论文信息 - Multi-stage dose-response models in carcinogenesis.

Multi-stage dose-response models in carcinogenesis.

Abstract A frequently proposed multi-stage dose-response model for carcinogenesis is evaluated theoretically and on the basis of existing experimental results. Several defects in this model are revealed. A modified form of the Weibull model, without these defects, is proposed as an alternative.

F W Carlborg

[1] R L Sielken,et al. Estimation of "safe doses" in carcinogenic experiments. , 1977, Journal of environmental pathology and toxicology.

[2] E. Farber,et al. The sequential analysis of cancer development. , 1980, Advances in cancer research.

[3] William G. Cochran,et al. Experimental designs, 2nd ed. , 1957 .

[4] William G. Cochran,et al. Experimental Designs, 2nd Edition , 1950 .

[5] F. W. Carlborg. Dose-response functions in carcinogenesis and the Weibull model. , 1981, Food and cosmetics toxicology.

[6] H. Druckrey. Quantitative Aspects in Chemical Carcinogenesis , 1967 .

[7] D G Hoel,et al. Fundamental carcinogenic processes and their implications for low dose risk assessment. , 1976, Cancer research.

[8] H. Guess,et al. Uncertainty estimates for low-dose-rate extrapolations of animal carcinogenicity data. , 1977, Cancer research.