Abstract The development of a comprehensive mesoscale atmospheric simulation system (MASS) is described in detail. The modeling system is designed for both research and real-time forecast applications. The 14-level numerical model, which has a 48 km grid mesh, can be run over most of North America and the adjacent oceanic regions. The model employs sixth-order accurate numerics, generalized similarity theory boundary-layer physics, a sophisticated cumulus parameterization scheme, and state of the art analysis and initialization techniques. Examples of model output on the synoptic and subsynoptic scales are presented for the AVE-SESAME I field experiment on 10–11 April 1979. The model output is subjectively compared to the observational analysis and the LFM II output on the synoptic scale. Subsynoptic model output is compared to analyses generated from the AVE-SESAME I data set.