Automated hippocampal subfields segmentation in late life depression.

Although a few automated hippocampal subfields segmentation methods have been developed, there has been no in vivo Magnetic Resonance Imaging (MRI) study on the hippocampal subfields volumes of Late Life Depression (LLD). The aim of this study was to investigate the hippocampal subfields volume differences between LLD subjects and healthy elderly controls using an automated hippocampal subfields segmentation technique. Thirty subjects with LLD and 30 group-matched healthy control subjects underwent 3T MRI scanning, and hippocampal subfields volumes were measured and compared between the groups. Subjects with LLD exhibited significant hippocampal volume reductions in the total hippocampus, subiculum, and Cornu Ammonis (CA) 2-3 areas compared with healthy subjects (uncorrected, p<0.001). This study is the first to elaborate the subfields volume differences of both hippocampi between controls and LLD patients. These structural changes in the hippocampal presubiculum, subiculum, and CA2-3 areas might be at the core of the underlying neurobiological mechanisms of hippocampal dysfunction in LLD.

[1]  J. Becker,et al.  Pathways linking late-life depression to persistent cognitive impairment and dementia , 2008, Dialogues in clinical neuroscience.

[2]  W. Deng,et al.  Changes of Brain Morphometry in First-Episode, Drug-Naïve, Non–Late-Life Adult Patients with Major Depression: An Optimized Voxel-Based Morphometry Study , 2010, Biological Psychiatry.

[3]  J. Morris.  The Clinical Dementia Rating (CDR) , 1993, Neurology.

[4]  Nick C Fox,et al.  Computer-assisted imaging to assess brain structure in healthy and diseased brains , 2003, The Lancet Neurology.

[5]  G. MacQueen,et al.  The role of the hippocampus in the pathophysiology of major depression. , 2004, Journal of psychiatry & neuroscience : JPN.

[6]  Paul M. Thompson,et al.  In vivo neuropathology of the hippocampal formation in AD: A radial mapping MR-based study , 2006, NeuroImage.

[7]  R. Sapolsky,et al.  The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. , 1991, Endocrine reviews.

[8]  Michael Weiner,et al.  Nearly automatic segmentation of hippocampal subfields in in vivo focal T2-weighted MRI , 2010, NeuroImage.

[9]  T. Hergueta,et al.  The mini international neuropsychiatric interview , 1998, European Psychiatry.

[10]  Peter McGuffin,et al.  Hippocampal atrophy in first episode depression: a meta-analysis of magnetic resonance imaging studies. , 2011, Journal of affective disorders.

[11]  M. Weiner,et al.  Selective effect of age, Apo e4, and Alzheimer's disease on hippocampal subfields , 2009, Hippocampus.

[12]  A M Dale,et al.  Measuring the thickness of the human cerebral cortex from magnetic resonance images. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[13]  P. Renshaw,et al.  Regional cerebral cortical thinning in bipolar disorder. , 2006, Bipolar disorders.

[14]  M. Hamilton,et al.  Development of a rating scale for primary depressive illness. , 1967, The British journal of social and clinical psychology.

[15]  H. Duvernoy,et al.  The Human Hippocampus: Functional Anatomy, Vascularization and Serial Sections with MRI , 1997 .

[16]  D. Sheehan,et al.  The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. , 1998, The Journal of clinical psychiatry.

[17]  Anders M. Dale,et al.  Cortical Surface-Based Analysis I. Segmentation and Surface Reconstruction , 1999, NeuroImage.

[18]  Thomas S. Huang,et al.  Image processing , 1971 .

[19]  Martin Styner,et al.  Hippocampus Shape Analysis and Late-Life Depression , 2008, PloS one.

[20]  Menno P. Witter,et al.  A pathophysiological framework of hippocampal dysfunction in ageing and disease , 2011, Nature Reviews Neuroscience.

[21]  Liberty S. Hamilton,et al.  Hippocampal morphology and distinguishing late-onset from early-onset elderly depression. , 2008, The American journal of psychiatry.

[22]  Polina Golland,et al.  Automated segmentation of hippocampal subfields from ultra‐high resolution in vivo MRI , 2009, Hippocampus.

[23]  Jong‐Han Park,et al.  Modification of the mini‐mental state examination for use in the elderly in a non‐western society. Part 1. Development of korean version of mini‐mental state examination , 1990 .

[24]  D. Loewenstein,et al.  How Late-Life Depression Affects Cognition: Neural Mechanisms , 2010, Current psychiatry reports.

[25]  Amy L. Byers,et al.  Depression and risk of developing dementia , 2011, Nature Reviews Neurology.

[26]  S. O’Mara,et al.  The subiculum: a review of form, physiology and function , 2001, Progress in Neurobiology.