论文信息 - Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators.

Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators.

A series of 5-substituted 2-benzoylaminobenzoic acids has been synthesized and assayed for PPARalpha/gamma activity. Both dual activators and selective PPARgamma agonists have been identified. This class of compounds was shown to activate the PPARgamma receptor through interaction with a novel binding site.

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