Intravoxel incoherent motion (IVIM) MR imaging of colorectal liver metastases: Are we only looking at tumor necrosis?

To determine if intra‐voxel incoherent motion diffusion‐weighted imaging (IVIM‐DWI) parameters, including free molecular‐based (D) and perfusion‐related (D*, f) diffusion parameters, correlate with the degree of tumor necrosis and viable tumor in colo‐rectal cancer (CRC) metastasis.

[1]  H. Z. B. Alaya Utility of diffusion-weighted MRI in distinguishing benign and malignant hepatic lesions , 2011 .

[2]  L. Shen,et al.  Apparent diffusion coefficient: potential imaging biomarker for prediction and early detection of response to chemotherapy in hepatic metastases. , 2008, Radiology.

[3]  T. Kurabayashi,et al.  Salivary glands and lesions: evaluation of apparent diffusion coefficients with split-echo diffusion-weighted MR imaging--initial results. , 2001, Radiology.

[4]  A. Luciani,et al.  Liver Cirrhosis : Intravoxel Incoherent Motion MR Imaging — Pilot Study 1 , 2008 .

[5]  B. Malassagne,et al.  Laparoscopic Liver Resections: A Feasibility Study in 30 Patients , 2000, Annals of surgery.

[6]  Bram Stieltjes,et al.  An in vivo verification of the intravoxel incoherent motion effect in diffusion‐weighted imaging of the abdomen , 2010, Magnetic resonance in medicine.

[7]  T. Hernandez-Boussard,et al.  Pathologic Response to Preoperative Chemotherapy in Colorectal Liver Metastases: Fibrosis, not Necrosis, Predicts Outcome , 2012, Annals of Surgical Oncology.

[8]  D. Collins,et al.  Predicting response of colorectal hepatic metastasis: value of pretreatment apparent diffusion coefficients. , 2007, AJR. American journal of roentgenology.

[9]  M. Pocard,et al.  Preoperative detection of hepatic metastases: comparison of diffusion-weighted, T2-weighted fast spin echo and gadolinium-enhanced MR imaging using surgical and histopathologic findings as standard of reference. , 2011, European journal of radiology.

[10]  Y. Ni,et al.  Effect of vascular targeting agent in rat tumor model: dynamic contrast-enhanced versus diffusion-weighted MR imaging. , 2005, Radiology.

[11]  Bram Stieltjes,et al.  Toward an optimal distribution of b values for intravoxel incoherent motion imaging. , 2011, Magnetic resonance imaging.

[12]  E. Vicaut,et al.  Differentiation between cavernous hemangiomas and untreated malignant neoplasms of the liver with free-breathing diffusion-weighted MR imaging: comparison with T2-weighted fast spin-echo MR imaging. , 2011, European journal of radiology.

[13]  L. Rubbia‐Brandt,et al.  Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

[14]  C. Couinaud [Definition of hepatic anatomical regions and their value during hepatectomy (author's transl)]. , 1980, Chirurgie; memoires de l'Academie de chirurgie.

[15]  C. Van de Wiele,et al.  Value of DCE-MRI and FDG-PET/CT in the prediction of response to preoperative chemotherapy with bevacizumab for colorectal liver metastases , 2012, British Journal of Cancer.

[16]  M. Kanematsu,et al.  Diffusion‐weighted imaging of the liver: Optimizing b value for the detection and characterization of benign and malignant hepatic lesions , 2008, Journal of magnetic resonance imaging : JMRI.

[17]  S. Curley,et al.  Association of computed tomography morphologic criteria with pathologic response and survival in patients treated with bevacizumab for colorectal liver metastases. , 2009, JAMA.

[18]  D. Collins,et al.  Intravoxel incoherent motion in body diffusion-weighted MRI: reality and challenges. , 2011, AJR. American journal of roentgenology.

[19]  E. Hecht,et al.  Focal liver lesion detection and characterization with diffusion-weighted MR imaging: comparison with standard breath-hold T2-weighted imaging. , 2008, Radiology.

[20]  J. Stoker,et al.  Evaluation of true diffusion, perfusion factor, and apparent diffusion coefficient in non-necrotic liver metastases and uncomplicated liver hemangiomas using black-blood echo planar imaging. , 2009, European journal of radiology.

[21]  Pierre-Yves Boëlle,et al.  Diffusion‐weighted magnetic resonance imaging for the assessment of fibrosis in chronic hepatitis C , 2007, Hepatology.

[22]  H. Amthauer,et al.  Early prediction of anticancer effects with diffusion-weighted MR imaging in patients with colorectal liver metastases following selective internal radiotherapy , 2010, European Radiology.

[23]  J. Stoker,et al.  Improved focal liver lesion detection: comparison of single-shot diffusion-weighted echoplanar and single-shot T2 weighted turbo spin echo techniques. , 2007, The British journal of radiology.

[24]  C T Moonen,et al.  On the precision of diffusion/perfusion imaging by gradient sensitization , 1992, Magnetic resonance in medicine.

[25]  D. Driman,et al.  Infarct-like Necrosis: A Distinct Form of Necrosis Seen in Colorectal Carcinoma Liver Metastases Treated With Perioperative Chemotherapy , 2012, The American journal of surgical pathology.

[26]  M. Kanematsu,et al.  Spectrum of MRI appearances of untreated metastases of the liver. , 2003, AJR. American journal of roentgenology.

[27]  R. Turner,et al.  Effects of intravoxel incoherent motions (IVIM) in steady‐state free precession (SSFP) imaging: application to molecular diffusion imaging , 1989, Magnetic resonance in medicine.

[28]  P. Soyer,et al.  Segmental anatomy of the liver: utility of a nomenclature accepted worldwide. , 1993, AJR. American journal of roentgenology.

[29]  E. Hecht,et al.  Diagnosis of liver metastases: value of diffusion-weighted MRI compared with gadolinium-enhanced MRI , 2010, European Radiology.

[30]  H. Rusinek,et al.  Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast‐enhanced MRI alone and in combination: Preliminary experience , 2010, Journal of magnetic resonance imaging : JMRI.

[31]  B. Taouli,et al.  Diffusion-weighted MR imaging of the liver. , 2010, Radiology.

[32]  D. Le Bihan,et al.  Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. , 1988, Radiology.

[33]  V. Paradis,et al.  Diffusion-weighted MR imaging for the regional characterization of liver tumors. , 2012, Radiology.

[34]  P. Grenier,et al.  MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. , 1986, Radiology.