Outlining Potential Biomarkers of Exposure and Effect to Critical Minerals: Nutritionally Essential Trace Elements and the Rare Earth Elements

Emerging and low-carbon technologies and innovations are driving a need for domestic sources, sustainable use, and availability of critical minerals (CMs)—those vital to the national and economic security of the United States. Understanding the known and potential health effects of exposures to such mineral commodities can inform prudent and environmentally responsible handling and harvesting. We review the occurrence, use, predominant exposure pathways, and adverse outcome pathways (AOP) for human and fish receptors of those CMs that are nutritionally essential trace metals (specifically, cobalt, chromium, manganese, nickel, and zinc), as well as the rare earth elements. Biological responses to some elements having comparable biogeochemistry can sometimes be similar. Candidate quantifiable biomarkers for assessing potential AOP are conveyed.

[1]  D. Chapman,et al.  Establishment of invasive Black Carp (Mylopharyngodon piceus) in the Mississippi River basin: identifying sources and year classes contributing to recruitment , 2022, Biological Invasions.

[2]  G. De Boeck,et al.  Distribution of metals in water, sediment and fish tissue. Consequences for human health risks due to fish consumption in Lake Hawassa, Ethiopia. , 2022, The Science of the total environment.

[3]  M. Naiel,et al.  Improving water quality, growth performance, and modulating some stress physiological biomarkers in Cyprinus carpio using raw date nuclei as a zinc adsorbent agent , 2022, Applied Water Science.

[4]  M. Foley,et al.  Anadromous fish as biomarkers for the combined impact of marine and freshwater heavy metal pollution. , 2022, Ecotoxicology and environmental safety.

[5]  J. C. Prata A One Health perspective on water contaminants , 2022, Water Emerging Contaminants & Nanoplastics.

[6]  K. Grice,et al.  Multivariate analysis of otolith microchemistry can discriminate the source of oil contamination in exposed fish. , 2021, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[7]  M. Hostim-Silva,et al.  Fish otolith microchemistry as a biomarker of the world's largest mining disaster. , 2021, The Science of the total environment.

[8]  K. Loukola-Ruskeeniemi,et al.  High manganese and nickel concentrations in human hair and well water and low calcium concentration in blood serum in a pristine area with sulphide-rich bedrock , 2021, Environmental Geochemistry and Health.

[9]  H. Stapleton,et al.  Establishment of baseline cytology metrics in nestling American kestrels (Falco sparverius): Immunomodulatory effects of the flame retardant isopropylated triarylphosphate isomers. , 2021, Environment international.

[10]  Hong-Jie Sun,et al.  Ecotoxicological assessment of spent battery extract using zebrafish embryotoxicity test: A multi-biomarker approach. , 2021, Chemosphere.

[11]  U. Kappler Metals, Microbes, and Minerals: The Biogeochemical Side of Life , 2021 .

[12]  M. Vassal,et al.  Metal Oxide Nanoparticles: Evidence of Adverse Effects on the Male Reproductive System , 2021, International journal of molecular sciences.

[13]  F. Gagné,et al.  Insights on the toxicity of selected rare earth elements in rainbow trout hepatocytes. , 2021, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[14]  V. Blazer,et al.  Perfluoroalkyl Substances in Plasma of Smallmouth Bass from the Chesapeake Bay Watershed , 2021, International journal of environmental research and public health.

[15]  Carla Cedillo Alvarez,et al.  Hexavalent chromium: Regulation and health effects. , 2021, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[16]  A. Piwowar,et al.  Chromium (III) and chromium (VI) as important players in the induction of genotoxicity - current view. , 2020, Annals of agricultural and environmental medicine : AAEM.

[17]  N. T. Nassar,et al.  Methodology and technical input for the 2021 review and revision of the U.S. Critical Minerals List , 2021 .

[18]  A. R. Butcher,et al.  Geometallurgy of cobalt ores: A review , 2021 .

[19]  K. Hudson-Edwards,et al.  Geochemistry, Mineralogy and Microbiology of Cobalt in Mining-Affected Environments , 2020, Minerals.

[20]  Forrest H Nielsen,et al.  Nickel. , 2020, Advances in nutrition.

[21]  D. Lyons,et al.  Review of Rare Earth Elements as Fertilizers and Feed Additives: A Knowledge Gap Analysis , 2020, Archives of Environmental Contamination and Toxicology.

[22]  F. Sharples,et al.  Predicting Human Health Effects from Environmental Exposures: Applying Translatable and Accessible Biomarkers of Effect , 2020 .

[23]  R. Sharma,et al.  A review on biogenic synthesis, applications and toxicity aspects of zinc oxide nanoparticles , 2020, EXCLI journal.

[24]  S. Haller,et al.  Assessment of diagnostic biomarkers of liver injury in the setting of microcystin-LR (MC-LR) hepatotoxicity. , 2020, Chemosphere.

[25]  Christos T. Chasapis,et al.  Recent aspects of the effects of zinc on human health , 2020, Archives of Toxicology.

[26]  M. Aschner,et al.  Manganese in diet: bioaccessibility, adequate intake and neurotoxicological effects. , 2020, Journal of agricultural and food chemistry.

[27]  E. Prenner,et al.  Mechanisms of Co, Ni, and Mn toxicity: From exposure and homeostasis to their interactions with and impact on lipids and biomembranes. , 2020, Biochimica et biophysica acta. Biomembranes.

[28]  M. Dvořáková,et al.  Evaluation of toxicity profiles of rare earth elements salts (lanthanides) , 2020 .

[29]  Joseph Gambogi,et al.  Evaluating the mineral commodity supply risk of the U.S. manufacturing sector , 2020, Science Advances.

[30]  A. Mehri Trace Elements in Human Nutrition (II) – An Update , 2020, International journal of preventive medicine.

[31]  P. Calow,et al.  Ecotoxicology , 2019, Encyclopedia of Theoretical Ecology.

[32]  Yunyun Liu,et al.  Prenatal exposure of rare earth elements cerium and ytterbium and neonatal thyroid stimulating hormone levels: Findings from a birth cohort study. , 2019, Environment international.

[33]  M. Burford,et al.  Uptake and accumulation of cadmium, manganese and zinc by fisheries species: Trophic differences in sensitivity to environmental metal accumulation. , 2019, The Science of the total environment.

[34]  I. Salcedo-Bellido,et al.  Toenails as biomarker of exposure to essential trace metals: A review. , 2019, Environmental research.

[35]  T. Cunha-Oliveira,et al.  Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress , 2019, International journal of molecular sciences.

[36]  L. Favaro,et al.  Feathers of Humboldt penguin are suitable bioindicators of Rare Earth Elements. , 2019, The Science of the total environment.

[37]  S. Lima,et al.  Use of fish scales in environmental monitoring by the application of Laser-Induced Breakdown Spectroscopy (LIBS). , 2019, Chemosphere.

[38]  D. M. Conde,et al.  The effect of vaginal erbium laser treatment on sexual function and vaginal health in women with a history of breast cancer and symptoms of the genitourinary syndrome of menopause: a prospective study. , 2019, Menopause.

[39]  B. Spears,et al.  Human health risk associated with the management of phosphorus in freshwaters using lanthanum and aluminium. , 2019, Chemosphere.

[40]  M. Peana,et al.  The essential metals for humans: a brief overview. , 2019, Journal of inorganic biochemistry.

[41]  Guangming Zhou,et al.  SF-1 mediates reproductive toxicity induced by Cerium oxide nanoparticles in male mice , 2019, Journal of Nanobiotechnology.

[42]  S. Robetto,et al.  Rare earth elements in marine and terrestrial matrices of Northwestern Italy: Implications for food safety and human health. , 2019, The Science of the total environment.

[43]  H. Juárez Olguín,et al.  The Use of Trace and Essential Elements in Common Clinical Disorders: Roles in Assessment of Health and Oxidative Stress Status , 2019, Nutrition and cancer.

[44]  Tyler D. Johnson,et al.  Elevated Manganese Concentrations in United States Groundwater, Role of Land Surface-Soil-Aquifer Connections. , 2018, Environmental science & technology.

[45]  A. Shanker,et al.  Chromium: Environmental Pollution, Health Effects and Mode of Action , 2019, Encyclopedia of Environmental Health.

[46]  C. Gagnon,et al.  Response of the freshwater mussel, Dreissena polymorpha to sub-lethal concentrations of samarium and yttrium after chronic exposure. , 2018, Ecotoxicology and environmental safety.

[47]  Jiujun Zhang,et al.  Challenges, mitigation strategies and perspectives in development of zinc-electrode materials and fabrication for rechargeable zinc–air batteries , 2018 .

[48]  Shreya Ghosh,et al.  Microbial recovery and recycling of manganese waste and their future application: a review , 2018, Geomicrobiology Journal.

[49]  J. Rose,et al.  Very low concentration of cerium dioxide nanoparticles induce DNA damage, but no loss of vitality, in human spermatozoa. , 2018, Toxicology in vitro : an international journal published in association with BIBRA.

[50]  S. Young,et al.  Chromium speciation in foodstuffs: A review. , 2018, Food chemistry.

[51]  C. Faggio,et al.  Antioxidant defense system, immune response and erythron profile modulation in gold fish, Carassius auratus, after acute manganese treatment , 2018, Fish & shellfish immunology.

[52]  J. Jenkins,et al.  Sperm quality biomarkers complement reproductive and endocrine parameters in investigating environmental contaminants in common carp (Cyprinus carpio) from the Lake Mead National Recreation Area , 2018, Environmental research.

[53]  Xiangke Wang,et al.  Toxic effects of different types of zinc oxide nanoparticles on algae, plants, invertebrates, vertebrates and microorganisms. , 2018, Chemosphere.

[54]  Joseph Gambogi,et al.  Draft critical mineral list—Summary of methodology and background information—U.S. Geological Survey technical input document in response to Secretarial Order No. 3359 , 2018 .

[55]  Jonghan Kim,et al.  Influence of iron metabolism on manganese transport and toxicity. , 2017, Metallomics : integrated biometal science.

[56]  Bart Vinck,et al.  Cobalt toxicity in humans-A review of the potential sources and systemic health effects. , 2017, Toxicology.

[57]  Jong-Choon Kim,et al.  Twenty-Eight-Day Repeated Inhalation Toxicity Study of Nano-Sized Neodymium Oxide in Male Sprague-Dawley Rats , 2017, Toxicological research.

[58]  E. Garman,et al.  The mechanisms of nickel toxicity in aquatic environments: An adverse outcome pathway analysis , 2017, Environmental toxicology and chemistry.

[59]  A. Yousafzai,et al.  Chromium toxicity in fish: A review article , 2017 .

[60]  M. Chartrand,et al.  Manganese exposure and neurotoxic effects in children , 2017, Environmental research.

[61]  Yu Zhang,et al.  Reference Values of 14 Serum Trace Elements for Pregnant Chinese Women: A Cross-Sectional Study in the China Nutrition and Health Survey 2010–2012 , 2017, Nutrients.

[62]  J. Slack,et al.  Cobalt: Chapter F of critical mineral resources of the United States - Economic and environmental geology and prospects for future supply , 2017 .

[63]  J. Teyssie,et al.  Comparative study of trophic transfer of the essential metals Co and Zn in two tropical fish: A radiotracer approach , 2017 .

[64]  M. Nordberg,et al.  Trace element research-historical and future aspects. , 2016, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[65]  Vikas Kumar,et al.  Toxicology of arsenic in fish and aquatic systems , 2016, Environmental Chemistry Letters.

[66]  Peng Li,et al.  Recent advances (2010-2015) in studies of cerium oxide nanoparticles' health effects. , 2016, Environmental toxicology and pharmacology.

[67]  T. Chakrabarti,et al.  Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity , 2016, BioMed research international.

[68]  M. Guida,et al.  Comparative toxicities of selected rare earth elements: Sea urchin embryogenesis and fertilization damage with redox and cytogenetic effects. , 2016, Environmental research.

[69]  M. Aschner,et al.  Exposure, epidemiology, and mechanism of the environmental toxicant manganese , 2016, Environmental Science and Pollution Research.

[70]  Ow,et al.  Secondary Drinking Water Standards: Guidance for Nuisance Chemicals , 2015 .

[71]  M. Guida,et al.  Health effects and toxicity mechanisms of rare earth elements-Knowledge gaps and research prospects. , 2015, Ecotoxicology and environmental safety.

[72]  H. Abbas,et al.  Use of Fish as Bio-indicator of the Effects of Heavy Metals Pollution , 2015 .

[73]  A. Fairbrother,et al.  Examination of rare earth element concentration patterns in freshwater fish tissues. , 2015, Chemosphere.

[74]  C. Klaassen,et al.  Casarett & Doull's Essentials of Toxicology , 2015 .

[75]  J. Jenkins,et al.  Assessing reproductive and endocrine parameters in male largescale suckers (Catostomus macrocheilus) along a contaminant gradient in the lower Columbia River, USA. , 2014, The Science of the total environment.

[76]  M. Krzyżowska,et al.  The role of Chromium III in the organism and its possible use in diabetes and obesity treatment. , 2014, Annals of agricultural and environmental medicine : AAEM.

[77]  S. Langer,et al.  Effect of Manganese on haematological parameters of fish, Garra gotyla gotyla , 2014 .

[78]  Sara Fripp A learning curve. , 2014, Midwives.

[79]  Zhiqiang Chen,et al.  A human health risk assessment of rare earth elements in soil and vegetables from a mining area in Fujian Province, Southeast China. , 2013, Chemosphere.

[80]  Vasile Coman,et al.  Nickel recovery/removal from industrial wastes: A review , 2013 .

[81]  V. Adam,et al.  The Role of Metallothionein in Oxidative Stress , 2013, International journal of molecular sciences.

[82]  R. Jeffree,et al.  Cobalt-induced genotoxicity in male zebrafish (Danio rerio), with implications for reproduction and expression of DNA repair genes. , 2013, Aquatic toxicology.

[83]  M. Javed Chronic Effects of Nickel and Cobalt on Fish Growth , 2013 .

[84]  M. Zaborowska,et al.  Deliberations on zinc - a trace mineral or a toxic element? , 2012 .

[85]  Z. Somosy,et al.  Reproductive toxicology of nickel – Review , 2012, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[86]  D. Alvarez,et al.  Patterns of metal composition and biological condition and their association in male common carp across an environmental contaminant gradient in Lake Mead National Recreation Area, Nevada and Arizona, USA. , 2012, The Science of the total environment.

[87]  B. S. Vijayavathi Nickel as an essential element and a toxicant , 2012 .

[88]  L. Eltis,et al.  The biological occurrence and trafficking of cobalt. , 2011, Metallomics : integrated biometal science.

[89]  W. Stark,et al.  Cerium oxide nanoparticle uptake kinetics from the gas-phase into lung cells in vitro is transport limited. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[90]  C. Hogstrand Homeostasis and Toxicology of Essential Metals , 2011 .

[91]  Wei Zheng,et al.  Biomarkers of manganese intoxication. , 2011, Neurotoxicology.

[92]  J. Cerdà,et al.  Piscine aquaporins: an overview of recent advances. , 2010, Journal of experimental zoology. Part A, Ecological genetics and physiology.

[93]  P. Tchounwou,et al.  Chromium-induced biochemical, genotoxic and histopathologic effects in liver and kidney of goldfish, carassius auratus. , 2010, Mutation research.

[94]  N. Brown‐Peterson,et al.  Morphological Deformities as Biomarkers in Fish from Contaminated Rivers in Taiwan , 2009, International journal of environmental research and public health.

[95]  B. Michalke,et al.  Comparison between exhaled breath condensate analysis as a marker for cobalt and tungsten exposure and biomonitoring in workers of a hard metal alloy processing plant , 2009, International archives of occupational and environmental health.

[96]  A. Hursthouse,et al.  Cobalt and secondary poisoning in the terrestrial food chain: data review and research gaps to support risk assessment. , 2008, Environment international.

[97]  Janet M. Thornton,et al.  Metal ions in biological catalysis: from enzyme databases to general principles , 2008, JBIC Journal of Biological Inorganic Chemistry.

[98]  M. Aschner,et al.  Manganese transport in eukaryotes: the role of DMT1. , 2008, Neurotoxicology.

[99]  Aleksandra Duda-Chodak,et al.  The impact of nickel on human health , 2008 .

[100]  H. Sigel,et al.  Metal Ions in Life Sciences , 2007 .

[101]  B. Fowler,et al.  Biological Monitoring and Biomarkers , 2007 .

[102]  Wei Zhu,et al.  Chronic toxicity of rare-earth elements on human beings , 2007, Biological Trace Element Research.

[103]  C. Wood,et al.  Interaction between dietary calcium supplementation and chronic waterborne zinc exposure in juvenile rainbow trout, Oncorhynchus mykiss. , 2006, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[104]  L. Barber,et al.  Accumulation of contaminants in fish from wastewater treatment wetlands. , 2006, Environmental science & technology.

[105]  Stephen B. Castor,et al.  RARE EARTH ELEMENTS , 2006 .

[106]  M. Cempel,et al.  Nickel: A Review of Its Sources and Environmental Toxicology , 2006 .

[107]  M. Vašák Advances in metallothionein structure and functions. , 2005, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[108]  D. Secor,et al.  Analysis of trace transition elements and heavy metals in fish otoliths as tracers of habitat use by American eels in the Hudson River estuary , 2005 .

[109]  Wei Zheng,et al.  Manganese toxicity upon overexposure , 2004, NMR in biomedicine.

[110]  Robert J. Klee,et al.  ELEMENTAL CYCLES: A Status Report on Human or Natural Dominance , 2004 .

[111]  Peter Agre,et al.  From structure to disease: the evolving tale of aquaporin biology , 2004, Nature Reviews Molecular Cell Biology.

[112]  U. Lindh,et al.  Metallothionein is induced and trace element balance changed in target organs of a common viral infection. , 2004, Toxicology.

[113]  J. Oris,et al.  Multiple biomarker response in rainbow trout during exposure to hexavalent chromium. , 2004, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[114]  S. Patierno,et al.  Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms. , 2003, Mutation research.

[115]  J. Kaiser Sipping From a Poisoned Chalice , 2003, Science.

[116]  Jonny Beyer,et al.  Fish bioaccumulation and biomarkers in environmental risk assessment: a review. , 2003, Environmental toxicology and pharmacology.

[117]  Atsushi Takeda,et al.  Manganese action in brain function , 2003, Brain Research Reviews.

[118]  K. Salnikow,et al.  Nickel carcinogenesis. , 1968, Mutation research.

[119]  Guo Hongyan,et al.  Physiological responses of Carassius auratus to ytterbium exposure. , 2002, Ecotoxicology and environmental safety.

[120]  Colin R. Janssen,et al.  The biotic ligand model: a historical overview. , 2002, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[121]  A. Farag,et al.  Bioavailability and toxicity of dietborne copper and zinc to fish. , 2002, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[122]  C. J. Schmitt Biomonitoring of Environmental Status and Trends (BEST) Program: Environmental contaminants and their effects on fish in the Mississippi River Basin , 2002 .

[123]  P. Hantson,et al.  Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. , 2002, Critical reviews in oncology/hematology.

[124]  C. Chimenti,et al.  Programmed cell death in the pancreas of Bufo bufo during metamorphosis , 2001, Journal of anatomy.

[125]  D. Macdonald,et al.  Development and Evaluation of Consensus-Based Sediment Quality Guidelines for Freshwater Ecosystems , 2000, Archives of environmental contamination and toxicology.

[126]  S. Davis,et al.  Metallothionein expression in animals: a physiological perspective on function. , 2000, The Journal of nutrition.

[127]  G F Nordberg,et al.  Toxicological aspects of metallothionein. , 2000, Cellular and molecular biology.

[128]  Xiaorong Wang,et al.  Distribution and bioavailability of rare earth elements in aquatic microcosm , 1999 .

[129]  N. Fisher,et al.  Delineating metal accumulation pathways for marine invertebrates , 1999 .

[130]  Michigan.,et al.  Toxicological profile for dichloropropenes , 2008 .

[131]  C. Metcalfe,et al.  Fish micronuclei for assessing genotoxicity in water. , 1995, Mutation research.

[132]  P. Fraker,et al.  Zinc: health effects and research priorities for the 1990s. , 1994, Environmental health perspectives.

[133]  C. J. Schmitt,et al.  National contaminant biomonitoring program: Concentrations of arsenic, cadmium, copper, lead, mercury, selenium, and zinc in U.S. Freshwater Fish, 1976–1984 , 1990, Archives of environmental contamination and toxicology.

[134]  R. Cipriano,et al.  SEROLOGICAL INVESTIGATION OF THE FISH PATHOGEN EDWARDSIELLA ICTALURI, CAUSE OF ENTERIC SEPTICEMIA OF CATFISH , 1990, Journal of wildlife diseases.

[135]  J. Hem Study and Interpretation of the Chemical Characteristics of Natural Water , 1989 .

[136]  M. Anke,et al.  Nickel--an essential element. , 1984, IARC scientific publications.

[137]  A. Srivastava,et al.  Haematological responses in a fresh water fish to experimental manganese poisoning. , 1980, Toxicology.

[138]  R. Garrels,et al.  Chemical cycles and the global environment: Assessing human influences , 1975 .

[139]  G. Eger Cobalt , 1961, Definitions.

[140]  A. C. Brown,et al.  XX.—On the Connection between Chemical Constitution and Physiological Action. Part II.—On the Physiological Action of the Ammonium Bases derived from Atropia and Conia , 1869, Transactions of the Royal Society of Edinburgh.