Initial response time measurement in eye movement for dementia screening test

This paper proposes a method for detecting eye movement by using a generic RGB camera such as the one in a laptop computer or a smartphone. This method is designed for diagnosis of brain dysfunction such as dementia. For such a diagnostic purpose, precise detection of the eye movement is required, e.g., ± 1 video frame. However, noisy iris localization makes it difficult. The proposed method detects the moments when the iris begins and finishes moving by binary classification of eye movement velocity. This classification is achieved by discriminant analysis for optimization of these moments. We developed two diagnostic systems using the aforementioned function. The first one is designed just for diagnosis in which a subject gazes at a target point that appears on a white screen. The second one is merged with a generic web browser in which the gaze of a subject is measured while he/she reads texts displayed on the browser. Experimental results with these two systems demonstrated that the proposed method can detect the moments when the iris begins and finishes moving more accurately than required for a dementia screening test.

[1]  L. Stark,et al.  Saccadic intrusions in Alzheimer-type dementia , 2004, Journal of Neurology.

[2]  Ivan Aprahamian,et al.  Eye movement analysis and cognitive processing: detecting indicators of conversion to Alzheimer’s disease , 2014, Neuropsychiatric disease and treatment.

[3]  G. Zaccara,et al.  Smooth-pursuit eye movements: alterations in Alzheimer's disease , 1992, Journal of the Neurological Sciences.

[4]  Fred Nicolls,et al.  Active shape models with SIFT descriptors and MARS , 2015, 2014 International Conference on Computer Vision Theory and Applications (VISAPP).

[5]  Satoshi Nakamura,et al.  Automatic detection of very early stage of dementia through multimodal interaction with computer avatars , 2016, ICMI.

[6]  Paul A. Viola,et al.  Robust Real-Time Face Detection , 2001, Proceedings Eighth IEEE International Conference on Computer Vision. ICCV 2001.

[7]  Jian-Gang Wang,et al.  Eye gaze estimation from a single image of one eye , 2003, Proceedings Ninth IEEE International Conference on Computer Vision.

[8]  Mario Fritz,et al.  Appearance-based gaze estimation in the wild , 2015, 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[9]  Andreas Bulling,et al.  EyeTab: model-based gaze estimation on unmodified tablet computers , 2014, ETRA.

[10]  Yu-Tzu Lin,et al.  Real-time eye-gaze estimation using a low-resolution webcam , 2012, Multimedia Tools and Applications.

[11]  Ajay Kumar,et al.  An Accurate Iris Segmentation Framework Under Relaxed Imaging Constraints Using Total Variation Model , 2015, 2015 IEEE International Conference on Computer Vision (ICCV).

[12]  T. Anderson,et al.  Eye movements in patients with neurodegenerative disorders , 2013, Nature Reviews Neurology.

[13]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[14]  Timothy F. Cootes,et al.  Active Shape Models-Their Training and Application , 1995, Comput. Vis. Image Underst..

[15]  Anita Madan,et al.  Mutual gaze in Alzheimer's disease, frontotemporal and semantic dementia couples. , 2011, Social cognitive and affective neuroscience.

[16]  H. Vankova Mini Mental State , 2010 .