X-Ray Imaging with a Grating Interferometer

Improved contrast in X-ray images can be obtained through phase contrast and dark-field imaging. Of the different methods for phase contrast imaging, the recently developed grating based interferometer is well suited for use at different X-ray sources, including a standard X-ray tube. This thesis explains the principles of a grating based interferometer, and the algorithms for tomographic reconstruction of differential phase contrast and dark-field images are derived. Experimental data recorded at three different X-ray sources are presented, and the data quality depending on source properties are discussed.

[1]  William Thomlinson,et al.  Implementation of diffraction-enhanced imaging experiments: at the NSLS and APS , 2000 .

[2]  I. Robinson.  Elements of Modern X-ray Physics , 2002 .

[3]  Atsushi Momose,et al.  Demonstration of X-Ray Talbot Interferometry , 2003 .

[4]  S W Wilkins,et al.  Phase-contrast imaging using a scanning-double-grating configuration. , 2008, Optics express.

[5]  R. Loewen,et al.  A compact light source: Design and technical feasibility study of a laser-electron storage ring X-ray source , 2004 .

[6]  O. Bunk,et al.  Hard-X-ray dark-field imaging using a grating interferometer. , 2008, Nature materials.

[7]  C. David,et al.  Differential x-ray phase contrast imaging using a shearing interferometer , 2002 .

[8]  O. Bunk,et al.  Shearing interferometer for quantifying the coherence of hard x-ray beams. , 2005, Physical review letters.

[9]  Franz Pfeiffer,et al.  High-resolution differential phase contrast imaging using a magnifying projection geometry with a microfocus x-ray source , 2007 .

[10]  U. Bonse,et al.  AN X‐RAY INTERFEROMETER WITH LONG SEPARATED INTERFERING BEAM PATHS , 1965 .

[11]  F Busch,et al.  X-ray microtomography (microCT) using phase contrast for the investigation of organic matter. , 1997, Journal of computer assisted tomography.

[12]  A Bravin,et al.  High-resolution brain tumor visualization using three-dimensional x-ray phase contrast tomography , 2007, Physics in medicine and biology.

[13]  Franz Pfeiffer,et al.  Hard X-ray phase-contrast imaging with the Compact Light Source based on inverse Compton X-rays. , 2009, Journal of synchrotron radiation.

[14]  Timm Weitkamp,et al.  Tomography with grating interferometers at low-brilliance sources , 2006, SPIE Optics + Photonics.

[15]  O. Bunk,et al.  The fractional Talbot effect in differential x‐ray phase‐contrast imaging for extended and polychromatic x‐ray sources , 2008, Journal of microscopy.

[16]  Françoise Peyrin,et al.  Observation of microstructure and damage in materials by phase sensitive radiography and tomography , 1997 .

[17]  G. Fowles,et al.  Introduction to modern optics , 1968 .

[18]  Franz Pfeiffer,et al.  X-ray dark-field and phase-contrast imaging using a grating interferometer , 2009 .

[19]  T J Suleski,et al.  Generation of Lohmann images from binary-phase Talbot array illuminators. , 1997, Applied optics.

[20]  A Bravin,et al.  Region-of-interest tomography for grating-based X-ray differential phase-contrast imaging. , 2008, Physical review letters.

[21]  N. Galatsanos,et al.  Multiple-image radiography. , 2003, Physics in medicine and biology.

[22]  S. Wilkins,et al.  Phase-contrast imaging using polychromatic hard X-rays , 1996, Nature.

[23]  O. Bunk,et al.  Tomographic reconstruction of three-dimensional objects from hard X-ray differential phase contrast projection images , 2007 .

[24]  O. Bunk,et al.  X-ray imaging with the PILATUS 100k detector. , 2008, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[25]  R. Ruth,et al.  Laser-Electron Storage Ring , 1998 .

[26]  O. Bunk,et al.  Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources , 2006 .

[27]  P. Cloetens,et al.  Holotomography: Quantitative phase tomography with micrometer resolution using hard synchrotron radiation x rays , 1999 .

[28]  A. Bravin,et al.  Exploiting the x-ray refraction contrast with an analyser: the state of the art , 2003 .

[29]  Atsushi Momose,et al.  Phase Tomography by X-ray Talbot Interferometry for Biological Imaging , 2006 .

[30]  A. Momose,et al.  Phase-contrast radiographs of nonstained rat cerebellar specimen. , 1995, Medical physics.

[31]  V. N. Ingal,et al.  X-ray plane-wave topography observation of the phase contrast from a non-crystalline object , 1995 .

[32]  Franz Pfeiffer,et al.  X-ray phase imaging with a grating interferometer. , 2005, Optics express.

[33]  O. Bunk,et al.  A two-directional approach for grating based differential phase contrast imaging using hard x-rays. , 2007, Optics express.

[34]  S. Wilkins,et al.  Phase-contrast imaging of weakly absorbing materials using hard X-rays , 1995, Nature.

[35]  Franz Pfeiffer,et al.  Soft-tissue phase-contrast tomography with an x-ray tube source , 2009, Physics in medicine and biology.

[36]  B. L. Henke,et al.  X-Ray Interactions: Photoabsorption, Scattering, Transmission, and Reflection at E = 50-30,000 eV, Z = 1-92 , 1993 .

[37]  Y. Itai,et al.  Phase-Contrast X-Ray Imaging Using an X-Ray Interferometer for Biological Imaging , 2002 .

[38]  A. Momose,et al.  X-ray Phase Microtomography by Single Transmission Grating , 2007 .

[39]  G. Hounsfield.  Computerized transverse axial scanning (tomography): Part I. Description of system. 1973. , 1973, The British journal of radiology.

[40]  O. Bunk,et al.  Hard x-ray phase tomography with low-brilliance sources. , 2007, Physical review letters.

[41]  Gilles Peix,et al.  Hard x-ray phase imaging using simple propagation of a coherent synchrotron radiation beam , 1999 .

[42]  Wave packet dynamics and factorization of numbers , 2002, quant-ph/0204040.

[43]  A. Cormack.  Representation of a Function by Its Line Integrals, with Some Radiological Applications , 1963 .

[44]  A. Snigirev,et al.  On the possibilities of x-ray phase contrast microimaging by coherent high-energy synchrotron radiation , 1995 .

[45]  H Toyokawa,et al.  The PILATUS 1M detector. , 2006, Journal of synchrotron radiation.

[46]  Franz Pfeiffer,et al.  Hard X-ray phase imaging and tomography using a grating interferometer , 2007 .

[47]  Franz Pfeiffer,et al.  Fabrication of diffraction gratings for hard X-ray phase contrast imaging , 2007 .

[48]  A. W. Lohmann,et al.  An interferometer based on the Talbot effect , 1971 .