Exposure to power frequency magnetic fields and risk of breast cancer in the Upper Cape Cod Cancer Incidence Study.

Investigators used a population-based case-control study to evaluate the relationship between breast cancer risk and exposure to 60-Hz magnetic fields from various sources. There was no increase in breast cancer risk associated with (a) holding a job with high (odds ratio [OR] = 1.2; 95% confidence interval [CI] = 0.4, 3.4) or medium (OR = 0.9; 95% CI = 0.5, 1.7) exposure to magnetic fields; (b) living in a home heated electrically (OR = 1.0; 95% CI = 0.7, 1.4); or (c) sleeping with an electric blanket (OR = 1.0; 95% CI = 0.7, 1.4). There was a nonsignificant 50% increase in risk for subjects who lived within 152 m (500 ft) of an electricity transmission line or substation (OR = 1.5; 95% CI = 0.6, 3.3). Although limited by small numbers and exposure misclassification, the data in this study did not support the hypothesis that exposure to 60-Hz magnetic fields increases the risk of breast cancer in women.

[1]  Tore Tynes,et al.  Electromagnetic fields and male breast cancer , 1990, The Lancet.

[2]  N. Wertheimer,et al.  Magnetic Field Exposure Related to Cancer Subtypes , 1987, Annals of the New York Academy of Sciences.

[3]  P C Dischinger,et al.  Occupational exposure to electromagnetic fields and the occurrence of brain tumors. An analysis of possible associations. , 1985, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[4]  D A Savitz,et al.  Update on methodological issues in the epidemiology of electromagnetic fields and cancer. , 1993, Epidemiologic reviews.

[5]  S. Hill,et al.  Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. , 1988, Cancer research.

[6]  D. Thomas,et al.  Exposure to magnetic fields among electrical workers in relation to leukemia risk in Los Angeles County. , 1994, American journal of industrial medicine.

[7]  J. B. Andersen,et al.  Incidence of cancer in persons with occupational exposure to electromagnetic fields in Denmark. , 1993, British journal of industrial medicine.

[8]  L. E. Anderson,et al.  Electric power, pineal function, and the risk of breast cancer , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  D. Loomis,et al.  Cancer of breast among men in electrical occupations , 1992, The Lancet.

[10]  S. Preston‐Martin,et al.  Myelogenous leukemia and electric blanket use. , 1988, Bioelectromagnetics.

[11]  R. Reiter,et al.  Static and extremely low frequency electromagnetic field exposure: Reported effects on the circadian production of melatonin , 1993, Journal of cellular biochemistry.

[12]  S. Milham,et al.  Mortality in workers exposed to electromagnetic fields. , 1985, Environmental health perspectives.

[13]  M. Mcdowall,et al.  Mortality of persons resident in the vicinity of electricity transmission facilities. , 1986, British Journal of Cancer.

[14]  J. Vena,et al.  Use of electric blankets and risk of postmenopausal breast cancer. , 1991, American journal of epidemiology.

[15]  G Thériault,et al.  Occupational and residential 60-Hz electromagnetic fields and high-frequency electric transients: exposure assessment using a new dosimeter. , 1988, American Industrial Hygiene Association journal.

[16]  M A Stuchly,et al.  Human exposure to static and time-varying magnetic fields. , 1986, Health physics.

[17]  R. Stevens,et al.  Electric power use and breast cancer: a hypothesis. , 1987, American journal of epidemiology.

[18]  G Thériault,et al.  Cancer risks associated with occupational exposure to magnetic fields among electric utility workers in Ontario and Quebec, Canada, and France: 1970-1989. , 1994, American journal of epidemiology.

[19]  F Sturmans,et al.  Cancer mortality and residence near electricity transmission equipment: a retrospective cohort study. , 1993, International journal of epidemiology.

[20]  P. Demers,et al.  Occupational exposure to electromagnetic fields and breast cancer in men. , 1991, American journal of epidemiology.

[21]  J. M. Silva,et al.  Magnetic field exposure assessment for adult residents of Maine who live near and far away from overhead transmission lines. , 1992, Bioelectromagnetics.

[22]  A. Ahlbom,et al.  Cancer morbidity among workers in the telecommunications industry. , 1985, British journal of industrial medicine.

[23]  T B Wenzl,et al.  Occupational Exposure to 60‐Hertz Magnetic Fields and Risk of Breast Cancer in Women , 1996, Epidemiology.

[24]  G. Matanoski,et al.  Electromagnetic field exposure and male breast cancer , 1991, The Lancet.

[25]  N. Breslow,et al.  The analysis of case-control studies , 1980 .

[26]  O. Miettinen,et al.  Estimability and estimation in case-referent studies. , 1976, American journal of epidemiology.

[27]  J R Marshall,et al.  Risk of premenopausal breast cancer and use of electric blankets. , 1994, American journal of epidemiology.

[28]  N. Breslow,et al.  Statistical methods in cancer research: volume 1- The analysis of case-control studies , 1980 .

[29]  P A Stewart,et al.  Re: Breast cancer mortality among female electrical workers in the United States. , 1995, Journal of the National Cancer Institute.

[30]  J. Vena,et al.  Occupational exposures associated with male breast cancer. , 1994, American journal of epidemiology.

[31]  Y. Touitou,et al.  Magnetic fields and pineal function in humans: evaluation of nocturnal acute exposure to extremely low frequency magnetic fields on serum melatonin and urinary 6-sulfatoxymelatonin circadian rhythms. , 1996, Life sciences.

[32]  H. Wachtel,et al.  Case-control study of childhood cancer and exposure to 60-Hz magnetic fields. , 1988, American journal of epidemiology.

[33]  N. E. Breslow.  Statistical Methods in Cancer Research , 1986 .

[34]  R. Liburdy,et al.  ELF magnetic fields, breast cancer, and melatonin: 60 Hz fields block melatonin's oncostatic action on ER+ breast cancer cell proliferation , 1993, Journal of pineal research.

[35]  K. Rothman,et al.  Epidemiologic Analysis with a Programmable Calculator , 1982 .

[36]  V Delpizzo.  A model to assess personal exposure to ELF magnetic fields from common household sources. , 1990, Bioelectromagnetics.

[37]  D A Savitz,et al.  Breast cancer mortality among female electrical workers in the United States. , 1994, Journal of the National Cancer Institute.

[38]  W. Kaune,et al.  Residential magnetic and electric fields. , 1987, Bioelectromagnetics.

[39]  S. Preston‐Martin.  Breast cancer and magnetic fields. , 1996, Epidemiology.

[40]  Michael R. Flynn,et al.  Validation of Expert Judgment in Assessing Occupational Exposure to Magnetic Fields in the Utility Industry , 1991 .