Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.

[1]  B. Cillero-Pastor,et al.  Differential effects of tumor necrosis factor-α and interleukin-1β on cell death in human articular chondrocytes , 2008 .

[2]  D. Shi,et al.  Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility , 2008, Journal of Human Genetics.

[3]  F. Breedveld,et al.  Innate production of tumour necrosis factor α and interleukin 10 is associated with radiological progression of knee osteoarthritis , 2007, Annals of the rheumatic diseases.

[4]  Monique M. B. Breteler,et al.  The Rotterdam Study: 2016 objectives and design update , 2015, European Journal of Epidemiology.

[5]  A. Hofman,et al.  The Rotterdam Study: objectives and design update , 2007, European Journal of Epidemiology.

[6]  S. Snelling,et al.  An SNP in the 5′-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage , 2007 .

[7]  S. Ikegawa New gene associations in osteoarthritis: what do they provide, and where are we going? , 2007, Current opinion in rheumatology.

[8]  T. Spector,et al.  The additive effect of individual genes in predicting risk of knee osteoarthritis , 2007, Annals of the rheumatic diseases.

[9]  Robert Plomin,et al.  Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies , 2007, BMC Genomics.

[10]  Yusuke Nakamura,et al.  A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis , 2007, Nature Genetics.

[11]  L. Southam,et al.  Extreme context specificity in differential allelic expression. , 2007, Human molecular genetics.

[12]  C. Platsoucas,et al.  The role of T cells in the pathogenesis of osteoarthritis. , 2007, Arthritis and rheumatism.

[13]  C. Duijn,et al.  Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes , 2006, European Journal of Human Genetics.

[14]  Yong Wang,et al.  Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese , 2006, Journal of Human Genetics.

[15]  J. Sinsheimer,et al.  Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus. , 2006, Rheumatology.

[16]  F. Berenbaum,et al.  Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene , 2006, Arthritis research & therapy.

[17]  M. Nevitt,et al.  Frizzled-related protein variants are risk factors for hip osteoarthritis. , 2006, Arthritis and rheumatism.

[18]  J. Sinsheimer,et al.  The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population. , 2006, Osteoarthritis and cartilage.

[19]  T. Spector,et al.  Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling. , 2006, Arthritis and rheumatism.

[20]  T. Spector,et al.  Radiographic Progression of Lumbar Spine Disc Degeneration Is Influenced by Variation at Inflammatory Genes: A Candidate SNP Association Study in the Chingford Cohort , 2005, Spine.

[21]  B. Bresnihan,et al.  Synovial tissue inflammation in early and late osteoarthritis , 2005, Annals of the rheumatic diseases.

[22]  F. Berenbaum,et al.  The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide. , 2004, Clinical orthopaedics and related research.

[23]  A. Uitterlinden,et al.  A new marker for osteoarthritis: cross-sectional and longitudinal approach. , 2004, Arthritis and rheumatism.

[24]  J. Pelletier,et al.  Cyclooxygenase-2 and prostaglandins in articular tissues. , 2003, Seminars in arthritis and rheumatism.

[25]  T. Spector,et al.  The St. Thomas' UK Adult Twin Registry. , 2002, Twin research : the official journal of the International Society for Twin Studies.

[26]  M. Currie,et al.  Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants. , 2002, Arthritis and rheumatism.

[27]  T. Spector,et al.  Are Twins and Singletons Comparable? A Study of Disease-related and Lifestyle Characteristics in Adult Women , 2001, Twin Research.

[28]  J Blangero,et al.  Large upward bias in estimation of locus-specific effects from genomewide scans. , 2001, American journal of human genetics.

[29]  F. Luyten,et al.  Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo. , 2001, Arthritis and rheumatism.

[30]  D. Gilroy,et al.  Inducible cyclooxygenase may have anti-inflammatory properties , 1999, Nature Medicine.

[31]  T. Sumida,et al.  Tumor necrosis factor alpha regulation of the FAS-mediated apoptosis-signaling pathway in synovial cells. , 1999, Arthritis and rheumatism.

[32]  S. Abramson,et al.  Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide. , 1997, The Journal of clinical investigation.

[33]  T. Spector,et al.  The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. , 1993, The Journal of rheumatology.

[34]  J. Pelletier,et al.  Modulation of glucocorticoid receptor expression in human articular chondrocytes by cAMP and prostaglandins. , 1991, The Journal of rheumatology. Supplement.

[35]  R. Moskowitz,et al.  Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. , 1986, Arthritis and rheumatism.

[36]  J. Garrow,et al.  A survey of heights and weights of adults in Great Britain, 1980. , 1985, Annals of human biology.

[37]  J. Kellgren,et al.  Genetic Factors in Generalized Osteo-Arthrosis , 1963, Annals of the rheumatic diseases.

[38]  T. Spector,et al.  Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. , 2007, Arthritis and rheumatism.

[39]  M. Skolnick,et al.  Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis , 2007, Genes and Immunity.

[40]  Kozo Nakamura,et al.  is associated with hip osteoarthritis in Japanese , 2005 .

[41]  Nathaniel Rothman,et al.  Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. , 2004, Journal of the National Cancer Institute.

[42]  David T Felson,et al.  An update on the pathogenesis and epidemiology of osteoarthritis. , 2004, Radiologic clinics of North America.

[43]  M. Merville,et al.  TNF-alpha protects human primary articular chondrocytes from nitric oxide-induced apoptosis via nuclear factor-kappaB. , 2002, Laboratory investigation; a journal of technical methods and pathology.

[44]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[45]  B. Kirkwood Essentials of medical statistics. , 1988 .