Insulinoma ó diagnosis and treatment

Insulinomas are the most common functioning endocrine tumors of pancreas. Approximately 10% are multiple, less than 10% can be malignant and 5n10% associated with the MEN-1 syndrome. Insulinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. The aim of this lecture is to present the up-to-date information concerning the prevalence, diagnosis and treatment of insulinoma. (Pol J Endocrinol 2007; (58) 1: 58n62)

[1]  A. Vinik,et al.  Clinical features and morphological characterization of 10 patients with noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS) , 2006, Clinical endocrinology.

[2]  A. Pupi,et al.  Multiple Effects of Somatostatin Analogs Verified in Three Cases of Metastasized Neuroendocrine Tumors of the Gastroenteropancreatic System , 2006, Tumori.

[3]  R. Arnold,et al.  Endocrine tumours of the gastrointestinal tract: Chemotherapy. , 2005, Best practice & research. Clinical gastroenterology.

[4]  O. Rorstad,et al.  The palliative role of 131I-MIBG and 111In-octreotide therapy in patients with metastatic progressive neuroendocrine neoplasms. , 2004, Surgery.

[5]  E. Krenning,et al.  Guidelines for the Diagnosis and Treatment of Neuroendocrine Gastrointestinal Tumours , 2005 .

[6]  G. Irvin,et al.  Rapid insulin assay for intraoperative confirmation of complete resection of insulinomas. , 2002, Surgery.

[7]  S. Matsuno,et al.  Role of intraoperative insulin monitoring in surgical management of insulinoma. , 2001, Journal of laparoendoscopic & advanced surgical techniques. Part A.

[8]  T. de Baère,et al.  Antitumour activity of somatostatin analogues in progressive metastatic neuroendocrine tumours. , 2001, European journal of cancer.

[9]  K. Öberg Established Clinical Use of Octreotide and Lanreotide in Oncology , 2001, Chemotherapy.

[10]  P. Ruszniewski,et al.  Hepatic Arterial Chemoembolization in the Management of Advanced Digestive Endocrine Tumors , 2000, Digestion.

[11]  P. Rougier,et al.  Chemotherapy in the Treatment of Neuroendocrine Malignant Tumors , 2000, Digestion.

[12]  B. Simon,et al.  Treatment of Neuroendocrine GEP Tumours with Somatostatin Analogues , 2000, Digestion.

[13]  U. Tylén,et al.  Interventional Treatment of Gastrointestinal Neuroendocrine Tumours , 2000, Digestion.

[14]  D. Roith Tumor-induced hypoglycemia. , 1999 .

[15]  B. Hoogwerf,et al.  Neuroglycopenic and other symptoms in patients with insulinomas. , 1999, The American journal of medicine.

[16]  F. Pattou,et al.  Intraoperative Insulin Measurement during Surgical Management of Insulinomas , 1998, World Journal of Surgery.

[17]  S. Fan,et al.  Surgical strategy for insulinomas in multiple endocrine neoplasia type I. , 1998, American journal of surgery.

[18]  G. Gill,et al.  Diazoxide treatment for insulinoma: a national UK survey. , 1997, Postgraduate medical journal.

[19]  Grant Cs Gastrointestinal endocrine tumours. Insulinoma. , 1996, Bailliere's clinical gastroenterology.

[20]  K. Öberg Neuroendocrine gastrointestinal tumours , 1996 .

[21]  R. Burney,et al.  Surgical approach to insulinomas. Assessing the need for preoperative localization. , 1992, Archives of surgery.

[22]  J. Farndon,et al.  Diazoxide in the management of patients with insulinoma , 1986, World Journal of Surgery.

[23]  E. Kaplan,et al.  Recent Advances in the Diagnosis and Treatment of lnsulinomas , 1979 .

[24]  M. C. Savanelli,et al.  Pre-clinical and clinical experiences with novel somatostatin ligands: advantages, disadvantages and new prospects. , 2005 .

[25]  E. VázquezQuintana The surgical management of insulinoma. , 2004 .

[26]  A. Scarpa,et al.  Surgical strategy in the treatment of gastrointestinal neuroendocrine tumours. , 2001, Annals of oncology : official journal of the European Society for Medical Oncology.

[27]  B. Eriksson,et al.  Summing up 15 years of somatostatin analog therapy in neuroendocrine tumors: future outlook. , 1999, Annals of oncology : official journal of the European Society for Medical Oncology.

[28]  R. Jensen,et al.  Pancreatic endocrine tumors: recent advances. , 1999, Annals of oncology : official journal of the European Society for Medical Oncology.

[29]  S. Bloom,et al.  Gastrointestinal endocrine tumours , 1996 .