Advanced electronic skin devices for healthcare applications.

Electronic skin, a kind of flexible electronic device and system inspired by human skin, has emerged as a promising candidate for wearable personal healthcare applications. Wearable electronic devices with skin-like properties will provide platforms for continuous and real-time monitoring of human physiological signals such as tissue pressure, body motion, temperature, metabolites, electrolyte balance, and disease-related biomarkers. Transdermal drug delivery devices can also be integrated into electronic skin to enhance its non-invasive, real-time dynamic therapy functions. This review summarizes the recent progress in electronic skin devices for applications in human health monitoring and therapy systems as well as several potential mass production technologies such as inkjet printing and 3D printing. The opportunities and challenges in broadening the applications of electronic skin devices in practical healthcare are also discussed.

[1]  B. D. Malhotra,et al.  Nanostructured zirconia decorated reduced graphene oxide based efficient biosensing platform for non-invasive oral cancer detection. , 2016, Biosensors & bioelectronics.

[2]  Itthipon Jeerapan,et al.  Highly Stretchable Fully-Printed CNT-Based Electrochemical Sensors and Biofuel Cells: Combining Intrinsic and Design-Induced Stretchability. , 2016, Nano letters.

[3]  Feng Yan,et al.  Highly Sensitive Detection of Protein Biomarkers with Organic Electrochemical Transistors , 2017, Advanced materials.

[4]  Jing Liu,et al.  Flexible Organic/Inorganic Hybrid Near‐Infrared Photoplethysmogram Sensor for Cardiovascular Monitoring , 2017, Advanced materials.

[5]  Jonah A Kaplan,et al.  Stretch-Induced Drug Delivery from Superhydrophobic Polymer Composites: Use of Crack Propagation Failure Modes for Controlling Release Rates. , 2016, Angewandte Chemie.

[6]  Youngjin Jeong,et al.  Highly Sensitive and Multimodal All‐Carbon Skin Sensors Capable of Simultaneously Detecting Tactile and Biological Stimuli , 2015, Advanced materials.

[7]  Benjamin C. K. Tee,et al.  25th Anniversary Article: The Evolution of Electronic Skin (E‐Skin): A Brief History, Design Considerations, and Recent Progress , 2013, Advanced materials.

[8]  Jeongdai Jo,et al.  A photonic sintering derived Ag flake/nanoparticle-based highly sensitive stretchable strain sensor for human motion monitoring. , 2018, Nanoscale.

[9]  Nam-Joon Cho,et al.  Flexible, Graphene‐Coated Biocomposite for Highly Sensitive, Real‐Time Molecular Detection , 2016 .

[10]  Wenzhao Jia,et al.  All‐Printed Stretchable Electrochemical Devices , 2015, Advanced materials.

[11]  Francisco J. Andrade,et al.  Balloon‐Embedded Sensors Withstanding Extreme Multiaxial Stretching and Global Bending Mechanical Stress: Towards Environmental and Security Monitoring , 2016 .

[12]  Joseph M. DeSimone,et al.  Controlling release from 3D printed medical devices using CLIP and drug‐loaded liquid resins , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[13]  Taehoon Kim,et al.  Bioinspired, Highly Stretchable, and Conductive Dry Adhesives Based on 1D-2D Hybrid Carbon Nanocomposites for All-in-One ECG Electrodes. , 2016, ACS nano.

[14]  Yi Shi,et al.  A nanostructured conductive hydrogels-based biosensor platform for human metabolite detection. , 2015, Nano letters.

[15]  Yolonda L Colson,et al.  Tension‐Activated Delivery of Small Molecules and Proteins from Superhydrophobic Composites , 2018, Advanced healthcare materials.

[16]  Christopher J Bettinger,et al.  Ultrasound-Mediated Self-Healing Hydrogels Based on Tunable Metal-Organic Bonding. , 2017, Biomacromolecules.

[17]  Hua Xu,et al.  A multifunctional wearable sensor based on a graphene/inverse opal cellulose film for simultaneous, in situ monitoring of human motion and sweat. , 2018, Nanoscale.

[18]  N. Lee,et al.  Stretchable, Transparent, Ultrasensitive, and Patchable Strain Sensor for Human-Machine Interfaces Comprising a Nanohybrid of Carbon Nanotubes and Conductive Elastomers. , 2015, ACS nano.

[19]  Nae-Eung Lee,et al.  Freestanding, Fiber‐Based, Wearable Temperature Sensor with Tunable Thermal Index for Healthcare Monitoring , 2018, Advanced healthcare materials.

[20]  Sung Min Seo,et al.  Self-powered humidity sensor based on graphene oxide composite film intercalated by poly(sodium 4-styrenesulfonate). , 2014, ACS applied materials & interfaces.

[21]  B. Derby,et al.  Fully printed high performance humidity sensors based on two-dimensional materials. , 2018, Nanoscale.

[22]  Yan Zhang,et al.  Self-powered implantable electronic-skin for in situ analysis of urea/uric-acid in body fluids and the potential applications in real-time kidney-disease diagnosis. , 2018, Nanoscale.

[23]  Yanlin Song,et al.  Inkjet printing wearable electronic devices , 2017 .

[24]  Patrick S. Schnable,et al.  High‐Resolution Patterning and Transferring of Graphene‐Based Nanomaterials onto Tape toward Roll‐to‐Roll Production of Tape‐Based Wearable Sensors , 2017 .

[25]  Dishit P. Parekh,et al.  3D Printing by Multiphase Silicone/Water Capillary Inks , 2017, Advanced materials.

[26]  Zhenan Bao,et al.  A stretchable and biodegradable strain and pressure sensor for orthopaedic application , 2018 .

[27]  Qiang Liu,et al.  High-Performance Strain Sensors with Fish-Scale-Like Graphene-Sensing Layers for Full-Range Detection of Human Motions. , 2016, ACS nano.

[28]  Benjamin C. K. Tee,et al.  Highly sensitive flexible pressure sensors with microstructured rubber dielectric layers. , 2010, Nature materials.

[29]  Wen Cheng,et al.  Conducting Polymers and Their Applications in Diabetes Management , 2016, Sensors.

[30]  Zhenan Bao,et al.  Skin-Inspired Electronics: An Emerging Paradigm. , 2018, Accounts of chemical research.

[31]  Mohammad Hasanzadeh,et al.  Non-invasive diagnosis of oral cancer: The role of electro-analytical methods and nanomaterials , 2017 .

[32]  Shichao Niu,et al.  High-performance flexible strain sensor with bio-inspired crack arrays. , 2018, Nanoscale.

[33]  Zhe Yin,et al.  Intrinsically Stretchable and Conductive Textile by a Scalable Process for Elastic Wearable Electronics. , 2017, ACS applied materials & interfaces.

[34]  Zhen Gu,et al.  Bioresponsive Microneedles with a Sheath Structure for H2 O2 and pH Cascade-Triggered Insulin Delivery. , 2018, Small.

[35]  Nae-Eung Lee,et al.  Transparent Stretchable Self-Powered Patchable Sensor Platform with Ultrasensitive Recognition of Human Activities. , 2015, ACS nano.

[36]  Albert Folch,et al.  The upcoming 3D-printing revolution in microfluidics. , 2016, Lab on a chip.

[37]  Yi Shi,et al.  Highly Sensitive, Printable Nanostructured Conductive Polymer Wireless Sensor for Food Spoilage Detection. , 2018, Nano letters (Print).

[38]  T. Thundat,et al.  Bioassay of prostate-specific antigen (PSA) using microcantilevers , 2001, Nature Biotechnology.

[39]  M D Luque de Castro,et al.  Sweat: a sample with limited present applications and promising future in metabolomics. , 2014, Journal of pharmaceutical and biomedical analysis.

[40]  Kwanwoo Shin,et al.  Low-voltage, high-sensitivity and high-reliability bimodal sensor array with fully inkjet-printed flexible conducting electrode for low power consumption electronic skin , 2017 .

[41]  G. Jabbour,et al.  Inkjet Printing—Process and Its Applications , 2010, Advanced materials.

[42]  Joseph M. DeSimone,et al.  Single-Step Fabrication of Computationally Designed Microneedles by Continuous Liquid Interface Production , 2016, PloS one.

[43]  Amay J. Bandodkar,et al.  Self‐Healing Inks for Autonomous Repair of Printable Electrochemical Devices , 2015 .

[44]  Shinya Kano,et al.  Fast-Response and Flexible Nanocrystal-Based Humidity Sensor for Monitoring Human Respiration and Water Evaporation on Skin. , 2017, ACS sensors.

[45]  Tao Shang,et al.  Evaluation of in vitro and in vivo biocompatibility of a myo-inositol hexakisphosphate gelated polyaniline hydrogel in a rat model , 2016, Scientific Reports.

[46]  P. Damasceno,et al.  A kirigami approach to engineering elasticity in nanocomposites through patterned defects. , 2015, Nature materials.

[47]  Lothar Frey,et al.  Human Sweat Analysis Using a Portable Device Based on a Screen‐printed Electrolyte Sensor , 2018 .

[48]  Ran Cao,et al.  A Breathable and Screen‐Printed Pressure Sensor Based on Nanofiber Membranes for Electronic Skins , 2018 .

[49]  Wei Li,et al.  Modifier-Free Microfluidic Electrochemical Sensor for Heavy-Metal Detection , 2017, ACS omega.

[50]  Evangelia Bouzos,et al.  Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion , 2018, Bioengineering.

[51]  Zhen Gu,et al.  Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules , 2017, Nano Research.

[52]  Nan Li,et al.  Tough Supramolecular Polymer Networks with Extreme Stretchability and Fast Room‐Temperature Self‐Healing , 2017, Advanced materials.

[53]  Ningqi Luo,et al.  Hollow‐Structured Graphene–Silicone‐Composite‐Based Piezoresistive Sensors: Decoupled Property Tuning and Bending Reliability , 2017, Advanced materials.

[54]  Xiaodong Chen,et al.  Highly Stretchable, Integrated Supercapacitors Based on Single‐Walled Carbon Nanotube Films with Continuous Reticulate Architecture , 2013, Advanced materials.

[55]  Yang Zou,et al.  Fully Bioabsorbable Natural‐Materials‐Based Triboelectric Nanogenerators , 2018, Advanced materials.

[56]  Chunya Wang,et al.  Carbonized Silk Nanofiber Membrane for Transparent and Sensitive Electronic Skin , 2017 .

[57]  C. Bettinger,et al.  Photoreconfigurable polymers for biomedical applications: chemistry and macromolecular engineering. , 2014, Biomacromolecules.

[58]  Kyle A. Williams,et al.  Towards electrically conductive, self-healing materials , 2007, Journal of The Royal Society Interface.

[59]  Md. Azahar Ali,et al.  Microfluidic Immuno-Biochip for Detection of Breast Cancer Biomarkers Using Hierarchical Composite of Porous Graphene and Titanium Dioxide Nanofibers. , 2016, ACS Applied Materials and Interfaces.

[60]  Metin Sitti,et al.  Recent Advances in Wearable Transdermal Delivery Systems , 2018, Advanced materials.

[61]  Zhen Gu,et al.  Stretch-Triggered Drug Delivery from Wearable Elastomer Films Containing Therapeutic Depots. , 2015, ACS nano.

[62]  Hyungpil Moon,et al.  Knitted fabrics made from highly conductive stretchable fibers. , 2014, Nano letters.

[63]  Mark A. Skylar-Scott,et al.  Laser-assisted direct ink writing of planar and 3D metal architectures , 2016, Proceedings of the National Academy of Sciences.

[64]  Robert Sinclair,et al.  Deformable Organic Nanowire Field‐Effect Transistors , 2018, Advanced materials.

[65]  Lili Wang,et al.  Ultrasensitive and ultraflexible e-skins with dual functionalities for wearable electronics , 2017 .

[66]  Zhenan Bao,et al.  Inducing Elasticity through Oligo‐Siloxane Crosslinks for Intrinsically Stretchable Semiconducting Polymers , 2016 .

[67]  Akira Harada,et al.  Self-Healing, Expansion-Contraction, and Shape-Memory Properties of a Preorganized Supramolecular Hydrogel through Host-Guest Interactions. , 2015, Angewandte Chemie.

[68]  Paolo Bollella,et al.  Microneedle-based biosensor for minimally-invasive lactate detection. , 2019, Biosensors & bioelectronics.

[69]  Changsoon Choi,et al.  Twistable and Stretchable Sandwich Structured Fiber for Wearable Sensors and Supercapacitors. , 2016, Nano letters.

[70]  Long Lin,et al.  Motion charged battery as sustainable flexible-power-unit. , 2013, ACS nano.

[71]  Zhong Lin Wang,et al.  All-in-One Shape-Adaptive Self-Charging Power Package for Wearable Electronics. , 2016, ACS nano.

[72]  Chun Li,et al.  Transparent, flexible, and stretchable WS2 based humidity sensors for electronic skin. , 2017, Nanoscale.

[73]  C. Fraga,et al.  Relevance, essentiality and toxicity of trace elements in human health. , 2005, Molecular aspects of medicine.

[74]  Yi Shi,et al.  Fast-Response and Low-Hysteresis Flexible Pressure Sensor Based on Silicon Nanowires , 2018, IEEE Electron Device Letters.

[75]  S. Baik,et al.  Extraordinarily High Conductivity of Stretchable Fibers of Polyurethane and Silver Nanoflowers. , 2015, ACS nano.

[76]  Li Li,et al.  Fabric Organic Electrochemical Transistors for Biosensors , 2018, Advanced materials.

[77]  Itthipon Jeerapan,et al.  Stretchable Biofuel Cells as Wearable Textile-based Self-Powered Sensors. , 2016, Journal of materials chemistry. A.

[78]  Guo-Jun Zhang,et al.  Detection of heart failure-related biomarker in whole blood with graphene field effect transistor biosensor. , 2017, Biosensors & bioelectronics.

[79]  Yaping Zang,et al.  Flexible and self-powered temperature–pressure dual-parameter sensors using microstructure-frame-supported organic thermoelectric materials , 2015, Nature Communications.

[80]  Martha E. Grady,et al.  Autonomic Restoration of Electrical Conductivity , 2012, Advanced materials.

[81]  Xiao Chuan Ong,et al.  Ultracompliant Hydrogel‐Based Neural Interfaces Fabricated by Aqueous‐Phase Microtransfer Printing , 2018 .

[82]  Zhenan Bao,et al.  Polypyrrole/Agarose-based electronically conductive and reversibly restorable hydrogel. , 2014, ACS nano.

[83]  Zhenan Bao,et al.  Tough and Water‐Insensitive Self‐Healing Elastomer for Robust Electronic Skin , 2018, Advanced materials.

[84]  Lain-Jong Li,et al.  Extraordinarily Stretchable All‐Carbon Collaborative Nanoarchitectures for Epidermal Sensors , 2017, Advanced materials.

[85]  Zhong Lin Wang,et al.  Recent Progress in Electronic Skin , 2015, Advanced science.

[86]  Andrea Ridolfi,et al.  BIOTEX—Biosensing Textiles for Personalised Healthcare Management , 2010, IEEE Transactions on Information Technology in Biomedicine.

[87]  Ho Won Jang,et al.  Self-Activated Transparent All-Graphene Gas Sensor with Endurance to Humidity and Mechanical Bending. , 2015, ACS nano.

[88]  Wenyong Lai,et al.  Inkjet printed large-area flexible circuits: a simple methodology for optimizing the printing quality , 2018 .

[89]  Wang Yi,et al.  Noninvasive and Continuous Blood Pressure Monitoring Using Wearable Body Sensor Networks , 2015, IEEE Intelligent Systems.

[90]  Ji Hoon Kim,et al.  Reverse‐Micelle‐Induced Porous Pressure‐Sensitive Rubber for Wearable Human–Machine Interfaces , 2014, Advanced materials.

[91]  Yi Shi,et al.  Flexible Pressure Sensor With High Sensitivity and Low Hysteresis Based on a Hierarchically Microstructured Electrode , 2018, IEEE Electron Device Letters.

[92]  Pianpian Ma,et al.  Glucose- and H2O2-Responsive Polymeric Vesicles Integrated with Microneedle Patches for Glucose-Sensitive Transcutaneous Delivery of Insulin in Diabetic Rats. , 2018, ACS applied materials & interfaces.

[93]  Zhong Lin Wang,et al.  Large‐Area All‐Textile Pressure Sensors for Monitoring Human Motion and Physiological Signals , 2017, Advanced materials.

[94]  Shuang Zhou,et al.  Wood Derived Composites for High Sensitivity and Wide Linear-Range Pressure Sensing. , 2018, Small.

[95]  Yang Zou,et al.  Biodegradable triboelectric nanogenerator as a life-time designed implantable power source , 2016, Science Advances.

[96]  Siyuan Ma,et al.  Fabrication of Novel Transparent Touch Sensing Device via Drop-on-Demand Inkjet Printing Technique. , 2015, ACS applied materials & interfaces.

[97]  Xiaochen Dong,et al.  Recent progress of flexible and wearable strain sensors for human-motion monitoring , 2018 .

[98]  Wei Shao,et al.  Glucose-Responsive Supramolecular Vesicles Based on Water-Soluble Pillar[5]arene and Pyridylboronic Acid Derivatives for Controlled Insulin Delivery. , 2017, Chemistry.

[99]  Mengmeng Liu,et al.  Self-Healable, Stretchable, Transparent Triboelectric Nanogenerators as Soft Power Sources. , 2018, ACS nano.

[100]  Gabriela Valdés-Ramírez,et al.  A wearable fingernail chemical sensing platform: pH sensing at your fingertips. , 2016, Talanta.

[101]  Wei Gao,et al.  Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids , 2016 .

[102]  Tingrui Pan,et al.  Flexible Transparent Iontronic Film for Interfacial Capacitive Pressure Sensing , 2015, Advanced materials.

[103]  Zheng Lou,et al.  Polymer‐Enhanced Highly Stretchable Conductive Fiber Strain Sensor Used for Electronic Data Gloves , 2016 .

[104]  Tibor Pasinszki,et al.  Carbon Nanomaterial Based Biosensors for Non-Invasive Detection of Cancer and Disease Biomarkers for Clinical Diagnosis , 2017, Sensors.

[105]  Peng Zhai,et al.  Highly Sensitive Metabolite Biosensor Based on Organic Electrochemical Transistor Integrated with Microfluidic Channel and Poly(N‐vinyl‐2‐pyrrolidone)‐Capped Platinum Nanoparticles , 2016 .

[106]  Won-Hyeong Park,et al.  Crack-Enhanced Microfluidic Stretchable E-Skin Sensor. , 2017, ACS applied materials & interfaces.

[107]  Q. Pei,et al.  Recent Advances in Stretchable and Transparent Electronic Materials , 2016 .

[108]  Taeghwan Hyeon,et al.  Multifunctional Wearable System that Integrates Sweat‐Based Sensing and Vital‐Sign Monitoring to Estimate Pre‐/Post‐Exercise Glucose Levels , 2018, Advanced Functional Materials.

[109]  R. Ghaffari,et al.  Recent Advances in Flexible and Stretchable Bio‐Electronic Devices Integrated with Nanomaterials , 2016, Advanced materials.

[110]  G. Malliaras,et al.  Organic Transistor Arrays Integrated with Finger‐Powered Microfluidics for Multianalyte Saliva Testing , 2016, Advanced healthcare materials.

[111]  Yun Liang,et al.  Network cracks-based wearable strain sensors for subtle and large strain detection of human motions , 2018 .

[112]  Jani Kivioja,et al.  Ultrafast graphene oxide humidity sensors. , 2013, ACS nano.

[113]  E. Kirowa-Eisner,et al.  Characteristics of subtractive anodic stripping voltammetry of Pb and Cd at silver and gold electrodes , 2002 .

[114]  Lu Yin,et al.  All-printed magnetically self-healing electrochemical devices , 2016, Science Advances.

[115]  F. Fan,et al.  Flexible Nanogenerators for Energy Harvesting and Self‐Powered Electronics , 2016, Advanced materials.

[116]  Hyungil Jung,et al.  Exendin-4–encapsulated dissolving microneedle arrays for efficient treatment of type 2 diabetes , 2018, Scientific Reports.

[117]  Dukhyun Choi,et al.  An Ultrasensitive, Visco‐Poroelastic Artificial Mechanotransducer Skin Inspired by Piezo2 Protein in Mammalian Merkel Cells , 2017, Advanced materials.

[118]  Q. Pei,et al.  A Water‐Based Silver‐Nanowire Screen‐Print Ink for the Fabrication of Stretchable Conductors and Wearable Thin‐Film Transistors , 2016, Advanced materials.

[119]  Wenzhao Jia,et al.  Wearable temporary tattoo sensor for real-time trace metal monitoring in human sweat , 2015 .

[120]  Zhen Gu,et al.  Enhanced Cancer Immunotherapy by Microneedle Patch-Assisted Delivery of Anti-PD1 Antibody. , 2016, Nano letters.

[121]  Kyungtaek Min,et al.  Protein-Based Electronic Skin Akin to Biological Tissues. , 2018, ACS nano.

[122]  Zheng Liu,et al.  Flexible Sensing Electronics for Wearable/Attachable Health Monitoring. , 2017, Small.

[123]  Hui Long,et al.  Multifunctional Sensor Based on Porous Carbon Derived from Metal-Organic Frameworks for Real Time Health Monitoring. , 2018, ACS applied materials & interfaces.

[124]  B. Shirinzadeh,et al.  A wearable and highly sensitive pressure sensor with ultrathin gold nanowires , 2014, Nature Communications.

[125]  Yan Zhang,et al.  Outputting Olfactory Bionic Electric Impulse by PANI/PTFE/PANI Sandwich Nanostructures and their Application as Flexible, Smelling Electronic Skin , 2016 .

[126]  Rodrigo Esparza,et al.  Surface functionalized halloysite nanotubes decorated with silver nanoparticles for enzyme immobilization and biosensing. , 2016, Journal of materials chemistry. B.

[127]  Michelle Khine,et al.  Flexible Piezoresistive Pressure Sensor Using Wrinkled Carbon Nanotube Thin Films for Human Physiological Signals , 2018 .

[128]  Guofa Cai,et al.  Extremely Stretchable Strain Sensors Based on Conductive Self‐Healing Dynamic Cross‐Links Hydrogels for Human‐Motion Detection , 2016, Advanced science.

[129]  N. Lee,et al.  Organic electrochemical transistor based immunosensor for prostate specific antigen (PSA) detection using gold nanoparticles for signal amplification. , 2010, Biosensors & bioelectronics.

[130]  Carmen C. Y. Poon,et al.  Flexible Piezoresistive Sensor Patch Enabling Ultralow Power Cuffless Blood Pressure Measurement , 2016 .

[131]  Hongda Chen,et al.  Poly(3,4-ethylenedioxythiophene) (PEDOT) as interface material for improving electrochemical performance of microneedles array-based dry electrode , 2013 .

[132]  J. Windmiller,et al.  Bandage-Based Wearable Potentiometric Sensor for Monitoring Wound pH , 2014 .

[133]  Zhen Gu,et al.  A melanin-mediated cancer immunotherapy patch , 2017, Science Immunology.

[134]  Han Zhang,et al.  Toward Stretchable Self‐Powered Sensors Based on the Thermoelectric Response of PEDOT:PSS/Polyurethane Blends , 2018 .

[135]  Wenzhao Jia,et al.  Tattoo-based potentiometric ion-selective sensors for epidermal pH monitoring. , 2013, The Analyst.

[136]  Joong Tark Han,et al.  Stretchable and Multimodal All Graphene Electronic Skin , 2016, Advanced materials.

[137]  Zheng Lou,et al.  Plant‐Based Modular Building Blocks for “Green” Electronic Skins , 2018, Advanced Functional Materials.

[138]  Somayeh Imani,et al.  Eyeglasses based wireless electrolyte and metabolite sensor platform. , 2017, Lab on a chip.

[139]  Francisco Molina-Lopez,et al.  An integrated self-healable electronic skin system fabricated via dynamic reconstruction of a nanostructured conducting network , 2018, Nature Nanotechnology.

[140]  Nae-Eung Lee,et al.  An All‐Elastomeric Transparent and Stretchable Temperature Sensor for Body‐Attachable Wearable Electronics , 2016, Advanced materials.

[141]  Zhenan Bao,et al.  A bioinspired flexible organic artificial afferent nerve , 2018, Science.

[142]  Yi Shi,et al.  All Inkjet-Printed Amperometric Multiplexed Biosensors Based on Nanostructured Conductive Hydrogel Electrodes. , 2018, Nano letters.

[143]  Shogo Nakata,et al.  Wearable, Flexible, and Multifunctional Healthcare Device with an ISFET Chemical Sensor for Simultaneous Sweat pH and Skin Temperature Monitoring. , 2017, ACS sensors.

[144]  Michele Caldara,et al.  Optical monitoring of sweat pH by a textile fabric wearable sensor based on covalently bonded litmus-3-glycidoxypropyltrimethoxysilane coating , 2016 .

[145]  Zhong Lin Wang,et al.  Skin-inspired highly stretchable and conformable matrix networks for multifunctional sensing , 2018, Nature Communications.

[146]  M. Meyyappan,et al.  Chitosan supported silver nanowires as a platform for direct electrochemistry and highly sensitive electrochemical glucose biosensing , 2016 .

[147]  Zhenan Bao,et al.  Pursuing prosthetic electronic skin. , 2016, Nature materials.

[148]  Zhiping Xu,et al.  Carbonized Silk Fabric for Ultrastretchable, Highly Sensitive, and Wearable Strain Sensors , 2016, Advanced materials.

[149]  Jeong Sook Ha,et al.  Skin-Attachable, Stretchable Electrochemical Sweat Sensor for Glucose and pH Detection. , 2018, ACS applied materials & interfaces.

[150]  S. Singh,et al.  Nonlithographic Fabrication of Plastic-Based Nanofibers Integrated Microfluidic Biochip for Sensitive Detection of Infectious Biomarker. , 2017, ACS applied materials & interfaces.

[151]  Jayakumar Rajadas,et al.  Polyvinylpyrrolidone microneedles enable delivery of intact proteins for diagnostic and therapeutic applications. , 2013, Acta biomaterialia.

[152]  John A Rogers,et al.  Skin-interfaced systems for sweat collection and analytics , 2018, Science Advances.

[153]  R. Dauskardt,et al.  An ultra-sensitive resistive pressure sensor based on hollow-sphere microstructure induced elasticity in conducting polymer film , 2014, Nature Communications.

[154]  Ting Wang,et al.  Mechano-Based Transductive Sensing for Wearable Healthcare. , 2018, Small.

[155]  Rong Zhu,et al.  Electronic Skin with Multifunction Sensors Based on Thermosensation , 2017, Advanced materials.

[156]  Huanyu Cheng,et al.  Bioresorbable silicon electronic sensors for the brain , 2016, Nature.

[157]  Guang-Zhong Yang,et al.  A wearable multisensing patch for continuous sweat monitoring. , 2017, Biosensors & bioelectronics.

[158]  Xiaodan Gu,et al.  Intrinsically stretchable and healable semiconducting polymer for organic transistors , 2016, Nature.

[159]  Yu Qin,et al.  A Stretchable Electrochemical Sensor for Inducing and Monitoring Cell Mechanotransduction in Real Time. , 2017, Angewandte Chemie.

[160]  Takao Someya,et al.  Inflammation-free, gas-permeable, lightweight, stretchable on-skin electronics with nanomeshes. , 2017, Nature nanotechnology.

[161]  Matiar M. R. Howlader,et al.  Inkjet Printing of a Highly Loaded Palladium Ink for Integrated, Low‐Cost pH Sensors , 2016 .

[162]  Hye Rim Cho,et al.  Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module , 2017, Science Advances.

[163]  Daisuke Yamamoto,et al.  Efficient Skin Temperature Sensor and Stable Gel‐Less Sticky ECG Sensor for a Wearable Flexible Healthcare Patch , 2017, Advanced healthcare materials.

[164]  Wei Gao,et al.  Wearable and flexible electronics for continuous molecular monitoring. , 2019, Chemical Society reviews.

[165]  Sam Emaminejad,et al.  Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis , 2016, Nature.

[166]  Zhong Lin Wang,et al.  Sliding-triboelectric nanogenerators based on in-plane charge-separation mechanism. , 2013, Nano letters.

[167]  Seiji Akita,et al.  Fully printed, highly sensitive multifunctional artificial electronic whisker arrays integrated with strain and temperature sensors. , 2014, ACS nano.

[168]  Boris Murmann,et al.  Highly stretchable polymer semiconductor films through the nanoconfinement effect , 2017, Science.

[169]  Xian Huang,et al.  Materials and applications of bioresorbable electronics , 2018 .

[170]  Beatrice Fraboni,et al.  Recent Progress in Wearable Fully Textile Chemical Sensors , 2018 .

[171]  Yang Li,et al.  Breathable and Wearable Energy Storage Based on Highly Flexible Paper Electrodes , 2016, Advanced materials.

[172]  Sam Emaminejad,et al.  A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca(2+) and pH. , 2016, ACS nano.

[173]  Zhibin Guan,et al.  Malleable and Self-Healing Covalent Polymer Networks through Tunable Dynamic Boronic Ester Bonds. , 2015, Journal of the American Chemical Society.

[174]  S. Singh,et al.  One step biofunctionalized electrospun multiwalled carbon nanotubes embedded zinc oxide nanowire interface for highly sensitive detection of carcinoma antigen-125. , 2017, Biosensors & bioelectronics.

[175]  Yi Shi,et al.  MXenes and Their Applications in Wearable Sensors , 2020, Frontiers in Chemistry.

[176]  Bin Du,et al.  Label-free electrochemical immunosensor based on flower-like Ag/MoS2/rGO nanocomposites for ultrasensitive detection of carcinoembryonic antigen , 2018 .

[177]  Gilles Lubineau,et al.  Human-Finger Electronics Based on Opposing Humidity-Resistance Responses in Carbon Nanofilms. , 2017, Small.

[178]  Swaminathan Rajaraman,et al.  3D Printing, Ink Casting and Micromachined Lamination (3D PICLμM): A Makerspace Approach to the Fabrication of Biological Microdevices , 2018, Micromachines.

[179]  Klaus-Viktor Peinemann,et al.  Embedding 1D Conducting Channels into 3D Isoporous Polymer Films for High-Performance Humidity Sensing. , 2018, Angewandte Chemie.

[180]  Minseok Seo,et al.  3D‐Printed Microfluidic Devices for Materials Science , 2018, Advanced Materials Technologies.

[181]  Zhitian Liu,et al.  Piezoresistive Pressure Sensor Based on Synergistical Innerconnect Polyvinyl Alcohol Nanowires/Wrinkled Graphene Film. , 2018, Small.

[182]  Guohua Jiang,et al.  Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin. , 2017, Materials science & engineering. C, Materials for biological applications.

[183]  Zhen Gu,et al.  Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery , 2015, Proceedings of the National Academy of Sciences.

[184]  Takao Someya,et al.  The rise of plastic bioelectronics , 2016, Nature.

[185]  Ying-Chih Lai,et al.  Actively Perceiving and Responsive Soft Robots Enabled by Self‐Powered, Highly Extensible, and Highly Sensitive Triboelectric Proximity‐ and Pressure‐Sensing Skins , 2018, Advanced materials.

[186]  Kai Li,et al.  3D Printing of Free‐Standing Stretchable Electrodes with Tunable Structure and Stretchability , 2017 .

[187]  Yan Du,et al.  Microwave-responsive polymeric core-shell microcarriers for high-efficiency controlled drug release. , 2017, Journal of materials chemistry. B.

[188]  Lina Zhang,et al.  Ultra‐Stretchable and Force‐Sensitive Hydrogels Reinforced with Chitosan Microspheres Embedded in Polymer Networks , 2016, Advanced materials.

[189]  Xinran Wang,et al.  A Self‐Healable, Highly Stretchable, and Solution Processable Conductive Polymer Composite for Ultrasensitive Strain and Pressure Sensing , 2018 .

[190]  Jeremiah J Gassensmith,et al.  Biodegradable 3D printed polymer microneedles for transdermal drug delivery. , 2018, Lab on a chip.

[191]  Randy H. Ewoldt,et al.  Particle‐Free Emulsions for 3D Printing Elastomers , 2018 .

[192]  Daisuke Yamamoto,et al.  Printed multifunctional flexible device with an integrated motion sensor for health care monitoring , 2016, Science Advances.

[193]  Ali K. Yetisen,et al.  Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery , 2017, Scientific Reports.

[194]  Itthipon Jeerapan,et al.  A Textile‐Based Stretchable Multi‐Ion Potentiometric Sensor , 2016, Advanced healthcare materials.

[195]  Jun Fu,et al.  Ultrastretchable Strain Sensors and Arrays with High Sensitivity and Linearity Based on Super Tough Conductive Hydrogels , 2018, Chemistry of Materials.

[196]  Lim Wei Yap,et al.  Highly Stretchy Black Gold E‐Skin Nanopatches as Highly Sensitive Wearable Biomedical Sensors , 2015 .

[197]  T. Trung,et al.  Flexible and Stretchable Physical Sensor Integrated Platforms for Wearable Human‐Activity Monitoringand Personal Healthcare , 2016, Advanced materials.

[198]  B. Blaiszik,et al.  A Self‐healing Conductive Ink , 2012, Advanced materials.

[199]  Ali Javey,et al.  Wearable sweat sensors , 2018 .

[200]  Jessica J. Cash,et al.  Room-Temperature Self-Healing Polymers Based on Dynamic-Covalent Boronic Esters , 2015 .

[201]  Zhigang Suo,et al.  Localization of Folds and Cracks in Thin Metal Films Coated on Flexible Elastomer Foams , 2013, Advanced materials.

[202]  Alex Chortos,et al.  A Sensitive and Biodegradable Pressure Sensor Array for Cardiovascular Monitoring , 2015, Advanced materials.

[203]  Yuan-Ting Zhang,et al.  Continuous Blood Pressure Measurement From Invasive to Unobtrusive: Celebration of 200th Birth Anniversary of Carl Ludwig , 2016, IEEE J. Biomed. Health Informatics.

[204]  Choon-Gi Choi,et al.  High Durability and Waterproofing rGO/SWCNT-Fabric-Based Multifunctional Sensors for Human-Motion Detection. , 2018, ACS applied materials & interfaces.

[205]  Haibo Zeng,et al.  Wearable and visual pressure sensors based on Zn2GeO4@polypyrrole nanowire aerogels , 2017 .

[206]  Chunya Wang,et al.  An All-Silk-Derived Dual-Mode E-skin for Simultaneous Temperature-Pressure Detection. , 2017, ACS applied materials & interfaces.

[207]  Yonggang Huang,et al.  Multifunctional Epidermal Electronics Printed Directly Onto the Skin , 2013, Advanced materials.

[208]  Y. Mei,et al.  Printable inorganic nanomaterials for flexible transparent electrodes: from synthesis to application , 2018 .

[209]  Chunhai Fan,et al.  Effective immobilization of Au nanoparticles on TiO2 loaded graphene for a novel sandwich-type immunosensor. , 2018, Biosensors & bioelectronics.

[210]  Dae-Hyeong Kim,et al.  Multifunctional wearable devices for diagnosis and therapy of movement disorders. , 2014, Nature nanotechnology.

[211]  Seunghoe Kim,et al.  Highly Sensitive Multifilament Fiber Strain Sensors with Ultrabroad Sensing Range for Textile Electronics. , 2018, ACS nano.

[212]  Joseph Wang,et al.  Solid-state pH nanoelectrode based on polyaniline thin film electrodeposited onto ion-beam etched carbon fiber , 2002 .

[213]  Chiara Daraio,et al.  Biomimetic temperature-sensing layer for artificial skins , 2015, Science Robotics.

[214]  Akira Harada,et al.  Highly Flexible, Tough, and Self-Healing Supramolecular Polymeric Materials Using Host-Guest Interaction. , 2016, Macromolecular rapid communications.

[215]  Allister F. McGuire,et al.  Biocompatible and totally disintegrable semiconducting polymer for ultrathin and ultralightweight transient electronics , 2017, Proceedings of the National Academy of Sciences.

[216]  Sang-Hoon Bae,et al.  Printable Ultrathin Metal Oxide Semiconductor-Based Conformal Biosensors. , 2015, ACS nano.

[217]  T. Trung,et al.  A Flexible Bimodal Sensor Array for Simultaneous Sensing of Pressure and Temperature , 2014, Advanced materials.

[218]  U. Chung,et al.  Highly Stretchable Resistive Pressure Sensors Using a Conductive Elastomeric Composite on a Micropyramid Array , 2014, Advanced materials.

[219]  Yoon Kyeung Lee,et al.  Advanced Materials and Devices for Bioresorbable Electronics. , 2018, Accounts of chemical research.

[220]  Fei Zhao,et al.  Multifunctional Nanostructured Conductive Polymer Gels: Synthesis, Properties, and Applications. , 2017, Accounts of chemical research.

[221]  Orawon Chailapakul,et al.  A novel paper-based device coupled with a silver nanoparticle-modified boron-doped diamond electrode for cholesterol detection. , 2015, Analytica chimica acta.

[222]  S. Ko,et al.  Highly Stretchable and Highly Conductive Metal Electrode by Very Long Metal Nanowire Percolation Network , 2012, Advanced materials.

[223]  Benjamin C. K. Tee,et al.  Flexible polymer transistors with high pressure sensitivity for application in electronic skin and health monitoring , 2013, Nature Communications.

[224]  Boris Murmann,et al.  Skin electronics from scalable fabrication of an intrinsically stretchable transistor array , 2018, Nature.

[225]  Ashutosh Sharma,et al.  PEDOT:PSS/PVA‐Nanofibers‐Decorated Conducting Paper for Cancer Diagnostics , 2016 .

[226]  Alexander M Seifalian,et al.  Conductive Polymers: Opportunities and Challenges in Biomedical Applications. , 2018, Chemical reviews.

[227]  Alberto Salleo,et al.  Organic Electronics for Point-of-Care Metabolite Monitoring. , 2018, Trends in biotechnology.

[228]  Xiaorong Ding,et al.  Textile‐Enabled Highly Reproducible Flexible Pressure Sensors for Cardiovascular Monitoring , 2018 .

[229]  Huisheng Peng,et al.  Superelastic Supercapacitors with High Performances during Stretching , 2015, Advanced materials.

[230]  Shuye Zhang,et al.  An Ultrastable Ionic Chemiresistor Skin with an Intrinsically Stretchable Polymer Electrolyte , 2018, Advanced materials.

[231]  Feng Yan,et al.  Flexible Organic Electrochemical Transistors for Highly Selective Enzyme Biosensors and Used for Saliva Testing , 2015, Advanced materials.

[232]  Dong Jun Lee,et al.  Transparent and Stretchable Interactive Human Machine Interface Based on Patterned Graphene Heterostructures , 2015 .

[233]  Huanyu Cheng,et al.  Large‐Area Ultrathin Graphene Films by Single‐Step Marangoni Self‐Assembly for Highly Sensitive Strain Sensing Application , 2016 .

[234]  Caizhi Liao,et al.  Highly sensitive glucose sensors based on enzyme-modified whole-graphene solution-gated transistors , 2015, Scientific Reports.

[235]  R. Guy,et al.  Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform , 2018, Nature Nanotechnology.

[236]  Shanshan Xiao,et al.  Glucose Oxidase-Based Glucose-Sensitive Drug Delivery for Diabetes Treatment , 2017, Polymers.

[237]  Yeongjun Lee,et al.  One-dimensional conjugated polymer nanomaterials for flexible and stretchable electronics , 2018 .

[238]  Cheng Xu,et al.  3D Orthogonal Woven Triboelectric Nanogenerator for Effective Biomechanical Energy Harvesting and as Self‐Powered Active Motion Sensors , 2017, Advanced materials.

[239]  Yong Zhu,et al.  Nanomaterial‐Enabled Wearable Sensors for Healthcare , 2018, Advanced healthcare materials.

[240]  Bing Wei,et al.  A POSS based hydrogel with mechanical robustness, cohesiveness and a rapid self-healing ability by electrostatic interaction. , 2017, Soft matter.

[241]  Yang Zou,et al.  Self‐Powered Pulse Sensor for Antidiastole of Cardiovascular Disease , 2017, Advanced materials.

[242]  T. Someya,et al.  Printable elastic conductors by in situ formation of silver nanoparticles from silver flakes. , 2017, Nature materials.

[243]  Yan Zhang,et al.  A Self-Powered Wearable Noninvasive Electronic-Skin for Perspiration Analysis Based on Piezo-Biosensing Unit Matrix of Enzyme/ZnO Nanoarrays. , 2017, ACS applied materials & interfaces.

[244]  Dae-Hyeong Kim,et al.  Stretchable electronics on another level , 2018, Nature Electronics.

[245]  Yonggang Huang,et al.  Ultrathin conformal devices for precise and continuous thermal characterization of human skin. , 2013, Nature materials.

[246]  Wook Kim,et al.  Ultrasensitive, Low-Power Oxide Transistor-Based Mechanotransducer with Microstructured, Deformable Ionic Dielectrics. , 2018, ACS applied materials & interfaces.

[247]  Yuan-Ting Zhang,et al.  Pulse Transit Time Based Continuous Cuffless Blood Pressure Estimation: A New Extension and A Comprehensive Evaluation , 2017, Scientific Reports.

[248]  Zefeng Chen,et al.  Flexible Piezoelectric-Induced Pressure Sensors for Static Measurements Based on Nanowires/Graphene Heterostructures. , 2017, ACS nano.

[249]  Wenlong Cheng,et al.  Toward Soft Skin‐Like Wearable and Implantable Energy Devices , 2017 .

[250]  Haoran Yan,et al.  An injectable supramolecular self-healing bio-hydrogel with high stretchability, extensibility and ductility, and a high swelling ratio. , 2017, Journal of materials chemistry. B.

[251]  Hua Yu,et al.  Highly Sensitive MoS2 Humidity Sensors Array for Noncontact Sensation , 2017, Advanced materials.

[252]  Carine Benadiba,et al.  Detecting nanoscale vibrations as signature of life , 2014, Proceedings of the National Academy of Sciences.