Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells

[1]  W. Dekant.  Chemical-induced nephrotoxicity mediated by glutathione S-conjugate formation. , 2001, Toxicology letters.

[2]  T. Monks,et al.  Serotonergic neurotoxicity of 3,4-(+/-)-methylenedioxyamphetamine and 3,4-(+/-)-methylendioxymethamphetamine (ecstasy) is potentiated by inhibition of gamma-glutamyl transpeptidase. , 2001, Chemical research in toxicology.

[3]  G. Schaaf,et al.  Characterization of biotransformation enzyme activities in primary rat proximal tubular cells. , 2001, Chemico-biological interactions.

[4]  F. Carvalho,et al.  Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)? An in vitro study using freshly isolated mouse hepatocytes , 2001, Archives of Toxicology.

[5]  K. Kreth,et al.  Identification of the human cytochromes P450 involved in the oxidative metabolism of "Ecstasy"-related designer drugs. , 2000, Biochemical pharmacology.

[6]  J. Bolton,et al.  Role of quinones in toxicology. , 2000, Chemical research in toxicology.

[7]  B. Halliwell,et al.  Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies. , 1999, Free radical research.

[8]  T. Monks,et al.  Glutathione and N-acetylcysteine conjugates of alpha-methyldopamine produce serotonergic neurotoxicity: possible role in methylenedioxyamphetamine-mediated neurotoxicity. , 1999, Chemical research in toxicology.

[9]  A. Walubo,et al.  Fatal multi-organ failure after suicidal overdose with MDMA, `Ecstasy': case report and review of the literature , 1999, Human & experimental toxicology.

[10]  T. Monks,et al.  Biological reactivity of polyphenolic-glutathione conjugates. , 1997, Chemical research in toxicology.

[11]  M. Cunningham.  Ecstasy-induced rhabdomyolysis and its role in the development of acute renal failure. , 1997, Intensive & critical care nursing.

[12]  R. T. Miller,et al.  2,5-Bis-(glutathion-S-yl)-alpha-methyldopamine, a putative metabolite of (+/-)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations. , 1997, European journal of pharmacology.

[13]  R. T. Miller,et al.  Metabolism of 5-(glutathion-S-yl)-alpha-methyldopamine following intracerebroventricular administration to male Sprague-Dawley rats. , 1995, Chemical research in toxicology.

[14]  N. Vermeulen,et al.  Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics. , 1995, Pharmacological reviews.

[15]  G. Woodrow,et al.  Acute renal failure due to accelerated hypertension following ingestion of 3,4-methylenedioxymethamphetamine ('ecstasy'). , 1995, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[16]  T. Monks,et al.  Oxidation and acetylation as determinants of 2-bromocystein-S-ylhydroquinone-mediated nephrotoxicity. , 1994, Chemical research in toxicology.

[17]  P. van Bladeren,et al.  Differential detoxification of two thioether conjugates of menadione in confluent monolayers of rat renal proximal tubular cells. , 1994, Toxicology in vitro : an international journal published in association with BIBRA.

[18]  A. Cho,et al.  Participation of cytochrome P450-2B and -2D isozymes in the demethylenation of methylenedioxymethamphetamine enantiomers by rats. , 1994, Molecular pharmacology.

[19]  S. Dawling,et al.  Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy") , 1992, The Lancet.

[20]  M. Yaqoob,et al.  Acute renal failure after ecstasy. , 1992, BMJ.

[21]  E. Lock,et al.  Nephrotoxicity of 4-Aminophenol Glutathione Conjugate , 1991, Human & experimental toxicology.

[22]  P. van Bladeren,et al.  Inhibition of γ-glutamyl transpeptidase potentiates the nephrotoxicity of glutathione-conjugated chlorohydroquinones , 1991 .

[23]  T. Monks,et al.  Nephrotoxicity of quinol/quinone-linked S-conjugates. , 1990, Toxicology letters.

[24]  A. Cho,et al.  Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct. , 1990, The Journal of pharmacology and experimental therapeutics.

[25]  T. Monks,et al.  Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution. , 1988, Molecular pharmacology.

[26]  T. Monks,et al.  2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: physiological, biochemical, and electrochemical determinants. , 1988, Molecular pharmacology.

[27]  T. Monks,et al.  Renal transport processes and glutathione conjugate-mediated nephrotoxicity. , 1987, Drug metabolism and disposition: the biological fate of chemicals.

[28]  T. Monks,et al.  Glutathione conjugates of 2-bromohydroquinone are nephrotoxic. , 1985, Drug metabolism and disposition: the biological fate of chemicals.

[29]  Y. Morino,et al.  γ‐Glutamyl Transpeptidase: Sidedness of Its Active Site on Renal Brush‐Border Membrane , 1978 .

[30]  P. van Bladeren.  Glutathione conjugation as a bioactivation reaction. , 2000, Chemico-biological interactions.

[31]  T. Monks,et al.  The pharmacology and toxicology of polyphenolic-glutathione conjugates. , 1998, Annual review of pharmacology and toxicology.

[32]  V. Rodilla,et al.  Isolation and culture of human renal cortical cells with characteristics of proximal tubules. , 1996, Methods in molecular medicine.

[33]  S. Lau,et al.  Quinone-thioether-mediated nephrotoxicity. , 1995, Drug metabolism reviews.

[34]  T. Monks.  Modulation of quinol/quinone-thioether toxicity by intramolecular detoxication. , 1995, Drug metabolism reviews.

[35]  T. Monks,et al.  Glutathione conjugation as a mechanism for the transport of reactive metabolites. , 1994, Advances in pharmacology.

[36]  C. Beddell,et al.  Studies on the effects of L(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) on 4-aminophenol-induced nephrotoxicity in the Fischer 344 rat. , 1993, Archives of toxicology.

[37]  T. Monks,et al.  Toxicology of quinone-thioethers. , 1992, Critical reviews in toxicology.

[38]  G. Mulder,et al.  Renal proximal tubular cells in suspension or in primary culture as in vitro models to study nephrotoxicity. , 1990, Chemico-biological interactions.

[39]  P. Anthony,et al.  Necrotizing renal vasculopathy resulting in chronic renal failure after ingestion of methamphetamine and 3,4-methylenedioxymethamphetamine ('ecstasy') , 1998, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.