A recombinant antibody fragment directed to the thymic stromal lymphopoietin receptor (CRLF2) efficiently targets pediatric Philadelphia chromosome-like acute lymphoblastic leukemia.
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S. Savvides | R. Lock | K. Verstraete | M. Kavallaris | D. Christ | Narges Bayat | P. Schofield | K. Sia | Karl-Heinz Friedrich | H. Mccalmont | S. M. Mohamed | A. Wohlmann | H. McCalmont | Peter Schofield
[1] R. Lock,et al. Targeting TSLP-Induced Tyrosine Kinase Signaling Pathways in CRLF2-Rearranged Ph-like ALL , 2020, Molecular Cancer Research.
[2] J. A. MacKay,et al. Anti-FLT3 nanoparticles for acute myeloid leukemia: Preclinical pharmacology and pharmacokinetics. , 2020, Journal of controlled release : official journal of the Controlled Release Society.
[3] C. Pui,et al. Immunotherapy in pediatric acute lymphoblastic leukemia , 2019, Cancer and Metastasis Reviews.
[4] Yongping Song,et al. Recent advances on blinatumomab for acute lymphoblastic leukemia , 2019, Experimental Hematology & Oncology.
[5] Louise N. Winteringham,et al. Expression Levels of Therapeutic Targets as Indicators of Sensitivity to Targeted Therapeutics , 2019, Molecular Cancer Therapeutics.
[6] P. Houghton,et al. Preclinical activity of the antibody‐drug conjugate denintuzumab mafodotin (SGN‐CD19A) against pediatric acute lymphoblastic leukemia xenografts , 2019, Pediatric blood & cancer.
[7] C. Mackall,et al. Tumor Antigen Escape from CAR T-cell Therapy. , 2018, Cancer discovery.
[8] J. Otlewski,et al. High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1 , 2018, International journal of molecular sciences.
[9] Benjamin T. Porebski,et al. Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination , 2018, Science.
[10] M. Loh,et al. Philadelphia chromosome-like acute lymphoblastic leukemia. , 2017, Blood.
[11] T. Valerius,et al. Antibody Isotypes for Tumor Immunotherapy , 2017, Transfusion Medicine and Hemotherapy.
[12] C. Pui,et al. Philadelphia Chromosome–like Acute Lymphoblastic Leukemia , 2017, Clinical lymphoma, myeloma & leukemia.
[13] S. Lipshultz,et al. Chemotherapy-induced cardiotoxicity in children , 2017, Expert opinion on drug metabolism & toxicology.
[14] V. Anderson,et al. The relationship between cognitive and neuroimaging outcomes in children treated for acute lymphoblastic leukemia with chemotherapy only: A systematic review , 2017, Pediatric blood & cancer.
[15] Pratyoosh Shukla,et al. Microbial platform technology for recombinant antibody fragment production: A review , 2017, Critical reviews in microbiology.
[16] M. Maus,et al. Catch me if you can: Leukemia Escape after CD19-Directed T Cell Immunotherapies , 2016, Computational and structural biotechnology journal.
[17] O. Abdel-Rahman. Correlation between PD-L1 expression and outcome of NSCLC patients treated with anti-PD-1/PD-L1 agents: A meta-analysis. , 2016, Critical reviews in oncology/hematology.
[18] D. Auguste,et al. Cancer targeted therapeutics: From molecules to drug delivery vehicles. , 2015, Journal of controlled release : official journal of the Controlled Release Society.
[19] J. Pourahmad,et al. Isolated Human Peripheral Blood Mononuclear Cell (PBMC), a Cost Effective Tool for Predicting Immunosuppressive Effects of Drugs and Xenobiotics , 2015, Iranian journal of pharmaceutical research : IJPR.
[20] Tamer Refaat,et al. Cancer active targeting by nanoparticles: a comprehensive review of literature , 2015, Journal of Cancer Research and Clinical Oncology.
[21] D. Schatz,et al. Mapping and Quantitation of the Interaction between the Recombination Activating Gene Proteins RAG1 and RAG2*♦ , 2015, The Journal of Biological Chemistry.
[22] Jeffrey E. Lee,et al. Measuring Protein‐Protein and Protein‐Nucleic Acid Interactions by Biolayer Interferometry , 2015, Current protocols in protein science.
[23] Christof Fellmann,et al. An optimized microRNA backbone for effective single-copy RNAi. , 2013, Cell reports.
[24] R. Nadeau,et al. Anti‐CRLF2 Antibody‐Armored Biodegradable Nanoparticles for Childhood B‐ALL , 2013, Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems.
[25] Matthew J. Brauer,et al. Development of a robust flow cytometry-based pharmacodynamic assay to detect phospho-protein signals for phosphatidylinositol 3-kinase inhibitors in multiple myeloma , 2013, Journal of Translational Medicine.
[26] W. Luttmann,et al. Expression analysis and specific blockade of the receptor for human thymic stromal lymphopoietin (TSLP) by novel antibodies to the human TSLPRα receptor chain. , 2013, Cytokine.
[27] Aik Choon Tan,et al. Patient-derived tumour xenografts as models for oncology drug development , 2012, Nature Reviews Clinical Oncology.
[28] J. Wolchok,et al. Antibody therapy of cancer , 2012, Nature Reviews Cancer.
[29] Akhilesh Pandey,et al. TSLP Signaling Network Revealed by SILAC-Based Phosphoproteomics* , 2012, Molecular & Cellular Proteomics.
[30] T. Wilson,et al. Resolution and optical sectioning in the confocal microscope , 2011, Journal of microscopy.
[31] J. Paulson,et al. CD22 Is a Recycling Receptor That Can Shuttle Cargo between the Cell Surface and Endosomal Compartments of B Cells , 2011, The Journal of Immunology.
[32] V. Ramakrishnan,et al. Investigational antibody-drug conjugates for hematological malignancies , 2011, Expert opinion on investigational drugs.
[33] W. Leonard,et al. Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7–induced signaling , 2010, Proceedings of the National Academy of Sciences.
[34] J. Downing,et al. Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. , 2010, Blood.
[35] Ww Cheng,et al. The use of single chain Fv as targeting agents for immunoliposomes: an update on immunoliposomal drugs for cancer treatment , 2010, Expert opinion on drug delivery.
[36] A. Mackensen,et al. Novel conjugates of single‐chain Fv antibody fragments specific for stem cell antigen CD123 mediate potent death of acute myeloid leukaemia cells , 2010, British journal of haematology.
[37] L. Hennighausen,et al. Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia , 2010, EMBO molecular medicine.
[38] Sebastian Krause,et al. Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function , 2010, Biological chemistry.
[39] A. Nelson. Antibody fragments , 2010, mAbs.
[40] Takashi Akasaka,et al. Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. , 2009, Blood.
[41] I. Pastan,et al. Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity. , 2008, Cancer research.
[42] A. Ullrich,et al. Paul Ehrlich's magic bullet concept: 100 years of progress , 2008, Nature Reviews Cancer.
[43] Michael M. Schmidt,et al. Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability , 2008, Cancer Immunology, Immunotherapy.
[44] A. Ebens,et al. Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma. , 2006, Blood.
[45] O. Trubiani,et al. Sphingolipid Microdomains Mediate CD38 Internalization: Topography of the Endocytosis , 2004, International journal of immunopathology and pharmacology.
[46] R. Lock,et al. Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies. , 2004, Blood.
[47] Theresa M Allen,et al. Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs. , 2002, Cancer research.
[48] J. Doré,et al. Internalization-Dependent and -Independent Requirements for Transforming Growth Factor β Receptor Signaling via the Smad Pathway , 2002, Molecular and Cellular Biology.
[49] R. Lock,et al. The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse. , 2002, Blood.
[50] R. de Waal Malefyt,et al. Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells1 , 2001, The Journal of Immunology.
[51] G. Adams,et al. High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules. , 2001, Cancer research.
[52] T M Allen,et al. In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma. , 1998, Cancer research.
[53] P. Bjorkman,et al. Crystal Structure of the Hemochromatosis Protein HFE and Characterization of Its Interaction with Transferrin Receptor , 1998, Cell.
[54] P. Sorensen,et al. Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein. , 2015, Blood.
[55] T M Allen,et al. Expression and purification of two anti-CD19 single chain Fv fragments for targeting of liposomes to CD19-expressing cells. , 2007, Biochimica et biophysica acta.
[56] B. Kroesen,et al. Simultaneous inhibition of EGFR signaling and enhanced activation of TRAIL-R-mediated apoptosis induction by an scFv:sTRAIL fusion protein with specificity for human EGFR. , 2022 .