Regulation of mitochondrial dehydrogenases by calcium ions.

[1]  Guy A Rutter,et al.  Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells. , 2009, Biochimica et biophysica acta.

[2]  A. Halestrap Mitochondrial calcium in health and disease. , 2009, Biochimica et biophysica acta.

[3]  G. Hajnóczky,et al.  SR/ER-mitochondrial local communication: calcium and ROS. , 2009, Biochimica et biophysica acta.

[4]  J. G. Inglis,et al.  Skeletal muscle type comparison of pyruvate dehydrogenase phosphatase activity and isoform expression: effects of obesity and endurance training. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

[5]  T. L. McGee,et al.  Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle , 2008, Nature Genetics.

[6]  P. Hart,et al.  Allosteric Motions in Structures of Yeast NAD+-specific Isocitrate Dehydrogenase* , 2008, Journal of Biological Chemistry.

[7]  C. Czupalla,et al.  Yeast Pyruvate Dehydrogenase Complex Is Regulated by a Concerted Activity of Two Kinases and Two Phosphatases* , 2008, Journal of Biological Chemistry.

[8]  H. Vogel,et al.  Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs. , 2007, The Biochemical journal.

[9]  J. Symerský,et al.  Crystal structure of pyruvate dehydrogenase phosphatase 1 and its functional implications. , 2007, Journal of molecular biology.

[10]  R. Colman,et al.  Role of α-Asp181, β-Asp192, and γ-Asp190 in the Distinctive Subunits of Human NAD-Specific Isocitrate Dehydrogenase† , 2007 .

[11]  R. Colman,et al.  Identification of Mn2+-binding Aspartates from α, β, and γ Subunits of Human NAD-dependent Isocitrate Dehydrogenase* , 2006, Journal of Biological Chemistry.

[12]  G. Rödel,et al.  YIL042c and YOR090c encode the kinase and phosphatase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex , 2006, FEBS letters.

[13]  M. Patel,et al.  Regulation of the pyruvate dehydrogenase complex. , 2006, Biochemical Society transactions.

[14]  C. Giulivi,et al.  Differential requirements of calcium for oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase under hypoxia: impact on the regulation of mitochondrial oxygen consumption. , 2005, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[15]  J. Mccormack,et al.  Characterization of the effects of Ca 2 + on the intramitochondrial Ca 2 +-sensitive enzymes from rat liver and within intact rat liver mitochondria , 2005 .

[16]  R. Denton,et al.  Role of Ca 2 ions in the regulation of intramitochondrial metabolism in rat heart , 2005 .

[17]  P. Byphili,et al.  Metabolic fuel selection: general integration at the whole-body level , 2005 .

[18]  T. Roche,et al.  Formation of a complex of the catalytic subunit of pyruvate dehydrogenase phosphatase isoform 1 (PDP1c) and the L2 domain forms a Ca2+ binding site and captures PDP1c as a monomer. , 2004, Biochemistry.

[19]  T. Roche,et al.  Organization of the Cores of the Mammalian Pyruvate Dehydrogenase Complex Formed by E2 and E2 Plus the E3-binding Protein and Their Capacities to Bind the E1 and E3 Components* , 2004, Journal of Biological Chemistry.

[20]  R. Denton,et al.  Towards the molecular basis for the regulation of mitochondrial dehydrogenases by calcium ions , 1995, Molecular and Cellular Biochemistry.

[21]  K. M. Popov,et al.  Characterization of the isozymes of pyruvate dehydrogenase phosphatase: implications for the regulation of pyruvate dehydrogenase activity. , 2003, Biochimica et biophysica acta.

[22]  D. Randall,et al.  Regulation of pyruvate dehydrogenase complex activity in plant cells. , 2003, European journal of biochemistry.

[23]  J. Zou,et al.  Identification of a mitochondrial glycerol‐3‐phosphate dehydrogenase from Arabidopsis thaliana: evidence for a mitochondrial glycerol‐3‐phosphate shuttle in plants , 2003, FEBS letters.

[24]  T. Roche,et al.  Structural Requirements within the Lipoyl Domain for the Ca2+-dependent Binding and Activation of Pyruvate Dehydrogenase Phosphatase Isoform 1 or Its Catalytic Subunit* , 2002, The Journal of Biological Chemistry.

[25]  T. Saheki,et al.  Citrin and aralar1 are Ca2+‐stimulated aspartate/glutamate transporters in mitochondria , 2001, The EMBO journal.

[26]  L. Reed A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes. , 2001, Journal of Biological Chemistry.

[27]  C. Klee,et al.  Calcium as a cellular regulator , 1999 .

[28]  V. Bunik,et al.  Subunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex. Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components. , 1998, The Journal of biological chemistry.

[29]  K. M. Popov,et al.  Isoenzymes of Pyruvate Dehydrogenase Phosphatase , 1998, The Journal of Biological Chemistry.

[30]  C. Richter,et al.  Nitric oxide synthase activity in mitochondria , 1997, FEBS letters.

[31]  T. Roche,et al.  Activated Function of the Pyruvate Dehydrogenase Phosphatase through Ca2+-facilitated Binding to the Inner Lipoyl Domain of the Dihydrolipoyl Acetyltransferase* , 1996, The Journal of Biological Chemistry.

[32]  J. E. Lawson,et al.  Role of the regulatory subunit of bovine pyruvate dehydrogenase phosphatase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[33]  L. Brown,et al.  Calcium activation of mitochondrial glycerol phosphate dehydrogenase restudied. , 1996, Archives of biochemistry and biophysics.

[34]  N. J. Edgell,et al.  The hormonal regulation of pyruvate dehydrogenase complex. , 1996, Advances in enzyme regulation.

[35]  Robert A. Harris,et al.  Alpha-Keto Acid Dehydrogenase Complexes , 1996, MCBU Molecular and Cell Biology Updates.

[36]  L. Hall,et al.  Molecular cloning and deduced amino acid sequences of the alpha- and beta- subunits of mammalian NAD(+)-isocitrate dehydrogenase. , 1995, The Biochemical journal.

[37]  T. Huh,et al.  Characterization of a cDNA clone for human NAD(+)-specific isocitrate dehydrogenase alpha-subunit and structural comparison with its isoenzymes from different species. , 1995, The Biochemical journal.

[38]  Nichols Bj Molecular regulation of NAD-isocitrate dehydrogenase. , 1995 .

[39]  M. Rigoulet,et al.  Comparison of the effects of Ca2+, adenine nucleotides and pH on the kinetic properties of mitochondrial NAD(+)-isocitrate dehydrogenase and oxoglutarate dehydrogenase from the yeast Saccharomyces cerevisiae and rat heart. , 1994, The Biochemical journal.

[40]  T. Scholz,et al.  Mitochondrial F1-ATPase activity of canine myocardium: effects of hypoxia and stimulation. , 1994, The American journal of physiology.

[41]  S. Moran,et al.  Sequence of rat mitochondrial glycerol-3-phosphate dehydrogenase cDNA. Evidence for EF-hand calcium-binding domains. , 1994, The Journal of biological chemistry.

[42]  L. Sazanov,et al.  Proton‐translocating transhydrogenase and NAD‐ and NADP‐linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria , 1994, FEBS letters.

[43]  L. Hall,et al.  Molecular cloning and deduced amino acid sequences of the gamma-subunits of rat and monkey NAD(+)-isocitrate dehydrogenases. , 1993, The Biochemical journal.

[44]  B. Rønnow,et al.  GUT2, a gene for mitochondrial glycerol 3‐phosphate dehydrogenase of Saccharomyces cerevisiae , 1993, Yeast.

[45]  J. E. Lawson,et al.  Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C. , 1993, Biochemistry.

[46]  C. Wollheim,et al.  Regulation of mitochondrial glycerol-phosphate dehydrogenase by Ca2+ within electropermeabilized insulin-secreting cells (INS-1). , 1992, Biochimica et biophysica acta.

[47]  D. Harris,et al.  Control of mitochondrial ATP synthesis in the heart. , 1991, The Biochemical journal.

[48]  R. Hansford Dehydrogenase activation by Ca2+ in cells and tissues , 1991, Journal of bioenergetics and biomembranes.

[49]  R. Hansford Dehydrogenase activation by Ca 2+ in cells and tissues , 1991 .

[50]  G. Rutter,et al.  Measurement of matrix free Mg2+ concentration in rat heart mitochondria by using entrapped fluorescent probes. , 1990, The Biochemical journal.

[51]  J. Mccormack,et al.  Role of calcium ions in regulation of mammalian intramitochondrial metabolism. , 1990, Physiological reviews.

[52]  B D Sykes,et al.  Calcium binding proteins. Elucidating the contributions to calcium affinity from an analysis of species variants and peptide fragments. , 1990, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[53]  A. Persechini,et al.  The EF-hand family of calcium-modulated proteins , 1989, Trends in Neurosciences.

[54]  N. Huzel,et al.  Calcium-binding ATPase inhibitor protein of bovine heart mitochondria. Role in ATP synthesis and effect of Ca2+. , 1989, Biochemistry.

[55]  G. Rutter,et al.  Studies into the Mechanism Whereby Insulin Activates Pyruvate Dehydrogenase Complex in Adipose Tissue a , 1989, Annals of the New York Academy of Sciences.

[56]  G. Rutter,et al.  The binding of Ca2+ ions to pig heart NAD+-isocitrate dehydrogenase and the 2-oxoglutarate dehydrogenase complex. , 1989, The Biochemical journal.

[57]  K F LaNoue,et al.  Regulation of citric acid cycle by calcium. , 1989, The Journal of biological chemistry.

[58]  A. Halestrap,et al.  Inhibition of mitochondrial-matrix inorganic pyrophosphatase by physiological [Ca2+], and its role in the hormonal regulation of mitochondrial matrix volume. , 1989, The Biochemical journal.

[59]  A. Halestrap The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism. , 1989, Biochimica et biophysica acta.

[60]  S. Yeaman,et al.  The 2-oxo acid dehydrogenase complexes: recent advances. , 1989, The Biochemical journal.

[61]  N. Huzel,et al.  The calcium-binding ATPase inhibitor protein from bovine heart mitochondria. Purification and properties. , 1988, The Journal of biological chemistry.

[62]  J. Hoek,et al.  Physiological roles of nicotinamide nucleotide transhydrogenase. , 1988, The Biochemical journal.

[63]  J. Mccormack,et al.  Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive dehydrogenases within intact rat-kidney mitochondria. , 1988, Biochimica et biophysica acta.

[64]  G. Rutter,et al.  Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with regulation by adenine nucleotides and NADH/NAD+ ratios. , 1988, The Biochemical journal.

[65]  J. Mccormack,et al.  The role of Ca2+ in the hormonal control of intramitochondrial metabolism in heart, liver, and adipose tissue. , 1988, Advances in second messenger and phosphoprotein research.

[66]  R. Hansford Relation between cytosolic free Ca2+ concentration and the control of pyruvate dehydrogenase in isolated cardiac myocytes. , 1987, The Biochemical journal.

[67]  L. Reed,et al.  Phosphorylation-dephosphorylation of pyruvate dehydrogenase from bakers' yeast. , 1986, Biochemistry.

[68]  W. C. McMurray,et al.  Purification and characterization of glycerol-3-phosphate dehydrogenase (flavin-linked) from rat liver mitochondria. , 1986, The Journal of biological chemistry.

[69]  J. Mccormack,et al.  Characterization of the effects of Ca2+ on the intramitochondrial Ca2+-sensitive enzymes from rat liver and within intact rat liver mitochondria. , 1985, The Biochemical journal.

[70]  J. Mccormack,et al.  Studies on the activation of rat liver pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase by adrenaline and glucagon. Role of increases in intramitochondrial Ca2+ concentration. , 1985, The Biochemical journal.

[71]  R. Hansford,et al.  Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes. , 1985, The Biochemical journal.

[72]  R. Hansford Relation between mitochondrial calcium transport and control of energy metabolism. , 1985, Reviews of physiology, biochemistry and pharmacology.

[73]  J. Mccormack,et al.  Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat heart. Evidence from studies with isolated mitochondria that adrenaline activates the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes by increasing the intramitochondrial concentration of Ca2+. , 1984, The Biochemical journal.

[74]  J. Mccormack,et al.  Role of Ca2+ ions in the regulation of intramitochondrial metabolism in rat epididymal adipose tissue. Evidence against a role for Ca2+ in the activation of pyruvate dehydrogenase by insulin. , 1984, The Biochemical journal.

[75]  J. Mccormack,et al.  Ruthenium Red inhibits the activation of pyruvate dehydrogenase caused by positive inotropic agents in the perfused rat heart. , 1983, The Biochemical journal.

[76]  R. Colman,et al.  Separation, recombination, and characterization of dissimilar subunits of the DPN-dependent isocitrate dehydrogenase from pig heart. , 1983, The Journal of biological chemistry.

[77]  W. M. Teague,et al.  Purification and properties of pyruvate dehydrogenase phosphatase from bovine heart and kidney. , 1982, Biochemistry.

[78]  J. Hoek,et al.  Role of calcium in the hormonal regulation of liver metabolism. , 1981, Biochimica et biophysica acta.

[79]  H. Lardy,et al.  Ca2+ stimulation of rat liver mitochondrial glycerophosphate dehydrogenase. , 1981, The Journal of biological chemistry.

[80]  R. Denton,et al.  A comparative study of the regulation of Ca2+ of the activities of the 2-oxoglutarate dehydrogenase complex and NAD+-isocitrate dehydrogenase from a variety of sources. , 1981, The Biochemical journal.

[81]  T. Roche,et al.  Regulation of bovine kidney alpha-ketoglutarate dehydrogenase complex by calcium ion and adenine nucleotides. Effects on S0.5 for alpha-ketoglutarate. , 1981, Biochemistry.

[82]  J. Fenton,et al.  Protease mitogenic response of chick embryo fibroblasts and receptor binding/processing of human alpha-thrombin. , 1981, The Journal of biological chemistry.

[83]  R. Hansford Effect of micromolar concentrations of free Ca2+ ions on pyruvate dehydrogenase interconversion in intact rat heart mitochondria. , 1981, The Biochemical journal.

[84]  R. Colman,et al.  Chemical characterization of distinct subunits of pig heart DPN-specific isocitrate dehydrogenase. , 1980, The Journal of biological chemistry.

[85]  R. Denton,et al.  On the role of the calcium transport cycle in heart and other mammalian mitochondria , 1980, FEBS letters.

[86]  J. Williamson,et al.  Regulation of the citric acid cycle in mammalian systems , 1980, FEBS letters.

[87]  N. J. Edgell,et al.  Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria. , 1980, The Biochemical journal.

[88]  A. Lehninger,et al.  The mechanisms and regulation of mitochondrial Ca2+ transport. , 1980, Federation proceedings.

[89]  M. Crompton,et al.  Mitochondrial calcium transport , 1980, FEBS letters.

[90]  R. Denton,et al.  The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex. , 1979, The Biochemical journal.

[91]  G. Plaut,et al.  Activities of NAD-specific and NADP-specific isocitrate dehydrogenases in rat-liver mitochondria. Studies with D-threo-alpha-methylisocitrate. , 1979, European journal of biochemistry.

[92]  E. Newsholme,et al.  Changes in the contents of adenine nucleotides and intermediates of glycolysis and the citric acid cycle in flight muscle of the locust upon flight and their relationship to the control of the cycle. , 1979, The Biochemical journal.

[93]  R. Denton,et al.  Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues. , 1978, The Biochemical journal.

[94]  T. P. Fondy,et al.  Isolation and characterization of flavin-linked glycerol-3-phosphate dehydrogenase from rabbit skeletal muscle mitochondria and comparison with the enzyme from rabbit brain. , 1978, The Journal of biological chemistry.

[95]  E. Newsholme,et al.  Effects of calcium ions and adenosine diphosphate on the activities of NAD+-linked isocitrate dehydrogenase from the radular muscles of the whelk and flight muscles of insects. , 1976, The Biochemical journal.

[96]  R. Hansford,et al.  The steady state concentrations of coenzyme A-SH and coenzyme A thioester, citrate, and isocitrate during tricarboxylate cycle oxidations in rabbit heart mitochondria. , 1975, The Journal of biological chemistry.

[97]  A. Fisher,et al.  Respiration of rat lung mitochondria and the influence of Ca 2+ on substrate utilization. , 1973, Biochemistry.

[98]  L. Bradham,et al.  Comparison of the effects of Ca 2+ and Mg 2+ on the adenyl cyclase of beef brain. , 1972, Biochimica et biophysica acta.

[99]  R. Denton,et al.  Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase. , 1972, The Biochemical journal.

[100]  R. Denton,et al.  Insulin activates pyruvate dehydrogenase in rat epididymal adipose tissue. , 1971, Nature: New biology.

[101]  E. Newsholme,et al.  The effects of calcium ions and adenosine diphosphats on the activity of nicotinamide-adenine dinucleotide-linked isocitrate dehydrogenase of muscle. , 1970, The Biochemical journal.

[102]  L. Reed,et al.  Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation. , 1969, Proceedings of the National Academy of Sciences of the United States of America.

[103]  R. Hansford,et al.  The effect of Ca2+ on the oxidation of glycerol phosphate by blowfly flight-muscle mitochondria. , 1967, Biochemical and biophysical research communications.

[104]  P. Caldwell,et al.  THE DEPENDENCE OF CONTRACTION AND RELAXATION OF MUSCLE FIBRES FROM THE CRAB MAIA SQUINADO ON THE INTERNAL CONCENTRATION OF FREE CALCIUM IONS. , 1964, Biochimica et biophysica acta.

[105]  R. Estabrook,et al.  alpha-Glycerophosphate oxidase of flight muscle mitochondria. , 1958, The Journal of biological chemistry.