Acinetobacter Metabolism in Infection and Antimicrobial Resistance

Acinetobacter infections have high rates of mortality due to an increasing incidence of infections by multidrug-resistant (MDR) and extensively-drug-resistant (XDR) strains. Therefore, new therapeutic strategies for the treatment of Acinetobacter infections are urgently needed. Acinetobacter spp. are Gram-negative coccobacilli that are obligate aerobes and can utilize a wide variety of carbon sources. Acinetobacter baumannii is the main cause of Acinetobacter infections, and recent work has identified multiple strategies A. baumannii uses to acquire nutrients and replicate in the face of host nutrient restriction. ABSTRACT Acinetobacter infections have high rates of mortality due to an increasing incidence of infections by multidrug-resistant (MDR) and extensively-drug-resistant (XDR) strains. Therefore, new therapeutic strategies for the treatment of Acinetobacter infections are urgently needed. Acinetobacter spp. are Gram-negative coccobacilli that are obligate aerobes and can utilize a wide variety of carbon sources. Acinetobacter baumannii is the main cause of Acinetobacter infections, and recent work has identified multiple strategies A. baumannii uses to acquire nutrients and replicate in the face of host nutrient restriction. Some host nutrient sources also serve antimicrobial and immunomodulatory functions. Hence, understanding Acinetobacter metabolism during infection may provide new insights into novel infection control measures. In this review, we focus on the role of metabolism during infection and in resistance to antibiotics and other antimicrobial agents and discuss the possibility that metabolism may be exploited to identify novel targets to treat Acinetobacter infections.

[1]  Amy K. Cain,et al.  Identification of a novel LysR family transcriptional regulator controlling acquisition of sulfur sources in Acinetobacter baumannii. , 2023, Microbial Physiology.

[2]  B. Eijkelkamp,et al.  Characterizing the role of phosphatidylglycerol-phosphate phosphatases in Acinetobacter baumannii cell envelope biogenesis and antibiotic resistance , 2022, Cell surface.

[3]  M. Bassetti,et al.  Clinical evidence supporting cefiderol for serious Acinetobacter baumannii infections , 2022, Current opinion in infectious diseases.

[4]  Ayush Kumar,et al.  Iron Acquisition Mechanisms and Their Role in the Virulence of Acinetobacter baumannii , 2022, Infection and immunity.

[5]  Eric P. Skaar,et al.  Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infection , 2022, PLoS pathogens.

[6]  G. Kardos,et al.  Faecal Carriage of Carbapenem-Resistant Acinetobacter baumannii: Comparison to Clinical Isolates from the Same Period (2017–2019) , 2022, Pathogens.

[7]  K. Dib,et al.  Histamine Produced by Gram-Negative Bacteria Impairs Neutrophil's Antimicrobial Response by Engaging the Histamine 2 Receptor , 2022, Journal of Innate Immunity.

[8]  Stacy R. Bedore,et al.  Regulation of l- and d-Aspartate Transport and Metabolism in Acinetobacter baylyi ADP1 , 2022, Applied and environmental microbiology.

[9]  W. Khan,et al.  Prevalence of ESKAPE pathogens in the environment: Antibiotic resistance status, community-acquired infection and risk to human health. , 2022, International journal of hygiene and environmental health.

[10]  Eric P. Skaar,et al.  Nutritional immunity: the battle for nutrient metals at the host–pathogen interface , 2022, Nature Reviews Microbiology.

[11]  A. Engevik,et al.  Acinetobacter calcoaceticus is Well Adapted to Withstand Intestinal Stressors and Modulate the Gut Epithelium , 2022, Frontiers in Physiology.

[12]  Nichollas E. Scott,et al.  The Phenylacetic Acid Catabolic Pathway Regulates Antibiotic and Oxidative Stress Responses in Acinetobacter , 2022, mBio.

[13]  Eric P. Skaar,et al.  Bacterial hydrophilins promote pathogen desiccation tolerance. , 2022, Cell host & microbe.

[14]  S. Barnini,et al.  Cefiderocol- Compared to Colistin-Based Regimens for the Treatment of Severe Infections Caused by Carbapenem-Resistant Acinetobacter baumannii , 2022, Antimicrobial agents and chemotherapy.

[15]  J. Bruce,et al.  CsrA-Controlled Proteins Reveal New Dimensions of Acinetobacter baumannii Desiccation Tolerance , 2022, Journal of bacteriology.

[16]  J. Li,et al.  Correlative proteomics identify the key roles of stress tolerance strategies in Acinetobacter baumannii in response to polymyxin and human macrophages , 2022, PLoS pathogens.

[17]  M. Powers,et al.  Acinetobactin-Mediated Inhibition of Commensal Bacteria by Acinetobacter baumannii , 2022, mSphere.

[18]  I. Ebersberger,et al.  Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumannii complex , 2022, bioRxiv.

[19]  Karl A. Hassan,et al.  The Impact of Omega-3 Fatty Acids on the Evolution of Acinetobacter baumannii Drug Resistance , 2021, Microbiology spectrum.

[20]  V. Müller,et al.  CsrA Coordinates Compatible Solute Synthesis in Acinetobacter baumannii and Facilitates Growth in Human Urine , 2021, Microbiology spectrum.

[21]  S. Satola,et al.  Does cefiderocol heteroresistance explain the discrepancy between the APEKS-NP and CREDIBLE-CR clinical trial results? , 2021, The Lancet. Microbe.

[22]  Lianqun Jia,et al.  Activation of the gut microbiota-kynurenine-liver axis contributes to the development of nonalcoholic hepatic steatosis in nondiabetic adults , 2021, Aging.

[23]  S. Sarma,et al.  The impact of carbon and nitrogen catabolite repression in microorganisms. , 2021, Microbiological research.

[24]  Karl A. Hassan,et al.  The Membrane Composition Defines the Spatial Organization and Function of a Major Acinetobacter baumannii Drug Efflux System , 2021, mBio.

[25]  Amy K. Cain,et al.  Acinetobacter baumannii Fatty Acid Desaturases Facilitate Survival in Distinct Environments. , 2021, ACS infectious diseases.

[26]  Nichollas E. Scott,et al.  Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages , 2021, bioRxiv.

[27]  W. Qin,et al.  Colonization With Extensively Drug-Resistant Acinetobacter baumannii and Prognosis in Critically Ill Patients: An Observational Cohort Study , 2021, Frontiers in Medicine.

[28]  Se Yeon Kim,et al.  The role of Zur-regulated lipoprotein A in bacterial morphology, antimicrobial susceptibility, and production of outer membrane vesicles in Acinetobacter baumannii , 2021, BMC microbiology.

[29]  M. Snel,et al.  To Make or Take: Bacterial Lipid Homeostasis during Infection , 2021, bioRxiv.

[30]  J. Li,et al.  Comparative metabolomics reveals key pathways associated with the synergistic activity of polymyxin B and rifampicin combination against multidrug-resistant Acinetobacter baumannii. , 2020, Biochemical pharmacology.

[31]  S. Baker,et al.  Developing new therapeutic approaches for treating infections caused by multi-drug resistant Acinetobacter baumannii: Acinetobacter baumannii therapeutics. , 2020, The Journal of infection.

[32]  D. Zurawski,et al.  GigC, a LysR Family Transcription Regulator, Is Required for Cysteine Metabolism and Virulence in Acinetobacter baumannii , 2020, Infection and Immunity.

[33]  R. Wunderink,et al.  Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial. , 2020, The Lancet. Infectious diseases.

[34]  Eric P. Skaar,et al.  Acinetobacter baumannii can use multiple siderophores for iron acquisition, but only acinetobactin is required for virulence , 2020, PLoS pathogens.

[35]  M. Adams,et al.  CsrA Supports both Environmental Persistence and Host-Associated Growth of Acinetobacter baumannii , 2020, Infection and Immunity.

[36]  B. Averhoff,et al.  In vivo synthesis of monolysocardiolipin and cardiolipin by Acinetobacter baumannii phospholipase D and effect on cationic antimicrobial peptide resistance. , 2020, Environmental microbiology.

[37]  Eric P. Skaar,et al.  Modulating Isoprenoid Biosynthesis Increases Lipooligosaccharides and Restores Acinetobacter baumannii Resistance to Host and Antibiotic Stress , 2020, Cell reports.

[38]  M. Powers,et al.  The Mla pathway in Acinetobacter baumannii has no demonstrable role in anterograde lipid transport , 2020, eLife.

[39]  Eric P. Skaar,et al.  The Response of Acinetobacter baumannii to Hydrogen Sulfide Reveals Two Independent Persulfide-Sensing Systems and a Connection to Biofilm Regulation , 2020, mBio.

[40]  H. Kim,et al.  Current biochemical understanding regarding the metabolism of acinetobactin, the major siderophore of the human pathogen Acinetobacter baumannii, and outlook for discovery of novel anti-infectious agents based thereon. , 2020, Natural product reports.

[41]  Eric P. Skaar,et al.  Histidine Utilization Is a Critical Determinant of Acinetobacter Pathogenesis , 2020, Infection and Immunity.

[42]  R. Patidar,et al.  A response regulator protein with antar domain, AvnR, in Acinetobacter baumannii ATCC 17978 impacts its virulence and amino acid metabolism. , 2020, Microbiology.

[43]  B. Averhoff,et al.  Identification of osmo-dependent and osmo-independent betaine-choline-carnitine transporters in Acinetobacter baumannii: role in osmostress protection and metabolic adaptation. , 2020, Environmental microbiology.

[44]  Prince Sharma,et al.  Multicopper oxidase of Acinetobacter baumannii: Assessing its role in metal homeostasis, stress management and virulence. , 2020, Microbial pathogenesis.

[45]  C. Ayoub Moubareck,et al.  Insights into Acinetobacter baumannii: A Review of Microbiological, Virulence, and Resistance Traits in a Threatening Nosocomial Pathogen , 2020, Antibiotics.

[46]  D. Merrell,et al.  Characterization of Acinetobacter baumannii Copper Resistance Reveals a Role in Virulence , 2020, Frontiers in Microbiology.

[47]  Amy K. Cain,et al.  The role of zinc efflux during Acinetobacter baumannii infection. , 2020, ACS infectious diseases.

[48]  P. Hu,et al.  L-lysine potentiates aminoglycosides against Acinetobacter baumannii via regulation of proton motive force and antibiotics uptake , 2020, Emerging microbes & infections.

[49]  Chul Hee Choi,et al.  Zur-regulated lipoprotein A contributes to the fitness of Acinetobacter baumannii , 2020, Journal of Microbiology.

[50]  Eric P. Skaar,et al.  The Manganese-Responsive Transcriptional Regulator MumR Protects Acinetobacter baumannii from Oxidative Stress , 2019, Infection and Immunity.

[51]  Eric P. Skaar,et al.  Metals as phagocyte antimicrobial effectors. , 2019, Current opinion in immunology.

[52]  J. Hrenović,et al.  Survival of emerging pathogen Acinetobacter baumannii in water environment exposed to different oxygen conditions. , 2019, Water science and technology : a journal of the International Association on Water Pollution Research.

[53]  Eric P. Skaar,et al.  The Acinetobacter baumannii Znu System Overcomes Host-Imposed Nutrient Zinc Limitation , 2019, Infection and Immunity.

[54]  A. Wilks,et al.  Heme uptake and utilization by hypervirulent Acinetobacter baumannii LAC-4 is dependent on a canonical heme oxygenase (abHemO). , 2019, Archives of biochemistry and biophysics.

[55]  R. Bonomo,et al.  Human Pleural Fluid Elicits Pyruvate and Phenylalanine Metabolism in Acinetobacter baumannii to Enhance Cytotoxicity and Immune Evasion , 2019, Front. Microbiol..

[56]  T. Velkov,et al.  Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii , 2019, Front. Pharmacol..

[57]  M. Gribskov,et al.  Comparative genome analysis reveals niche-specific genome expansion in Acinetobacter baumannii strains , 2019, PloS one.

[58]  Eric P. Skaar,et al.  Multi-metal Restriction by Calprotectin Impacts De Novo Flavin Biosynthesis in Acinetobacter baumannii. , 2019, Cell chemical biology.

[59]  F. Schreiber,et al.  Metabolic Responses to Polymyxin Treatment in Acinetobacter baumannii ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling , 2019, mSystems.

[60]  Karl A. Hassan,et al.  Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies , 2019, mBio.

[61]  P. Visca,et al.  Contribution of Active Iron Uptake to Acinetobacter baumannii Pathogenicity , 2019, Infection and Immunity.

[62]  Neal D. Hammer,et al.  Nutrient sulfur acquisition strategies employed by bacterial pathogens. , 2019, Current opinion in microbiology.

[63]  Eric P. Skaar,et al.  An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration. , 2019, Cell reports.

[64]  Karl A. Hassan,et al.  The Role of the CopA Copper Efflux System in Acinetobacter baumannii Virulence , 2019, International journal of molecular sciences.

[65]  Guang-Huey Lin,et al.  Biological roles of indole-3-acetic acid in Acinetobacter baumannii. , 2018, Microbiological research.

[66]  G. Dimopoulos,et al.  New treatments of multidrug-resistant Gram-negative ventilator-associated pneumonia. , 2018, Annals of translational medicine.

[67]  B. Averhoff,et al.  Identification and characterization of a carnitine transporter in Acinetobacter baumannii , 2018, MicrobiologyOpen.

[68]  M. Powers,et al.  Phospholipid retention in the absence of asymmetry strengthens the outer membrane permeability barrier to last-resort antibiotics , 2018, Proceedings of the National Academy of Sciences.

[69]  Samuel I. Miller,et al.  The Acinetobacter baumannii Mla system and glycerophospholipid transport to the outer membrane , 2018, bioRxiv.

[70]  B. Arulanandam,et al.  Acinetobacter baumannii Gastrointestinal Colonization Is Facilitated by Secretory IgA Which Is Reductively Dissociated by Bacterial Thioredoxin A , 2018, mBio.

[71]  P. Rather,et al.  A high-frequency phenotypic switch links bacterial virulence and environmental survival in Acinetobacter baumannii , 2018, Nature Microbiology.

[72]  G. Bou,et al.  Pneumonia infection in mice reveals the involvement of the feoA gene in the pathogenesis of Acinetobacter baumannii , 2018, Virulence.

[73]  L. Actis,et al.  Mucin acts as a nutrient source and a signal for the differential expression of genes coding for cellular processes and virulence factors in Acinetobacter baumannii , 2018, PloS one.

[74]  T. Jouenne,et al.  Unsaturated Fatty Acids Affect Quorum Sensing Communication System and Inhibit Motility and Biofilm Formation of Acinetobacter baumannii , 2018, International journal of molecular sciences.

[75]  Kerri A. Thom,et al.  Risk Factors and Outcomes Associated with Multidrug-Resistant Acinetobacter baumannii upon Intensive Care Unit Admission , 2017, Antimicrobial Agents and Chemotherapy.

[76]  T. Nishikawa,et al.  In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria , 2017, Antimicrobial Agents and Chemotherapy.

[77]  A. Nemec,et al.  Acinetobacter colistiniresistens sp. nov. (formerly genomic species 13 sensu Bouvet and Jeanjean and genomic species 14 sensu Tjernberg and Ursing), isolated from human infections and characterized by intrinsic resistance to polymyxins. , 2017, International journal of systematic and evolutionary microbiology.

[78]  J. Arthur,et al.  Siderophore‐mediated iron acquisition and modulation of host‐bacterial interactions , 2017, Free radical biology & medicine.

[79]  Brian T. Tsuji,et al.  Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii , 2017, Scientific Reports.

[80]  Karl A. Hassan,et al.  Zinc stress induces copper depletion in Acinetobacter baumannii , 2017, BMC Microbiology.

[81]  C. Rumbo,et al.  Assessment of antivirulence activity of several d-amino acids against Acinetobacter baumannii and Pseudomonas aeruginosa. , 2016, The Journal of antimicrobial chemotherapy.

[82]  Eric P. Skaar,et al.  Transition Metals and Virulence in Bacteria. , 2016, Annual review of genetics.

[83]  Eric P. Skaar,et al.  Acinetobacter baumannii Coordinates Urea Metabolism with Metal Import To Resist Host-Mediated Metal Limitation , 2016, mBio.

[84]  K. Schulze,et al.  Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis , 2016, Proceedings of the National Academy of Sciences.

[85]  A. Le Gouellec,et al.  Tryptophan catabolism in Pseudomonas aeruginosa and potential for inter-kingdom relationship , 2016, BMC Microbiology.

[86]  Eric P. Skaar,et al.  The Response of Acinetobacter baumannii to Zinc Starvation. , 2016, Cell host & microbe.

[87]  D. Hoban,et al.  Regional differences and trends in antimicrobial susceptibility of Acinetobacter baumannii. , 2016, International journal of antimicrobial agents.

[88]  P. Ježek,et al.  Taxonomy of haemolytic and/or proteolytic strains of the genus Acinetobacter with the proposal of Acinetobacter courvalinii sp. nov. (genomic species 14 sensu Bouvet & Jeanjean), Acinetobacter dispersus sp. nov. (genomic species 17), Acinetobacter modestus sp. nov., Acinetobacter proteolyticus sp. n , 2016, International journal of systematic and evolutionary microbiology.

[89]  Ronald N. Jones,et al.  In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria. , 2016, The Journal of antimicrobial chemotherapy.

[90]  Matthew D. Johnson,et al.  Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii , 2016, Scientific Reports.

[91]  H. Mobley,et al.  Acinetobacter baumannii Is Dependent on the Type II Secretion System and Its Substrate LipA for Lipid Utilization and In Vivo Fitness , 2015, Journal of bacteriology.

[92]  L. Peterson,et al.  Joint Transcriptional Control of Virulence and Resistance to Antibiotic and Environmental Stress in Acinetobacter baumannii , 2015, mBio.

[93]  H. Mobley,et al.  Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection , 2015, mSphere.

[94]  A. Nemec,et al.  Acinetobacter albensis sp. nov., isolated from natural soil and water ecosystems. , 2015, International journal of systematic and evolutionary microbiology.

[95]  I. Ebersberger,et al.  Acinetobacter baumannii Virulence Is Mediated by the Concerted Action of Three Phospholipases D , 2015, PloS one.

[96]  P. Nordmann,et al.  Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii: Mechanisms and epidemiology. , 2015, International journal of antimicrobial agents.

[97]  Xi Li,et al.  Global transcriptional response of Acinetobacter baumannii to a subinhibitory concentration of tigecycline. , 2014, International journal of antimicrobial agents.

[98]  A. Le Gouellec,et al.  Scavenging of reactive oxygen species by tryptophan metabolites helps Pseudomonas aeruginosa escape neutrophil killing. , 2014, Free radical biology & medicine.

[99]  Paolo Visca,et al.  Acinetobacter baumannii: evolution of a global pathogen. , 2014, Pathogens and disease.

[100]  A. Peleg,et al.  A global virulence regulator in Acinetobacter baumannii and its control of the phenylacetic acid catabolic pathway. , 2014, The Journal of infectious diseases.

[101]  Mark J. Mandel,et al.  Genome-Wide Identification of Acinetobacter baumannii Genes Necessary for Persistence in the Lung , 2014, mBio.

[102]  Eric P. Skaar,et al.  Acinetobacter baumannii Response to Host-Mediated Zinc Limitation Requires the Transcriptional Regulator Zur , 2014, Journal of bacteriology.

[103]  Eric P. Skaar,et al.  The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host , 2013, Front. Cell. Infect. Microbiol..

[104]  Karl A. Hassan,et al.  The Complete Genome and Phenome of a Community-Acquired Acinetobacter baumannii , 2013, PloS one.

[105]  Eric P. Skaar,et al.  Identification of an Acinetobacter baumannii Zinc Acquisition System that Facilitates Resistance to Calprotectin-mediated Zinc Sequestration , 2012, PLoS pathogens.

[106]  R. Bender,et al.  Regulation of the Histidine Utilization (Hut) System in Bacteria , 2012, Microbiology and Molecular Reviews.

[107]  Eric P. Skaar,et al.  Nutritional immunity: transition metals at the pathogen–host interface , 2012, Nature Reviews Microbiology.

[108]  L. Actis,et al.  The Acinetobacter baumannii entA Gene Located Outside the Acinetobactin Cluster Is Critical for Siderophore Production, Iron Acquisition and Virulence , 2012, PloS one.

[109]  L. Vécsei,et al.  The kynurenine system and immunoregulation , 2012, Journal of Neural Transmission.

[110]  J. Gaddy,et al.  Role of Acinetobactin-Mediated Iron Acquisition Functions in the Interaction of Acinetobacter baumannii Strain ATCC 19606T with Human Lung Epithelial Cells, Galleria mellonella Caterpillars, and Mice , 2012, Infection and Immunity.

[111]  N. Soares,et al.  Proteomic and functional analyses reveal a unique lifestyle for Acinetobacter baumannii biofilms and a key role for histidine metabolism. , 2011, Journal of proteome research.

[112]  S. Quattrucci,et al.  Neutrophil unsaturated fatty acid release by GM-CSF is impaired in cystic fibrosis , 2010, Lipids in Health and Disease.

[113]  D. Rasko,et al.  Patients with Acinetobacter baumannii bloodstream infections are colonized in the gastrointestinal tract with identical strains. , 2010, American journal of infection control.

[114]  F. Rojo.  Carbon catabolite repression in Pseudomonas : optimizing metabolic versatility and interactions with the environment. , 2010, FEMS microbiology reviews.

[115]  W. Eisenreich,et al.  Bacterial phenylalanine and phenylacetate catabolic pathway revealed , 2010, Proceedings of the National Academy of Sciences.

[116]  Eric P. Skaar,et al.  Inactivation of Phospholipase D Diminishes Acinetobacter baumannii Pathogenesis , 2010, Infection and Immunity.

[117]  J. Weissenbach,et al.  Acinetobacter baylyi ADP1 as a model for metabolic system biology. , 2009, Current opinion in microbiology.

[118]  U. Gerischer,et al.  Role of Acinetobacter baylyi Crc in Catabolite Repression of Enzymes for Aromatic Compound Catabolism , 2009, Journal of bacteriology.

[119]  G. Guillemin,et al.  Kynurenine Pathway Metabolites in Humans: Disease and Healthy States , 2009, International journal of tryptophan research : IJTR.

[120]  U. Gerischer,et al.  Aromatic degradative pathways in Acinetobacter baylyi underlie carbon catabolite repression. , 2008, Microbiology.

[121]  B. Görke,et al.  Carbon catabolite repression in bacteria: many ways to make the most out of nutrients , 2008, Nature Reviews Microbiology.

[122]  Harald Seifert,et al.  Acinetobacter baumannii: Emergence of a Successful Pathogen , 2008, Clinical Microbiology Reviews.

[123]  N. M. Kredich.  Biosynthesis of Cysteine , 2008, EcoSal Plus.

[124]  A. Viale,et al.  CarO, an Acinetobacter baumannii outer membrane protein involved in carbapenem resistance, is essential for l‐ornithine uptake , 2007, FEBS letters.

[125]  L. Dijkshoorn,et al.  An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii , 2007, Nature Reviews Microbiology.

[126]  T. Kelesidis,et al.  Community-acquired Acinetobacter infections , 2007, European Journal of Clinical Microbiology & Infectious Diseases.

[127]  Mark Gerstein,et al.  New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis. , 2007, Genes & development.

[128]  L. Marnett,et al.  Lipid profiling reveals arachidonate deficiency in RAW264.7 cells: Structural and functional implications. , 2006, Biochemistry.

[129]  C. Donskey.  Antibiotic regimens and intestinal colonization with antibiotic-resistant gram-negative bacilli. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[130]  P. Fournier,et al.  The epidemiology and control of Acinetobacter baumannii in health care facilities. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[131]  S. Narimatsu,et al.  Identification and transcriptional organization of a gene cluster involved in biosynthesis and transport of acinetobactin, a siderophore produced by Acinetobacter baumannii ATCC 19606T. , 2004, Microbiology.

[132]  U. Gerischer,et al.  Multiple operons connected with catabolism of aromatic compounds in Acinetobacter sp. strain ADP1 are under carbon catabolite repression. , 2002, Journal of molecular microbiology and biotechnology.

[133]  J. Ariza,et al.  Epidemiological significance of cutaneous, pharyngeal, and digestive tract colonization by multiresistant Acinetobacter baumannii in ICU patients. , 1997, The Journal of hospital infection.

[134]  J. Ariza,et al.  Relevance of digestive tract colonization in the epidemiology of nosocomial infections due to multiresistant Acinetobacter baumannii. , 1996, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[135]  J. Carlet,et al.  The digestive tract is a major site for Acinetobacter baumannii colonization in intensive care unit patients. , 1993, The Journal of infectious diseases.

[136]  P. Grimont,et al.  Identification and biotyping of clinical isolates of Acinetobacter. , 1987, Annales de l'Institut Pasteur. Microbiology.

[137]  J. G. Kuenen,et al.  Non-coordinated synthesis of glucose dehydrogenase and its prosthetic group PQQ in Acinetobacter and Pseudomonas species , 1984 .

[138]  L. Dechatelet,et al.  Release and metabolism of arachidonic acid in human neutrophils. , 1981, The Journal of biological chemistry.

[139]  K. Matsushita,et al.  Membrane-bound D-Glucose Dehydrogenase from Pseudomonas sp.: Solubilization, Purification and Characterization , 1980 .

[140]  C. Breuil,et al.  Characteristics of a facultatively psychrophilic Acinetobacter species isolated from river sediment. , 1975, Canadian Journal of Microbiology (print).

[141]  E. Juni,et al.  Nutritional Requirements of Acinetobacter Strains Isolated from Soil, Water, and Sewage , 1972, Journal of bacteriology.

[142]  E. Juni.  Interspecies Transformation of Acinetobacter: Genetic Evidence for a Ubiquitous Genus , 1972, Journal of bacteriology.

[143]  P. Baumann.  Isolation of Acinetobacter from Soil and Water , 1968, Journal of bacteriology.

[144]  M. Doudoroff,et al.  A Study of the Moraxella Group II. Oxidative-negative Species (Genus Acinetobacter) , 1968, Journal of bacteriology.

[145]  W. H. Taylor,et al.  Pathways for biosynthesis of a bacterial capsular polysaccharide. I. Carbohydrate metabolism and terminal oxidation mechanisms of a capsuleproducing coccus. , 1961, Journal of bacteriology.

[146]  W. H. Taylor,et al.  PATHWAYS FOR BIOSYNTHESIS OF A BACTERIAL CAPSULAR POLYSACCHARIDE I , 1961, The Journal of biological chemistry.

[147]  W. H. Taylor,et al.  PATHWAYS FOR BIOSYNTHESIS OF A BACTERIAL CAPSULAR POLYSACCHARIDE II , 1961 .

[148]  T. Velkov,et al.  Global Metabolic Analyses of Acinetobacter baumannii. , 2019, Methods in molecular biology.

[149]  L. Dijkshoorn,et al.  Phylogenetic signal in phenotypic traits related to carbon source assimilation and chemical sensitivity in Acinetobacter species , 2016, Applied Microbiology and Biotechnology.

[150]  M. Vaneechoutte,et al.  Acinetobacter, Chryseobacterium, Moraxella, and other Nonfermentative Gram-Negative Rods , 2010 .

[151]  E. Juni.  Genetics and physiology of Acinetobacter. , 1978, Annual review of microbiology.

[152]  L. N. Ornston,et al.  The beta-ketoadipate pathway. , 1973, Advances in microbial physiology.

[153]  W. H. Taylor,et al.  Pathways for biosynthesis of a bacterial capsular polysaccharide. I. Characterization of the organism and polysaccharide. , 1961, Journal of bacteriology.