Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders.

[1]  C. J. Landmark,et al.  Antiepileptic Drugs in Non-Epilepsy Disorders , 2012 .

[2]  D. Chuang,et al.  Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice. , 2011, The international journal of neuropsychopharmacology.

[3]  C. B. Smith,et al.  Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome. , 2011, The international journal of neuropsychopharmacology.

[4]  Istvan Pirko,et al.  The relevance of animal models in multiple sclerosis research. , 2011, Pathophysiology : the official journal of the International Society for Pathophysiology.

[5]  J. Sweatt,et al.  Deficiency in the Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3 Increases Sensitivity to Mood Disturbances , 2010, Neuropsychopharmacology.

[6]  Aaron J. Bell,et al.  Age-dependent cognitive impairment in a Drosophila Fragile X model and its pharmacological rescue , 2010, Biogerontology.

[7]  R. Conwit,et al.  Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial , 2010, The Lancet Neurology.

[8]  F. Baertling,et al.  TTC staining of damaged brain areas after MCA occlusion in the rat does not constrict quantitative gene and protein analyses , 2010, Journal of Neuroscience Methods.

[9]  L. Piedrafita,et al.  Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord , 2010, Neuroscience.

[10]  J. Sweatt,et al.  Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome. , 2010, Biochemical pharmacology.

[11]  F. Fornai,et al.  A systematic study of brainstem motor nuclei in a mouse model of ALS, the effects of lithium , 2010, Neurobiology of Disease.

[12]  A. Hackam,et al.  Lithium chloride regulates the proliferation of stem-like cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway , 2010, Molecular vision.

[13]  A. Contestabile,et al.  Lithium Restores Neurogenesis in the Subventricular Zone of the Ts65Dn Mouse, a Model for Down Syndrome , 2010, Brain pathology.

[14]  P. Fletcher,et al.  Abnormalities in brain structure and behavior in GSK-3alpha mutant mice , 2009, Molecular Brain.

[15]  Yan Leng,et al.  Multiple roles of HDAC inhibition in neurodegenerative conditions , 2009, Trends in Neurosciences.

[16]  B. Appleby Psychotropic medications and the treatment of human prion diseases. , 2009, CNS & neurological disorders drug targets.

[17]  Peng Liu,et al.  miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation , 2009, Brain Research Bulletin.

[18]  R. Baldessarini,et al.  Long-term lithium treatment in the prevention of suicidal behavior in bipolar disorder patients , 2009, Epidemiologia e Psichiatria Sociale.

[19]  T. Duka,et al.  α‐Synuclein contributes to GSK‐3β‐catalyzed Tau phosphorylation in Parkinson's disease models , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  S. Perrin,et al.  No Benefit from Chronic Lithium Dosing in a Sibling-Matched, Gender Balanced, Investigator-Blinded Trial Using a Standard Mouse Model of Familial ALS , 2009, PloS one.

[21]  Derick R. Peterson,et al.  Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment , 2009, Journal of NeuroVirology.

[22]  H. Möller,et al.  Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. , 2009, The Journal of clinical psychiatry.

[23]  M. Pallàs,et al.  Calpains as a target for therapy of neurodegenerative diseases: putative role of lithium. , 2009, Current drug metabolism.

[24]  Guang Chen,et al.  Evidence for Selective microRNAs and Their Effectors as Common Long-Term Targets for the Actions of Mood Stabilizers , 2009, Neuropsychopharmacology.

[25]  C. B. Smith,et al.  Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome , 2009, Neuroscience Letters.

[26]  H. Schätzl,et al.  Lithium induces clearance of protease resistant prion protein in prion‐infected cells by induction of autophagy , 2009, Journal of neurochemistry.

[27]  Xuan Liu,et al.  Lithium chloride protects retinal neurocytes from nutrient deprivation by promoting DNA non-homologous end-joining. , 2009, Biochemical and biophysical research communications.

[28]  Huanxing Su,et al.  Lithium enhances the neuronal differentiation of neural progenitor cells in vitro and after transplantation into the avulsed ventral horn of adult rats through the secretion of brain‐derived neurotrophic factor , 2009, Journal of neurochemistry.

[29]  F. Terro,et al.  Inhibition of glycogen synthase kinase-3β downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A , 2009, Brain Research.

[30]  M. Pallàs,et al.  Evidence of calpain/cdk5 pathway inhibition by lithium in 3-nitropropionic acid toxicity in vivo and in vitro , 2009, Neuropharmacology.

[31]  R. Jope,et al.  Elevated glycogen synthase kinase-3 activity in Fragile X mice: Key metabolic regulator with evidence for treatment potential , 2009, Neuropharmacology.

[32]  Hiroyuki Nishikawa,et al.  Glucocorticoids and Lithium Reciprocally Regulate the Proliferation of Adult Dentate Gyrus-Derived Neural Precursor Cells Through GSK-3β and β-Catenin/TCF Pathway , 2009, Neuropsychopharmacology.

[33]  K. Arai,et al.  Lithium Upregulates Vascular Endothelial Growth Factor in Brain Endothelial Cells and Astrocytes , 2009, Stroke.

[34]  O. Forlenza,et al.  Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease , 2009, European Archives of Psychiatry and Clinical Neuroscience.

[35]  R. DePinho,et al.  Forkhead Box, Class O Transcription Factors in Brain: Regulation and Behavioral Manifestation , 2009, Biological Psychiatry.

[36]  C. Bendotti,et al.  Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice , 2009, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

[37]  Carlos A. Garcia,et al.  Antigenic Experience Dictates Functional Role of Glycogen Synthase Kinase-3 in Human CD4+ T Cell Responses1 , 2008, The Journal of Immunology.

[38]  F. Mármol Lithium: Bipolar disorder and neurodegenerative diseases Possible cellular mechanisms of the therapeutic effects of lithium , 2008, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[39]  K. Broadie,et al.  Motor Deficit in a Drosophila Model of Mucolipidosis Type IV due to Defective Clearance of Apoptotic Cells , 2008, Cell.

[40]  A. Musarò,et al.  Skeletal muscle is a primary target of SOD1G93A-mediated toxicity. , 2008, Cell metabolism.

[41]  P. Andersen,et al.  Lithium treatment and risk of dementia. , 2008, Archives of general psychiatry.

[42]  Wenzhong Du,et al.  Lithium Chloride Preconditioning Optimizes Skeletal Myoblast Functions for Cellular Cardiomyoplasty in vitro via Glycogen Synthase Kinase-3β/β-Catenin Signaling , 2008, Cells Tissues Organs.

[43]  Z. Qin,et al.  Synergistic effects of prostaglandin E1 and lithium in a rat model of cerebral ischemia , 2008, Acta Pharmacologica Sinica.

[44]  Shuxin Li,et al.  Inactivation of Glycogen Synthase Kinase 3 Promotes Axonal Growth and Recovery in the CNS , 2008, The Journal of Neuroscience.

[45]  D. Chuang,et al.  Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model , 2008, Neuroscience.

[46]  M. Kaster,et al.  Antidepressant-like effect of the novel thiadiazolidinone NP031115 in mice , 2008, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[47]  I. Weiler,et al.  Open-Label Treatment Trial of Lithium to Target the Underlying Defect in Fragile X Syndrome , 2008, Journal of developmental and behavioral pediatrics : JDBP.

[48]  T. P. Neufeld,et al.  The cell biology of autophagy in metazoans: a developing story , 2008, Development.

[49]  D. Alessi,et al.  Lithium Prevents and Ameliorates Experimental Autoimmune Encephalomyelitis 1 , 2008 .

[50]  S. Lovestone,et al.  A feasibility and tolerability study of lithium in Alzheimer's disease , 2008, International journal of geriatric psychiatry.

[51]  N. Vanacore,et al.  A clinical specification for a randomized clinical trial on lithium in amyotrophic lateral sclerosis , 2008, Proceedings of the National Academy of Sciences.

[52]  S. Koh,et al.  Inhibition of glycogen synthase kinase-3 reduces L-DOPA-induced neurotoxicity. , 2008, Toxicology.

[53]  H. Manji,et al.  Generation and behavioral characterization of β-catenin forebrain-specific conditional knock-out mice , 2008, Behavioural Brain Research.

[54]  D. Chen,et al.  Promoting Optic Nerve Regeneration in Adult Mice with Pharmaceutical Approach , 2008, Neurochemical Research.

[55]  G. Olmos,et al.  Vascular endothelial growth factor protects spinal cord motoneurons against glutamate‐induced excitotoxicity via phosphatidylinositol 3‐kinase , 2008, Journal of neurochemistry.

[56]  R. Bedlack,et al.  Lithium may slow progression of amyotrophic lateral sclerosis, but further study is needed , 2008, Proceedings of the National Academy of Sciences.

[57]  F. Terro,et al.  Lithium down-regulates tau in cultured cortical neurons: A possible mechanism of neuroprotection , 2008, Neuroscience Letters.

[58]  E. Head,et al.  Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer's Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2 , 2008, The Journal of Neuroscience.

[59]  C. Vadász,et al.  Lithium blocks ethanol-induced modulation of protein kinases in the developing brain. , 2008, Biochemical and biophysical research communications.

[60]  Z. Marinova,et al.  Synergistic Neuroprotective Effects of Lithium and Valproic Acid or Other Histone Deacetylase Inhibitors in Neurons: Roles of Glycogen Synthase Kinase-3 Inhibition , 2008, The Journal of Neuroscience.

[61]  D H Geschwind,et al.  Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation , 2008, Molecular Psychiatry.

[62]  J. Wendland,et al.  Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling , 2008, Molecular and Cellular Neuroscience.

[63]  M. Strong,et al.  Upregulation of GSK3β expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci) , 2008, Brain Research.

[64]  Gabriele Siciliano,et al.  Lithium delays progression of amyotrophic lateral sclerosis , 2008, Proceedings of the National Academy of Sciences.

[65]  J. Os,et al.  Evidence that lithium protects against tardive dyskinesia: The Curaçao Extrapyramidal Syndromes study VI , 2008, European Neuropsychopharmacology.

[66]  Y. R. Kim,et al.  Functional MRI of Delayed Chronic Lithium Treatment in Rat Focal Cerebral Ischemia , 2008, Stroke.

[67]  R. Rodriguiz,et al.  Role of GSK3β in behavioral abnormalities induced by serotonin deficiency , 2008, Proceedings of the National Academy of Sciences.

[68]  R. Moon,et al.  Active (cid:2) -Catenin Signaling Is an Inhibitory Pathway for Human Immunodeficiency Virus Replication in Peripheral Blood Mononuclear Cells (cid:1) , 2008 .

[69]  D. Rubinsztein,et al.  A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. , 2008, Human molecular genetics.

[70]  Guido Kroemer,et al.  Autophagy in the Pathogenesis of Disease , 2008, Cell.

[71]  R. Rodriguiz,et al.  A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior , 2008, Cell.

[72]  J. Crandall,et al.  Cdk5 Regulates the Phosphorylation of Tyrosine 1472 NR2B and the Surface Expression of NMDA Receptors , 2008, The Journal of Neuroscience.

[73]  M. Rajadhyaksha,et al.  An Unusual Member of the Cdk Family: Cdk5 , 2008, Cellular and Molecular Neurobiology.

[74]  V. Meininger,et al.  Lithium therapy in ALS , 2008, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

[75]  D. Chuang,et al.  GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder , 2007, Neuroscience & Biobehavioral Reviews.

[76]  Mark F. Bear,et al.  Correction of Fragile X Syndrome in Mice , 2007, Neuron.

[77]  C. Nocjar,et al.  Chronic lithium treatment magnifies learning in rats , 2007, Neuroscience.

[78]  O. Martinez,et al.  Latent Membrane Protein 1 of EBV Activates Phosphatidylinositol 3-Kinase to Induce Production of IL-101 , 2007, The Journal of Immunology.

[79]  Xiaohua Li,et al.  Lithium Reduces FoxO3a Transcriptional Activity by Decreasing Its Intracellular Content , 2007, Biological Psychiatry.

[80]  D. Chuang,et al.  Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral deficits in gerbils , 2007, Brain Research.

[81]  N. Sousa,et al.  Lithium prevents stress-induced reduction of vascular endothelium growth factor levels , 2007, Neuroscience Letters.

[82]  A. Baxter,et al.  The origin and application of experimental autoimmune encephalomyelitis , 2007, Nature Reviews Immunology.

[83]  H. Manji,et al.  β-Catenin Overexpression in the Mouse Brain Phenocopies Lithium-Sensitive Behaviors , 2007, Neuropsychopharmacology.

[84]  F. Takahashi‐Yanaga,et al.  The Wnt/β-Catenin Signaling Pathway as a Target in Drug Discovery , 2007 .

[85]  Guido Kroemer,et al.  Self-eating and self-killing: crosstalk between autophagy and apoptosis , 2007, Nature Reviews Molecular Cell Biology.

[86]  Roland Martin,et al.  Multiple sclerosis: a complicated picture of autoimmunity , 2007, Nature Immunology.

[87]  Jiang-Ning Zhou,et al.  Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia , 2007, Neuropharmacology.

[88]  J. Lucas,et al.  N-terminal Cleavage of GSK-3 by Calpain , 2007, Journal of Biological Chemistry.

[89]  D. van der Kooy,et al.  Ciliary margin transdifferentiation from neural retina is controlled by canonical Wnt signaling. , 2007, Developmental biology.

[90]  Huanxing Su,et al.  Lithium enhances proliferation and neuronal differentiation of neural progenitor cells in vitro and after transplantation into the adult rat spinal cord , 2007, Experimental Neurology.

[91]  Z. Qin,et al.  Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia , 2007, Acta Pharmacologica Sinica.

[92]  H. Manji,et al.  In Search of the Holy Grail for the Treatment of Neurodegenerative Disorders: Has a Simple Cation Been Overlooked? , 2007, Biological Psychiatry.

[93]  Kiralee M. Hayashi,et al.  Greater Cortical Gray Matter Density in Lithium-Treated Patients with Bipolar Disorder , 2007, Biological Psychiatry.

[94]  C. Shaw,et al.  Lithium Therapy Improves Neurological Function and Hippocampal Dendritic Arborization in a Spinocerebellar Ataxia Type 1 Mouse Model , 2007, PLoS Medicine.

[95]  Guo-Yuan Yang,et al.  Therapeutic Angiogenesis for Brain Ischemia: A Brief Review , 2007, Journal of Neuroimmune Pharmacology.

[96]  J. Shin,et al.  Concurrent Administration of Neu2000 and Lithium Produces Marked Improvement of Motor Neuron Survival, Motor Function, and Mortality in a Mouse Model of Amyotrophic Lateral Sclerosis , 2007, Molecular Pharmacology.

[97]  D. Rubinsztein,et al.  Potential therapeutic applications of autophagy , 2007, Nature Reviews Drug Discovery.

[98]  O. Forlenza,et al.  Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder , 2007, British Journal of Psychiatry.

[99]  R. Gainetdinov,et al.  The Akt-GSK-3 signaling cascade in the actions of dopamine. , 2007, Trends in pharmacological sciences.

[100]  R. Jope,et al.  Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics , 2007, Neurochemical Research.

[101]  Shanshan Wang,et al.  Lithium improves the behavioral disorder in rats subjected to transient global cerebral ischemia , 2007, Behavioural Brain Research.

[102]  E. Masliah,et al.  Neuroprotective Effects of Regulators of the Glycogen Synthase Kinase-3β Signaling Pathway in a Transgenic Model of Alzheimer's Disease Are Associated with Reduced Amyloid Precursor Protein Phosphorylation , 2007, The Journal of Neuroscience.

[103]  K. Jin,et al.  Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice , 2007, The Journal of Neuroscience.

[104]  W. Yao,et al.  Lithium protects ethanol-induced neuronal apoptosis. , 2006, Biochemical and biophysical research communications.

[105]  D. Chuang,et al.  Regulation and Function of Glycogen Synthase Kinase-3 Isoforms in Neuronal Survival* , 2006, Journal of Biological Chemistry.

[106]  E. Zrenner,et al.  Citicoline and lithium rescue retinal ganglion cells following partial optic nerve crush in the rat. , 2006, Experimental eye research.

[107]  G. Terstappen,et al.  Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1 , 2006, Neurobiology of Disease.

[108]  Hong Liu,et al.  Mapping canonical Wnt signaling in the developing and adult retina. , 2006, Investigative ophthalmology & visual science.

[109]  P. S. Klein,et al.  Multiple roles for glycogen synthase kinase-3 as a drug target in Alzheimer's disease. , 2006, Current drug targets.

[110]  M. Roh,et al.  Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions. , 2006, Current drug targets.

[111]  D. Chuang,et al.  Differential Roles of Glycogen Synthase Kinase-3 Isoforms in the Regulation of Transcriptional Activation* , 2006, Journal of Biological Chemistry.

[112]  Mark P Mattson,et al.  Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders. , 2006, Antioxidants & redox signaling.

[113]  J. Qin,et al.  SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity , 2006, Cell.

[114]  D. Cleveland,et al.  ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors , 2006, Neuron.

[115]  Chiara Braschi,et al.  Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment , 2006, The European journal of neuroscience.

[116]  M. Pallàs,et al.  The role of CDK5/P25 formation/inhibition in neurodegeneration. , 2006, Drug news & perspectives.

[117]  E. Masliah,et al.  Lithium improves HIV-associated neurocognitive impairment , 2006, AIDS.

[118]  T. Steckler,et al.  Transgenic Mice Overexpressing Glycogen Synthase Kinase 3β: A Putative Model of Hyperactivity and Mania , 2006, The Journal of Neuroscience.

[119]  T. Terao,et al.  Lithium and dementia: A preliminary study , 2006, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[120]  Z. Qin,et al.  Enhancement of neuroprotection and heat shock protein induction by combined prostaglandin A1 and lithium in rodent models of focal ischemia , 2006, Brain Research.

[121]  Lawrence Steinman,et al.  How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis , 2006, Annals of neurology.

[122]  M. Yenari,et al.  Influence of hypothermia on post-ischemic inflammation: Role of nuclear factor kappa B (NFκB) , 2006, Neurochemistry International.

[123]  E. Mazzon,et al.  Glycogen synthase kinase-3beta inhibition attenuates the degree of arthritis caused by type II collagen in the mouse. , 2006, Clinical immunology.

[124]  T. Wyss-Coray Tgf-Beta pathway as a potential target in neurodegeneration and Alzheimer's. , 2006, Current Alzheimer research.

[125]  Carlos A. Zarate,et al.  Cellular Plasticity Cascades: Targets for the Development of Novel Therapeutics for Bipolar Disorder , 2006, Biological Psychiatry.

[126]  R. Medcalf,et al.  Tissue-Type Plasminogen Activator: A Multifaceted Modulator of Neurotransmission and Synaptic Plasticity , 2006, Neuron.

[127]  S. Warren,et al.  Transcription, translation and fragile X syndrome. , 2006, Current opinion in genetics & development.

[128]  D. Chuang,et al.  Potential use of lithium in neurodegenerative disorders , 2006 .

[129]  M. Bauer,et al.  Lithium in neuropsychiatry : the comprehensive guide , 2006 .

[130]  Alexei Degterev,et al.  Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1* , 2006, Journal of Biological Chemistry.

[131]  D. Rubinsztein,et al.  Inositol and IP3 Levels Regulate Autophagy—Biology and Therapeutic Speculations , 2006, Autophagy.

[132]  F. Biagioni,et al.  A hypothesis on prion disorders: Are infectious, inherited, and sporadic causes so distinct? , 2006, Brain Research Bulletin.

[133]  P. Higgins The TGF-β1/Upstream Stimulatory Factor-Regulated PAI-1 Gene: Potential Involvement and a Therapeutic Target in Alzheimer's Disease , 2006, Journal of biomedicine & biotechnology.

[134]  J. Olson,et al.  Regional and cellular gene expression changes in human Huntington's disease brain. , 2006, Human molecular genetics.

[135]  C. Thiemermann,et al.  Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase‐3β , 2006, British journal of pharmacology.

[136]  Xiujun Sun,et al.  Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells. , 2006, Life sciences.

[137]  Bai Lu,et al.  Regulation of Cortical Interneurons by Neurotrophins: From Development to Cognitive Disorders , 2006, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[138]  D. Rubinsztein,et al.  Rapamycin alleviates toxicity of different aggregate-prone proteins. , 2006, Human molecular genetics.

[139]  C. Ali,et al.  Transforming growth factor-β signalling in brain disorders , 2006 .

[140]  M. Chopp,et al.  Biphasic effects of exogenous VEGF on VEGF expression of adult neural progenitors , 2006, Neuroscience Letters.

[141]  M. Fernando,et al.  Expression of Vascular Endothelial Growth Factor and Its Receptors in the Central Nervous System in Amyotrophic Lateral Sclerosis , 2006, Journal of neuropathology and experimental neurology.

[142]  M. Pallàs,et al.  Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium , 2005, Neuroscience.

[143]  M. Tranfaglia,et al.  Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP , 2005, Neuropharmacology.

[144]  Subramaniam Sriram,et al.  Experimental allergic encephalomyelitis: A misleading model of multiple sclerosis , 2005, Annals of neurology.

[145]  R. Kreutz,et al.  Low-dose lithium combined with captopril prevents stroke and improves survival in salt-loaded, stroke-prone spontaneously hypertensive rats , 2005, Journal of hypertension.

[146]  K. Marquis,et al.  The inhibition of glycogen synthase kinase 3β by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Aβ peptides , 2005 .

[147]  E. Greer,et al.  FOXO transcription factors at the interface between longevity and tumor suppression , 2005, Oncogene.

[148]  L. Steinman,et al.  Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis. , 2005, Trends in immunology.

[149]  Claire H. Michel,et al.  Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway. , 2005, Human molecular genetics.

[150]  J. Trojanowski,et al.  Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies , 2005, Acta Neuropathologica.

[151]  R. Paylor,et al.  Altered anxiety‐related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome , 2005, Genes, brain, and behavior.

[152]  Huda Y. Zoghbi,et al.  Diseases of Unstable Repeat Expansion: Mechanisms and Common Principles , 2005, Nature Reviews Genetics.

[153]  D. Rubinsztein,et al.  Lithium induces autophagy by inhibiting inositol monophosphatase , 2005, The Journal of cell biology.

[154]  H. Xiong,et al.  Neuroprotective Mechanisms of Lithium in Murine Human Immunodeficiency Virus-1 Encephalitis , 2005, The Journal of Neuroscience.

[155]  P. Hagerman,et al.  Recent advances in fragile X: a model for autism and neurodegeneration , 2005, Current opinion in psychiatry.

[156]  S. Foster,et al.  GSK-3β inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat* , 2005, Critical care medicine.

[157]  F. Gomes,et al.  Emerging roles for TGF-β1 in nervous system development , 2005, International Journal of Developmental Neuroscience.

[158]  A. Reiss,et al.  Cortical Magnetic Resonance Imaging Findings in Familial Pediatric Bipolar Disorder , 2005, Biological Psychiatry.

[159]  D. Chuang The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials. , 2005, Annals of the New York Academy of Sciences.

[160]  T. Sotnikova,et al.  An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior , 2005, Cell.

[161]  P. Martinez,et al.  Younger, premenopausal women with major depressive disorder have more abdominal fat and increased serum levels of prothrombotic factors: implications for greater cardiovascular risk. , 2005, Metabolism: clinical and experimental.

[162]  A. Reiss,et al.  Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. , 2005, Journal of the American Academy of Child and Adolescent Psychiatry.

[163]  W. Noble,et al.  Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[164]  D. Kupfer,et al.  1H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patients. , 2005, Journal of affective disorders.

[165]  W. Lieberthal,et al.  Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors. , 2005, American journal of physiology. Renal physiology.

[166]  Roland Martin,et al.  Immunology of multiple sclerosis. , 2005, Annual review of immunology.

[167]  Yan Wang,et al.  Pharmacological Rescue of Synaptic Plasticity, Courtship Behavior, and Mushroom Body Defects in a Drosophila Model of Fragile X Syndrome , 2005, Neuron.

[168]  R. Nixon Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases , 2005, Neurobiology of Aging.

[169]  M. Joëls,et al.  Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk‐1 protein expression , 2005, The European journal of neuroscience.

[170]  K. Roth,et al.  Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: Protection by mood stabilizers and imipramine , 2005, Biological Psychiatry.

[171]  M. Chopp,et al.  Atorvastatin Induction of VEGF and BDNF Promotes Brain Plasticity after Stroke in Mice , 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[172]  K. Roth,et al.  Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: therapeutic implications. , 2005, Current drug targets. CNS and neurological disorders.

[173]  G. Agam,et al.  Low GSK-3β in schizophrenia as a consequence of neurodevelopmental insult , 2005, European Neuropsychopharmacology.

[174]  F. Terro,et al.  Linking Alterations in Tau Phosphorylation and Cleavage during Neuronal Apoptosis* , 2004, Journal of Biological Chemistry.

[175]  M. Klagsbrun,et al.  VEGF is required for the maintenance of dorsal root ganglia blood vessels but not neurons during development , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[176]  H. Manji,et al.  AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. , 2004, The international journal of neuropsychopharmacology.

[177]  A. Mørk,et al.  The effect of escitalopram, desipramine, electroconvulsive seizures and lithium on brain-derived neurotrophic factor mRNA and protein expression in the rat brain and the correlation to 5-HT and 5-HIAA levels , 2004, Brain Research.

[178]  D. Chuang,et al.  Lithium neuroprotection: molecular mechanisms and clinical implications , 2004, Expert Reviews in Molecular Medicine.

[179]  M. Keshavan,et al.  1H MRS Study of Dorsolateral Prefrontal Cortex in Healthy Individuals before and after Lithium Administration , 2004, Neuropsychopharmacology.

[180]  H. Manji,et al.  Molecular effects of lithium. , 2004, Molecular interventions.

[181]  D. Kupfer,et al.  Reduced left anterior cingulate volumes in untreated bipolar patients , 2004, Biological Psychiatry.

[182]  P. Greengard,et al.  Pharmacological inhibitors of glycogen synthase kinase 3. , 2004, Trends in pharmacological sciences.

[183]  Peter T. Lansbury,et al.  Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy , 2004, Science.

[184]  K. So,et al.  Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury. , 2004, Journal of neurotrauma.

[185]  S. Lovestone,et al.  GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila , 2004, Molecular Psychiatry.

[186]  Yong Liu,et al.  Lithium suppressed Tyr-402 phosphorylation of proline-rich tyrosine kinase (Pyk2) and interactions of Pyk2 and PSD-95 with NR2A in rat hippocampus following cerebral ischemia , 2004, Neuroscience Research.

[187]  H. Manji,et al.  Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers , 2004, Molecular Psychiatry.

[188]  Ana Maria Cuervo,et al.  Autophagy: Many paths to the same end , 2004, Molecular and Cellular Biochemistry.

[189]  J. Woodgett,et al.  Glycogen Synthase Kinase-3β Haploinsufficiency Mimics the Behavioral and Molecular Effects of Lithium , 2004, The Journal of Neuroscience.

[190]  Mark F Bear,et al.  The mGluR theory of fragile X mental retardation , 2004, Trends in Neurosciences.

[191]  C. Thiele,et al.  Glycogen synthase kinase 3β (GSK3β) mediates 6‐ hydroxydopamine‐induced neuronal death , 2004 .

[192]  E. Aronica,et al.  Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain , 2004, The Journal of Neuroscience.

[193]  Marc G Caron,et al.  Desensitization of G protein-coupled receptors and neuronal functions. , 2004, Annual review of neuroscience.

[194]  Jesús Avila,et al.  Glycogen synthase kinase 3: a drug target for CNS therapies , 2004, Journal of neurochemistry.

[195]  L. Tsai,et al.  A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease , 2004, Current Opinion in Neurobiology.

[196]  M. Youdim,et al.  Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax , 2004, Neuropharmacology.

[197]  Francesco Scaravilli,et al.  Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease , 2004, Nature Genetics.

[198]  F. Liu,et al.  Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing. , 2004, Biochemistry.

[199]  T. Aw,et al.  Apoptosis in acute and chronic neurological disorders. , 2004, Frontiers in bioscience : a journal and virtual library.

[200]  Abraham Weizman,et al.  Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on β-catenin in mouse hippocampus , 2004, Biological Psychiatry.

[201]  T. Sotnikova,et al.  Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[202]  M. Pallàs,et al.  Lithium prevents colchicine-induced apoptosis in rat cerebellar granule neurons. , 2004, Bipolar disorders.

[203]  D. Chuang,et al.  Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington's disease , 2004, Molecular Psychiatry.

[204]  Subhabrata Sanyal,et al.  Retrograde Regulation in the CNS Neuron-Specific Interpretations of TGF-β Signaling , 2004, Neuron.

[205]  F. E. Bertrand,et al.  JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis , 2004, Leukemia.

[206]  W. Shen,et al.  Implication of serum concentration monitoring in patients with lithium intoxication , 2004, Psychiatry and clinical neurosciences.

[207]  R. Jope,et al.  The glamour and gloom of glycogen synthase kinase-3. , 2004, Trends in biochemical sciences.

[208]  L. Tsai,et al.  Cyclin-Dependent Kinase 5 Phosphorylates the N-Terminal Domain of the Postsynaptic Density Protein PSD-95 in Neurons , 2004, The Journal of Neuroscience.

[209]  J. Kiss,et al.  VEGF is a chemoattractant for FGF-2–stimulated neural progenitors , 2003, The Journal of cell biology.

[210]  John C Reed,et al.  Heat-shock proteins as regulators of apoptosis , 2003, Oncogene.

[211]  C. Sugimoto,et al.  PI3K/Akt and apoptosis: size matters , 2003, Oncogene.

[212]  E. Huang,et al.  Trk receptors: roles in neuronal signal transduction. , 2003, Annual review of biochemistry.

[213]  C. Phiel,et al.  Molecular targets of lithium action. , 2003, Annual review of pharmacology and toxicology.

[214]  R. Ferrante,et al.  Sequential activation of individual caspases, and of alterations in Bcl‐2 proapoptotic signals in a mouse model of Huntington's disease , 2003, Journal of neurochemistry.

[215]  Ying E. Zhang,et al.  Smad-dependent and Smad-independent pathways in TGF-β family signalling , 2003, Nature.

[216]  E. Claro,et al.  Opposed effects of lithium on the MEK‐ERK pathway in neural cells: inhibition in astrocytes and stimulation in neurons by GSK3 independent mechanisms , 2003, Journal of neurochemistry.

[217]  R. Post,et al.  Potential Mechanisms of Action of Lamotrigine in the Treatment of Bipolar Disorders , 2003, Journal of clinical psychopharmacology.

[218]  J. Melchor,et al.  The Tissue Plasminogen Activator-Plasminogen Proteolytic Cascade Accelerates Amyloid-β (Aβ) Degradation and Inhibits Aβ-Induced Neurodegeneration , 2003, The Journal of Neuroscience.

[219]  Guang-yi Zhang,et al.  Lithium reduced N-methyl-d-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia , 2003, Neuroscience Letters.

[220]  T. Herdegen,et al.  Lithium Blocks the c-Jun Stress Response and Protects Neurons via Its Action on Glycogen Synthase Kinase 3 , 2003, Molecular and Cellular Biology.

[221]  R. Jope Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. , 2003, Trends in pharmacological sciences.

[222]  N. Wood,et al.  Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington’s disease mutation , 2003, Brain Research Bulletin.

[223]  C. Phiel,et al.  Inhibitory Phosphorylation of Glycogen Synthase Kinase-3 (GSK-3) in Response to Lithium , 2003, Journal of Biological Chemistry.

[224]  Jeremy N. Skepper,et al.  α-Synuclein Is Degraded by Both Autophagy and the Proteasome* , 2003, Journal of Biological Chemistry.

[225]  W. Kuschinsky,et al.  Expression of vascular endothelial growth factor and its receptors in rat neural stem cells , 2003, Neuroscience Letters.

[226]  H. Manji,et al.  Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice. , 2003, Pharmacological research.

[227]  P. Weinstein,et al.  Overexpression of Rat Heat Shock Protein 70 is Associated with Reduction of Early Mitochondrial Cytochrome c Release and Subsequent DNA Fragmentation after Permanent Focal Ischemia , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[228]  Christina A. Wilson,et al.  GSK-3α regulates production of Alzheimer's disease amyloid-β peptides , 2003, Nature.

[229]  A. I. Rojo,et al.  Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3. , 2003, The Biochemical journal.

[230]  D. Chuang,et al.  Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[231]  S. Brecht,et al.  Chronic Treatment With a Low Dose of Lithium Protects the Brain Against Ischemic Injury by Reducing Apoptotic Death , 2003, Stroke.

[232]  D. Rubinsztein,et al.  Transcriptional abnormalities in Huntington disease. , 2003, Trends in genetics : TIG.

[233]  B. Kaang,et al.  Lithium enhances long‐term potentiation independently of hippocampal neurogenesis in the rat dentate gyrus , 2003, Journal of neurochemistry.

[234]  M. Mattson,et al.  Mitochondria in cell death: novel targets for neuroprotection and cardioprotection. , 2003, Trends in molecular medicine.

[235]  K. Soares-Weiser,et al.  Miscellaneous treatments for neuroleptic-induced tardive dyskinesia. , 2003, The Cochrane database of systematic reviews.

[236]  H. Son,et al.  Chronic lithium enhances hippocampal long-term potentiation, but not neurogenesis, in the aged rat dentate gyrus. , 2003, Biochemical and biophysical research communications.

[237]  H. Manji,et al.  Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression , 2003, Biological Psychiatry.

[238]  Robert M Friedlander,et al.  Apoptosis and caspases in neurodegenerative diseases. , 2003, The New England journal of medicine.

[239]  M. Chesselet,et al.  Apoptosis in Huntington's disease , 2003, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[240]  F. Goodwin Rationale for using lithium in combination with other mood stabilizers in the management of bipolar disorder. , 2003, The Journal of clinical psychiatry.

[241]  S. Tsuji,et al.  Lithium, but not valproate, induces the serine/threonine phosphatase activity of protein phosphatase 2A in the rat brain, without affecting its expression , 2003, Journal of Neural Transmission.

[242]  D. Chuang,et al.  Lithium stimulates progenitor proliferation in cultured brain neurons , 2003, Neuroscience.

[243]  M. Herman,et al.  Lithium inhibits Aβ‐induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation , 2003, Journal of neuroscience research.

[244]  D. Chuang,et al.  Lithium‐induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N‐methyl‐D‐aspartate receptor‐mediated excitotoxicity , 2003, FEBS letters.

[245]  K. Akassoglou,et al.  Fibrin is a regulator of Schwann cell migration after sciatic nerve injury in mice , 2003, Neuroscience Letters.

[246]  J. McCubrey,et al.  Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review). , 2003, International journal of oncology.

[247]  B. McEwen,et al.  Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior , 2003, Nature Neuroscience.

[248]  D. Chuang,et al.  Regulation of c‐Jun N‐terminal kinase, p38 kinase and AP‐1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection , 2003, Journal of neurochemistry.

[249]  C. Globas,et al.  Cognitive deficits in spinocerebellar ataxia type 1, 2, and 3 , 2003, Journal of Neurology.

[250]  N. Inestrosa,et al.  Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils , 2003, Molecular Psychiatry.

[251]  J. F. Wang,et al.  Valproate inhibits oxidative damage to lipid and protein in primary cultured rat cerebrocortical cells , 2003, Neuroscience.

[252]  D. Chuang,et al.  Chronic lithium treatment antagonizes glutamate-induced decrease of phosphorylated CREB in neurons via reducing protein phosphatase 1 and increasing MEK activities , 2003, Neuroscience.

[253]  D. Chuang,et al.  Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: An essential step for neuroprotection against glutamate excitotoxicity , 2002, Neuropharmacology.

[254]  Xiaohua Li,et al.  Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium , 2002, Neuropharmacology.

[255]  R. Jope,et al.  Central Role of Glycogen Synthase Kinase-3β in Endoplasmic Reticulum Stress-induced Caspase-3 Activation* , 2002, The Journal of Biological Chemistry.

[256]  Yong Liu,et al.  Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn–PSD95–NR2A complex after transient brain ischemia , 2002, Brain Research.

[257]  C. B. Smith,et al.  Increased rates of cerebral glucose metabolism in a mouse model of fragile X mental retardation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[258]  E. Masliah,et al.  Lithium Ameliorates HIV-gp120-Mediated Neurotoxicity , 2002, Molecular and Cellular Neuroscience.

[259]  M. Mattson,et al.  p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism , 2002, Annals of neurology.

[260]  Joerg Huelsken,et al.  The Wnt signalling pathway , 2002, Journal of Cell Science.

[261]  A. Martelli,et al.  The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. , 2002, Biochimica et biophysica acta.

[262]  D. Rubinsztein,et al.  Glycogen Synthase Kinase-3β Inhibitors Prevent Cellular Polyglutamine Toxicity Caused by the Huntington's Disease Mutation* , 2002, The Journal of Biological Chemistry.

[263]  A. Newton,et al.  The Turn Motif Is a Phosphorylation Switch That Regulates the Binding of Hsp70 to Protein Kinase C* , 2002, The Journal of Biological Chemistry.

[264]  K. Jin,et al.  Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[265]  R. Raffa,et al.  LiCl Attenuates M1AChR-Mediated Intrathecal Pilocarpine-Induced Reciprocal Hindlimb Scratching in Mice , 2002, Pharmacology.

[266]  D. Crawford,et al.  Prevalence of the fragile X syndrome in African-Americans. , 2002, American journal of medical genetics.

[267]  L. Ellerby,et al.  Calpain Activation in Huntington's Disease , 2002, The Journal of Neuroscience.

[268]  J. Ávila,et al.  Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease. , 2002, Bipolar disorders.

[269]  A. Harwood,et al.  A common mechanism of action for three mood-stabilizing drugs , 2002, Nature.

[270]  Rainer Duden,et al.  Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. , 2002, Human molecular genetics.

[271]  M. Karin,et al.  AP-1 as a regulator of cell life and death , 2002, Nature Cell Biology.

[272]  M. Frye,et al.  Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders? , 2002, Journal of affective disorders.

[273]  K. M. Nicholson,et al.  The protein kinase B/Akt signalling pathway in human malignancy. , 2002, Cellular signalling.

[274]  R. Duman,et al.  Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression , 2002, The Journal of Neuroscience.

[275]  D. Chuang,et al.  Neuroprotective effects of lithium in cultured cells and animal models of diseases. , 2002, Bipolar disorders.

[276]  D. Rubinsztein Lessons from animal models of Huntington's disease. , 2002, Trends in genetics : TIG.

[277]  A. Takashima,et al.  Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100 , 2002, Neuroscience Letters.

[278]  F. Hartl,et al.  Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein , 2002, Science.

[279]  Takanobu Nakazawa,et al.  Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation , 2002, Journal of neurochemistry.

[280]  P. Andreasen,et al.  The Molecular Basis for Anti-Proteolytic and Non-Proteolytic Functions of Plasminogen Activator Inhibitor Type-1: Roles of the Reactive Centre Loop, the Shutter Region, the Flexible Joint Region and the Small Serpin Fragment , 2002, Biological chemistry.

[281]  L. Hendershot,et al.  The Unfolding Tale of the Unfolded Protein Response , 2001, Cell.

[282]  Ping Zhu,et al.  Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells , 2001, The EMBO journal.

[283]  R. Jope,et al.  Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3β and attenuated by lithium , 2001, Brain Research.

[284]  R. Sapolsky,et al.  Overexpression of HSP72 after Induction of Experimental Stroke Protects Neurons from Ischemic Damage , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[285]  R. Jope,et al.  The multifaceted roles of glycogen synthase kinase 3β in cellular signaling , 2001, Progress in Neurobiology.

[286]  Huachun Sang,et al.  Phosphorylation of tau by glycogen synthase kinase 3β in intact mammalian cells influences the stability of microtubules , 2001, Neuroscience Letters.

[287]  Y. Okamoto,et al.  Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain , 2001, Psychopharmacology.

[288]  N. Knuckey,et al.  Suppression subtraction hybridization and northern analysis reveal upregulation of heat shock, trkB, and sodium calcium exchanger genes following global cerebral ischemia in the rat. , 2001, Brain research. Molecular brain research.

[289]  M. Guenther,et al.  Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen* , 2001, The Journal of Biological Chemistry.

[290]  D. Chuang,et al.  Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington’s disease , 2001, Neuroscience.

[291]  S. Fujita,et al.  Inhibition of Protein Phosphatase 2A Overrides Tau Protein Kinase I/Glycogen Synthase Kinase 3β and Cyclin-dependent Kinase 5 Inhibition and Results in Tau Hyperphosphorylation in the Hippocampus of Starved Mouse* , 2001, The Journal of Biological Chemistry.

[292]  Josef M. Penninger,et al.  Heat-shock protein 70 antagonizes apoptosis-inducing factor , 2001, Nature Cell Biology.

[293]  X. Hou,et al.  NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion , 2001, Brain Research.

[294]  K. Fukuchi,et al.  [Hepatitis C virus genotyping by restriction fragment length polymorphism of polymerase chain reaction products generated with a HCV detection kit]. , 2001, Rinsho byori. The Japanese journal of clinical pathology.

[295]  Blair R. Leavitt,et al.  Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease , 2001, Science.

[296]  S. R. Datta,et al.  Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway , 2001, Current Opinion in Neurobiology.

[297]  W. Drevets,et al.  The cellular neurobiology of depression , 2001, Nature Medicine.

[298]  S. Dewhurst,et al.  Activation of glycogen synthase kinase 3 beta (GSK‐3β) by platelet activating factor mediates migration and cell death in cerebellar granule neurons , 2001, The European journal of neuroscience.

[299]  D. Selkoe Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.

[300]  W. Drevets Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders , 2001, Current Opinion in Neurobiology.

[301]  C. Culmsee,et al.  A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid β‐peptide , 2001 .

[302]  C. Bown,et al.  Identification of mood stabilizer-regulated genes by differential-display PCR. , 2001, The international journal of neuropsychopharmacology.

[303]  S. Korsmeyer,et al.  Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[304]  A. Harwood,et al.  Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. , 2001, Biochemical and biophysical research communications.

[305]  R. Jope,et al.  Opposing Actions of Phosphatidylinositol 3‐Kinase and Glycogen Synthase Kinase‐3β in the Regulation of HSF‐1 Activity , 2000, Journal of neurochemistry.

[306]  S. Emr,et al.  Autophagy as a regulated pathway of cellular degradation. , 2000, Science.

[307]  N. Inestrosa,et al.  Acetylcholinesterase–amyloid‐β‐peptide interaction and Wnt signaling involvement in Aβ neurotoxicity , 2000 .

[308]  Huiling He,et al.  Involvement of c-Fos in signaling grp78 induction following ER calcium release , 2000, Oncogene.

[309]  Junying Yuan,et al.  Apoptosis in the nervous system , 2000, Nature.

[310]  G. Moore,et al.  Lithium-induced increase in human brain grey matter , 2000, The Lancet.

[311]  R. Morimoto,et al.  The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis , 2000, Molecular and Cellular Biology.

[312]  R. Neumar,et al.  Brain ischemia and reperfusion: molecular mechanisms of neuronal injury , 2000, Journal of the Neurological Sciences.

[313]  Jun-Feng Wang,et al.  Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells , 2000, Neuropharmacology.

[314]  G. Rajkowska,et al.  Enhancement of Hippocampal Neurogenesis by Lithium , 2000, Journal of neurochemistry.

[315]  C. W. Scott,et al.  Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[316]  J. Woodgett,et al.  Glycogen Synthase Kinase 3β Negatively Regulates Both DNA-binding and Transcriptional Activities of Heat Shock Factor 1* , 2000, The Journal of Biological Chemistry.

[317]  Dick D. Mosser,et al.  Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome , 2000, Nature Cell Biology.

[318]  Guang Chen,et al.  Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2’s neurotrophic effects? , 2000, Biological Psychiatry.

[319]  F R Sharp,et al.  Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction , 2000, Annals of neurology.

[320]  L. Tsai,et al.  Neurotoxicity induces cleavage of p35 to p25 by calpain , 2000, Nature.

[321]  Mark P Mattson,et al.  Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders , 2000, Trends in Neurosciences.

[322]  K. Mielke,et al.  JNK and p38 stresskinases — degenerative effectors of signal-transduction-cascades in the nervous system , 2000, Progress in Neurobiology.

[323]  René Hen,et al.  Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease , 2000, Cell.

[324]  D. Chuang,et al.  beta-amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment. , 2000, European journal of pharmacology.

[325]  R. Jope,et al.  Glycogen Synthase Kinase-3β Facilitates Staurosporine- and Heat Shock-induced Apoptosis , 2000, The Journal of Biological Chemistry.

[326]  M. Shibata,et al.  Intrathecal lithium reduces neuropathic pain responses in a rat model of peripheral neuropathy , 2000, Pain.

[327]  S. Rapoport,et al.  Brain myo‐inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment , 2000, Neuroreport.

[328]  F. Gage,et al.  Mammalian neural stem cells. , 2000, Science.

[329]  J. Behrens,et al.  Biochemical interactions in the wnt pathway. , 2000, Biochimica et biophysica acta.

[330]  Heidi Phillips,et al.  Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System , 2000, Neuron.

[331]  S. Finkbeiner CREB Couples Neurotrophin Signals to Survival Messages , 2000, Neuron.

[332]  Kevin K. W Wang,et al.  Calpain and caspase: can you tell the difference? , 2000, Trends in Neurosciences.

[333]  L. Tsai,et al.  Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration , 1999, Nature.

[334]  Françoise Condé,et al.  Replicating Huntington's disease phenotype in experimental animals , 1999, Progress in Neurobiology.

[335]  Y. Itoyama,et al.  Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response , 1999, Nature Cell Biology.

[336]  P. Carmeliet,et al.  Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[337]  K. Robison,et al.  Functional and structural diversity of the human Dickkopf gene family. , 1999, Gene.

[338]  S. Dewhurst,et al.  HIV‐1 Tat‐Mediated Activation of Glycogen Synthase Kinase‐3β Contributes to Tat‐Mediated Neurotoxicity , 1999, Journal of neurochemistry.

[339]  D. Chuang,et al.  Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[340]  R. Post,et al.  Elevated basal and thapsigargin-stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay , 1999, Biological Psychiatry.

[341]  J. Ávila,et al.  Lithium protects cultured neurons against β‐amyloid‐induced neurodegeneration , 1999 .

[342]  R. Kaufman,et al.  Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. , 1999, Genes & development.

[343]  A. Fink Chaperone-mediated protein folding. , 1999, Physiological reviews.

[344]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[345]  D. Chuang,et al.  Long Term Lithium Treatment Suppresses p53 and Bax Expression but Increases Bcl-2 Expression , 1999, The Journal of Biological Chemistry.

[346]  R. Jope Anti-bipolar therapy: mechanism of action of lithium , 1999, Molecular Psychiatry.

[347]  C. Bown,et al.  Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78. , 1999, Molecular pharmacology.

[348]  M. Mattson,et al.  The Endoplasmic Reticulum Stress-Responsive Protein GRP78 Protects Neurons Against Excitotoxicity and Apoptosis: Suppression of Oxidative Stress and Stabilization of Calcium Homeostasis , 1999, Experimental Neurology.

[349]  H. Manji,et al.  The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS , 1999, Journal of neurochemistry.

[350]  P. Lipton,et al.  Ischemic cell death in brain neurons. , 1999, Physiological reviews.

[351]  J. M. Fuentes,et al.  Partial lithium‐associated protection against apoptosis induced by C2‐ceramide in cerebellar granule neurons , 1998, Neuroreport.

[352]  M. Hori,et al.  Amelioration of hippocampal neuronal damage after global ischemia by neuronal overexpression of BCL-2 in transgenic mice. , 1998, Stroke.

[353]  Stanley B. Prusiner,et al.  Nobel Lecture: Prions , 1998 .

[354]  H. Manji,et al.  Lithium: A Molecular Transducer of Mood-Stabilization in the Treatment of Bipolar Disorder , 1998, Neuropsychopharmacology.

[355]  V. Asghari,et al.  Differential effects of mood stabilizers on Fos/Jun proteins and AP-1 DNA binding activity in human neuroblastoma SH-SY5Y cells. , 1998, Brain research. Molecular brain research.

[356]  D. Chuang,et al.  Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine. , 1998, The Journal of pharmacology and experimental therapeutics.

[357]  D. Chuang,et al.  Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats , 1998, Neuroreport.

[358]  D. Bredesen,et al.  Bcl‐2 Protects Against Apoptosis in Neuronal Cell Line Caused by Thapsigargin‐Induced Depletion of Intracellular Calcium Stores , 1998, Journal of neurochemistry.

[359]  Michael Karin Mitogen‐Activated Protein Kinase Cascades as Regulators of Stress Responses , 1998, Annals of the New York Academy of Sciences.

[360]  E. Melamed,et al.  Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[361]  I. Grundke‐Iqbal,et al.  The regulation of phosphorylation of τ in SY5Y neuroblastoma cells: the role of protein phosphatases , 1998, FEBS letters.

[362]  D. Chuang,et al.  Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[363]  P. Cohen,et al.  Mechanism of activation and function of protein kinase B. , 1998, Current opinion in genetics & development.

[364]  Olaf Riess,et al.  AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease , 1998, Nature Genetics.

[365]  D. Chuang,et al.  Lithium Increases Transcription Factor Binding to AP‐1 and Cyclic AMP‐Responsive Element in Cultured Neurons and Rat Brain , 1997, Journal of neurochemistry.

[366]  Virginia M. Y. Lee,et al.  Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3* , 1997, The Journal of Biological Chemistry.

[367]  Huiling He,et al.  Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2 , 1997, The Journal of cell biology.

[368]  J. Gurd,et al.  Transient Ischemia Differentially Increases Tyrosine Phosphorylation of NMDA Receptor Subunits 2A and 2B , 1997, Journal of neurochemistry.

[369]  J. Ávila,et al.  Lithium inhibits Alzheimer's disease‐like tau protein phosphorylation in neurons , 1997, FEBS letters.

[370]  Robert L. Nussbaum,et al.  Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease , 1997 .

[371]  R. Lam,et al.  Effects of chronic lithium treatment on retinal electrophysiologic function , 1997, Biological Psychiatry.

[372]  James R. Woodgett,et al.  Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells , 1996, Current Biology.

[373]  Brendan D. Price,et al.  Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1* , 1996, The Journal of Biological Chemistry.

[374]  R. Davis,et al.  Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways , 1996, Journal of Molecular Medicine.

[375]  D. Melton,et al.  A molecular mechanism for the effect of lithium on development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[376]  D. Reis,et al.  Heat Shock Protein 70 Suppresses Astroglial-inducible Nitric-oxide Synthase Expression by Decreasing NFκB Activation* , 1996, The Journal of Biological Chemistry.

[377]  D. Brooks,et al.  Proton magnetic resonance spectroscopy in Huntington's disease: Evidence in favour of the glutamate excitotoxic theory? , 1996, Movement disorders : official journal of the Movement Disorder Society.

[378]  M. Caron,et al.  Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization , 1996, Science.

[379]  J. Trojanowski,et al.  Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[380]  S. Holroyd,et al.  Disabling Parkinsonism Due to Lithium: A Case Report , 1995, Journal of geriatric psychiatry and neurology.

[381]  Guy Nagels,et al.  Fmr1 knockout mice: A model to study fragile X mental retardation , 1994, Cell.

[382]  G. Dubyak,et al.  Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[383]  M. Ciotti,et al.  LiCl promotes survival of GABAergic neurons from cerebellum and cerebral cortex: LiCl induces survival of GABAergic neurons , 1994, Neuroscience Letters.

[384]  S. D’Mello,et al.  Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons. , 1994, Experimental cell research.

[385]  D. Moscovich Lithium neurotoxicity at normal therapeutic levels , 1993, British Journal of Psychiatry.

[386]  D. Chuang,et al.  Long-term biphasic effects of lithium treatment on phospholipase C-coupled m3-muscarinic acetylcholine receptors in cultured cerebellar granule cells , 1993, Neurochemistry International.

[387]  Manish S. Shah,et al.  A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes , 1993, Cell.

[388]  J. Haines,et al.  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.

[389]  Ben A. Oostra,et al.  Absence of expression of the FMR-1 gene in fragile X syndrome , 1991, Cell.

[390]  Tony Hunter,et al.  Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity , 1991, Cell.

[391]  H. Lachman,et al.  Lithium augmentsfos protoonocogene expression in PC12 pheochromocytoma cells: implications for therapeutic action of lithium , 1990, Brain Research.

[392]  Michael J. Berridge,et al.  Neural and developmental actions of lithium: A unifying hypothesis , 1989, Cell.

[393]  Williams Go,et al.  Management of depression in the elderly. , 1989 .

[394]  M. Caron,et al.  Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[395]  J. Seggie Lithium and the retina , 1988, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[396]  G. Simon,et al.  In vitro effects of thymosin and lithium on lymphoproliferative responses of normal donors and HIV seropositive male homosexuals with AIDS-related complex. , 1987, Clinical immunology and immunopathology.

[397]  B. Agranoff,et al.  Receptor Activation and Inositol Lipid Hydrolysis in Neural Tissues , 1987, Journal of neurochemistry.

[398]  J. Gusella,et al.  Huntington's disease. Pathogenesis and management. , 1986, The New England journal of medicine.

[399]  L. Munsell,et al.  Effects of lithium on phosphoinositide metabolism in vivo. , 1986, Federation proceedings.

[400]  A. Asch,et al.  Therapists with disabilities: theoretical and clinical issues. , 1985, Psychiatry.

[401]  N. Pomara,et al.  Lithium-induced increases in red blood cell choline and memory performance in Alzheimer-type dementia. , 1984, Biological psychiatry.

[402]  R. Schwarcz,et al.  On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds , 1983, Neuropharmacology.

[403]  C. Coffey,et al.  Treatment of the “on‐off” phenomenon in parkisnonism with lithium carbonate , 1982, Annals of neurology.

[404]  G. Gopinathan,et al.  Treatment of “on‐off” phenomena with lithium , 1982, Annals of neurology.

[405]  R. Schwarcz,et al.  Post-mortem high affinity glutamate uptake in human brain , 1982, Neuroscience.

[406]  C. Coffey,et al.  "On-off" syndrome treated with lithium carbonate: a case report. , 1981, The American journal of psychiatry.

[407]  R. Wyatt,et al.  Lithium combined with neuroleptics in chronic schizophrenic and schizoaffective patients. , 1981, The Journal of clinical psychiatry.

[408]  W. Bunney,et al.  Long-term treatment with lithium prevents the development of dopamine receptor supersensitivity. , 1978, Science.

[409]  D. Pickar,et al.  Tardive dyskinesia in younger patients. , 1978, The American journal of psychiatry.

[410]  P. Vestergaard,et al.  Lithium treatment of Huntington's chorea , 1977, Acta psychiatrica Scandinavica.

[411]  D. W. Swanson,et al.  Tardive dyskinesia: relationship with a primary affective disorder. , 1977, Diseases of the nervous system.

[412]  F. Regli,et al.  [Lithium therapy of extrapyramidal movement disorders-an attempt (author's transl)]. , 1977, Der Nervenarzt.

[413]  L. Dintenfass,et al.  MYOCARDIAL DAMAGE DUE TO FAULTY HEAT EXCHANGE , 1976, The Lancet.

[414]  L. Klenerman,et al.  INCOMPRESSIBLE VESSELS , 1976, The Lancet.

[415]  J. Small,et al.  Lithium combined with neuroleptics in the treatment of chronic schizophrenia. , 1976, Psychopharmacology bulletin.

[416]  G. Simpson,et al.  Lithium in Tardive Dyskinesia* , 1976, Pharmakopsychiatrie, Neuro-Psychopharmakologie.

[417]  I. Persson,et al.  BRAN AND BLOOD-LIPIDS , 1975, The Lancet.

[418]  J. Small,et al.  A placebo-controlled study of lithium combined with neuroleptics in chronic schizophrenic patients. , 1975, The American journal of psychiatry.

[419]  R. V. Mummery Letter: Caries under composite restorations , 1975, British Dental Journal.

[420]  P. Shannon,et al.  A Double Blind Trial of Lithium Carbonate and Haloperidol in Huntington's Chorea* , 1975 .

[421]  Scanlan Jm,et al.  Lithium carbonate in the treatment of tardive dyskinesia. , 1975 .

[422]  K. Thorsen,et al.  Effect of Lithium on Neuroleptic-induced Tardive Dyskinesia Compared with Placebo in a Double-Blind Cross-over Trial , 1975, Pharmakopsychiatrie, Neuro-Psychopharmakologie.

[423]  P. Shannon,et al.  A double blind trial of lithium carbonate and haloperidol in Huntington's chorea. , 1974, The Australian and New Zealand journal of psychiatry.

[424]  G. Stern,et al.  LITHIUM IN PARKINSON'S DISEASE , 1974 .

[425]  I. Shoulson,et al.  HUNTINGTON'S CHOREA TREATED WITH LITHIUM CARBONATE , 1974 .

[426]  H. Leijnse-Ybema,et al.  HUNTINGTON'S CHOREA AND LEVODOPA , 1974 .

[427]  M. Aminoff,et al.  Treatment of Huntington's chorea with lithium carbonate. A double-blind trial. , 1974, Lancet.

[428]  N. Andén,et al.  Baclofen and lithium in Huntington's chorea. , 1973, Lancet.

[429]  M. V. Van Woert,et al.  Lithium and levodopa in parkinsonism. , 1973, Lancet.

[430]  E. Bravo-Fernandez,et al.  Lithium carbonate in Huntington's chorea. , 1973, Lancet.

[431]  B. Mattsson Huntington's chorea and lithium therapy. , 1973, Lancet.

[432]  P. Dalén Lithium therapy in Huntington's chorea and tardive dyskinesia. , 1973, Lancet.

[433]  A. Lowenthal,et al.  [Hydrosoluble proteins of the nervous system of man and the animal]. , 1969, Acta zoologica et pathologica Antverpiensia.

[434]  G. Niemeyer,et al.  Side Effects of Drugs , 1953, British medical journal.

[435]  L. Buée,et al.  Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology. , 2010, Journal of Alzheimer's disease : JAD.

[436]  R. Jope,et al.  Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3). , 2010, Trends in immunology.

[437]  J. Hardy,et al.  The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .

[438]  Z. Marinova,et al.  The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons , 2009, Molecular Psychiatry.

[439]  H. Basun,et al.  Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease. , 2009, Journal of Alzheimer's disease : JAD.

[440]  J. Aubry,et al.  Lithium: Updated Human Knowledge Using an Evidence-Based Approach , 2009, CNS Drugs.

[441]  A. Strasser,et al.  The BCL-2 protein family: opposing activities that mediate cell death , 2008, Nature Reviews Molecular Cell Biology.

[442]  C. Johannessen Landmark,et al.  Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy. , 2008, CNS drugs.

[443]  H. Eldar-Finkelman,et al.  Lithium-mediated phosphorylation of glycogen synthase kinase-3β involves PI3 kinase-dependent activation of protein kinase C-α , 2007, Journal of Molecular Neuroscience.

[444]  S. Tsai The possible role of tissue-type plasminogen activator and the plasminogen system in the pathogenesis of major depression. , 2006, Medical hypotheses.

[445]  L. Yatham,et al.  Polytherapy in Bipolar Disorder , 2006, CNS drugs.

[446]  N. Maulik,et al.  Glycogen synthase kinase-3beta/beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF, Bcl-2 and survivin expression in rat ischemic preconditioned myocardium. , 2006, Journal of molecular and cellular cardiology.

[447]  D. Chuang,et al.  Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases. , 2005, Annual review of pharmacology and toxicology.

[448]  K. Fukunaga,et al.  Transcriptional regulation of neuronal genes and its effect on neural functions: expression and function of forkhead transcription factors in neurons. , 2005, Journal of pharmacological sciences.

[449]  P Leeds,et al.  Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2 , 2005, The Pharmacogenomics Journal.

[450]  S. Stahl,et al.  Toward convergence in the medication treatment of bipolar disorder and schizophrenia. , 2005, Harvard review of psychiatry.

[451]  Guang Chen,et al.  In Vivo Evidence in the Brain for Lithium Inhibition of Glycogen Synthase Kinase-3 , 2004, Neuropsychopharmacology.

[452]  D. Chuang Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases? , 2004, Critical reviews in neurobiology.

[453]  Jesús Avila,et al.  Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model. , 2003, Journal of Alzheimer's disease : JAD.

[454]  H. Manji,et al.  Support of retinal ganglion cell survival and axon regeneration by lithium through a Bcl-2-dependent mechanism. , 2003, Investigative ophthalmology & visual science.

[455]  V. Kuchroo,et al.  T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. , 2002, Annual review of immunology.

[456]  J. Rosales,et al.  Controversies over p25 in Alzheimer's disease. , 2002, Journal of Alzheimer's disease : JAD.

[457]  J. Kane,et al.  Extending indications for long-term pharmacotherapy: opportunities and challenges. , 2002, The American journal of psychiatry.

[458]  J. Collinge Prion diseases of humans and animals: their causes and molecular basis. , 2001, Annual review of neuroscience.

[459]  H. Manji,et al.  Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics. , 2001, Psychopharmacology bulletin.

[460]  H. Zoghbi,et al.  Spinocerebellar ataxia type 1. , 2014, Handbook of clinical neurology.

[461]  J. Ávila,et al.  Glycogen Synthase Kinase-3 Modulates Neurite Outgrowth in Cultured Neurons: Possible Implications for Neurite Pathology in Alzheimer's Disease. , 1999, Journal of Alzheimer's disease : JAD.

[462]  R. Jope A bimodal model of the mechanism of action of lithium , 1999, Molecular Psychiatry.

[463]  T. Honjo,et al.  Induction of Bip mRNA upon programmed cell death of differentiated PC12 cells as well as rat sympathetic neurons. , 1997, Journal of biochemistry.

[464]  M. Greenberg,et al.  Intracellular signaling pathways activated by neurotrophic factors. , 1996, Annual review of neuroscience.

[465]  V. Gallicchio,et al.  Effect of lithium in murine immunodeficiency virus infected animals. , 1993, Pathobiology : journal of immunopathology, molecular and cellular biology.

[466]  F. Hartl,et al.  Molecular chaperone functions of heat-shock proteins. , 1993, Annual review of biochemistry.

[467]  A. Tamura,et al.  Lithium ion does not protect brain against transient ischemia in gerbils. , 1991, Stroke.

[468]  S. Lindquist The heat-shock response. , 1986, Annual review of biochemistry.

[469]  M. Mázló,et al.  Morphological study of the kidneys of lithium treated rats. , 1983, Acta morphologica Hungarica.

[470]  Y T Feng,et al.  The necessity for a collection development policy statement. , 1979, Library resources & technical services.

[471]  A. Jus,et al.  Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. , 1978, Neuropsychobiology.

[472]  W. Weiner,et al.  The effect of lithium on an animal model of tardive dyskinesia. , 1977, Progress in neuro-psychopharmacology.

[473]  C. Randall Letter: Temporary paralysis in childhood after influenza B. , 1975, Lancet.