Clinical Implementation of 3D Printing in the Construction of Patient Specific Bolus for Photon Beam Radiotherapy for Mycosis Fungoides

Mycosis fungoides (MF), also known as Alibert-Bazin syndrome or granuloma fungoides, are a common subset of cutaneous T-cell lymphoma, with peak incidence in the 55~60 years age range. Radiation therapy is the most effective treatment method of MF, these dramatic responses of low dose X-ray therapy to MF were reported by Sholtz in 1902. Radiation therapy induces cell death predominantly by apoptosis in hematopoietic lineages, and is able to achieve complete response (CR) at a much lower dose compared to solid cancers. Since electrons penetrate much lesser than X-rays, MF is commonly treated with electron-beam therapy. Even though electron beam has many advantages over photon beam, treating irregular surfaces, such as finger or feet, with electron beam cause inadequate tumor coverage and excess dose. Therefore, irregular surface is treated Progress in Medical Physics 28(1), March 2017 https://doi.org/10.14316/pmp.2017.28.1.33 pISSN 2508-4445, eISSN 2508-4453

[1]  T. Suh,et al.  Customized 3D Printed Bolus for Breast Reconstruction for Modified Radical Mastectomy (MRM) , 2016 .

[2]  K. Ng,et al.  On the Use of Optically Stimulated Luminescent Dosimeter for Surface Dose Measurement during Radiotherapy , 2015, PloS one.

[3]  Y. Rong,et al.  Treating Cutaneous T-Cell Lymphoma with Highly Irregular Surfaces with Photon Irradiation Using Rice as Tissue Compensator , 2015, Front. Oncol..

[4]  Byungchul Cho,et al.  Development of New 4D Phantom Model in Respiratory Gated Volumetric Modulated Arc Therapy for Lung SBRT , 2014 .

[5]  Jin Sung Kim,et al.  New technique for developing a proton range compensator with use of a 3-dimensional printer. , 2014, International journal of radiation oncology, biology, physics.

[6]  Santi Tofani,et al.  Dosimetric characterization and use of GAFCHROMIC EBT3 film for IMRT dose verification , 2013, Journal of applied clinical medical physics.

[7]  R. Hoppe Mycosis fungoides: radiation therapy , 2003, Dermatologic therapy.

[8]  G. Kantor,et al.  Radiotherapy for unilesional mycosis fungoides. , 1998, International journal of radiation oncology, biology, physics.

[9]  J. Palta,et al.  Comprehensive QA for radiation oncology: report of AAPM Radiation Therapy Committee Task Group 40. , 1994, Medical physics.

[10]  Z. Fuks,et al.  Electron-beam therapy for mycosis fungoides: the Stanford University experience. , 1979, Cancer treatment reports.

[11]  W. Scholtz Ueber den Einfluss der Röntgenstrahlen auf die Haut in gesundem und krankem Zustande , 2005, Archiv für Dermatologie und Syphilis.