Genomic trade-offs: are autism and schizophrenia the steep price of the human brain?

[1]  J. Sikela,et al.  Changing the name of the NBPF/DUF1220 domain to the Olduvai domain , 2017, F1000Research.

[2]  Robert Plomin,et al.  Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence , 2017, Nature Genetics.

[3]  B. Frey,et al.  Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder , 2017, Nature Neuroscience.

[4]  S. Pääbo,et al.  A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification , 2016, Science Advances.

[5]  Bernard J. Crespi,et al.  Autism As a Disorder of High Intelligence , 2016, Front. Neurosci..

[6]  G. Cioni,et al.  Focal cortical dysplasia, microcephaly and epilepsy in a boy with 1q21.1-q21.3 duplication. , 2016, European journal of medical genetics.

[7]  J. Flint.  Rare genetic variants and schizophrenia , 2016, Nature Neuroscience.

[8]  John P. John,et al.  Assessing Neurocognition via Gamified Experimental Logic: A Novel Approach to Simultaneous Acquisition of Multiple ERPs , 2016, Front. Neurosci..

[9]  J. Sikela,et al.  DUF1220 copy number is associated with schizophrenia risk and severity: implications for understanding autism and schizophrenia as related diseases , 2015, Translational Psychiatry.

[10]  J. Sikela,et al.  DUF1220 protein domains drive proliferation in human neural stem cells and are associated with increased cortical volume in anthropoid primates , 2015, Brain Structure and Function.

[11]  P. Bolton,et al.  Heritability of Autism Spectrum Disorder in a UK Population-Based Twin Sample. , 2015, JAMA psychiatry.

[12]  S. Montgomery,et al.  Phylogenetic Analysis Supports a Link between DUF1220 Domain Number and Primate Brain Expansion , 2015, bioRxiv.

[13]  Janet Kelso,et al.  Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion , 2015, Science.

[14]  J. Sikela,et al.  Replicated linear association between DUF1220 copy number and severity of social impairment in autism , 2015, Human Genetics.

[15]  Samuel L. Wolock,et al.  Molecular Genetic Evidence for Shared Etiology of Autism and Prodigy , 2015, Human Heredity.

[16]  J. Sikela,et al.  Generation of Mice Lacking DUF1220 Protein Domains: Effects on Fecundity and Hyperactivity , 2015, Mammalian Genome.

[17]  E. Callaway.  'Smart genes' prove elusive , 2014, Nature.

[18]  Ian J. Deary,et al.  Common genetic variants associated with cognitive performance identified using the proxy-phenotype method , 2014, Proceedings of the National Academy of Sciences.

[19]  J. Sikela,et al.  The case for DUF1220 domain dosage as a primary contributor to anthropoid brain expansion , 2014, Front. Hum. Neurosci..

[20]  A. Sharp,et al.  Digital Genotyping of Macrosatellites and Multicopy Genes Reveals Novel Biological Functions Associated with Copy Number Variation of Large Tandem Repeats , 2014, PLoS genetics.

[21]  C. Hultman,et al.  The familial risk of autism. , 2014, JAMA.

[22]  J. Sikela,et al.  DUF1220 Dosage Is Linearly Associated with Increasing Severity of the Three Primary Symptoms of Autism , 2014, PLoS genetics.

[23]  Krzysztof J. Gorgolewski,et al.  Dynamic network participation of functional connectivity hubs assessed by resting-state fMRI , 2014, Front. Hum. Neurosci..

[24]  Jinke Wang,et al.  NBPF is a potential DNA-binding transcription factor that is directly regulated by NF-κB. , 2013, The international journal of biochemistry & cell biology.

[25]  R. Kahn,et al.  Brain volumes in schizophrenia: a meta-analysis in over 18 000 subjects. , 2013, Schizophrenia bulletin.

[26]  Jonathan P. Beauchamp,et al.  GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment , 2013, Science.

[27]  Stephan J Sanders,et al.  High rate of disease-related copy number variations in childhood onset schizophrenia , 2013, Molecular Psychiatry.

[28]  J. Lupski,et al.  DUF1220-domain copy number implicated in human brain-size pathology and evolution. , 2012, American journal of human genetics.

[29]  Joanne M. Ruthsatz,et al.  Child prodigy: A novel cognitive profile places elevated general intelligence, exceptional working memory and attention to detail at the root of prodigiousness , 2012 .

[30]  C. Michael Dickens,et al.  Evolutionary History and Genome Organization of DUF1220 Protein Domains , 2012, G3: Genes | Genomes | Genetics.

[31]  S. Herculano‐Houzel.  The remarkable, yet not extraordinary, human brain as a scaled-up primate brain and its associated cost , 2012, Proceedings of the National Academy of Sciences.

[32]  E. Courchesne,et al.  Neuron number and size in prefrontal cortex of children with autism. , 2011, JAMA.

[33]  Jay Neitz,et al.  The genetics of normal and defective color vision , 2011, Vision Research.

[34]  T. Crow,et al.  ‘The missing genes: what happened to the heritability of psychiatric disorders?’ , 2011, Molecular Psychiatry.

[35]  J. Sikela,et al.  The ethics of using transgenic non-human primates to study what makes us human , 2010, Nature Reviews Genetics.

[36]  F. van Roy,et al.  Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma. , 2010, Experimental cell research.

[37]  B. Crespi,et al.  Comparative genomics of autism and schizophrenia , 2010, Proceedings of the National Academy of Sciences.

[38]  Gayane Yenokyan,et al.  Characteristics and concordance of autism spectrum disorders among 277 twin pairs. , 2009, Archives of pediatrics & adolescent medicine.

[39]  S. Herculano‐Houzel.  The Human Brain in Numbers: A Linearly Scaled-up Primate Brain , 2009, Front. Hum. Neurosci..

[40]  B. Crespi,et al.  Genomic sister-disorders of neurodevelopment: an evolutionary approach , 2009, Evolutionary applications.

[41]  P. Stankiewicz,et al.  Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities , 2008, Nature Genetics.

[42]  C. Baker,et al.  Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes. , 2008, The New England journal of medicine.

[43]  Thomas W. Mühleisen,et al.  Large recurrent microdeletions associated with schizophrenia , 2008, Nature.

[44]  B. Crespi,et al.  Psychosis and autism as diametrical disorders of the social brain. , 2008, The Behavioral and brain sciences.

[45]  Robert O Deaner,et al.  Overall Brain Size, and Not Encephalization Quotient, Best Predicts Cognitive Ability across Non-Human Primates , 2007, Brain, Behavior and Evolution.

[46]  J. Burns.  The Descent of Madness: Evolutionary Origins of Psychosis and the Social Brain , 2007 .

[47]  J. Kaas,et al.  Cellular scaling rules for primate brains , 2007, Proceedings of the National Academy of Sciences.

[48]  M. Guha.  The Descent of Madness: Evolutionary origins of psychosis and the social brain , 2007 .

[49]  Gerald J Wyckoff,et al.  Human Lineage–Specific Amplification, Selection, and Neuronal Expression of DUF1220 Domains , 2006, Science.

[50]  J. Burns,et al.  Psychosis: A costly by-product of social brain evolution in Homo sapiens , 2006, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[51]  F. Speleman,et al.  A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. , 2005, Molecular biology and evolution.

[52]  H. Garner,et al.  Molecular origins of rapid and continuous morphological evolution , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[53]  J. Burns.  An evolutionary theory of schizophrenia: Cortical connectivity, metarepresentation, and the social brain , 2004, Behavioral and Brain Sciences.

[54]  Ruth A. Carper,et al.  Evidence of brain overgrowth in the first year of life in autism. , 2003, JAMA.

[55]  E. Courchesne,et al.  Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study , 2001, Neurology.

[56]  H. Ellegren.  Microsatellite mutations in the germline: implications for evolutionary inference. , 2000, Trends in genetics : TIG.

[57]  T. Crow.  Schizophrenia as the price that Homo sapiens pays for language: a resolution of the central paradox in the origin of the species , 2000, Brain Research Reviews.

[58]  T. Crow.  Is schizophrenia the price that Homo sapiens pays for language? , 1997, Schizophrenia Research.

[59]  T. Crow,et al.  A theory of the evolutionary origins of psychosis , 1995, European Neuropsychopharmacology.

[60]  T. Crow,et al.  A continuum of psychosis, one human gene, and not much else — the case for homogeneity , 1995, Schizophrenia Research.

[61]  J. Karlsson.  Partly Dominant Transmission of Schizophrenia in Iceland , 1988, British Journal of Psychiatry.

[62]  J. Karlsson.  Family Transmission of Schizophrenia: A Review and Synthesis , 1982, British Journal of Psychiatry.

[63]  T. Crow,et al.  Molecular pathology of schizophrenia: more than one disease process? , 1980, British medical journal.

[64]  W. James,et al.  Schizophrenia as a Genetic Morphism , 1970, Nature.

[65]  A. Hoffer,et al.  Schizophrenia as a Genetic Morphism , 1964, Nature.

[66]  A. Allison.  The distribution of the sickle-cell trait in East Africa and elsewhere, and its apparent relationship to the incidence of subtertian malaria. , 1954, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[67]  J. Sikela,et al.  DUF1220 copy number is linearly associated with increased cognitive function as measured by total IQ and mathematical aptitude scores , 2014, Human Genetics.

[68]  P. McGuffin,et al.  Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings. , 2013, JAMA psychiatry.

[69]  S. Herculano‐Houzel.  Neuronal scaling rules for primate brains: the primate advantage. , 2012, Progress in brain research.

[70]  J. Sikela,et al.  DUF1220 domains, cognitive disease, and human brain evolution. , 2009, Cold Spring Harbor symposia on quantitative biology.

[71]  J. Langer,et al.  Biology, brains, and behavior : the evolution of human development , 2000 .

[72]  M. Goodman,et al.  The genomic record of Humankind's evolutionary roots. , 1999, American journal of human genetics.

[73]  M. Lemonick.  Smart genes? , 1999, Time.

[74]  J. Karlsson.  Inheritance of schizophrenia. , 1974, Acta psychiatrica Scandinavica. Supplementum.