Dysfunctions of the Iga system: a common link between intestinal and renal diseases

Immunoglobulin A (Iga)-isotype antibodies play an important role in immunity owing to their structure, glycosylation, localization and receptor interactions. Dysfunctions in this system can lead to multiple types of pathology. This review describes the characteristics of Iga and discusses the involvement of abnormalities in the Iga system on the development of celiac disease and Iga nephropathy.

[1]  M. Cooper,et al.  Definition of immunoglobulin A receptors on eosinophils and their enhanced expression in allergic individuals. , 1993, The Journal of clinical investigation.

[2]  F. Vrtovsnik,et al.  Fcα receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcRγ adaptor , 2007 .

[3]  M. Eibl,et al.  Human serum IgA downregulates the release of inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6) in human monocytes. , 1994, Blood.

[4]  M. Sato,et al.  Antimouse laminin antibodies in IgA nephropathy and various glomerular diseases. , 1990, Nephron.

[5]  G. Rostoker,et al.  Increased intestinal intra-epithelial T lymphocytes in primary glomerulonephritis: a role of oral tolerance breakdown in the pathophysiology of human primary glomerulonephritides? , 2001, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[6]  J. Mestecky.  Immunobiology of IgA. , 1988, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[7]  R. Monteiro,et al.  Fcα Receptor (Cd89) Mediates the Development of Immunoglobulin a (Iga) Nephropathy (Berger's Disease) , 2000, The Journal of experimental medicine.

[8]  R. Coppo,et al.  Dietary antigens and primary immunoglobulin A nephropathy. , 1992, Journal of the American Society of Nephrology : JASN.

[9]  V. D’Agati,et al.  Coeliac sprue-associated membranoproliferative glomerulonephritis (MPGN). , 2009, Nephrology, Dialysis and Transplantation.

[10]  B. Julian,et al.  IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy. , 2008, Seminars in nephrology.

[11]  M. Kagnoff.  Overview and pathogenesis of celiac disease. , 2005, Gastroenterology.

[12]  G. D'Amico,et al.  IgA-antigliadin antibodies in IgA mesangial nephropathy (Berger's disease). , 1987, British medical journal.

[13]  P. Bjorkman,et al.  Insights into IgA-mediated immune responses from the crystal structures of human FcαRI and its complex with IgA1-Fc , 2003, Nature.

[14]  I. Korponay-Szabó,et al.  In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies , 2004, Gut.

[15]  R. Coppo,et al.  Effects of a gluten-free diet in primary IgA nephropathy. , 1990, Clinical nephrology.

[16]  B. Julian,et al.  Role of Aberrant Glycosylation of IgA1 Molecules in the Pathogenesis of IgA Nephropathy , 2008, Kidney and Blood Pressure Research.

[17]  J Nishikido,et al.  Evidence for involvement of IgA1 hinge glycopeptide in the IgA1-IgA1 interaction in IgA nephropathy. , 1997, Journal of the American Society of Nephrology : JASN.

[18]  J. Galla.  IgA nephropathy. , 1995, Kidney international.

[19]  R. Greco,et al.  Antiendomysial antibodies in Berger's disease. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[20]  B. Corthésy.  Roundtrip Ticket for Secretory IgA: Role in Mucosal Homeostasis?1 , 2007, The Journal of Immunology.

[21]  J. Woof,et al.  Function of immunoglobulin A in immunity , 2000, Gut.

[22]  B. Julian,et al.  IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells. , 2005, Kidney international.

[23]  L. Peruzzi,et al.  In human IgA nephropathy uteroglobin does not play the role inferred from transgenic mice. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[24]  B. Julian,et al.  Shared idiotypes in mesangial deposits in IgA nephropathy are not disease-specific. , 1993, Kidney international.

[25]  F. Koning,et al.  Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. , 1998, Journal of immunology.

[26]  F. Vrtovsnik,et al.  Fc alpha receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcR gamma adaptor. , 2007, European Journal of Immunology.

[27]  J. Mestecky,et al.  The differences in carbohydrate composition between the subclasses of IgA immunoglobulins. , 1976, Immunochemistry.

[28]  B. Julian,et al.  Binding of serum immunoglobulins to collagens in IgA nephropathy and HIV infection. , 1992, Kidney international.

[29]  R. Monteiro,et al.  Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice. , 2000, The Journal of experimental medicine.

[30]  J. Berger,et al.  Recurrence of mesangial deposition of IgA after renal transplantation. , 1975, Kidney international.

[31]  K. Lundin,et al.  Diagnosis and treatment of celiac disease , 2009, Mucosal Immunology.

[32]  E. Haddad,et al.  Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy. , 2005, Journal of the American Society of Nephrology : JASN.

[33]  H. Prydz,et al.  Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins , 1984, Nature.

[34]  H. Wolf,et al.  Anti‐inflammatory properties of human serum IgA: induction of IL‐1 receptor antagonist and FcαR (CD89)‐mediated down‐regulation of tumour necrosis factor‐alpha (TNF‐α) and IL‐6 in human monocytes , 1996 .

[35]  P. Venge,et al.  Gluten sensitivity in patients with IgA nephropathy. , 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[36]  I. Velasco,et al.  Enhanced expression of Fc alpha receptor I on blood phagocytes of patients with gram-negative bacteremia is associated with tyrosine phosphorylation of the FcR-gamma subunit. , 2001, Shock.

[37]  Yusuke Suzuki,et al.  Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity. , 2009, The Journal of clinical investigation.

[38]  E. Haddad,et al.  Glycosylation and size of IgA1 are essential for interaction with mesangial transferrin receptor in IgA nephropathy. , 2004, Journal of the American Society of Nephrology : JASN.

[39]  Y. Hiki,et al.  Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy. , 2001, Kidney international.

[40]  J. Wilton.  Suppression by IgA of IgG-mediated phagocytosis by human polymorphonuclear leucocytes. , 1978, Clinical and experimental immunology.

[41]  S. Targan,et al.  Bacterial flagellin is a dominant antigen in Crohn disease. , 2004, The Journal of clinical investigation.

[42]  J. Olivo-Marin,et al.  Anti-inflammatory role for intracellular dimeric immunoglobulin a by neutralization of lipopolysaccharide in epithelial cells. , 2003, Immunity.

[43]  E. Haddad,et al.  Pathogenic significance of IgA receptor interactions in IgA nephropathy. , 2002, Trends in molecular medicine.

[44]  M. Cooper,et al.  Identification of the Transferrin Receptor as a Novel Immunoglobulin (Ig)a1 Receptor and Its Enhanced Expression on Mesangial Cells in Iga Nephropathy , 2001, The Journal of experimental medicine.

[45]  P. Krajči,et al.  Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. , 1995, Gut.

[46]  M. Eibl,et al.  Anti-inflammatory properties of human serum IgA: induction of IL-1 receptor antagonist and Fc alpha R (CD89)-mediated down-regulation of tumour necrosis factor-alpha (TNF-alpha) and IL-6 in human monocytes. , 1996, Clinical and experimental immunology.

[47]  I. Moura,et al.  Identification of FcαRI as an Inhibitory Receptor that Controls Inflammation: Dual Role of FcRγ ITAM , 2005 .

[48]  G. Alarcón,et al.  IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1. , 2008, The Journal of clinical investigation.

[49]  J. Egido,et al.  Characterization of circulating idiotypes containing immune complexes and their presence in the glomerular mesangium in patients with IgA nephropathy. , 1989, Clinical and experimental immunology.

[50]  D. Schuppan,et al.  Identification of tissue transglutaminase as the autoantigen of celiac disease , 1997, Nature Medicine.

[51]  L. Noel,et al.  Charge and size of mesangial IgA in IgA nephropathy. , 1985, Kidney international.

[52]  E. van Garderen,et al.  IgA and the IgA Fc receptor. , 2001, Trends in immunology.

[53]  S. Morrison,et al.  IgA: an immune glycoprotein. , 2005, Clinical immunology.

[54]  F. Vrtovsnik,et al.  Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation. , 2008, Journal of immunology.

[55]  P. Bjorkman,et al.  Crystal structure of human FcaRI , 2003 .

[56]  K. Kaukinen,et al.  Celiac disease and HLA DQ in patients with IgA nephropathy. , 2002 .

[57]  I. Moura,et al.  Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease , 2008, The Journal of experimental medicine.

[58]  R. Monteiro.  Role of IgA and IgA Fc Receptors in Inflammation , 2009, Journal of Clinical Immunology.

[59]  M. Kerr,et al.  The structure and function of human IgA. , 1990, The Biochemical journal.

[60]  L. Peruzzi,et al.  Functional consequences of the binding of gliadin to cultured rat mesangial cells: bridging immunoglobulin A to cells and modulation of eicosanoid synthesis and altered cytokine production. , 1994, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[61]  T. Reunala,et al.  Glomerular IgA deposits in patients with celiac disease. , 1990, Clinical nephrology.

[62]  M. Greco,et al.  Production of antiendomysial antibodies after in-vitro gliadin challenge of small intestine biopsy samples from patients with coeliac disease , 1996, The Lancet.

[63]  M. Russell,et al.  Dual function of human IgA antibodies: inhibition of phagocytosis in circulating neutrophils and enhancement of responses in IL‐8‐stimulated cells , 1995, Journal of leukocyte biology.

[64]  P. Pantaleo,et al.  Multiple immune disorders in unrecognized celiac disease: a case report. , 2003, World journal of gastroenterology.

[65]  M. van Egmond,et al.  The Fc receptor for IgA (FcalphaRI, CD89). , 2004, Immunology letters.

[66]  H. Schwarz,et al.  Immunomodulatory properties of human serum immunoglobulin A: anti‐inflammatory and pro‐inflammatory activities in human monocytes and peripheral blood mononuclear cells , 2005, Clinical and experimental immunology.

[67]  I. Moura,et al.  Identification of FcalphaRI as an inhibitory receptor that controls inflammation: dual role of FcRgamma ITAM. , 2005, Immunity.

[68]  P. Hogarth,et al.  IgA receptors in health and disease. , 2006, Tissue antigens.

[69]  T. Kovács,et al.  Do intestinal hyperpermeability and the related food antigens play a role in the progression of IgA nephropathy? I. Study of intestinal permeability. , 1996, American journal of nephrology.

[70]  R. Goertsches,et al.  Immunoglobulins—Basic considerations , 2006, Journal of Neurology.

[71]  R. Williams,et al.  Suppression of human PMN bactericidal activity by human IgA paraproteins. , 1978, Cellular immunology.

[72]  J. Ward,et al.  Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice , 1999, Nature Medicine.

[73]  D. Heinegård,et al.  Circulating complexes containing IgA and fibronectin in patients with primary IgA nephropathy. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[74]  M. Kerr,et al.  Irreversible aggregation of the Fc fragment derived from polymeric but not monomeric serum IgA1--implications in IgA-mediated disease. , 2008, Molecular immunology.

[75]  L. Maiuri,et al.  Interleukin 15 mediates epithelial changes in celiac disease. , 2000, Gastroenterology.

[76]  R. Monteiro,et al.  Alternative Endocytic Pathway for Immunoglobulin A Fc Receptors (CD89) Depends on the Lack of FcRγ Association and Protects against Degradation of Bound Ligand* , 1999, The Journal of Biological Chemistry.

[77]  G. Corazza,et al.  Coeliac disease , 2005, Journal of Clinical Pathology.

[78]  M. Rescigno,et al.  The biology of intestinal immunoglobulin A responses. , 2008, Immunity.

[79]  A. Solomon.  Monoclonal Immunoglobulins As Biomarkers Of Cancer , 1980 .

[80]  M. Daha,et al.  Circulating and mesangial secretory component-binding IgA-1 in primary IgA nephropathy. , 1984, Kidney international.

[81]  M. Kerr,et al.  The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: a study by X-ray and neutron solution scattering and homology modelling. , 1999, Journal of molecular biology.

[82]  K. McCoy,et al.  The immune geography of IgA induction and function , 2008, Mucosal Immunology.

[83]  S. Fagarasan.  Evolution, development, mechanism and function of IgA in the gut. , 2008, Current opinion in immunology.

[84]  J. Mestecky,et al.  Tissue origins of human polymeric and monomeric IgA. , 1982, Journal of immunology.

[85]  H. Alpay,et al.  The co-existence of membranoproliferatıve glomerulonephritis type 1 and coeliac disease: a case report , 2009, Pediatric Nephrology.

[86]  Ralph,et al.  Suppression of leukocyte chemotaxis by human IgA myeloma components , 1976, The Journal of experimental medicine.

[87]  M. Nakazawa.  [Circulating immune complexes in IgA nephropathy]. , 1982, Nihon Jinzo Gakkai shi.

[88]  K. Kaukinen,et al.  Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac disease , 2006, Alimentary pharmacology & therapeutics.

[89]  J. Mestecky,et al.  Immunoglobulin M and Secretory Immunoglobulin A: Presence of a Common Polypeptide Chain Different from Light Chains , 1971, Science.

[90]  T Pawson,et al.  SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. , 1991, Science.