Development and Validation of Analytical Method for Estimation of Cefixime in Swab Samples

The objective of the current study was to develop and validate simple and precise UV spectrophotometric method for estimation of Cefixime Trihydrate in the swab samples to validate cleaning procedure. The swabbing procedure was optimized in order to obtain a suitable recovery from stainless steel surface using Tex wipe polyurethane swab stick. Detection wavelength selected was 289 nm. The proposed method was validated in terms of Linearity, precision, accuracy, limit of detection and limit of quantitation. Linearity was studied over concentration range of 0.5 3 μg / ml and correlation coefficient was found to be 0.9998 for regression line. A mean recovery obtained was 86.55 %.