Preparation,in vitro Release and Percutaneous Penetration of Ligustrazine Hydrochloride Transdermal Delivery System

A novel microheterogeneous and macrohomogeneous transdermal delivery system loaded with ligustrazine hydrochloride was prepared by blending acrylic pressure-sensitive adhesive (PSA) with gum arabic (GA). The effect of the structure of microheterogeneous matrix on the in vitro release and permeation profiles of the drug through the hairless mice skin were investigated.The results showed that 15% GA could inhibit the drug to crystallize out in the patches containing 5% ligustrazine hydrochloride,and increase the in vitro release and permeation amount. There was no significant effect of amount of GA on adhesive property of the patches.