This paper presents a comprehensive socio-technical framework for the design and development of a Clinical and Translational Science Informatics Infrastructure (CTSII). Based on our experience with developing and applying the framework we present a case study to illustrate the issues that arise in the creating a CTSII, and how possibly these issues can be resolved. The framework is presented as a menu with six columns, each column representing a dimension of the framework. The categories within each dimension can be concatenated, with the conjunctive phrases/words between the columns, to form sentences that describe all the functions of the CTSII. Elucidation of all the combinations will provide an exhaustive list of all the possible functions of CTSII.
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