Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer
暂无分享,去创建一个
[1] Andrew V. Nguyen,et al. Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution. , 2000, Development.
[2] Y. Bang,et al. Transcriptional repression of the transforming growth factor-β type I receptor gene by DNA methylation results in the development of TGF-β resistance in human gastric cancer , 1999, Oncogene.
[3] R. Coffey,et al. Mammary tumor suppression by transforming growth factor beta 1 transgene expression. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[4] C. Corless,et al. Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis. , 2005, The Journal of clinical investigation.
[5] R. Hynes,et al. Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo , 1998, Cell.
[6] J. Massagué,et al. TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. , 2005, Cancer cell.
[7] S. Farrington,et al. Mutation frequency in coding and non-coding repeat sequences in mismatch repair deficient cells derived from normal human tissue , 2001, Oncogene.
[8] U. Bogdahn,et al. Intracerebral and intrathecal infusion of the TGF-beta 2-specific antisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: toxicology and safety. , 2005, Oligonucleotides.
[9] D. Mercola,et al. Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[10] R. Ransohoff,et al. TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression. , 1997, Journal of immunology.
[11] H. Moses,et al. Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. , 2005, Developmental biology.
[12] U. Bogdahn,et al. Targeted tumor therapy with the TGF-β2 antisense compound AP 12009 , 2006 .
[13] L. Chodosh,et al. Conditional Overexpression of Active Transforming Growth Factor β1 In vivo Accelerates Metastases of Transgenic Mammary Tumors , 2004, Cancer Research.
[14] M. Barcellos-Hoff,et al. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. , 2000, Cancer research.
[15] X. Wang,et al. Blocking transforming growth factor beta signaling in transgenic epidermis accelerates chemical carcinogenesis: a mechanism associated with increased angiogenesis. , 1999, Cancer research.
[16] Allan Balmain,et al. TGF-β signaling in tumor suppression and cancer progression , 2001, Nature Genetics.
[17] B. Pasche. Role of transforming growth factor beta in cancer , 2001, Journal of cellular physiology.
[18] Mahlon D. Johnson,et al. Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression. , 1993, The Journal of clinical investigation.
[19] Allan Balmain,et al. TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice , 1996, Cell.
[20] Jae Youn Yi,et al. Type I Transforming Growth Factor β Receptor Binds to and Activates Phosphatidylinositol 3-Kinase* , 2005, Journal of Biological Chemistry.
[21] C. Hill,et al. Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. , 2006, Cytokine & growth factor reviews.
[22] R. Flavell,et al. Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells , 2001, Nature Medicine.
[23] R. Cardiff,et al. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease , 1992, Molecular and cellular biology.
[24] J. Tschopp,et al. Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape , 1996, Science.
[25] Carlos L Arteaga,et al. Dual role of transforming growth factor beta in mammary tumorigenesis and metastatic progression. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.
[26] M. Karin,et al. A role for MEK kinase 1 in TGF‐β/activin‐induced epithelium movement and embryonic eyelid closure , 2003, The EMBO journal.
[27] H. Lodish,et al. The Soluble Exoplasmic Domain of the Type II Transforming Growth Factor (TGF)-β Receptor , 1995, The Journal of Biological Chemistry.
[28] Jonas Larsson,et al. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. , 2003, Molecular cell.
[29] Y. Wan,et al. TGF-β-induced p38 activation is mediated by Rac1-regulated generation of reactive oxygen species in cultured human keratinocytes , 2001 .
[30] M. Reiss,et al. Targeting Endogenous Transforming Growth Factor β Receptor Signaling in SMAD4-Deficient Human Pancreatic Carcinoma Cells Inhibits Their Invasive Phenotype 1 , 2004, Cancer Research.
[31] A. Roberts,et al. Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation. , 1988, Journal of immunology.
[32] Jeffrey L. Wrana,et al. TGFβ signals through a heteromeric protein kinase receptor complex , 1992, Cell.
[33] L. Wakefield,et al. Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation. , 2002, The American journal of pathology.
[34] J. Massagué,et al. Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.
[35] A. Reith,et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. , 2002, Molecular pharmacology.
[36] P. ten Dijke,et al. The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. , 2006, Cancer research.
[37] P. Schirmacher,et al. Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development , 1998, Oncogene.
[38] B. Hogan,et al. Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice , 1990, Cell.
[39] Nathan A. Mundell,et al. Transforming Growth Factor- (cid:1) Stimulates Epithelial–Mesenchymal Transformation in the Proepicardium , 2022 .
[40] M. V. Dinther,et al. The Tumor Suppressor Smad 4 Is Required for Transforming Growth Factor B – Induced Epithelial to Mesenchymal Transition and Bone Metastasis of Breast Cancer Cells , 2006 .
[41] C. Nathan,et al. Modulation of Macrophage Function by Transforming Growth Factor β, Interleukin‐4, and Interleukin‐10 a , 1993, Annals of the New York Academy of Sciences.
[42] A. Balmain,et al. Concerted action of TGF-beta 1 and its type II receptor in control of epidermal homeostasis in transgenic mice. , 1995, Genes & development.
[43] S. Wahl,et al. TGF‐β: the perpetrator of immune suppression by regulatory T cells and suicidal T cells , 2004, Journal of leukocyte biology.
[44] T. Witham,et al. Expression of a soluble transforming growth factor-β (TGFβ) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcomain vivo , 2003, Journal of Neuro-Oncology.
[45] Y. Shyr,et al. Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation. , 2003, The American journal of pathology.
[46] Yue Zhang,et al. Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity , 2005, Science.
[47] D. Ma,et al. Transforming growth factor-beta down-regulates major histocompatibility complex class I antigen expression and increases the susceptibility of uveal melanoma cells to natural killer cell-mediated cytolysis. , 1995, Immunology.
[48] R. Flavell,et al. Transforming growth factor-β in T-cell biology , 2002, Nature Reviews Immunology.
[49] C. Arteaga,et al. Evidence for a positive role of transforming growth factor‐β in human breast cancer cell tumorigenesis , 1993, Journal of cellular biochemistry. Supplement.
[50] A. Balmain,et al. Altered epidermal cell growth control in vivo by inducible expression of transforming growth factor beta 1 in the skin of transgenic mice. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[51] M. Barcellos-Hoff,et al. Proliferation of Estrogen Receptor- (cid:1) -Positive Mammary Epithelial Cells Is Restrained by Transforming Growth Factor- (cid:2) 1 in Adult Mice , 2005 .
[52] M. Freedman,et al. Transforming growth factor-β1 differentially regulates proliferation and MHC class-II antigen expression in forebrain and brainstem astrocyte primary cultures , 1992, Brain Research.
[53] J. Dasch,et al. Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification. , 1989, Journal of immunology.
[54] M. Sporn,et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[55] I. Figari,et al. The autocrine production of transforming growth factor-beta 1 during lymphocyte activation. A study with a monoclonal antibody-based ELISA. , 1990, Journal of immunology.
[56] V. Fadok,et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. , 1998, The Journal of clinical investigation.
[57] G. Proetzel,et al. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease , 1992, Nature.
[58] K. Frei,et al. Expression of TGF-beta 2 in human glioblastoma: a role in resistance to immune rejection? , 1991, Ciba Foundation symposium.
[59] D. Kletsas,et al. TGF-beta regulates differentially the proliferation of fetal and adult human skin fibroblasts via the activation of PKA and the autocrine action of FGF-2. , 2006, Cellular signalling.
[60] R. Weinberg,et al. Expression cloning and characterization of the TGF-β type III receptor , 1991, Cell.
[61] K. Irie,et al. Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction , 1995, Science.
[62] M. Matzuk,et al. Genetic models for transforming growth factor β superfamily signaling in ovarian follicle development , 2004, Molecular and Cellular Endocrinology.
[63] R. Keri,et al. Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice , 2005, Oncogene.
[64] R. Cardiff,et al. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[65] K. Kinzler,et al. Cancer genes and the pathways they control , 2004, Nature Medicine.
[66] M. Reiss,et al. Selective inhibitors of type I receptor kinase block cellular transforming growth factor-beta signaling. , 2004, Biochemical pharmacology.
[67] S. A. Watkins,et al. Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition. , 2005, Biochemistry.
[68] D. Adams,et al. Transforming growth factor-beta induces human T lymphocyte migration in vitro. , 1991, Journal of immunology.
[69] Robert D. Cardiff,et al. Selective Evolution of Stromal Mesenchyme with p53 Loss in Response to Epithelial Tumorigenesis , 2005, Cell.
[70] R. Ignotz,et al. TGF‐beta inhibits proliferation of and promotes differentiation of human promonocytic leukemia cells , 1992, Journal of cellular physiology.
[71] Natasa Przulj,et al. High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells , 2005, Science.
[72] Martin A. Nowak,et al. The significance of unstable chromosomes in colorectal cancer , 2003, Nature Reviews Cancer.
[73] R. Weinberg,et al. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase , 1992, Cell.
[74] M. Kitamura,et al. Identification of an inhibitor targeting macrophage production of monocyte chemoattractant protein-1 as TGF-beta 1. , 1997, Journal of immunology.
[75] R. Derynck,et al. TGF-β signaling in cancer – a double-edged sword , 2001 .
[76] K. Malcolm,et al. Cross-talk between ERK and p38 MAPK Mediates Selective Suppression of Pro-inflammatory Cytokines by Transforming Growth Factor-β* , 2002, The Journal of Biological Chemistry.
[77] G. Nabel,et al. Regulation of the proinflammatory effects of Fas ligand (CD95L). , 1998, Science.
[78] D. Constam,et al. Modulation of the immune response by transforming growth factor beta. , 1992, International archives of allergy and immunology.
[79] R. Derynck,et al. Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition , 1997 .
[80] K. Wagner,et al. Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-β1 expression , 2005, Oncogene.
[81] WM Kast,et al. Effects of TGF-β on the immune system: implications for cancer immunotherapy , 1999, Leukemia.
[82] C. Heldin,et al. Smad7 is required for TGF-β-induced activation of the small GTPase Cdc42 , 2004, Journal of Cell Science.
[83] M. Reiss. TGF- and cancer , 1999 .
[84] Brian Bierie,et al. Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. , 2005, Cancer research.
[85] R. Field,et al. A fully human antibody neutralising biologically active human TGFbeta2 for use in therapy. , 1999, Journal of immunological methods.
[86] B. O’Malley,et al. Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[87] T. Lee,et al. Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[88] Ying E. Zhang,et al. Smad-dependent and Smad-independent pathways in TGF-β family signalling , 2003, Nature.
[89] R. Alon,et al. TGF‐β1 enhances SDF‐1α‐induced chemotaxis and homing of naive T cells by up‐regulating CXCR4 expression and downstream cytoskeletal effector molecules , 2002, European journal of immunology.
[90] K. Irie,et al. TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction , 1996, Science.
[91] S. Rosenberg,et al. TGF-β1 Attenuates the Acquisition and Expression of Effector Function by Tumor Antigen-Specific Human Memory CD8 T Cells , 2005, Journal of Immunology.
[92] H. Lodish,et al. Oligomeric Structure of Type I and Type II Transforming Growth Factor β Receptors: Homodimers Form in the ER and Persist at the Plasma Membrane , 1998, The Journal of cell biology.
[93] R. Cardiff,et al. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[94] V. Calvert,et al. Role of Tyrosine Phosphorylation in Ligand-independent Sequestration of CXCR4 in Human Primary Monocytes-Macrophages* , 2001, The Journal of Biological Chemistry.
[95] J. Crow. Early American genetics journals , 2005, Nature Reviews Genetics.
[96] R. Derynck,et al. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors , 1994, The Journal of cell biology.
[97] C. Arteaga,et al. Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases , 2002 .
[98] L. Hennighausen,et al. Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population. , 1995, Developmental biology.
[99] L. Wakefield,et al. TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression , 2003 .
[100] D. Hanahan,et al. The Hallmarks of Cancer , 2000, Cell.
[101] C. Boulanger,et al. Reducing mammary cancer risk through premature stem cell senescence , 2001, Oncogene.
[102] Ximing J. Yang,et al. Adoptive transfer of tumor-reactive transforming growth factor-beta-insensitive CD8+ T cells: eradication of autologous mouse prostate cancer. , 2005, Cancer research.
[103] Dana M. Brantley-Sieders,et al. Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1 , 2003, Molecular and Cellular Biology.
[104] N. Kaminski,et al. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. , 1999, Cell.
[105] S. Ledbetter,et al. Minimal Effects on Immune Parameters Following Chronic Anti-TGF-β Monoclonal Antibody Administration to Normal Mice , 2003, Immunopharmacology and immunotoxicology.
[106] K. M. Mulder,et al. Activation of p21ras by transforming growth factor beta in epithelial cells. , 1992, The Journal of biological chemistry.
[107] V. Fadok,et al. Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells. , 1999, Journal of immunology.
[108] H. Moses,et al. Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching. , 1999, Molecular biology of the cell.
[109] Xiao‐Jing Wang,et al. Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFβRII , 2000, Oncogene.
[110] P. Pandolfi,et al. Cytoplasmic PML function in TGF-β signalling , 2004, Nature.
[111] Robert A. Weinberg,et al. TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation , 2001, Nature Cell Biology.
[112] C. Heldin,et al. Non-Smad TGF-β signals , 2005, Journal of Cell Science.
[113] J. Massagué,et al. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer , 2003, Nature Reviews Cancer.
[114] R. Derynck,et al. Ligand-independent Activation of Transforming Growth Factor (TGF) β Signaling Pathways by Heteromeric Cytoplasmic Domains of TGF-β Receptors* , 1996, The Journal of Biological Chemistry.
[115] David Botstein,et al. Diversity, topographic differentiation, and positional memory in human fibroblasts , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[116] H. Lodish,et al. The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand. , 1993, The Journal of biological chemistry.
[117] T. Witham,et al. Expression of a Soluble Transforming Growth Factor-β (TGFβ) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcoma in vivo , 2004, Journal of Neuro-Oncology.
[118] S. Markowitz,et al. Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis , 2000 .
[119] Takeshi Imamura,et al. The ALK‐5 inhibitor A‐83‐01 inhibits Smad signaling and epithelial‐to‐mesenchymal transition by transforming growth factor‐β , 2005, Cancer science.
[120] F. López‐Casillas,et al. Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft. , 2002, Cancer research.
[121] B. Weeks,et al. Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis. , 2001, Cancer research.
[122] A. Geiser,et al. Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. , 1993, The EMBO journal.
[123] B. Hogan,et al. Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1. , 1993, Genes & development.
[124] A. Roberts,et al. SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. , 2004, Molecular pharmacology.
[125] M. Shaw,et al. Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. , 2000, Developmental biology.
[126] J. Massagué. How cells read TGF-beta signals. , 2000, Nature reviews. Molecular cell biology.
[127] Dennis C. Sgroi,et al. Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion , 2005, Cell.
[128] P. Khaw,et al. Human anti-transforming growth factor-beta2 antibody: a new glaucoma anti-scarring agent. , 1999, Investigative ophthalmology & visual science.
[129] S. Wahl,et al. TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression , 2003 .
[130] P. Dijke,et al. TGF-h receptor function in the endothelium , 2005 .
[131] R. Derynck,et al. SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS , 2005 .
[132] M. Washington,et al. TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia , 2004, Science.
[133] S. Hayward,et al. Malignant transformation in a nontumorigenic human prostatic epithelial cell line. , 2001, Cancer research.
[134] H. Beug,et al. TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis , 1998, Current Biology.
[135] S. Karlsson,et al. Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. , 2002, Blood.
[136] M. O’Connor-McCourt,et al. Expression of TGF‐β type II receptor antisense RNA impairs TGF‐β signaling in vitro and promotes mammary gland differentiation in vivo , 2003, International journal of cancer.
[137] M. Goumans,et al. Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways. , 2003, Trends in cardiovascular medicine.
[138] L. Wakefield,et al. Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects. , 2002, The Journal of clinical investigation.
[139] R. Flavell,et al. Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease , 2000 .
[140] I. Stamenkovic,et al. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. , 2000, Genes & development.
[141] J. Massagué,et al. How cells read TGF-β signals , 2000, Nature Reviews Molecular Cell Biology.
[142] M. Barcellos-Hoff,et al. Activated type I TGFβ receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression , 2006, Oncogene.
[143] K. Kinzler,et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. , 1995, Science.
[144] S. Murphy,et al. Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3 , 2003, Molecular and Cellular Biology.
[145] M. Sporn,et al. Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[146] L. Sun,et al. A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells. , 1999, Cancer research.
[147] François Vaillant,et al. Generation of a functional mammary gland from a single stem cell , 2006, Nature.
[148] N. Kaminski,et al. A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1 , 1999, Cell.
[149] T. Utsunomiya,et al. Clinical significance of the expression of activin A in esophageal carcinoma. , 2003, International journal of oncology.
[150] H. Moses,et al. Transforming growth factor beta 1 can induce estrogen-independent tumorigenicity of human breast cancer cells in athymic mice. , 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[151] K. Black,et al. Prolonged survival of rats with intracranial C6 gliomas by treatment with TGF-beta antisense gene. , 1998, Neurological research.
[152] M. Smyth,et al. CD4+CD25+ T Regulatory Cells Suppress NK Cell-Mediated Immunotherapy of Cancer1 , 2006, The Journal of Immunology.
[153] A. Balmain,et al. TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest , 2000 .
[154] Jonathan M. Yingling,et al. Development of TGF-β signalling inhibitors for cancer therapy , 2004, Nature Reviews Drug Discovery.
[155] H. Moses,et al. Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. , 2001, Molecular biology of the cell.
[156] W. Grady. Genomic instability and colon cancer , 2004, Cancer and Metastasis Reviews.
[157] Lothar Hennighausen,et al. Information networks in the mammary gland , 2005, Nature Reviews Molecular Cell Biology.
[158] M. Weller,et al. SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma Cells In vitro and In vivo , 2004, Cancer Research.
[159] R. Kalluri,et al. Integrin α1β1 and Transforming Growth Factor-β1 Play Distinct Roles in Alport Glomerular Pathogenesis and Serve as Dual Targets for Metabolic Therapy , 2000 .
[160] Richard N. Mitchell,et al. Essential Role for Smad3 in Regulating MCP-1 Expression and Vascular Inflammation , 2004, Circulation Research.
[161] H. Lodish,et al. Signaling by chimeric erythropoietin‐TGF‐beta receptors: homodimerization of the cytoplasmic domain of the type I TGF‐beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction. , 1996, The EMBO journal.
[162] S. Hayward,et al. Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks , 2005, Oncogene.