Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation

[1]  A. Kaushik,et al.  Electro-Magnetic Nano-Particle Bound Beclin1 siRNA Crosses the Blood–Brain Barrier to Attenuate the Inflammatory Effects of HIV-1 Infection in Vitro , 2017, Journal of Neuroimmune Pharmacology.

[2]  K. Kataoka,et al.  Recent progress in development of siRNA delivery vehicles for cancer therapy. , 2016, Advanced drug delivery reviews.

[3]  Wei Huang,et al.  Inhibition of murine breast cancer growth and metastasis by survivin-targeted siRNA using disulfide cross-linked linear PEI. , 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[4]  A. Ewe,et al.  Cationic Lipid-Coated Polyplexes (Lipopolyplexes) for DNA and Small RNA Delivery. , 2016, Methods in molecular biology.

[5]  Richard C. Lau,et al.  A randomized, double‐blind phase I/IIa study of intranasal glutathione in Parkinson's disease , 2015, Movement disorders : official journal of the Movement Disorder Society.

[6]  D. Rubinsztein,et al.  Therapeutic targeting of autophagy in neurodegenerative and infectious diseases , 2015, The Journal of experimental medicine.

[7]  G. Baldi,et al.  Nanomaterial Applications in Multiple Sclerosis Inflamed Brain , 2015, Journal of Neuroimmune Pharmacology.

[8]  J. Kehrl,et al.  Roles of autophagy in HIV infection , 2015, Immunology and cell biology.

[9]  V. Gorelik,et al.  Local Raman spectroscopy of DNA , 2014 .

[10]  A. Nath Eradication of human immunodeficiency virus from brain reservoirs , 2014, Journal of NeuroVirology.

[11]  S. Snider,et al.  Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine , 2014, AIDS.

[12]  Sung Ha Park,et al.  Long dsRNA-mediated RNA interference and immunostimulation: a targeted delivery approach using polyethyleneimine based nano-carriers. , 2014, Molecular pharmaceutics.

[13]  D. Klionsky,et al.  An overview of autophagy: morphology, mechanism, and regulation. , 2014, Antioxidants & redox signaling.

[14]  D. Gewirtz,et al.  HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse , 2014, Journal of Virology.

[15]  J. Wessberg,et al.  Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions. , 2013, Social cognitive and affective neuroscience.

[16]  Seth M. Dever,et al.  A novel bivalent HIV-1 entry inhibitor reveals fundamental differences in CCR5-&mgr;-opioid receptor interactions between human astroglia and microglia , 2013, AIDS.

[17]  K. Jeang,et al.  RNAi Therapy for HIV Infection , 2012, BioDrugs.

[18]  X. Shuai,et al.  Delivery of cationic polymer-siRNA nanoparticles for gene therapies in neural regeneration. , 2012, Biochemical and biophysical research communications.

[19]  R. Thorne,et al.  Intranasal delivery of biologics to the central nervous system. , 2012, Advanced drug delivery reviews.

[20]  D. Rubinsztein,et al.  Control of autophagy as a therapy for neurodegenerative disease , 2012, Nature Reviews Neurology.

[21]  E. Masliah,et al.  Autophagy in Dementias , 2012, Brain pathology.

[22]  T. Uzu,et al.  Autophagy as a Therapeutic Target in Diabetic Nephropathy , 2011, Experimental diabetes research.

[23]  J. Fine,et al.  Intranasal delivery of deferoxamine reduces spatial memory loss in APP/PS1 mice , 2012, Drug Delivery and Translational Research.

[24]  L. Ene,et al.  How much do antiretroviral drugs penetrate into the central nervous system? , 2011, Journal of medicine and life.

[25]  Helgi B. Schiöth,et al.  Intranasal insulin as a therapeutic option in the treatment of cognitive impairments , 2011, Experimental Gerontology.

[26]  J. Rossi,et al.  An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice , 2011, Science Translational Medicine.

[27]  Rebecca R. Gray,et al.  Human immunodeficiency virus-1 evolutionary patterns associated with pathogenic processes in the brain , 2010, Journal of NeuroVirology.

[28]  M. Churchill,et al.  Transcriptional activity of blood- and cerebrospinal fluid-derived nef/long-terminal repeat sequences isolated from a slow progressor infected with nef-deleted human immunodeficiency virus type 1 (HIV-1) who developed HIV-associated dementia , 2006, Journal of NeuroVirology.

[29]  J. Born,et al.  Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men , 2010, Diabetes.

[30]  M. Schwab,et al.  Protective effects of intranasal losartan in the APP/PS1 transgenic mouse model of Alzheimer disease. , 2010, Rejuvenation research.

[31]  W. Frey,et al.  Intranasal delivery to the central nervous system: mechanisms and experimental considerations. , 2010, Journal of pharmaceutical sciences.

[32]  D. Peer,et al.  RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

[33]  F. Heppner,et al.  Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion , 2009, Proceedings of the National Academy of Sciences.

[34]  V. Deretic,et al.  Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages , 2009, The Journal of cell biology.

[35]  Yu-cheng Tseng,et al.  Lipid-based systemic delivery of siRNA. , 2009, Advanced drug delivery reviews.

[36]  V. Robert-Hebmann,et al.  Differential Role of Autophagy in CD4 T Cells and Macrophages during X4 and R5 HIV-1 Infection , 2009, PloS one.

[37]  D. R. Marks,et al.  Awake Intranasal Insulin Delivery Modifies Protein Complexes and Alters Memory, Anxiety, and Olfactory Behaviors , 2009, The Journal of Neuroscience.

[38]  Michael S. Goldberg,et al.  Development of lipidoid-siRNA formulations for systemic delivery to the liver. , 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

[39]  Achim Goepferich,et al.  Layer-by-layer assembled gold nanoparticles for siRNA delivery. , 2009, Nano letters.

[40]  T. Minko,et al.  Internally cationic polyamidoamine PAMAM-OH dendrimers for siRNA delivery: effect of the degree of quaternization and cancer targeting. , 2009, Biomacromolecules.

[41]  M. Hallschmid,et al.  Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial , 2008, Journal of Medical Genetics.

[42]  Dale L. Greiner,et al.  T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice , 2008, Cell.

[43]  S. Wong,et al.  Luciferin detection after intranasal vector delivery is improved by intranasal rather than intraperitoneal luciferin administration. , 2008, Human gene therapy.

[44]  Ralph A. Nixon,et al.  Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease , 2008, The Journal of Neuroscience.

[45]  J. Born,et al.  Differential sensitivity of men and women to anorexigenic and memory-improving effects of intranasal insulin. , 2008, The Journal of clinical endocrinology and metabolism.

[46]  P. Mehta,et al.  Intranasal insulin improves cognition and modulates β-amyloid in early AD , 2008, Neurology.

[47]  H. Fenniri,et al.  Nanotechnology-based drug delivery systems , 2007, Journal of occupational medicine and toxicology.

[48]  M. Mattson,et al.  Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage , 2007, Journal of Molecular Neuroscience.

[49]  W. Pardridge shRNA and siRNA delivery to the brain. , 2007, Advanced drug delivery reviews.

[50]  C. Culmsee,et al.  siRNA delivery by a transferrin‐associated lipid‐based vector: a non‐viral strategy to mediate gene silencing , 2007, The journal of gene medicine.

[51]  W. Pardridge,et al.  Blood-brain barrier delivery. , 2007, Drug discovery today.

[52]  Ling Peng,et al.  PAMAM dendrimers for efficient siRNA delivery and potent gene silencing. , 2006, Chemical communications.

[53]  J. Rossi RNAi therapeutics: SNALPing siRNAs in vivo , 2006, Gene Therapy.

[54]  V. Torchilin,et al.  siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene , 2006, Journal of Controlled Release.

[55]  Trond Holand,et al.  Breath Actuated Device Improves Delivery to Target Sites Beyond the Nasal Valve , 2006, The Laryngoscope.

[56]  Peter Kirsch,et al.  Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans , 2005, The Journal of Neuroscience.

[57]  J. Lieberman,et al.  Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV. , 2005, Blood.

[58]  A. Aigner,et al.  RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo , 2005, Gene Therapy.

[59]  J. G. Patton,et al.  siRNA therapeutics: big potential from small RNAs , 2005, Gene Therapy.

[60]  J. Zwiller,et al.  Activation of the cGMP Pathway in Dopaminergic Structures Reduces Cocaine-Induced EGR-1 Expression and Locomotor Activity , 2004, The Journal of Neuroscience.

[61]  Jan Born,et al.  Intranasal insulin improves memory in humans , 2004, Psychoneuroendocrinology.

[62]  R. Kole,et al.  Antisense Pharmacodynamics: Critical Issues in the Transport and Delivery of Antisense Oligonucleotides , 1999, Pharmaceutical Research.

[63]  C. Kirschbaum,et al.  Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress , 2003, Biological Psychiatry.

[64]  J. Lieberman,et al.  siRNA-directed inhibition of HIV-1 infection , 2002, Nature Medicine.

[65]  Jan Born,et al.  Sniffing neuropeptides: a transnasal approach to the human brain , 2002, Nature Neuroscience.

[66]  S. Sánchez‐Cortés,et al.  Adsorption of polyethyleneimine on silver nanoparticles and its interaction with a plasmid DNA: a surface-enhanced Raman scattering study. , 2002, Biomacromolecules.

[67]  Stuart A. Lipton,et al.  Pathways to neuronal injury and apoptosis in HIV-associated dementia , 2001, Nature.

[68]  J. Born,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society The Melanocortin Melanocyte-Stimulating Hormone/Adrenocorticotropin 4–10 Decreases Body Fat in Humans* , 2022 .

[69]  I. Gozes,et al.  Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze. , 2000, The Journal of pharmacology and experimental therapeutics.

[70]  J. Born,et al.  Central nervous system effects of intranasally administered insulin during euglycemia in men. , 1999, Diabetes.

[71]  Y. Rahman,et al.  Delivery of Nerve Growth Factor to the Brain via the Olfactory Pathway. , 1998, Journal of Alzheimer's disease : JAD.

[72]  E. Gunnarsson,et al.  Olfactory Absorption of Insulin to the Brain , 1997 .

[73]  A. Nath,et al.  HIV dementia and the basal ganglia. , 1997, Intervirology.

[74]  D. Scherman,et al.  A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[75]  O. Selnes,et al.  Clinical‐neuropathologic correlation in HIV‐associated dementia , 1993, Neurology.

[76]  E. Masliah,et al.  Spectrum of human immunodeficiency virus–associated neocortical damage , 1992, Annals of neurology.

[77]  T. Cotton,et al.  Flow injection analysis and real-time detection of RNA bases by surface-enhanced Raman spectroscopy. , 1990, Analytical chemistry.

[78]  C. Cheng‐Mayer,et al.  Distinct Biological Properties of Human and Serological , 2004 .