Prostate cancer magnetic resonance imaging (MRI): multidisciplinary standpoint.

Prostate cancer is the most common cancer diagnosed in men and a leading cause of death. Accurate assessment is a prerequisite for optimal clinical management and therapy selection of prostate cancer. There are several parameters and nomograms to differentiate between patients with clinically insignificant disease and patients in need of treatment. Magnetic resonance imaging (MRI) is a technique which provides more detailed anatomical images due to high spatial resolution, superior contrast resolution, and multiplanar capability. State-of-the-art MRI techniques, such as diffusion weighted imaging (DWI), MR spectroscopic imaging (MRSI), dynamic contrast enhanced MRI (DCE-MRI), improve interpretation of prostate cancer imaging. In this article, we review the major role of MRI in the advanced management of prostate cancer to noninvasively improve tumor staging, biologic potential, treatment planning, therapy response, local recurrence, and to guide target biopsy for clinical suspected cancer with previous negative biopsy. Finally, future challenges and opportunities in prostate cancer management in the area of functional MRI are discussed as well.

[1]  M. Kattan,et al.  Pretreatment nomogram that predicts 5-year probability of metastasis following three-dimensional conformal radiation therapy for localized prostate cancer. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[2]  Michael W Kattan,et al.  Cancer control with radical prostatectomy alone in 1,000 consecutive patients. , 2002, The Journal of urology.

[3]  K. Nepple,et al.  Concordance of preoperative prostate endorectal MRI with subsequent prostatectomy specimen in high-risk prostate cancer patients. , 2013, Urologic oncology.

[4]  C C Schulman,et al.  Prospective evaluation of prostate cancer detected on biopsies 1, 2, 3 and 4: when should we stop? , 2001, The Journal of urology.

[5]  Robert E Lenkinski,et al.  Prostate cancer: accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging--initial results. , 2007, Radiology.

[6]  J. Fowler,et al.  Clinical outcome in patients with prostate cancer treated with external beam radiotherapy and high dose-rate iridium 192 brachytherapy boost: A 6-year follow-up , 2007, Acta oncologica.

[7]  Benjamin M Yeh,et al.  Peripheral zone prostate cancer: accuracy of different interpretative approaches with MR and MR spectroscopic imaging. , 2008, Radiology.

[8]  B. Bloch,et al.  Prediction of prostate cancer extracapsular extension with high spatial resolution dynamic contrast-enhanced 3-T MRI , 2012, European Radiology.

[9]  Bernd Hamm,et al.  Patients with a history of elevated prostate-specific antigen levels and negative transrectal US-guided quadrant or sextant biopsy results: value of MR imaging. , 2002, Radiology.

[10]  D. Johnston,et al.  Analysis of clinicopathologic factors predicting outcome after radical prostatectomy , 2001, Cancer.

[11]  J. Karstens,et al.  Definitive conformal radiotherapy for localized high-risk prostate cancer: a long-term follow-up study with PSA course. , 2007, Anticancer research.

[12]  Michel Bolla,et al.  [EAU guidelines on prostate cancer]. , 2009, Actas urologicas espanolas.

[13]  T. Scheenen,et al.  Prostate and lymph node proton magnetic resonance (MR) spectroscopic imaging with external array coils at 3 T to detect recurrent prostate cancer after radiation therapy. , 2007, Investigative radiology.

[14]  J. Epstein.  An update of the Gleason grading system. , 2010, The Journal of urology.

[15]  V. Moyer,et al.  Screening for Prostate Cancer: U.S. Preventive Services Task Force Recommendation Statement , 2012, Annals of Internal Medicine.

[16]  A. Gelabert-Más,et al.  The value of endorectal MRI in the early diagnosis of prostate cancer. , 2003, European urology.

[17]  Jan J W Lagendijk,et al.  MRI-guided robotic system for transperineal prostate interventions: proof of principle , 2010, Physics in medicine and biology.

[18]  K. Harada,et al.  Usefulness of the Nadir Value of Serum Prostate-Specific Antigen Measured by an Ultrasensitive Assay as a Predictor of Biochemical Recurrence after Radical Prostatectomy for Clinically Localized Prostate Cancer , 2006, Urologia Internationalis.

[19]  Anke M Hövels,et al.  Prostate cancer: detection of lymph node metastases outside the routine surgical area with ferumoxtran-10-enhanced MR imaging. , 2009, Radiology.

[20]  R. Caivano,et al.  Prostate cancer in magnetic resonance imaging: diagnostic utilities of spectroscopic sequences , 2012, Journal of medical imaging and radiation oncology.

[21]  T. Kessler,et al.  Nerve sparing open radical retropubic prostatectomy--does it have an impact on urinary continence? , 2006, The Journal of urology.

[22]  Hugh J. Lavery,et al.  Endorectal magnetic resonance imaging has limited clinical ability to preoperatively predict pT3 prostate cancer , 2011, BJU international.

[23]  P. Dahm,et al.  Screening for prostate cancer. , 2013, The Cochrane database of systematic reviews.

[24]  H. Lepor,et al.  Site of positive surgical margins influences biochemical recurrence after radical prostatectomy , 2009, BJU international.

[25]  E. Adang,et al.  The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with prostate cancer: a meta-analysis. , 2008, Clinical radiology.

[26]  Lawrence H Schwartz,et al.  Combined endorectal and phased-array MRI in the prediction of pelvic lymph node metastasis in prostate cancer. , 2006, AJR. American journal of roentgenology.

[27]  I. Sesterhenn,et al.  World health organization classifications of tumours. pathology and genetics of tumours of the urinary system and male genital organs , 2005 .

[28]  Josep Comet,et al.  Usefulness of prebiopsy multifunctional and morphologic MRI combined with free-to-total prostate-specific antigen ratio in the detection of prostate cancer. , 2011, AJR. American journal of roentgenology.

[29]  D. Lubeck,et al.  Under staging and under grading in a contemporary series of patients undergoing radical prostatectomy: results from the Cancer of the Prostate Strategic Urologic Research Endeavor database. , 2001, The Journal of urology.

[30]  H. Hricak,et al.  Detection of prostate cancer with MR spectroscopic imaging: an expanded paradigm incorporating polyamines. , 2007, Radiology.

[31]  Alan W Partin,et al.  Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy. , 2005, JAMA.

[32]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.

[33]  Matthias Taupitz,et al.  Evaluation of Normal Prostate Tissue, Chronic Prostatitis, and Prostate Cancer by Quantitative Perfusion Analysis Using a Dynamic Contrast-Enhanced Inversion-Prepared Dual-Contrast Gradient Echo Sequence , 2008, Investigative radiology.

[34]  Detection of local recurrent prostate cancer after radical prostatectomy in terms of salvage radiotherapy using dynamic contrast enhanced-MRI without endorectal coil , 2012, Radiation oncology.

[35]  G. De Meerleer,et al.  Comparison of qualitative and quantitative approach to prostate MR spectroscopy in peripheral zone cancer detection. , 2012, European journal of radiology.

[36]  H. Hricak,et al.  Incremental value of multiplanar cross-referencing for prostate cancer staging with endorectal MRI. , 2007, AJR. American journal of roentgenology.

[37]  Ralph Weissleder,et al.  Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. , 2003, The New England journal of medicine.

[38]  Evis Sala,et al.  Endorectal MR imaging before salvage prostatectomy: tumor localization and staging. , 2006, Radiology.

[39]  Cher Heng Tan,et al.  Diffusion-weighted MRI in the detection of prostate cancer: meta-analysis. , 2012, AJR. American journal of roentgenology.

[40]  M. Scherr,et al.  Proton MR spectroscopy of the prostate. , 2007, European journal of radiology.

[41]  Andrew J Vickers,et al.  Prostate cancer-specific mortality after radical prostatectomy for patients treated in the prostate-specific antigen era. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[42]  D. Beyersdorff,et al.  MRI before and after external beam intensity-modulated radiotherapy of patients with prostate cancer: the feasibility of monitoring of radiation-induced tissue changes using a dynamic contrast-enhanced inversion-prepared dual-contrast gradient echo sequence. , 2009, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[43]  K. Fareed,et al.  When serial prostate biopsy is recommended: most cancers detected are clinically insignificant , 2012, BJU international.

[44]  A W Partin,et al.  Prognostic significance of Gleason score 3+4 versus Gleason score 4+3 tumor at radical prostatectomy. , 2000, Urology.

[45]  D. Dearnaley,et al.  Diffusion-weighted MRI for locally recurrent prostate cancer after external beam radiotherapy. , 2012, AJR. American journal of roentgenology.

[46]  David A Jaffray,et al.  Changes in apparent diffusion coefficient and T2 relaxation during radiotherapy for prostate cancer , 2013, Journal of magnetic resonance imaging : JMRI.

[47]  Thomas Hambrock,et al.  Magnetic resonance imaging guided prostate biopsy in men with repeat negative biopsies and increased prostate specific antigen. , 2010, The Journal of urology.

[48]  T. H. van der Kwast,et al.  Lesions predictive for prostate cancer in a screened population: First and second screening round findings , 2004, The Prostate.

[49]  H. Huisman,et al.  Interpatient variation in normal peripheral zone apparent diffusion coefficient: effect on the prediction of prostate cancer aggressiveness. , 2012, Radiology.

[50]  H. Schlemmer,et al.  Impact of Clinical Parameters on the Diagnostic Accuracy of Endorectal Coil MRI for the Detection of Prostate Cancer , 2011, Urologia Internationalis.

[51]  F. Migliorini,et al.  Accuracy of preoperative endo-rectal coil magnetic resonance imaging in detecting clinical under-staging of localized prostate cancer , 2013, World Journal of Urology.

[52]  Tom W J Scheenen,et al.  Feasibility of a pneumatically actuated MR-compatible robot for transrectal prostate biopsy guidance. , 2011, Radiology.

[53]  R. Lenkinski,et al.  Body MR imaging at 3.0 T: understanding the opportunities and challenges. , 2007, Radiographics : a review publication of the Radiological Society of North America, Inc.

[54]  Michael Uder,et al.  Magnetic Resonance Image-Guided Biopsies with a High Detection Rate of Prostate Cancer , 2012, TheScientificWorldJournal.

[55]  Hedvig Hricak,et al.  Pretreatment evaluation of prostate cancer: role of MR imaging and 1H MR spectroscopy. , 2004, Radiographics : a review publication of the Radiological Society of North America, Inc.

[56]  A. Jemal,et al.  Cancer statistics, 2013 , 2013, CA: a cancer journal for clinicians.

[57]  J R Griffiths,et al.  DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: A feasibility study , 2012, Magnetic resonance in medicine.

[58]  L. Kiemeney,et al.  A comparison of the diagnostic performance of systematic versus ultrasound-guided biopsies of prostate cancer , 2006, European Radiology.

[59]  B. K. Park,et al.  Diffusion‐weighted MR imaging for the evaluation of seminal vesicle invasion in prostate cancer: Initial results , 2008, Journal of magnetic resonance imaging : JMRI.

[60]  Jiani Hu,et al.  The clinical value of diffusion-weighted imaging in combination with T2-weighted imaging in diagnosing prostate carcinoma: a systematic review and meta-analysis. , 2012, AJR. American journal of roentgenology.

[61]  Jurgen J Fütterer,et al.  MR imaging in local staging of prostate cancer. , 2007, European journal of radiology.

[62]  Lars Egevad,et al.  A contemporary update on pathology reporting for prostate cancer: biopsy and radical prostatectomy specimens. , 2012, European urology.

[63]  D Jacqmin,et al.  Lymph node metastases: safety and effectiveness of MR imaging with ultrasmall superparamagnetic iron oxide particles--initial clinical experience. , 1998, Radiology.

[64]  S. Prasad,et al.  Salvage radical prostatectomy as management of locally recurrent prostate cancer: outcomes and complications , 2013, World Journal of Urology.

[65]  H. Yin,et al.  Seminal vesicle invasion in prostate cancer: prediction with combined T2-weighted and diffusion-weighted MR imaging , 2009, European Radiology.

[66]  M. Oefelein.  Prospective predictors of urinary continence after anatomical radical retropubic prostatectomy: a multivariate analysis , 2004, World Journal of Urology.

[67]  C. Compton,et al.  AJCC Cancer Staging Manual , 2002, Springer New York.

[68]  Michael W Kattan,et al.  Prostate cancer: incremental value of endorectal MR imaging findings for prediction of extracapsular extension. , 2004, Radiology.

[69]  M. Hekimgil,et al.  The potential value of power Doppler ultrasound imaging compared with grey-scale ultrasound findings in the diagnosis of local recurrence after radical prostatectomy. , 2006, Clinical radiology.

[70]  L. Turnbull,et al.  Description of magnetic resonance imaging‐derived enhancement variables in pathologically confirmed prostate cancer and normal peripheral zone regions , 2009, BJU international.

[71]  Thomas Hambrock,et al.  Thirty-Two-Channel Coil 3T Magnetic Resonance-Guided Biopsies of Prostate Tumor Suspicious Regions Identified on Multimodality 3T Magnetic Resonance Imaging: Technique and Feasibility , 2008, Investigative radiology.

[72]  W. I. Tseng,et al.  Washout gradient in dynamic contrast‐enhanced MRI is associated with tumor aggressiveness of prostate cancer , 2012, Journal of magnetic resonance imaging : JMRI.

[73]  Jian-Rong Xu,et al.  Usefulness of diffusion-weighted magnetic resonance imaging in the diagnosis of prostate cancer. , 2012, Academic radiology.

[74]  S. Hussain,et al.  Post-processing of dynamic gadolinium-enhanced magnetic resonance imaging exams of the liver: explanation and potential clinical applications for color-coded qualitative and quantitative analysis , 2008, Acta radiologica.

[75]  A. Jemal,et al.  Global Patterns of Cancer Incidence and Mortality Rates and Trends , 2010, Cancer Epidemiology, Biomarkers & Prevention.

[76]  M. Kattan,et al.  Prediction of organ-confined prostate cancer: incremental value of MR imaging and MR spectroscopic imaging to staging nomograms. , 2006, Radiology.

[77]  H. Hricak,et al.  Assessment of biologic aggressiveness of prostate cancer: correlation of MR signal intensity with Gleason grade after radical prostatectomy. , 2008, Radiology.

[78]  Mesut Remzi,et al.  PSA progression following radical prostatectomy and radiation therapy: new standards in the new Millennium. , 2003, European urology.

[79]  M. Kattan,et al.  Predicting the presence and side of extracapsular extension: a nomogram for staging prostate cancer. , 2004, The Journal of urology.

[80]  Baris Turkbey,et al.  Overview of dynamic contrast-enhanced MRI in prostate cancer diagnosis and management. , 2012, AJR. American journal of roentgenology.

[81]  A. Partin,et al.  Long-term cancer control of radical prostatectomy in men younger than 50 years of age: update 2003. , 2003, Urology.

[82]  C. Ganter,et al.  Preliminary Results for Characterization of Pelvic Lymph Nodes in Patients With Prostate Cancer by Diffusion-Weighted MR-Imaging , 2010, Investigative radiology.

[83]  E. Feuer,et al.  Cancer surveillance series: interpreting trends in prostate cancer--part I: Evidence of the effects of screening in recent prostate cancer incidence, mortality, and survival rates. , 1999, Journal of the National Cancer Institute.

[84]  Baris Turkbey,et al.  Is apparent diffusion coefficient associated with clinical risk scores for prostate cancers that are visible on 3-T MR images? , 2011, Radiology.

[85]  Maria Triantafyllou,et al.  Combined ultrasmall superparamagnetic particles of iron oxide-enhanced and diffusion-weighted magnetic resonance imaging reliably detect pelvic lymph node metastases in normal-sized nodes of bladder and prostate cancer patients. , 2009, European urology.

[86]  G.S. Fischer,et al.  MRI-Compatible Pneumatic Robot for Transperineal Prostate Needle Placement , 2008, IEEE/ASME Transactions on Mechatronics.

[87]  G. Dohle,et al.  Sexual function before and after radical retropubic prostatectomy: A systematic review of prognostic indicators for a successful outcome. , 2006, European urology.

[88]  J C Presti,et al.  Prostate cancer: assessment of risk using digital rectal examination, tumor grade, prostate-specific antigen, and systematic biopsy. , 2000, Radiologic clinics of North America.

[89]  Heinz-Peter Schlemmer,et al.  MRI-guided biopsy of the prostate increases diagnostic performance in men with elevated or increasing PSA levels after previous negative TRUS biopsies. , 2006, European urology.

[90]  Thomas Hambrock,et al.  Prostate cancer: multiparametric MR imaging for detection, localization, and staging. , 2011, Radiology.

[91]  A. Partin,et al.  Time to prostate specific antigen recurrence after radical prostatectomy and risk of prostate cancer specific mortality. , 2006, The Journal of urology.

[92]  P. Scardino.  Continuing refinements in radical prostatectomy: more evidence that technique matters. , 2005, The Journal of urology.

[93]  J. Ferlay,et al.  Estimates of the cancer incidence and mortality in Europe in 2006. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

[94]  M. Menon,et al.  A critical analysis of the current knowledge of surgical anatomy related to optimization of cancer control and preservation of continence and erection in candidates for radical prostatectomy. , 2010, European urology.

[95]  Kevin J Chang,et al.  3.0-T MR imaging of the abdomen: comparison with 1.5 T. , 2008, Radiographics : a review publication of the Radiological Society of North America, Inc.