Discovery and Biosynthesis of the Cytotoxic Polyene Terpenomycin in Human Pathogenic Nocardia.
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Spencer J. Williams | K. Voigt | L. Judd | K. Ishida | C. Hertweck | T. Stinear | S. Pidot | B. Howden | H. Dahse | Marion Herisse | Jordan Staiger-Creed
[1] W. Shieh,et al. Updated Review on Nocardia Species: 2006–2021 , 2022, Clinical microbiology reviews.
[2] Phillip S. Naimo,et al. Identification and antimicrobial susceptibility of referred Nocardia isolates in Victoria, Australia 2009-2019. , 2022, Journal of medical microbiology.
[3] H. Gross,et al. Natural Products from Nocardia and Their Role in Pathogenicity , 2021, Microbial Physiology.
[4] D. Jakimowicz,et al. Combining transposon mutagenesis and reporter genes to identify novel regulators of the topA promoter in Streptomyces , 2021, Microbial Cell Factories.
[5] Alexander M. Kloosterman,et al. antiSMASH 6.0: improving cluster detection and comparison capabilities , 2021, Nucleic Acids Res..
[6] C. Khosla,et al. Properties of a "Split-and-Stuttering" Module of an Assembly Line Polyketide Synthase. , 2021, Journal of Organic Chemistry.
[7] Constance B. Bailey,et al. Site‐Directed Mutagenesis of Modular Polyketide Synthase Ketoreductase Domains for Altered Stereochemical Control , 2020, Chembiochem : a European journal of chemical biology.
[8] B. Walker,et al. Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes , 2020, Proceedings of the National Academy of Sciences.
[9] Huimin Zhao,et al. Unraveling the iterative type I polyketide synthases hidden in Streptomyces , 2020, Proceedings of the National Academy of Sciences.
[10] Changhua Hu,et al. Transposon-based screen identifies a XRE family regulator crucial for candicidin biosynthesis in Streptomyces albus J1074 , 2020, Science China Life Sciences.
[11] K. Ishida,et al. Identification and mobilization of a cryptic antibiotic biosynthesis gene locus from a human-pathogenic Nocardia isolate. , 2019, ACS chemical biology.
[12] Roger G. Linington,et al. MIBiG 2.0: a repository for biosynthetic gene clusters of known function , 2019, Nucleic Acids Res..
[13] H. Jenke-Kodama,et al. Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases , 2019, Nature Communications.
[14] T. Seemann,et al. The ΦBT1 large serine recombinase catalyzes DNA integration at pseudo-attB sites in the genus Nocardia , 2018, PeerJ.
[15] Michael A. Skinnider,et al. PRISM 3: expanded prediction of natural product chemical structures from microbial genomes , 2017, Nucleic Acids Res..
[16] D. Mitchell,et al. Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. , 2016, Bioorganic & medicinal chemistry.
[17] C. Khosla,et al. Partial In Vitro Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis. , 2016, ACS chemical biology.
[18] A. Luzhetskyy,et al. Cloning and Heterologous Expression of the Grecocycline Biosynthetic Gene Cluster , 2016, PloS one.
[19] A. Hosoyama,et al. Genome based analysis of type-I polyketide synthase and nonribosomal peptide synthetase gene clusters in seven strains of five representative Nocardia species , 2014, BMC Genomics.
[20] K. Ishida,et al. Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line. , 2014, Angewandte Chemie.
[21] C. Hertweck,et al. Multifactorial control of iteration events in a modular polyketide assembly line. , 2013, Angewandte Chemie.
[22] Roland J. Siezen,et al. Classification of the Adenylation and Acyl-Transferase Activity of NRPS and PKS Systems Using Ensembles of Substrate Specific Hidden Markov Models , 2013, PloS one.
[23] D. Sherman,et al. Characterization of the Bafilomycin Biosynthetic Gene Cluster from Streptomyces lohii , 2013, Chembiochem : a European journal of chemical biology.
[24] P. Dorrestein,et al. Biosynthetic multitasking facilitates thalassospiramide structural diversity in marine bacteria. , 2013, Journal of the American Chemical Society.
[25] E. Y. Kim,et al. Identification of the biosynthetic gene cluster for the antibiotic polyketide L-155,175 in Streptomyces hygroscopicus , 2012, Folia Microbiologica.
[26] C. Fairhead,et al. Insertion site preference of Mu, Tn5, and Tn7 transposons , 2012, Mobile DNA.
[27] Jing He,et al. Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. , 2010, Journal of the American Chemical Society.
[28] Georgia Giannoukos,et al. Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung , 2009, Proceedings of the National Academy of Sciences.
[29] A. Keatinge-Clay,et al. A tylosin ketoreductase reveals how chirality is determined in polyketides. , 2007, Chemistry & biology.
[30] Minoru Kanehisa,et al. Comprehensive analysis of distinctive polyketide and nonribosomal peptide structural motifs encoded in microbial genomes. , 2007, Journal of molecular biology.
[31] Hung‐wen Liu,et al. Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies. , 2007, Biochemistry.
[32] C. Unkefer,et al. On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A. , 2006, Journal of the American Chemical Society.
[33] P. Leadlay,et al. Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449. , 2005, Microbiology.
[34] W. Dai,et al. Structures and total syntheses of the plecomacrolides. , 2005, Current medicinal chemistry.
[35] S. Grond,et al. Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A. , 2004, The Journal of antibiotics.
[36] C. Hertweck,et al. Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster. , 2003, Chemistry & biology.
[37] J. Staunton,et al. Active-site residue, domain and module swaps in modular polyketide synthases , 2003, Journal of Industrial Microbiology and Biotechnology.
[38] L. Bai,et al. The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[39] Linquan Bai,et al. Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B. , 2002, Journal of the American Chemical Society.
[40] L. Chung,et al. The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. , 2000, Gene.
[41] H. Naganawa,et al. Formamicin, a novel antifungal antibiotic produced by a strain of Saccharothrix sp. II. Structure elucidation of formamicin. , 1997, The Journal of antibiotics.
[42] S. Tanaka,et al. PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. II. Isolation, physico-chemical properties and structure elucidation. , 1993, The Journal of antibiotics.
[43] K. Altendorf,et al. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[44] Christine J. Martin,et al. Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. , 2004, Chemistry & biology.
[45] K. Altendorf,et al. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. , 1997, The Journal of experimental biology.