Acquired factor XI inhibitors in congenitally deficient patients

Four factor XI (F XI)‐deficient patients are described, all of whom formed circulating anticoagulants against F X1. In the three most severely affected patients (F XI 0%–6% activity), the anticoagulant appeared to have been stimulated by plasma infusion. However, in the milder case (25% F XI activity), no infusion had been documented. The findings in these cases emphasize the diversity of F XI inhibitors in congenitally deficient patients. Awareness of the potential development of these inhibitors will be helpful in both daily management and perioperative care of such patients.

[1]  J. J. Michiels,et al.  Factor VIII inhibitor postpartum. , 2009, Scandinavian journal of haematology.

[2]  H. Wada,et al.  [Factor VIII inhibitor postpartum]. , 1986, [Rinsho ketsueki] The Japanese journal of clinical hematology.

[3]  O. Ratnoff,et al.  Studies on a circulating anticoagulant inhibiting factor XI in a patient with congenital deficiency and carcinoma of the prostate , 1986, British journal of haematology.

[4]  D. Feinstein,et al.  Acquired Factor XI Inhibitors in Two Patients with Hereditary Factor XI Deficiency , 1984, Thrombosis and Haemostasis.

[5]  N. Dainiak,et al.  Correction of Clotting Factor “Deficiencies” in Plasma from Patients with Lupus-Like Anticoagulants , 1984, Thrombosis and Haemostasis.

[6]  E. Reece,et al.  Spontaneous factor XI inhibitors. Seven additional cases and a review of the literature. , 1984, Archives of internal medicine.

[7]  D. Stern,et al.  Acquired antibody to factor XI in a patient with congenital factor XI deficiency. , 1982, The Journal of clinical investigation.

[8]  R. Hoffman,et al.  In vitro correction of anticoagulant activity and specific clotting factor assays in SLE. , 1980, Thrombosis research.

[9]  U. Seligsohn,et al.  High gene frequency of factor XI (PTA) deficiency in Ashkenazi Jews. , 1978, Blood.

[10]  W. Muir,et al.  The prevalence of plasma thromboplastin antecedent (PTA, factor XI) deficiency. , 1974, Blood.

[11]  R. Biggs.  Jaundice and Antibodies Directed against Factors VIII and IX in Patients Treated for Haemophilia or Christmas Disease in the United Kingdom , 1974, British journal of haematology.

[12]  L. Clyne,et al.  Circulating anticoagulants against factors IX and XI in systemic lupus erythematosus. , 1972, Annals of internal medicine.

[13]  D. Green.  Spontaneous Inhibitors of Factor VIII , 1968 .

[14]  R. Lisker,et al.  Demonstration of a circulating anticoagulant in plasma thromboplastin antecedent deficiency. , 1958, The Journal of clinical investigation.

[15]  D. Sinha,et al.  Comparison of bleeding tendency, factor XI coagulant activity, and factor XI antigen in 25 factor XI-deficient kindreds. , 1985, Blood.

[16]  J. Lobel,et al.  Spontaneously acquired Factor IX inhibitors in childhood. , 1981, The American journal of pediatric hematology/oncology.

[17]  E. Jaffe,et al.  A clinical study of the lupus anticoagulant. , 1976, Blood.

[18]  D. Green,et al.  A More Uniform Measurement of Factor VIII Inhibitors , 1975, Thrombosis and Haemostasis.

[19]  S. Rapaport,et al.  Acquired inhibitors of blood coagulation. , 1972, Progress in hemostasis and thrombosis.