Cerebral Metabolic Relationships for Selected Brain Regions in Healthy Adults

The local cerebral metabolic rate for glucose was determined in 26 regions of the brain in 31 healthy subjects who underwent resting fluorodeoxyglucose positron emission tomography. Intercorrelations among the 26 regional measures were accepted as reliable at p < 0.01 (r > 0.45), uncorrected for the number of measures. From the matrix two apparently separate functional metabolic systems were identified: (1) a superior system involving the superior and middle frontal gyri, the inferior parietal lobule, and the occipital cortex; and (2) an inferior system involving the inferior frontal, Broca's, and posterior temporal regions. Evidence is presented to suggest that the superior system is involved in visual processing, memory recognition, and decision making, while the inferior system seems to at least participate in language-related functions.

[1]  J C Mazziotta,et al.  Tomographic mapping of human cerebral metabolism , 1982, Neurology.

[2]  J. Risberg,et al.  Hemispheric specialization in normal man studied by bilateral measurements of the regional cerebral blood flow. A study with the 133-Xe inhalation technique. , 1975, Brain : a journal of neurology.

[3]  M. Mesulam.  A cortical network for directed attention and unilateral neglect , 1981, Annals of neurology.

[4]  J Risberg,et al.  Patterns of activation in the grey matter of the dominant hemisphere during memorizing and reasoning. A study of regional cerebral blood flow changes during psychological testing in a group of neurologically normal patients. , 1973, Brain : a journal of neurology.

[5]  Michael E. Phelps,et al.  Effects of Human Aging on Patterns of Local Cerebral Glucose Utilization Determined by the [18F] Fluorodeoxyglucose Method , 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[6]  E. Skinhøj,et al.  TRANSNEURAL DEPRESSION OF THE CEREBRAL HEMISPHERIC METABOLISM IN MAN , 1964, Acta neurologica Scandinavica.

[7]  M E Phelps,et al.  18FDG positron emission computed tomography in a study of aphasia , 1981, Annals of neurology.

[8]  Michael E. Phelps,et al.  Tomographic mapping of human cerebral metabolism , 1981, Neurology.

[9]  M E Phelps,et al.  EFFECTS OF STROKE ON LOCAL CEREBRAL METABOLISM AND PERFUSION: MAPPING BY EMISSION COMPUTED TOMOGRAPHY OF 18FDG AND 13NH3 , 1980, Annals of neurology.

[10]  O B Paulson,et al.  Regional cerebral blood flow in apoplexy without arterial occlusion , 1970, Neurology.

[11]  Jarl Risberg,et al.  Observations on the functional significance of regional cerebral blood flow in “resting” normal subjects , 1980, Neuropsychologia.

[12]  J. Mazziotta,et al.  TOMOGRAPHIC MAPPING OF HUMAN CEREBRAL METABOLISM: NORMAL UNSTIMULATED STATE , 1981 .

[13]  D Comar,et al.  "Crossed cerebellar diaschisis" in human supratentorial brain infarction. , 1981, Transactions of the American Neurological Association.

[14]  A. Hirano,et al.  AN ATLAS OF THE HUMAN BRAIN FOR COMPUTERIZED TOMOGRAPHY. , 1978 .

[15]  E. Hoffman,et al.  Noninvasive determination of local cerebral metabolic rate of glucose in man. , 1980, The American journal of physiology.

[16]  E. Hoffman,et al.  Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method , 1979, Annals of neurology.

[17]  A. Alavi,et al.  The [18F]Fluorodeoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization in Mane , 1979, Circulation research.

[18]  F. Sakai,et al.  Regional cerebral blood flow, diaschisis, and steal after stroke. , 1979, Neurological research.

[19]  J. Mazziotta,et al.  Tomographic mapping of human cerebral metabolism , 1981, Neurology.

[20]  E. Hoffman,et al.  TOMOGRAPHIC MEASUREMENT OF LOCAL CEREBRAL GLUCOSE METABOLIC RATE IN HUMANS WITH (F‐18)2‐FLUORO-2‐DEOXY-D‐GLUCOSE: VALIDATION OF METHOD , 1980, Annals of neurology.

[21]  J C Mazziotta,et al.  Cerebral Glucose Metabolism as a Function of Age in Man: Influence of the Rate Constants in the Fluorodeoxyglucose Method , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  Michael E. Phelps,et al.  Effects of stroke on local cerebral metabolism and perfusion: Mapping by emission computed tomography of 18FDG and 13NH3 , 1980, Annals of neurology.

[23]  J E Bogen,et al.  Cerebral commissurotomy. A second case report. , 1965, JAMA.

[24]  J C Mazziotta,et al.  Quantitation in Positron Emission Computed Tomography: 5. Physical–Anatomical Effects , 1981, Journal of computer assisted tomography.

[25]  D. Ingvar.  “Hyperfrontal” distribution of the cerebral grey matter flow in resting wakefulness; on the functional anatomy of the conscious state , 1979, Acta neurologica Scandinavica.

[26]  J. Risberg,et al.  Changes of cortical activity patterns during habituation to a reasoning test A study with the 133Xe inhalation technique for measurement or regional cerebral blood flow , 1977, Neuropsychologia.

[27]  J. Mazziotta,et al.  CEREBRAL GLUCOSE METABOLISM AS A FUNCTION OF AGE: THE INFLUENCE OF THE RATE CONSTANTS IN THE FDG METHOD , 1982 .

[28]  W D Obrist,et al.  Sex and handedness differences in cerebral blood flow during rest and cognitive activity. , 1982, Science.

[29]  M E Phelps,et al.  ECAT: a new computerized tomographic imaging system for positron-emitting radiopharmaceuticals. , 1978, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.