine Phosphorylation of the Low Density Lipoprotein Receptor-related Protein (LRP) , 2002, The Journal of Biological Chemistry.
[145] H. Bading,et al. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways , 2002, Nature Neuroscience.
[146] W. K. Cullen,et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo , 2002, Nature.
[147] A. Fagan,et al. Human and Murine ApoE Markedly Alters Aβ Metabolism before and after Plaque Formation in a Mouse Model of Alzheimer's Disease , 2002, Neurobiology of Disease.
[148] C. Göritz,et al. CNS synaptogenesis promoted by glia-derived cholesterol. , 2001, Science.
[149] B. Hyman,et al. Demonstration by Fluorescence Resonance Energy Transfer of Two Sites of Interaction between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein: Role of the Intracellular Adapter Protein Fe65 , 2001, The Journal of Neuroscience.
[150] Xianlin Han,et al. Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice , 2001, Neurochemistry International.
[151] A. Guidotti,et al. Dendritic Spine Hypoplasticity and Downregulation of Reelin and GABAergic Tone in Schizophrenia Vulnerability , 2001, Neurobiology of Disease.
[152] Johnm . Taylor,et al. Two Distal Downstream Enhancers Direct Expression of the Human Apolipoprotein E Gene to Astrocytes in the Brain , 2001, The Journal of Neuroscience.
[153] D. Holtzman,et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. , 2000, The Journal of clinical investigation.
[154] B. Hyman,et al. Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid β-peptide deposition in homozygous APPV717F transgenic mice , 2000, Acta Neuropathologica.
[155] B. Aronow,et al. Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis. , 2000, The Journal of clinical investigation.
[156] E. Boerwinkle,et al. Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene. , 2000, Genome research.
[157] Joachim Herz,et al. Apolipoprotein E receptors: linking brain development and alzheimer's disease , 2000, Nature Reviews Neuroscience.
[158] J. Richardson,et al. Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction* , 2000, The Journal of Biological Chemistry.
[159] W. Schneider,et al. The Reelin Receptor ApoER2 Recruits JNK-interacting Proteins-1 and -2* , 2000, Journal of Biological Chemistry.
[160] G. Cole,et al. Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta‐protein , 2000, Microscopy research and technique.
[161] A Rostagno,et al. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. , 2000, The Biochemical journal.
[162] A. Fagan,et al. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model , 2000, Annals of neurology.
[163] A. Fagan,et al. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[164] B. Hyman,et al. Modulation of β-Amyloid Precursor Protein Processing by the Low Density Lipoprotein Receptor-related Protein (LRP) , 2000, The Journal of Biological Chemistry.
[165] Q. Fan,et al. Apolipoprotein E Exhibits Isoform‐Specific Promotion of Lipid Efflux from Astrocytes and Neurons in Culture , 2000, Journal of neurochemistry.
[166] D. Holtzman,et al. Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation , 2000, The Journal of Neuroscience.
[167] S. Paul,et al. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[168] Joachim Herz,et al. Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation , 1999, Neuron.
[169] Ramin Homayouni,et al. Reelin Is a Ligand for Lipoprotein Receptors , 1999, Neuron.
[170] John Shelton,et al. Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2 , 1999, Cell.
[171] R. Martins,et al. Apolipoprotein E promotes the binding and uptake of β-amyloid into Chinese hamster ovary cells in an isoform-specific manner , 1999, Neuroscience.
[172] J. Gilbert,et al. Sialylated Human Apolipoprotein E (apoEs) Is Preferentially Associated with Neuron-Enriched Cultures from APOE Transgenic Mice , 1999, Neurobiology of Disease.
[173] J. Poirier,et al. The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease , 1999, Neuroscience Letters.
[174] J. Borg,et al. Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein* , 1998, The Journal of Biological Chemistry.
[175] A. Fagan,et al. Evidence for Normal Aging of the Septo-Hippocampal Cholinergic System in apoE (−/−) Mice but Impaired Clearance of Axonal Degeneration Products Following Injury , 1998, Experimental Neurology.
[176] T. Morgan,et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[177] D. Holtzman,et al. Nascent Astrocyte Particles Differ from Lipoproteins in CSF , 1998, Journal of neurochemistry.
[178] J. Poirier,et al. β‐Amyloid Peptides Increase the Binding and Internalization of Apolipoprotein E to Hippocampal Neurons , 1998, Journal of neurochemistry.
[179] T. Bliss,et al. Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse , 1998, Neuroscience.
[180] S. Paul,et al. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition , 1997, Nature Genetics.
[181] D. Holtzman,et al. α2‐Macroglobulin Complexes with and Mediates the Endocytosis of β‐Amyloid Peptide via Cell Surface Low‐Density Lipoprotein Receptor‐Related Protein , 1997 .
[182] J. Haines,et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. , 1997, JAMA.
[183] Dan Goldowitz,et al. Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice , 1997, Nature.
[184] C. Abraham,et al. Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease. , 1997, Biochemistry.
[185] R. Martins,et al. Characterization of the Binding of Amyloid‐β Peptide to Cell Culture‐Derived Native Apolipoprotein E2, E3, and E4 Isoforms and to Isoforms from Human Plasma , 1997, Journal of neurochemistry.
[186] M. Frotscher,et al. A role for Cajal–Retzius cells and reelin in the development of hippocampal connections , 1997, Nature.
[187] A. Fagan,et al. Apolipoprotein E-containing High Density Lipoprotein Promotes Neurite Outgrowth and Is a Ligand for the Low Density Lipoprotein Receptor-related Protein* , 1996, The Journal of Biological Chemistry.
[188] R. Wetzel,et al. Seeding of A beta fibril formation is inhibited by all three isotypes of apolipoprotein E. , 1996, Biochemistry.
[189] D K Burns,et al. Defective forebrain development in mice lacking gp330/megalin. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[190] I. McKeith,et al. Effects of apolipoprotein E genotype on cortical neuropathology in senile dementia of the Lewy body and Alzheimer's disease. , 1995, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.
[191] A. Roses,et al. Neurodegeneration in the Central Nervous System of apoE-Deficient Mice , 1995, Experimental Neurology.
[192] D. Holtzman,et al. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[193] B. Hyman,et al. Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy , 1995 .
[194] B. Hyman,et al. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation , 1995, Cell.
[195] H. Soininen,et al. Alzheimer pathology of patients carrying apoliprotein E ϵ4 allele , 1995, Neurobiology of Aging.
[196] T. Wisniewski,et al. Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E. , 1995, The Biochemical journal.
[197] B. Hyman,et al. Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein , 1995, Annals of neurology.
[198] P. Lansbury,et al. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[199] H. Brewer,et al. Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments , 1994, Nature.
[200] T Vogel,et al. Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. , 1994, The American journal of pathology.
[201] G. Getz,et al. Isoform-specific binding of apolipoprotein E to beta-amyloid. , 1994, The Journal of biological chemistry.
[202] A. Roses,et al. Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. , 1994, The Journal of clinical investigation.
[203] A. M. Saunders,et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease , 1994, Nature Genetics.
[204] R. Mahley,et al. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. , 1994, Science.
[205] A D Roses,et al. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[206] B. Hyman,et al. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions , 1993, Neuron.
[207] M. Pericak-Vance,et al. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[208] J. Haines,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.
[209] M. Pericak-Vance,et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[210] R. Hammer,et al. LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation , 1992, Cell.
[211] Thomas Wisniewski,et al. Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid , 1992, Neuroscience Letters.
[212] E. Otomo,et al. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease , 1991, Brain Research.
[213] R. Mahley,et al. Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. , 1990, The Journal of biological chemistry.
[214] R. Mahley,et al. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. , 1988, Science.
[215] L. Rudel,et al. Apolipoprotein (apo) A-I production and mRNA abundance explain plasma apoA-I and high density lipoprotein differences between two nonhuman primate species with high and low susceptibilities to diet-induced hypercholesterolemia. , 1988, The Journal of biological chemistry.
[216] R. Mahley,et al. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. , 1987, Biochimica et biophysica acta.
[217] J. Herz,et al. Differential functions of the Apoer2 intracellular domain in selenium uptake and cell signaling , 2009, Biological chemistry.
[218] S. Strittmatter,et al. Cellular Prion Protein Mediates the Toxicity of-Amyloid Oligomers Implications for Alzheimer Disease , 2009 .
[219] D. Blacker,et al. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database , 2007, Nature Genetics.
[220] P. Greengard,et al. Regulation of NMDA receptor trafficking by amyloid-beta. , 2005, Nature neuroscience.
[221] R. Martins,et al. Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding. , 2005, Journal of Alzheimer's disease : JAD.
[222] S Lovestone,et al. GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila , 2004, Molecular Psychiatry.
[223] D. Loukinov,et al. Platelet-derived Growth Factor (PDGF)-induced Tyrosine Phosphorylation of the Low Density Lipoprotein Receptor-related Protein (LRP) EVIDENCE FOR INTEGRATED CO-RECEPTOR FUNCTION BETWEEN LRP AND THE PDGF* , 2002 .
[224] Donald,et al. Isoform-specific Binding of Apolipoprotein E to p-Amyloid* , 2001 .
[225] R. Mahley,et al. Apolipoprotein E: far more than a lipid transport protein. , 2000, Annual review of genomics and human genetics.
[226] Jonathan A. Cooper,et al. Mouse disabled (mDab1): a Src binding protein implicated in neuronal development , 1997, The EMBO journal.
[227] H. Soininen,et al. Alzheimer pathology of patients carrying apolipoprotein E epsilon 4 allele. , 1995, Neurobiology of aging.
[228] J. Ma,et al. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. , 1994, Nature.
[229] W. H. Heaton,et al. Plasma apolipoprotein A-1 absence associated with a marked reduction of high density lipoproteins and premature coronary artery disease. , 1982, Arteriosclerosis.