Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4.
暂无分享,去创建一个
[1] R. Lyons,et al. Toll‐like receptor‐4‐mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors , 2008, Immunology.
[2] Linden J. Gearing,et al. Glucocorticoids Inhibit IRF3 Phosphorylation in Response to Toll-like Receptor-3 and -4 by Targeting TBK1 Activation* , 2008, Journal of Biological Chemistry.
[3] P. Andrew,et al. Streptococcus pneumoniae deficient in pneumolysin or autolysin has reduced virulence in meningitis. , 2008, The Journal of infectious diseases.
[4] H. Wagner,et al. Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses. , 2007, The American journal of pathology.
[5] H. Wagner,et al. MyD88-dependent immune response contributes to hearing loss in experimental pneumococcal meningitis. , 2007, The Journal of infectious diseases.
[6] S. Akira,et al. Toll‐like receptor 9 acts at an early stage in host defence against pneumococcal infection , 2007, Cellular microbiology.
[7] R. Nau,et al. Microglial cells and peritoneal macrophages release activin A upon stimulation with Toll-like receptor agonists , 2007, Neuroscience Letters.
[8] C. Snapper,et al. TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae. , 2007, Cellular immunology.
[9] H. Pfister,et al. Complement C1q and C3 Are Critical for the Innate Immune Response to Streptococcus pneumoniae in the Central Nervous System1 , 2007, The Journal of Immunology.
[10] H. Pfister,et al. Oxidative stress in pneumococcal meningitis: A future target for adjunctive therapy? , 2006, Progress in Neurobiology.
[11] B. Mishra,et al. Expression and distribution of Toll‐like receptors in the brain during murine neurocysticercosis , 2006, Journal of Neuroimmunology.
[12] J. Timsit,et al. Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: The PNEUMOREA prospective multicenter study* , 2006, Critical care medicine.
[13] R. Spíšek,et al. Glucocorticoids severely impair differentiation and antigen presenting function of dendritic cells despite upregulation of Toll-like receptors. , 2006, Clinical immunology.
[14] S. Paludan,et al. Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll‐like receptors 2, 4, and 9 in species‐specific patterns , 2006, Journal of leukocyte biology.
[15] H. Pfister,et al. Protein expression pattern in experimental pneumococcal meningitis. , 2006, Microbes and infection.
[16] R. Landmann,et al. Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis , 2005, Journal of Neuroimmunology.
[17] R. Landmann,et al. Regulation of Streptococcus pneumoniae distribution by Toll-like receptor 2 in vivo. , 2005, Immunobiology.
[18] C. Snapper,et al. Both Innate Immunity and Type 1 Humoral Immunity to Streptococcus pneumoniae Are Mediated by MyD88 but Differ in Their Relative Levels of Dependence on Toll-Like Receptor 2 , 2005, Infection and Immunity.
[19] P. Andrew,et al. The role of pneumolysin in pneumococcal pneumonia and meningitis , 2004, Clinical and experimental immunology.
[20] A. Kato,et al. Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells. , 2004, American journal of respiratory cell and molecular biology.
[21] S. Miller,et al. Microglia Initiate Central Nervous System Innate and Adaptive Immune Responses through Multiple TLRs1 , 2004, The Journal of Immunology.
[22] N. Suttorp,et al. Nucleotide-binding Oligomerization Domain Proteins Are Innate Immune Receptors for Internalized Streptococcus pneumoniae* , 2004, Journal of Biological Chemistry.
[23] H. Wagner,et al. MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS. , 2004, Brain : a journal of neurology.
[24] S. Dower,et al. Penicillin enhances the toll-like receptor 2-mediated proinflammatory activity of Streptococcus pneumoniae. , 2003, The Journal of infectious diseases.
[25] I. Marriott,et al. Cultured astrocytes express toll‐like receptors for bacterial products , 2003, Glia.
[26] H. Pfister,et al. Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. , 2003, Brain : a journal of neurology.
[27] M. Lipsitch,et al. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[28] W. Binder,et al. Dexamethasone in adults with bacterial meningitis. , 2003, The New England journal of medicine.
[29] A. Wellmer,et al. Decreased Virulence of a Pneumolysin-Deficient Strain of Streptococcus pneumoniae in Murine Meningitis , 2002, Infection and Immunity.
[30] K. Frei,et al. Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. , 2002, The Journal of infectious diseases.
[31] R. Flavell,et al. Role of Caspase‐1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase‐1‐deficient mice , 2002, Annals of neurology.
[32] H. Pfister,et al. Meningitis-Associated Central Nervous System Complications are Mediated by the Activation of Poly(ADP-ribose) Polymerase , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[33] U. Dirnagl,et al. Immune surveillance of mouse brain perivascular spaces by blood‐borne macrophages , 2001, The European journal of neuroscience.
[34] M. Lipsitch,et al. Intranasal Immunization with Killed Unencapsulated Whole Cells Prevents Colonization and Invasive Disease by Capsulated Pneumococci , 2001, Infection and Immunity.
[35] A. Aderem,et al. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism , 2001, Nature Immunology.
[36] S. Akira,et al. A Toll-like receptor recognizes bacterial DNA , 2000, Nature.
[37] D. Golenbock,et al. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. , 1999, Journal of immunology.
[38] A. Tomasz,et al. The relative role of bacterial cell wall and capsule in the induction of inflammation in pneumococcal meningitis. , 1985, The Journal of infectious diseases.