Pathogenicity of chicken anaemia agent in bursectomised chickens.

Bursectomised (Bx) chickens, but not intact chickens, developed anaemia when inoculated with chicken anaemia agent (CAA) at 2 weeks of age. No antibodies against CAA were produced in the Bx chickens and CAA was persistently recovered from them. In contrast, CAA disappeared from the intact chickens with the development of high titres of antibody. It was strongly suggested that the pathogenicity of CAA was dependent on the production of humoral antibody against CAA in infected chickens. Histopathologically, no inclusion bodies suggestive of parvovirus infection were observed in the tissues of affected chickens.

[1]  K. Imai,et al.  Aetiological examination of an outbreak of haemorrhagic syndrome in a broiler flock in Japan. , 1987, Avian pathology : journal of the W.V.P.A.

[2]  R. Rudolph,et al.  Avian Infectious Anaemia Caused by Chicken Anaemia Agent (CAA) , 1986 .

[3]  K. Imai,et al.  Pathogenicity and antigenicity of eleven isolates of chicken anaemia agent (CAA). , 1986, Avian pathology : journal of the W.V.P.A.

[4]  K. Imai,et al.  Survey of antibody against chicken anaemia agent (CAA) by an indirect immunofluorescent antibody technique in breeder flocks in Japan. , 1985, Avian pathology : journal of the W.V.P.A.

[5]  T. Umemura,et al.  Parvoviral myocarditis in cyclophosphamide-treated chicks. , 1985, Nihon juigaku zasshi. The Japanese journal of veterinary science.

[6]  H. Hihara,et al.  Isolation of chicken anemia agent with MDCC-MSB1 cells from chickens in the field. , 1983, National Institute of Animal Health quarterly.

[7]  N. Yuasa.  Propagation and infectivity titration of the Gifu-1 strain of chicken anemia agent in a cell line (MDCC-MSB1) derived from Marek's disease lymphoma. , 1983, National Institute of Animal Health quarterly.

[8]  T. Taniguchi,et al.  Chronological observations on hemato-pathological changes in chicks inoculated with chicken anemia agent. , 1983, National Institute of Animal Health quarterly.

[9]  T. Taniguchi,et al.  Hematopathological changes in dead and moribund chicks induced by chicken anemia agent. , 1982, National Institute of Animal Health quarterly.

[10]  M. Sakata,et al.  Modification of low virulent Newcastle disease virus infection in chickens infected with reticuloendotheliosis virus. , 1981, National Institute of Animal Health quarterly.

[11]  K. Furuta,et al.  Maternal antibody and its effect on the susceptibility of chicks to chicken anemia agent. , 1980 .

[12]  T. Taniguchi,et al.  Effect of infectious bursal disease virus infection on incidence of anemia by chicken anemia agent. , 1980 .

[13]  L. Lee,et al.  Depression of vaccinal immunity to Marek's disease by infection with reticuloendotheliosis virus , 1979, Infection and immunity.

[14]  T. Taniguchi,et al.  Isolation and some characteristics of an agent inducing anemia in chicks. , 1979 .

[15]  H. Bose,,et al.  Depression of mitogen response in spleen cells from reticuloendotheliosis virus-infected chickens and their suppressive effect on normal lymphocyte response. , 1978, Journal of immunology.

[16]  T. Hiraga,et al.  Effect of cyclophosphamide on the thymus and the bursa of Fabricius in chickens. , 1976, The Japanese journal of veterinary research.

[17]  W. H. Allan,et al.  Immunosuppressive effect of the infectious bursal agent in the chicken. , 1972, Nature: New biology.

[18]  C. Morris,et al.  Depression of thymus-and bursa-dependent immune systems chicks with Marek's disease. , 1971, Avian diseases.

[19]  P. Biggs,et al.  Effect of lymphoid leukosis and Marek's disease on the immunological responsiveness of the chicken. , 1968, Journal of the National Cancer Institute.