Signaling Control of Differentiation of Embryonic Stem Cells toward Mesendoderm.

[1]  K. Hansen,et al.  β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4. , 2015, Cell stem cell.

[2]  K. Jones,et al.  SMADs and YAP compete to control elongation of β-catenin:LEF-1-recruited RNAPII during hESC differentiation. , 2015, Molecular cell.

[3]  Bing Ren,et al.  Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates. , 2015, Cell stem cell.

[4]  Antonella Galli,et al.  Activin/Nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark , 2015, Genes & development.

[5]  Jing Liang,et al.  Chromatin architecture reorganization during stem cell differentiation , 2015, Nature.

[6]  Roger A. Pedersen,et al.  NANOG and CDX2 pattern distinct subtypes of human mesoderm during exit from pluripotency. , 2014, Cell stem cell.

[7]  Benjamin S. Freedman,et al.  Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers. , 2014, Journal of the American Society of Nephrology : JASN.

[8]  Robert Tjian,et al.  Charting Brachyury-mediated developmental pathways during early mouse embryogenesis , 2014, Proceedings of the National Academy of Sciences.

[9]  J. Wrana,et al.  Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells. , 2013, Cell reports.

[10]  Sharon Y. R. Dent,et al.  Chromatin modifiers and remodellers: regulators of cellular differentiation , 2013, Nature Reviews Genetics.

[11]  K. Shirahige,et al.  A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants. , 2013, Developmental cell.

[12]  Michael Q. Zhang,et al.  Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells , 2013, Cell.

[13]  W. Birchmeier,et al.  Wnt signaling in stem and cancer stem cells. , 2013, Current opinion in cell biology.

[14]  Wei Shi,et al.  Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2. , 2013, Cell reports.

[15]  Jonathan Schug,et al.  Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. , 2013, Cell stem cell.

[16]  Ye Guang Chen,et al.  BMP Induces Cochlin Expression to Facilitate Self-renewal and Suppress Neural Differentiation of Mouse Embryonic Stem Cells* , 2013, The Journal of Biological Chemistry.

[17]  Zhongwei Li,et al.  Functions of BMP signaling in embryonic stem cell fate determination. , 2013, Experimental cell research.

[18]  R. Young,et al.  The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. , 2012, Cell stem cell.

[19]  Wei Jiang,et al.  Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway , 2012, Cell Research.

[20]  Mo Li,et al.  Navigating the epigenetic landscape of pluripotent stem cells , 2012, Nature Reviews Molecular Cell Biology.

[21]  J. Massagué,et al.  TGF‐β control of stem cell differentiation genes , 2012, FEBS letters.

[22]  S. Gygi,et al.  The histone H 3 Lys 27 demethylase JMJD 3 regulates gene expression by impacting transcriptional elongation , 2012 .

[23]  Hans Clevers,et al.  Wnt/β-Catenin Signaling and Disease , 2012, Cell.

[24]  David M Reynolds,et al.  Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. , 2012, Cell stem cell.

[25]  M. Hosoya,et al.  Small molecules induce efficient differentiation into insulin-producing cells from human induced pluripotent stem cells. , 2012, Stem cell research.

[26]  N. Hou,et al.  BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. , 2012, Cell stem cell.

[27]  D. Patel,et al.  A Poised Chromatin Platform for TGF-β Access to Master Regulators , 2011, Cell.

[28]  T. Blauwkamp,et al.  Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells , 2011, Nature Cell Biology.

[29]  K. Niakan,et al.  BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages , 2011, Cell stem cell.

[30]  B. Lim,et al.  Activin/Nodal Signaling Controls Divergent Transcriptional Networks in Human Embryonic Stem Cells and in Endoderm Progenitors , 2011, Stem cells.

[31]  Bin Zhao,et al.  The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal , 2011, Nature Cell Biology.

[32]  P. Wong,et al.  Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: essential role of bone morphogenetic protein 4 , 2011, Development.

[33]  M. Welham,et al.  A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3 , 2011, Journal of Cell Science.

[34]  Stuart H. Orkin,et al.  Chromatin Connections to Pluripotency and Cellular Reprogramming , 2011, Cell.

[35]  Richard A Young,et al.  Control of the Embryonic Stem Cell State , 2011, Cell.

[36]  G. Pan,et al.  FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation. , 2011, Cell stem cell.

[37]  M. Trotter,et al.  Pluripotency factors regulate definitive endoderm specification through eomesodermin. , 2011, Genes & development.

[38]  D. Reinberg,et al.  The Polycomb complex PRC2 and its mark in life , 2011, Nature.

[39]  K. Xia,et al.  Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells , 2010, Cell Research.

[40]  Krishanu Saha,et al.  Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues , 2010, Cell.

[41]  M. Kuehn,et al.  Nodal Signaling Recruits the Histone Demethylase Jmjd3 to Counteract Polycomb-Mediated Repression at Target Genes , 2010, Science Signaling.

[42]  P. Tam,et al.  Extrinsic regulation of pluripotent stem cells , 2010, Nature.

[43]  Ye Guang Chen,et al.  Dishevelled: The hub of Wnt signaling. , 2010, Cellular signalling.

[44]  D. Seldin,et al.  Dynamic expression of a LEF‐EGFP Wnt reporter in mouse development and cancer , 2010, Genesis.

[45]  Ludovic Vallier,et al.  Signaling Pathways Controlling Pluripotency and Early Cell Fate Decisions of Human Induced Pluripotent Stem Cells , 2009, Stem cells.

[46]  C. Heldin,et al.  The regulation of TGFβ signal transduction , 2009, Development.

[47]  Yunyu Zhang,et al.  Wnt3a‐Induced Mesoderm Formation and Cardiomyogenesis in Human Embryonic Stem Cells , 2009, Stem cells.

[48]  Xi He,et al.  Wnt/beta-catenin signaling: components, mechanisms, and diseases. , 2009, Developmental cell.

[49]  Roger A. Pedersen,et al.  Early Cell Fate Decisions of Human Embryonic Stem Cells and Mouse Epiblast Stem Cells Are Controlled by the Same Signalling Pathways , 2009, PloS one.

[50]  M. Trotter,et al.  Activin/Nodal signalling maintains pluripotency by controlling Nanog expression , 2009, Development.

[51]  Ziying Liu,et al.  Regulation of TGF-β signaling by Smad7 , 2009, Acta biochimica et biophysica Sinica.

[52]  C. Hill,et al.  Tgf-beta superfamily signaling in embryonic development and homeostasis. , 2009, Developmental cell.

[53]  I. Burtscher,et al.  Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo , 2009, Development.

[54]  R. Moon,et al.  Noncanonical Wnt signaling orchestrates early developmental events toward hematopoietic cell fate from human embryonic stem cells. , 2009, Cell stem cell.

[55]  A. Hadjantonakis,et al.  The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages. , 2008, Developmental cell.

[56]  Catherine Payne,et al.  Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling , 2008, Proceedings of the National Academy of Sciences.

[57]  G. Pan,et al.  NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. , 2008, Cell stem cell.

[58]  Gordon Keller,et al.  Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development , 2008, Cell.

[59]  Lin Chen,et al.  Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. , 2008, Blood.

[60]  J. Massagué,et al.  Genome-wide Impact of the BRG1 SWI/SNF Chromatin Remodeler on the Transforming Growth Factor β Transcriptional Program* , 2008, Journal of Biological Chemistry.

[61]  M. Capecchi,et al.  Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. , 2007, Developmental biology.

[62]  R. McKay,et al.  New cell lines from mouse epiblast share defining features with human embryonic stem cells , 2007, Nature.

[63]  D. Loebel,et al.  Gene function in mouse embryogenesis: get set for gastrulation , 2007, Nature Reviews Genetics.

[64]  M. Shen Nodal signaling: developmental roles and regulation , 2007, Development.

[65]  Kristian Helin,et al.  The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation , 2007, Molecular and Cellular Biology.

[66]  H. Ko,et al.  Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1 , 2007, Proceedings of the National Academy of Sciences.

[67]  I. Komuro,et al.  Developmental stage-specific biphasic roles of Wnt/β-catenin signaling in cardiomyogenesis and hematopoiesis , 2006, Proceedings of the National Academy of Sciences.

[68]  Hans Clevers,et al.  Wnt/β-Catenin Signaling in Development and Disease , 2006, Cell.

[69]  Gordon Keller,et al.  BMP-4 is required for hepatic specification of mouse embryonic stem cell–derived definitive endoderm , 2006, Nature Biotechnology.

[70]  Michael Kyba,et al.  Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm , 2006, Development.

[71]  G. Wheeler,et al.  Frizzled7 mediates canonical Wnt signaling in neural crest induction. , 2006, Developmental biology.

[72]  K. Kaestner,et al.  The Foxa family of transcription factors in development and metabolism , 2006, Cellular and Molecular Life Sciences CMLS.

[73]  J. Zeitlinger,et al.  Polycomb complexes repress developmental regulators in murine embryonic stem cells , 2006, Nature.

[74]  Sheng Ding,et al.  Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[75]  Megan F. Cole,et al.  Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells , 2006, Cell.

[76]  T. Magnuson,et al.  Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65 , 2006, Molecular and Cellular Biology.

[77]  E. Kroon,et al.  Efficient differentiation of human embryonic stem cells to definitive endoderm , 2005, Nature Biotechnology.

[78]  V. Papaioannou,et al.  T-box genes in vertebrate development. , 2005, Annual review of genetics.

[79]  R. Derynck,et al.  SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS , 2005 .

[80]  S. Kattman,et al.  Germ layer induction from embryonic stem cells. , 2005, Experimental hematology.

[81]  Joseph Locker,et al.  Rybp/DEDAF Is Required for Early Postimplantation and for Central Nervous System Development , 2005, Molecular and Cellular Biology.

[82]  Elias T. Zambidis,et al.  Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development. , 2005, Blood.

[83]  E. Willems,et al.  Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[84]  M. Kühl,et al.  Non-canonical Wnt Signaling Enhances Differentiation of Human Circulating Progenitor Cells to Cardiomyogenic Cells* , 2005, Journal of Biological Chemistry.

[85]  E. Stanley,et al.  The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells , 2005, Development.

[86]  Kristian Helin,et al.  Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity , 2004, The EMBO journal.

[87]  Gordon Keller,et al.  Development of definitive endoderm from embryonic stem cells in culture , 2004, Development.

[88]  C. Mummery,et al.  Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin , 2004, Journal of Cell Science.

[89]  A. Schier Nodal signaling in vertebrate development. , 2003, Annual review of cell and developmental biology.

[90]  J. Nichols,et al.  BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3 , 2003, Cell.

[91]  Tim Jordan,et al.  Fox's in development and disease. , 2003, Trends in genetics : TIG.

[92]  S. Dupont,et al.  Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[93]  J. Voncken,et al.  Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[94]  Guang-Quan Zhao,et al.  Consequences of knocking out BMP signaling in the mouse , 2003, Genesis.

[95]  J. Thomson,et al.  BMP4 initiates human embryonic stem cell differentiation to trophoblast , 2002, Nature Biotechnology.

[96]  E. Li Chromatin modification and epigenetic reprogramming in mammalian development , 2002, Nature Reviews Genetics.

[97]  R. Teasdale,et al.  Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. , 2002, Developmental cell.

[98]  A. Hart,et al.  Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. , 2002, Development.

[99]  A. Roberts,et al.  Conditional knockout of the Smad1 gene , 2002, Genesis.

[100]  E. Robertson,et al.  Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. , 2001, Development.

[101]  T. Yamaguchi,et al.  Heads or tails: Wnts and anterior–posterior patterning , 2001, Current Biology.

[102]  A. Brivanlou,et al.  The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. , 2001, Genes & development.

[103]  A. Kispert,et al.  Expression patterns of Wnt genes in mouse gut development , 2001, Mechanisms of Development.

[104]  J. Rossant,et al.  FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. , 2001, Developmental cell.

[105]  R. Beddington,et al.  Nodal signalling in the epiblast patterns the early mouse embryo , 2001, Nature.

[106]  M. Matzuk,et al.  Smad5 is required for mouse primordial germ cell development , 2001, Mechanisms of Development.

[107]  Karl Mechtler,et al.  Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins , 2001, Nature.

[108]  C. Roberts,et al.  Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[109]  F Randazzo,et al.  A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes. , 2000, Molecular cell.

[110]  Yoichi Kato,et al.  LDL-receptor-related proteins in Wnt signal transduction , 2000, Nature.

[111]  X. F. Wang,et al.  The Smads: transcriptional regulation and mouse models. , 2000, Cytokine & growth factor reviews.

[112]  J. Massagué,et al.  Controlling TGF-β signaling , 2000, Genes & Development.

[113]  M. Svensson,et al.  Neural stem cells in the adult human brain. , 1999, Experimental cell research.

[114]  R. Kucherlapati,et al.  Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[115]  Allan Bradley,et al.  Requirement for Wnt3 in vertebrate axis formation , 1999, Nature Genetics.

[116]  M. Matzuk,et al.  Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. , 1999, Development.

[117]  J. Massagué,et al.  A Smad Transcriptional Corepressor , 1999, Cell.

[118]  C. Deng,et al.  Fibroblast growth factor receptors (FGFRs) and their roles in limb development , 1999, Cell and Tissue Research.

[119]  B. Hogan,et al.  Bmp4 is required for the generation of primordial germ cells in the mouse embryo. , 1999, Genes & development.

[120]  E. Coucouvanis,et al.  BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo. , 1999, Development.

[121]  M. Lako,et al.  Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. , 1998, Gene.

[122]  C. Deng,et al.  Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[123]  E. Li,et al.  Smad2 role in mesoderm formation, left–right patterning and craniofacial development , 1998, Nature.

[124]  B. Hogan,et al.  Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo , 1998, Mechanisms of Development.

[125]  P. Hoodless,et al.  Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo , 1998, Cell.

[126]  R. Behringer,et al.  Mouse gastrulation: the formation of a mammalian body plan , 1997, Mechanisms of Development.

[127]  J. Rossant,et al.  Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. , 1997, Development.

[128]  B. Hogan,et al.  Bone morphogenetic proteins: multifunctional regulators of vertebrate development. , 1996, Genes & development.

[129]  Salvador Martinez,et al.  Midbrain development induced by FGF8 in the chick embryo , 1996, Nature.

[130]  R. Behringer,et al.  Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development. , 1995, Development.

[131]  B. Hogan,et al.  Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. , 1995, Genes & development.

[132]  J. Rossant,et al.  Fibroblast growth factors in mammalian development. , 1995, Current opinion in genetics & development.

[133]  D. Wilkinson,et al.  Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development , 1995, Mechanisms of Development.

[134]  G. Martin,et al.  The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. , 1995, Development.

[135]  T. Magnuson,et al.  The eed mutation disrupts anterior mesoderm production in mice. , 1995, Development.

[136]  P. Leder,et al.  Murine FGFR-1 is required for early postimplantation growth and axial organization. , 1994, Genes & development.

[137]  F. Conlon,et al.  A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. , 1994, Development.

[138]  G. Martin,et al.  Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. , 1992, Development.

[139]  P. Adler,et al.  A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains , 1989, Nature.

[140]  A. McMahon,et al.  Expression of the FGF‐related proto‐oncogene int‐2 during gastrulation and neurulation in the mouse. , 1988, The EMBO journal.

[141]  E. Li,et al.  The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation , 2009, Nature Genetics.

[142]  R. Moon,et al.  Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. , 2008, Blood.

[143]  C. Heldin,et al.  Smad Signal Transduction , 2006 .

[144]  B. Herrmann,et al.  Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos. , 1994, Developmental biology.