Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors

J. Neurochem. (2010) 114, 130–141.

[1]  J. Ribeiro,et al.  Cannabinoid CB(1) and adenosine A(1) receptors independently inhibit hippocampal synaptic transmission. , 2009, European journal of pharmacology.

[2]  Z. C. Xu,et al.  Transient enhancement of inhibitory synaptic transmission in hippocampal CA1 pyramidal neurons after cerebral ischemia , 2009, Neuroscience.

[3]  D. Hovda,et al.  The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat. , 2009, Journal of neurotrauma.

[4]  Jong M. Rho,et al.  The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies , 2009, Brain Research Reviews.

[5]  J. Velazquez,et al.  The effects of a ketogenic diet on ATP concentrations and the number of hippocampal mitochondria in Aldh5a1(-/-) mice. , 2009, Biochimica et biophysica acta.

[6]  S. Shapses,et al.  Bone mineral density and content during weight cycling in female rats: effects of dietary amylase-resistant starch , 2008, Nutrition & metabolism.

[7]  J. Rho,et al.  Oxidative impairment of hippocampal long‐term potentiation involves activation of protein phosphatase 2A and is prevented by ketone bodies , 2008, Journal of neuroscience research.

[8]  P. Calabresi,et al.  Electrophysiology and Pharmacology of Striatal Neuronal Dysfunction Induced by Mitochondrial Complex I Inhibition , 2008, The Journal of Neuroscience.

[9]  S. Jarrett,et al.  The ketogenic diet increases mitochondrial glutathione levels , 2008, Journal of neurochemistry.

[10]  T. Casoli,et al.  Ketogenic diets cause opposing changes in synaptic morphology in CA1 hippocampus and dentate gyrus of late-adult rats. , 2008, Rejuvenation research.

[11]  S. Masino,et al.  Are purines mediators of the anticonvulsant/neuroprotective effects of ketogenic diets? , 2008, Trends in Neurosciences.

[12]  J. Pedraza-Chaverri,et al.  Antioxidant capacity contributes to protection of ketone bodies against oxidative damage induced during hypoglycemic conditions , 2008, Experimental Neurology.

[13]  J. Rho,et al.  The ketogenic diet and epilepsy , 2008, Current opinion in clinical nutrition and metabolic care.

[14]  R. Cunha,et al.  Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses , 2008, Neuron.

[15]  M. Prins,et al.  Cerebral Metabolic Adaptation and Ketone Metabolism after Brain Injury , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[16]  D. Keating.  Mitochondrial dysfunction, oxidative stress, regulation of exocytosis and their relevance to neurodegenerative diseases , 2007, Journal of neurochemistry.

[17]  Steven W. Johnson,et al.  Rotenone potentiates NMDA currents in substantia nigra dopamine neurons , 2007, Neuroscience Letters.

[18]  J. Rho,et al.  Ketone bodies are protective against oxidative stress in neocortical neurons , 2007, Journal of neurochemistry.

[19]  Vidya N. Nukala,et al.  Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury. , 2007, Journal of neurotrauma.

[20]  J. Rho,et al.  Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation , 2007, Neuroscience.

[21]  Hoon-Chul Kang,et al.  Safe and Effective Use of the Ketogenic Diet in Children with Epilepsy and Mitochondrial Respiratory Chain Complex Defects , 2007, Epilepsia.

[22]  Kenji Nakashima,et al.  D‐β‐hydroxybutyrate protects dopaminergic SH‐SY5Y cells in a rotenone model of Parkinson's disease , 2006 .

[23]  M. Beal,et al.  Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases , 2006, Nature.

[24]  C. Parsons,et al.  3‐Nitropropionic acid toxicity in hippocampus: Protection through N‐methyl‐D‐aspartate receptor antagonism , 2006, Hippocampus.

[25]  Y. Smith,et al.  Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet , 2006, Annals of neurology.

[26]  C. Arias,et al.  Role of oxidative stress on β-amyloid neurotoxicity elicited during impairment of energy metabolism in the hippocampus: Protection by antioxidants , 2006, Experimental Neurology.

[27]  D. Heal,et al.  KTX 0101: a potential metabolic approach to cytoprotection in major surgery and neurological disorders. , 2006, CNS drug reviews.

[28]  Dennis A. Turner,et al.  Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration , 2006, Progress in Neurobiology.

[29]  D. MacGrogan,et al.  A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis , 2006, BMC Neuroscience.

[30]  M. Rice,et al.  Partial Mitochondrial Inhibition Causes Striatal Dopamine Release Suppression and Medium Spiny Neuron Depolarization via H2O2 Elevation, Not ATP Depletion , 2005, The Journal of Neuroscience.

[31]  J. Monahan,et al.  D‐β‐hydroxybutyrate is neuroprotective against hypoxia in serum‐free hippocampal primary cultures , 2005, Journal of neuroscience research.

[32]  Xi Chen,et al.  ABAD enhances Aβ‐induced cell stress via mitochondrial dysfunction , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[33]  Keith Hyland,et al.  Distinct Mechanisms of Neurodegeneration Induced by Chronic Complex I Inhibition in Dopaminergic and Non-dopaminergic Cells* , 2004, Journal of Biological Chemistry.

[34]  Eric Klann,et al.  Reactive oxygen species and synaptic plasticity in the aging hippocampus , 2004, Ageing Research Reviews.

[35]  R. Veech.  The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism. , 2004, Prostaglandins, leukotrienes, and essential fatty acids.

[36]  Hong Wang,et al.  Glutathione Peroxidase-Catalase Cooperativity Is Required for Resistance to Hydrogen Peroxide by Mature Rat Oligodendrocytes , 2004, The Journal of Neuroscience.

[37]  C. Elger,et al.  Characterization of Superoxide-producing Sites in Isolated Brain Mitochondria* , 2004, Journal of Biological Chemistry.

[38]  Alba I. Rodríguez,et al.  ANTIOXIDANT EFFECTS OF TAURINE, VITAMIN C, AND VITAMIN E ON OXIDATIVE DAMAGE IN HIPPOCAMPUS CAUSED BY THE ADMINISTRATION OF 3-NITROPROPIONIC ACID IN RATS , 2004, The International journal of neuroscience.

[39]  C. Gottfried,et al.  Ketogenic Diet Increases Glutathione Peroxidase Activity in Rat Hippocampus , 2003, Neurochemical Research.

[40]  T. Yagi,et al.  Mechanism of Toxicity in Rotenone Models of Parkinson's Disease , 2003, The Journal of Neuroscience.

[41]  M. Vila,et al.  D-beta-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease. , 2003, The Journal of clinical investigation.

[42]  M. Segal,et al.  Hydrogen Peroxide Modulation of Synaptic Plasticity , 2003, The Journal of Neuroscience.

[43]  M. Yüksel,et al.  Effect of mitochondrial electron transport chain inhibitors on superoxide radical generation in rat hippocampal and striatal slices. , 2001, Antioxidants & redox signaling.

[44]  P. Carlen,et al.  Dynamics of intracellular calcium and free radical production during ischemia in pyramidal neurons. , 2001, Free radical biology & medicine.

[45]  P. Greengard,et al.  Inhibition of Mitochondrial Complex II Induces a Long-Term Potentiation of NMDA-Mediated Synaptic Excitation in the Striatum Requiring Endogenous Dopamine , 2001, The Journal of Neuroscience.

[46]  Britton Chance,et al.  Ketone Bodies, Potential Therapeutic Uses , 2001, IUBMB life.

[47]  M. Rice,et al.  Mechanisms underlying H2O2-mediated inhibition of synaptic transmission in rat hippocampal slices , 2000, Brain Research.

[48]  Michael B. Smith,et al.  Increased Plasma Beta-Hydroxybutyrate, Preserved Cerebral Energy Metabolism, and Amelioration of Brain Damage During Neonatal Hypoxia Ischemia with Dexamethasone Pretreatment , 2000, Pediatric Research.

[49]  K. Clarke,et al.  D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[50]  E. Klann,et al.  Modulation of protein kinases and protein phosphatases by reactive oxygen species: Implications for hippocampal synaptic plasticity , 1999, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[51]  D. Cassarino,et al.  An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration , 1999, Brain Research Reviews.

[52]  R. Faull,et al.  3‐Nitropropionic acid's lethal triplet: cooperative pathways of neurodegeneration , 1998, Neuroreport.

[53]  Y. Izumi,et al.  beta-Hydroxybutyrate fuels synaptic function during development. Histological and physiological evidence in rat hippocampal slices. , 1998, The Journal of clinical investigation.

[54]  J. Cummings,et al.  Huntington's disease. , 1997, The Psychiatric clinics of North America.

[55]  D. Vivo,et al.  The Ketogenic Diet Revisited: Back to the Future , 1997, Epilepsia.

[56]  J. Geddes,et al.  Mechanisms of Cell Death Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Acute Excitotoxic Necrosis and Delayed Apoptosis , 1997, The Journal of Neuroscience.

[57]  B. Lei,et al.  The effect of hypothermia on H2O2 production during ischemia and reperfusion: a microdialysis study in the gerbil hippocampus , 1997, Neuroscience Letters.

[58]  L. Phebus,et al.  Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat: correlation with the cytotoxic potential of H2O2 in vitro , 1995, Brain Research.

[59]  G. Celesia.  Persistent vegetative state , 1993, Neurology.

[60]  T. Pellmar.  Peroxide alters neuronal excitability in the CA1 region of guinea-pig hippocampus in vitro , 1987, Neuroscience.

[61]  G. Paulson,et al.  Dementia in Parkinson's disease. , 1986, Archives of neurology.

[62]  S. Palay.  SYNAPSES IN THE CENTRAL NERVOUS SYSTEM , 1956, The Journal of biophysical and biochemical cytology.

[63]  M. Beal.  Mitochondria and neurodegeneration. , 2007, Novartis Foundation symposium.

[64]  J. Cano,et al.  Mitochondrial toxins and neurodegenerative diseases. , 2007, Frontiers in bioscience : a journal and virtual library.

[65]  이준수,et al.  Safe and Effective Use of the Ketogenic Diet in Children with Epilepsy and Mitochondrial Respiratory Chain Complex Defects , 2007 .

[66]  Gabriele Siciliano,et al.  Mitochondrial dysfunction, oxidative stress and neurodegeneration. , 2006, Journal of Alzheimer's disease : JAD.

[67]  K. Nakashima,et al.  D-beta-hydroxybutyrate protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease. , 2006, Journal of neuroscience research.

[68]  Alexander Sasha Rabchevsky,et al.  Mitochondrial permeability transition in CNS trauma: Cause or effect of neuronal cell death? , 2005, Journal of neuroscience research.

[69]  T. Sherer,et al.  Rotenone Model of Parkinson Disease MULTIPLEBRAINMITOCHONDRIADYSFUNCTIONSAFTERSHORTTERMSYSTEMIC ROTENONEINTOXICATION , 2005 .

[70]  T. Sato,et al.  Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats. , 2001, Japanese journal of pharmacology.

[71]  M. Rice,et al.  Mechanisms underlying H(2)O(2)-mediated inhibition of synaptic transmission in rat hippocampal slices. , 2000, Brain research.