The Myc/Max/Mad network and the transcriptional control of cell behavior.
暂无分享,去创建一个
R. Eisenman | S. Cowley | C. Grandori | L. James | R N Eisenman | C Grandori | S M Cowley | L P James
[1] P. Leder,et al. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor , 1983, Cell.
[2] M. Cole,et al. The c-Myc Transactivation Domain Is a Direct Modulator of Apoptotic versus Proliferative Signals , 2000, Molecular and Cellular Biology.
[3] O. Volpert,et al. An in vivo function for the transforming Myc protein: elicitation of the angiogenic phenotype. , 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[4] G. Prendergast,et al. c‐Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II. , 1994, The EMBO journal.
[5] S. Goff,et al. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. , 1993, Science.
[6] G. Prendergast,et al. Methylation-sensitive sequence-specific DNA binding by the c-Myc basic region. , 1991, Science.
[7] Ken Chen,et al. Gene-target recognition among members of the Myc superfamily and implications for oncogenesis , 2000, Nature Genetics.
[8] J. Hopfield,et al. From molecular to modular cell biology , 1999, Nature.
[9] J L Cleveland,et al. The ornithine decarboxylase gene is a transcriptional target of c-Myc. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[10] G. Evan,et al. The c‐Myc protein induces cell cycle progression and apoptosis through dimerization with Max. , 1993, The EMBO journal.
[11] N. Jenkins,et al. Mga, a dual‐specificity transcription factor that interacts with Max and contains a T‐domain DNA‐binding motif , 1999, The EMBO journal.
[12] R. Eisenman,et al. Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 , 1995, Cell.
[13] A T Bankier,et al. Characterization of a transcription factor involved in mother cell specific transcription of the yeast HO gene. , 1988, The EMBO journal.
[14] G. D. Spotts,et al. Enhanced translation and increased turnover of c-myc proteins occur during differentiation of murine erythroleukemia cells , 1990, Molecular and cellular biology.
[15] S. Werner,et al. Expression of Mad, an antagonist of Myc oncoprotein function, in differentiating keratinocytes during tumorigenesis of the skin. , 1996, British Journal of Cancer.
[16] J. Rossant,et al. Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. , 1993, Development.
[17] M. Barone,et al. Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src , 1995, Nature.
[18] L. Chin,et al. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression , 1997, nature.
[19] R. Eisenman,et al. Sin Meets NuRD and Other Tails of Repression , 1999, Cell.
[20] R. DePinho,et al. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus , 1999, Nature.
[21] R. Eisenman,et al. c-Myc enhances protein synthesis and cell size during B lymphocyte development. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[22] P. Leder,et al. Functional role for c-myc in mitogenic response to platelet-derived growth factor , 1984, Nature.
[23] M. Eilers,et al. Control of cell proliferation by Myc. , 1998, Trends in cell biology.
[24] J. Nevins,et al. Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals , 1997, Molecular and cellular biology.
[25] D. Wechsler,et al. MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells. , 1997, Cancer research.
[26] C. Cultraro,et al. Function of the c-Myc antagonist Mad1 during a molecular switch from proliferation to differentiation , 1997, Molecular and cellular biology.
[27] G. Prendergast,et al. Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation , 1991, Cell.
[28] Q. Zhan,et al. Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents , 1998, Oncogene.
[29] J. Karn,et al. Regulation of cell cycle duration by c-myc levels. , 1989, Oncogene.
[30] G. Evan,et al. c‐Myc‐induced apoptosis in fibroblasts is inhibited by specific cytokines. , 1994, The EMBO journal.
[31] R. Eisenman,et al. A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation. , 1993, Genes & development.
[32] Wei Gu,et al. Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain , 1997, Cell.
[33] F. Alt,et al. Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes. , 1992, Genes & development.
[34] M. Eilers,et al. Activation of c-Myc uncouples DNA replication from activation of G1-cyclin-dependent kinases , 1997, Oncogene.
[35] R. Brent,et al. Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. , 1994, Oncogene.
[36] A. J. Walhout,et al. c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene. , 1997, Nucleic acids research.
[37] R. Eisenman,et al. Sequential expression of the MAD family of transcriptional repressors during differentiation and development , 1998, Oncogene.
[38] B. Amati,et al. Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death. , 1994, Current opinion in genetics & development.
[39] C. Dang,et al. Do products of the myc proto-oncogene play a role in transcriptional regulation of the prothymosin alpha gene? , 1995, Molecular and cellular biology.
[40] M. Roussel,et al. Inhibition of cell proliferation by the Mad1 transcriptional repressor , 1996, Molecular and cellular biology.
[41] C. Dang,et al. Max: functional domains and interaction with c-Myc. , 1992, Genes & development.
[42] Gerard I. Evan,et al. Induction of apoptosis in fibroblasts by c-myc protein , 1992, Cell.
[43] E. Prochownik,et al. Commonly occurring loss and mutation of the MXI1 gene in prostate cancer , 1998, Genes, chromosomes & cancer.
[44] V. Sorrentino,et al. Potentiation of growth factor activity by exogenous c-myc expression. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[45] J. Barrett,et al. An amino-terminal c-myc domain required for neoplastic transformation activates transcription , 1990, Molecular and cellular biology.
[46] M. Linial,et al. Viral Myc Oncoproteins in Infected Fibroblasts Down-modulate Thrombospondin-1, a Possible Tumor Suppressor Gene* , 1996, The Journal of Biological Chemistry.
[47] D. Ledbetter,et al. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non‐canonical E box and acts as a transcriptional repressor , 1997, The EMBO journal.
[48] A Ciechanover,et al. Degradation of nuclear oncoproteins by the ubiquitin system in vitro. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[49] R. DePinho,et al. Repression by the Mad(Mxi1)‐Sin3 complex , 1998, BioEssays : news and reviews in molecular, cellular and developmental biology.
[50] E. Ziff,et al. Mxi1 Is a Repressor of the c-myc Promoter and Reverses Activation by USF* , 1999, The Journal of Biological Chemistry.
[51] R. Tjian,et al. Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II , 1995, Cell.
[52] S. Mai,et al. c-Myc overexpression associated DHFR gene amplification in hamster, rat, mouse and human cell lines. , 1996, Oncogene.
[53] R. Eisenman,et al. Functional analysis of the AUG- and CUG-initiated forms of the c-Myc protein. , 1994, Molecular biology of the cell.
[54] G. Falcone,et al. Interaction with normal cells suppresses the transformed phenotype of v-myc-transformed quail muscle cells , 1989, Cell.
[55] C. Dang,et al. Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[56] D. Gillespie,et al. The leucine zipper domain of avian cMyc is required for transformation and autoregulation. , 1990, Oncogene.
[57] V. D’Agati,et al. Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD). , 1996, Oncogene.
[58] A. Manning,et al. Multiple signals converging on NF-κB , 1999 .
[59] R. Eisenman,et al. Myc‐Max heterodimers activate a DEAD box gene and interact with multiple E box‐related sites in vivo. , 1996, The EMBO journal.
[60] D. Beach,et al. Cdc25 cell-cycle phosphatase as a target of c-myc , 1996, Nature.
[61] G. Hannon,et al. Myc activates telomerase. , 1998, Genes & development.
[62] G. Evan,et al. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. , 1995, Nucleic acids research.
[63] R. Eisenman,et al. Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. , 1997, Genes & development.
[64] M. DePamphilis,et al. Is c-myc protein directly involved in DNA replication? , 1988, Science.
[65] R. Davis,et al. Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[66] K. Isselbacher,et al. Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[67] John R. Yates,et al. Tra1p Is a Component of the Yeast Ada·Spt Transcriptional Regulatory Complexes* , 1998, The Journal of Biological Chemistry.
[68] H. Varmus,et al. Definition of regions in human c-myc that are involved in transformation and nuclear localization , 1987, Molecular and cellular biology.
[69] A. Joyner,et al. A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung. , 1992, Genes & development.
[70] D. Gillespie,et al. Gene-regulatory properties of Myc helix-loop-helix/leucine zipper mutants: Max-dependent DNA binding and transcriptional activation in yeast correlates with transforming capacity. , 1993, Oncogene.
[71] R. Eeles,et al. No germline mutations in the dimerization domain of MXI1 in prostate cancer clusters. The CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group. , 1997, British Journal of Cancer.
[72] K. Arai,et al. Signal transduction by the high‐affinity GM‐CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. , 1993, The EMBO journal.
[73] Stephen K. Burley,et al. Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain , 1993, Nature.
[74] G. Inghirami,et al. Down-regulation of LFA-1 adhesion receptors by C-myc oncogene in human B lymphoblastoid cells. , 1990, Science.
[75] M. Kastan,et al. Altered cytoplasmic/nuclear distribution of the c-myc protein in differentiating ML-1 human myeloid leukemia cells. , 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[76] K Kornfeld,et al. Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. , 1999, Genes & development.
[77] Chi V. Dang,et al. c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism , 1999, Molecular and Cellular Biology.
[78] M. Cole,et al. max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors. , 1992, Oncogene.
[79] P. Farnham,et al. Identification of target genes of oncogenic transcription factors. , 1999, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[80] M. Polymenis,et al. An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc , 1996, Molecular and cellular biology.
[81] F M Watt,et al. c-Myc promotes differentiation of human epidermal stem cells. , 1997, Genes & development.
[82] L. Chin,et al. Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc , 1999, Oncogene.
[83] D. Green,et al. Apoptotic cell death induced by c-myc is inhibited by bcl-2 , 1992, Nature.
[84] M. Sporn,et al. Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor , 1986, Molecular and cellular biology.
[85] T. Lee,et al. Myc represses transcription of the growth arrest gene gas1. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[86] T. McDonnell,et al. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18) , 1991, Nature.
[87] G. Evan,et al. Cooperative interaction between c-myc and bcl-2 proto-oncogenes , 1992, Nature.
[88] M. Birrer,et al. A transfected L-myc gene can substitute for c-myc in blocking murine erythroleukemia differentiation , 1989, Molecular and cellular biology.
[89] J. L. Quesne,et al. C-Myc 5′ untranslated region contains an internal ribosome entry segment , 1998, Oncogene.
[90] David Baltimore,et al. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins , 1989, Cell.
[91] B. Emerson,et al. Transcription of chromatin: these are complex times. , 1998, Current opinion in genetics & development.
[92] D. Hanahan,et al. Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis. , 1995, Oncogene.
[93] K. Kinzler,et al. Genetic instabilities in human cancers , 1998, Nature.
[94] F. Watt,et al. Changes in expression of members of the fos and jun families and myc network during terminal differentiation of human keratinocytes. , 1995, Oncogene.
[95] Javier León,et al. c-Myc antagonizes the effect of p53 on apoptosis and p21WAF1 transactivation in K562 leukemia cells , 2000, Oncogene.
[96] D. Prober,et al. Drosophila myc Regulates Cellular Growth during Development , 1999, Cell.
[97] J. Shay,et al. Role of telomerase in cellular proliferation and cancer , 1999, Journal of cellular physiology.
[98] A. Sewing,et al. Cyclins D1 and D2 mediate Myc‐induced proliferation via sequestration of p27Kip1 and p21Cip1 , 1999, The EMBO journal.
[99] W. Schulz,et al. Dynamic expression pattern of the myc protooncogene in midgestation mouse embryos. , 1989, Science.
[100] M. Groudine,et al. Control of c-myc regulation in normal and neoplastic cells. , 1991, Advances in cancer research.
[101] L. Desbarats,et al. Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc. , 1996, Genes & development.
[102] Joseph R. Nevins,et al. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F , 1997, Nature.
[103] C. Dang,et al. Definition of the activities and properties of c-myc required to inhibit cell differentiation. , 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[104] Didier Picard,et al. Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells , 1989, Nature.
[105] S. Mai,et al. Myc-induced cyclin D2 genomic instability in murine B cell neoplasms. , 1999, Current topics in microbiology and immunology.
[106] T. Taniguchi,et al. IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc , 1992, Cell.
[107] S. Ishii,et al. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. , 1999, Genes & development.
[108] Olivier Delattre,et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer , 1998, Nature.
[109] B. Safer,et al. Formation of α-Pal/Max Heterodimers Synergistically Activates the eIF2-α Promoter* , 1998, The Journal of Biological Chemistry.
[110] A. Berns,et al. Retroviral insertional mutagenesis as a strategy to identify cancer genes. , 1996, Biochimica et biophysica acta.
[111] J. Cleveland,et al. Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis , 1994, Molecular and cellular biology.
[112] N. Hay,et al. Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. , 1994, Genes & development.
[113] P. Brown,et al. Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[114] R. Dalla‐Favera,et al. Direct activation of TERT transcription by c-MYC , 1999, Nature Genetics.
[115] Hisato Kondoh,et al. Transition of localization of the N-Myc protein from nucleus to cytoplasm in differentiating neurons , 1993, Neuron.
[116] W. Schulz,et al. A comparative analysis of N-myc and c-myc expression and cellular proliferation in mouse organogenesis , 1991, Mechanisms of Development.
[117] S. Schreiber,et al. Three proteins define a class of human histone deacetylases related to yeast Hda1p. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[118] Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc , 1998, Oncogene.
[119] P. Leder,et al. An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence. , 1992, Genes & development.
[120] E. Prochownik,et al. MYC oncogenes and human neoplastic disease , 1999, Oncogene.
[121] D. Brough,et al. An essential domain of the c-myc protein interacts with a nuclear factor that is also required for E1A-mediated transformation , 1995, Molecular and cellular biology.
[122] K. Struhl,et al. Repression by Ume6 Involves Recruitment of a Complex Containing Sin3 Corepressor and Rpd3 Histone Deacetylase to Target Promoters , 1997, Cell.
[123] E. Prochownik,et al. The leucine zipper of c-Myc is required for full inhibition of erythroleukemia differentiation , 1990, Molecular and cellular biology.
[124] P. Neiman,et al. The effect of alterations in myc gene expression on B cell development in the bursa of fabricius , 1987, Cell.
[125] R. DePinho,et al. Erratum: Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells (Nature Medicine (1995) 1 (638-643)) , 1995 .
[126] S. Cory,et al. Transgenic mice and oncogenesis. , 1988, Annual review of immunology.
[127] J L Cleveland,et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. , 1998, Genes & development.
[128] Stuart L Schreiber,et al. Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A , 1997, Cell.
[129] S. Schreiber,et al. A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p , 1996, Science.
[130] J. Nevins,et al. erratum: Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F , 1997, Nature.
[131] W. Ansorge,et al. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27 , 1999, The EMBO journal.
[132] L. Chin,et al. An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3 , 1995, Cell.
[133] F. Alt,et al. myc family oncogenes in the development of normal and neoplastic cells. , 1991, Advances in cancer research.
[134] L. Chin,et al. Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse , 1999, Cell.
[135] Arthur R. Brothman,et al. Mutation of the MXI1 gene in prostate cancer , 1995, Nature Genetics.
[136] H. Weintraub,et al. Acquisition of myogenic specificity by replacement of three amino acid residues from MyoD into E12. , 1992, Science.
[137] D. Ayer,et al. Mlx, a Novel Max-like BHLHZip Protein That Interacts with the Max Network of Transcription Factors* , 1999, The Journal of Biological Chemistry.
[138] R. DePinho,et al. Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[139] J. Cleveland,et al. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. , 1991, Oncogene.
[140] S. Mai,et al. The ribonucleotide reductase R2 gene is a non-transcribed target of c-Myc-induced genomic instability. , 1999, Gene.
[141] G. Evan,et al. Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. , 1999, Molecular cell.
[142] L. Chin,et al. Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1. , 1996, Oncogene.
[143] R. DePinho,et al. Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth , 1998, Nature.
[144] A. Perkins,et al. Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. , 1992, Genes & development.
[145] M. Cole,et al. The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc , 2000, Molecular and Cellular Biology.
[146] R. Eisenman,et al. Analysis of Myc/Max/Mad network members in adipogenesis: Inhibition of the proliferative burst and differentiation by ectopically expressed Mad1 , 2000, Journal of cellular physiology.
[147] M. Cole,et al. Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment , 1986, Nature.
[148] J. Dunlap. Molecular Bases for Circadian Clocks , 1999, Cell.
[149] W. Gu,et al. Opposite regulation of gene transcription and cell proliferation by c-Myc and Max. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[150] U. Pettersson,et al. Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[151] C. Seelos,et al. Differential effects by Mad and Max on transformation by cellular and viral oncoproteins. , 1995, Oncogene.
[152] H. Weintraub,et al. The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation , 1990, Cell.
[153] G. Evan,et al. Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis. , 1997, Science.
[154] A. Strasser,et al. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2 , 1990, Nature.
[155] J. Cleveland,et al. c-Myc and apoptosis. , 1995, Biochimica et biophysica acta.
[156] R. E. Esposito,et al. RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes , 1991, Molecular and cellular biology.
[157] R. DePinho,et al. Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[158] M. Roussel,et al. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. , 1999, Genes & development.
[159] C. Dang,et al. Binding and suppression of the Myc transcriptional activation domain by p107. , 1994, Science.
[160] John M. Sedivy,et al. c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression at Multiple Independent Points , 1999, Molecular and Cellular Biology.
[161] C. Dang,et al. c-Myc Overexpression Uncouples DNA Replication from Mitosis , 1999, Molecular and Cellular Biology.
[162] Kou-Juey Wu,et al. Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. , 1999, Science.
[163] R. Eisenman,et al. Myc and Max proteins possess distinct transcriptional activities , 1992, Nature.
[164] R. Klebe,et al. Overview of matrix metalloproteinase expression in cultured human cells. , 1998, Matrix biology : journal of the International Society for Matrix Biology.
[165] R. Davis,et al. Cell cycle regulation of the c-Myc transcriptional activation domain , 1993, Molecular and cellular biology.
[166] R. Versteeg,et al. c‐myc down‐regulates class I HLA expression in human melanomas. , 1988, The EMBO journal.
[167] M. Vidal,et al. RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae , 1991, Molecular and cellular biology.
[168] R. Eisenman,et al. Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells , 1984, Molecular and cellular biology.
[169] A. Chartier,et al. Year : 1998 A Drosophila RNA helicase gene , pitchoune , is required for cell growth and proliferation and is a potential target of d-Myc , 2006 .
[170] J. Sedivy. Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[171] L. Penn,et al. Negative autoregulation of c‐myc transcription. , 1990, The EMBO journal.
[172] N. Copeland,et al. Mad3 and Mad4: novel Max‐interacting transcriptional repressors that suppress c‐myc dependent transformation and are expressed during neural and epidermal differentiation. , 1995, The EMBO journal.
[173] H. Kondoh,et al. Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes. , 1991, The New biologist.
[174] I. Magrath. The pathogenesis of Burkitt's lymphoma. , 1990, Advances in cancer research.
[175] U. Weidle,et al. Control of cell growth by c-Myc in the absence of cell division , 1999, Current Biology.
[176] M. V. Heiden,et al. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[177] Emmett V Schmidt,et al. The role of c-myc in cellular growth control , 1999, Oncogene.
[178] D. Felsher,et al. Reversible tumorigenesis by MYC in hematopoietic lineages. , 1999, Molecular cell.
[179] T. Ceska,et al. The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. , 1997, Structure.
[180] M. Cole,et al. The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins , 1998, Cell.
[181] T. Kiyono,et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells , 1998, Nature.
[182] Amanda G Paulovich,et al. When Checkpoints Fail , 1997, Cell.
[183] E. Gabrielson,et al. c-Myc suppresses the tumorigenicity of lung cancer cells and down-regulates vascular endothelial growth factor expression. , 2000, Cancer research.
[184] G. Carmichael,et al. An alternative pathway for gene regulation by Myc , 1997, The EMBO journal.
[185] M. Cole. The myc oncogene: its role in transformation and differentiation. , 1986, Annual review of genetics.
[186] R. Eisenman,et al. Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation , 1998, The EMBO journal.
[187] F. Alt,et al. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. , 2000, Genes & development.
[188] C. Dang,et al. A unique glucose-dependent apoptotic pathway induced by c-Myc. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[189] H. Ariga,et al. Possible function of the c‐myc product: promotion of cellular DNA replication. , 1987, The EMBO journal.
[190] S. Cory. Activation of cellular oncogenes in hemopoietic cells by chromosome translocation. , 1986, Advances in cancer research.
[191] S Gaubatz,et al. Transcriptional activation by Myc is under negative control by the transcription factor AP‐2. , 1995, The EMBO journal.
[192] G. Gaidano,et al. p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[193] B. Amati,et al. Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. , 1993, Nucleic acids research.
[194] S. Salghetti,et al. Destruction of Myc by ubiquitin‐mediated proteolysis: cancer‐associated and transforming mutations stabilize Myc , 1999, The EMBO journal.
[195] M. Kasten,et al. SIN3-dependent transcriptional repression by interaction with the Mad1 DNA-binding protein , 1996, Molecular and cellular biology.
[196] J F Barrett,et al. Identification of CDK4 as a target of c-MYC. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[197] K. Alitalo,et al. Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro , 1995, The Journal of cell biology.
[198] G. Evan,et al. c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release. , 1999, Genes & development.
[199] J. Rossant,et al. Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles , 1998, Current Biology.
[200] M. Henriksson,et al. Proteins of the Myc network: essential regulators of cell growth and differentiation. , 1996, Advances in cancer research.
[201] R. Eisenman,et al. Dwarfism and dysregulated proliferation in mice overexpressing the MYC antagonist MAD1. , 1999, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[202] M. Shen,et al. Molecular genetics of prostate cancer. , 2000, Genes & development.
[203] R. DePinho,et al. Expression and activity of L-Myc in normal mouse development , 1996, Molecular and cellular biology.
[204] W. Atchley,et al. Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[205] K. Alitalo,et al. Repression of cyclin D1: a novel function of MYC. , 1994, Molecular and cellular biology.
[206] T. P. Neufeld,et al. Coordination of Growth and Cell Division in the Drosophila Wing , 1998, Cell.
[207] R. Eisenman,et al. Myc and Max Homologs in Drosophila , 1996, Science.
[208] Bruno Amati,et al. Oncogenic activity of the c-Myc protein requires dimerization with Max , 1993, Cell.
[209] S. Coughlin,et al. c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF , 1985, Cell.
[210] A. Ferré-D’Amaré,et al. Structure and function of the b/HLH/Z domain of USF , 1994 .
[211] C. Busch,et al. myc Boxes, Which Are Conserved in myc Family Proteins, Are Signals for Protein Degradation via the Proteasome , 1998, Molecular and Cellular Biology.
[212] James M. Roberts,et al. Cyclin-dependent regulation of G1 in mammalian fibroblasts. , 1993, Science.
[213] P. Farnham,et al. Coexamination of Site-Specific Transcription Factor Binding and Promoter Activity in Living Cells , 1999, Molecular and Cellular Biology.
[214] S. Freytag. Enforced expression of the c-myc oncogene inhibits cell differentiation by precluding entry into a distinct predifferentiation state in G0/G1 , 1988, Molecular and cellular biology.
[215] T. Halazonetis,et al. Determination of the c-MYC DNA-binding site. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[216] R. Eisenman,et al. Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network. , 1999, Biochimica et biophysica acta.
[217] M. Pagano,et al. Identification of a Myc‐dependent step during the formation of active G1 cyclin‐cdk complexes. , 1995, The EMBO journal.
[218] R. DePinho,et al. Essential role for Max in early embryonic growth and development. , 2000, Genes & development.
[219] R. Eisenman,et al. Myc target genes. , 1997, Trends in biochemical sciences.
[220] M. Dickens,et al. c-Myc Protein Synthesis Is Initiated from the Internal Ribosome Entry Segment during Apoptosis , 2000, Molecular and Cellular Biology.
[221] Robert A. Weinberg,et al. Creation of human tumour cells with defined genetic elements , 1999, Nature.
[222] G. Evan,et al. Traps to catch unwary oncogenes. , 1998, Trends in genetics : TIG.
[223] Wen‐Ming Yang,et al. Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression , 1997, Cell.
[224] R. Eisenman,et al. Mad proteins contain a dominant transcription repression domain , 1996, Molecular and cellular biology.
[225] R. Eisenman,et al. Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein-protein interactions. , 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[226] D. Anderson,et al. Immortalization and controlled in vitro differentiation of murine multipotent neural crest stem cells. , 1997, Journal of neurobiology.
[227] L. M. Facchini,et al. The molecular role of Myc in growth and transformation: recent discoveries lead to new insights , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[228] A. Bradley,et al. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. , 1993, Genes & development.
[229] G. Evan,et al. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max , 1992, Nature.
[230] D. Gillespie,et al. Transcription activation by Myc and Max: flanking sequences target activation to a subset of CACGTG motifs in vivo. , 1993, The EMBO journal.
[231] Mikhail Chernov,et al. Regulation of c‐myc expression by IFN‐γ through Stat1‐dependent and ‐independent pathways , 2000 .
[232] R. Eisenman,et al. Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity , 1993, Cell.
[233] T. P. Neufeld,et al. Connections between growth and the cell cycle. , 1998, Current opinion in cell biology.
[234] K. Georgopoulos,et al. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes , 1999, The EMBO journal.
[235] M. Cole,et al. The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation , 1999, Oncogene.
[236] R. Eisenman,et al. Myc and Max associate in vivo. , 1992, Genes & development.
[237] C. Dang,et al. Association of the decreased expression of alpha3beta1 integrin with the altered cell: environmental interactions and enhanced soft agar cloning ability of c-myc-overexpressing small cell lung cancer cells. , 1998, Cancer research.
[238] A. Ciechanover,et al. Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[239] R. Stein,et al. Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[240] Wen‐Ming Yang,et al. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[241] R. Eisenman,et al. The Mad protein family links transcriptional repression to cell differentiation. , 1998, Cold Spring Harbor symposia on quantitative biology.
[242] M. Grunstein. Histone acetylation in chromatin structure and transcription , 1997, Nature.
[243] S. Lowe,et al. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. , 1999, Genes & development.
[244] M. West,et al. Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway , 1998, Oncogene.
[245] Y. Jan,et al. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence , 1989, Cell.
[246] P. Farnham,et al. c-Myc target gene specificity is determined by a post-DNAbinding mechanism. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[247] Jun Liu,et al. A 13-Amino Acid Amphipathic α-Helix Is Required for the Functional Interaction between the Transcriptional Repressor Mad1 and mSin3A* , 1999, The Journal of Biological Chemistry.
[248] J. Sedivy,et al. Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis. , 1998, Genes & development.
[249] R A Jungmann,et al. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[250] J. Bishop,et al. Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo. , 1989, Genes & development.
[251] R. Roeder,et al. Direct role for Myc in transcription initiation mediated by interactions with TFII-I , 1993, Nature.
[252] J. Sedivy,et al. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[253] P. Leder,et al. Translocations among antibody genes in human cancer. , 1983, Science.
[254] I. Magrath,et al. Point mutations in the c–Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas , 1993, Nature Genetics.
[255] T. Suuronen,et al. Expression of transcriptional repressor protein mSin3A but not mSin3B is induced during neuronal apoptosis. , 1998, Biochemical and biophysical research communications.
[256] R. Eisenman,et al. c-myc and c-myb protein degradation: effect of metabolic inhibitors and heat shock , 1988, Molecular and cellular biology.
[257] S. Shurtleff,et al. Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling , 1991, Nature.
[258] E. Kremmer,et al. Identification and Characterization of Specific DNA-binding Complexes Containing Members of the Myc/Max/Mad Network of Transcriptional Regulators* , 1998, The Journal of Biological Chemistry.
[259] E. Lander,et al. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[260] R Ohba,et al. Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. , 1997, Genes & development.
[261] R. Brent,et al. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites , 1993, Cell.
[262] M. Helmer-Citterich,et al. Design and properties of a Myc derivative that efficiently homodimerizes , 1998, Oncogene.
[263] C. Cerni,et al. YY1 can inhibit c-Myc function through a mechanism requiring DNA binding of YY1 but neither its transactivation domain nor direct interaction with c-Myc , 1998, Oncogene.
[264] J. Nevins,et al. Ras enhances Myc protein stability. , 1999, Molecular cell.
[265] G. Prendergast,et al. New Myc-interacting proteins: a second Myc network emerges , 1999, Oncogene.
[266] W. Shoji,et al. Direct association of YY-1 with c-Myc and the E-box binding protein in regulation of glycophorin gene expression , 1998, Oncogene.
[267] J. Moore,et al. Large induction of c-Myc is not essential for the mitogenic response of Swiss 3T3 fibroblasts. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[268] B. Amati,et al. Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis. , 2000, Nucleic acids research.
[269] V. Stewart,et al. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. , 1992, Genes & development.
[270] P R Nicholson,et al. The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs , 1990, Molecular and cellular biology.
[271] Andreas Sewing,et al. Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27Kip1 binding to newly formed complexes , 1997, Oncogene.
[272] L. Larsson,et al. Expression of mad, mxi1, max and c-myc during induced differentiation of hematopoietic cells: opposite regulation of mad and c-myc. , 1994, Oncogene.
[273] J. Kennison,et al. dMi-2, a hunchback-interacting protein that functions in polycomb repression. , 1998, Science.
[274] R. Roeder,et al. A Human SPT3-TAFII31-GCN5-L Acetylase Complex Distinct from Transcription Factor IID* , 1998, The Journal of Biological Chemistry.
[275] A. Bradley,et al. Mutation of N-myc in mice: what does the phenotype tell us? , 1993, BioEssays : news and reviews in molecular, cellular and developmental biology.
[276] M. Cole,et al. c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets. , 1998, Genes & development.
[277] P. Goodfellow,et al. Mxi1 tumor suppressor gene is not mutated in primary pancreatic adenocarcinoma. , 1996, Cancer letters.
[278] A. W. Harris,et al. The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells , 1988, The Journal of experimental medicine.
[279] R. DePinho,et al. Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer. , 1994, Seminars in cancer biology.
[280] H. Wang,et al. Transcriptional repression in Saccharomyces cerevisiae by a SIN3-LexA fusion protein , 1993, Molecular and cellular biology.
[281] R. Eisenman,et al. FH3, a v-myc avian retrovirus with limited transforming ability , 1989, Journal of virology.
[282] S. G. Cheng,et al. c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function , 1999, Nature Genetics.
[283] R. DePinho,et al. Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells , 1995, Nature Medicine.
[284] J. Neil,et al. Protein stabilization: a common consequence of mutations in independently derived v-Myc alleles , 1999, Oncogene.
[285] H. Hermeking,et al. Mediation of c-Myc-induced apoptosis by p53. , 1994, Science.
[286] H. Kondoh,et al. Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse. , 1993, Development.
[287] P. Neiman,et al. Angiogenesis is an early event in the generation of myc-induced lymphomas , 2000, Oncogene.
[288] L. Chin,et al. Essential role for oncogenic Ras in tumour maintenance , 1999, Nature.
[289] D. Felsher,et al. Transient excess of MYC activity can elicit genomic instability and tumorigenesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[290] S Gaubatz,et al. An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-myc , 1994, Molecular and cellular biology.