Sixty‐hertz stimulation improves bradykinesia and amplifies subthalamic low‐frequency oscillations

The objective of this study was to investigate the hypothesis that attenuation of subthalamic nucleus (STN) alpha‐/beta‐band oscillations is causal to improvement in bradykinesia.

[1]  A. Priori,et al.  Adaptive deep brain stimulation (aDBS) controlled by local field potential oscillations , 2013, Experimental Neurology.

[2]  Peter Brown,et al.  Effects of low-frequency stimulation of the subthalamic nucleus on movement in Parkinson's disease , 2007, Experimental Neurology.

[3]  C. Hass,et al.  Selective use of low frequency stimulation in Parkinson's disease based on absence of tremor. , 2013, NeuroRehabilitation.

[4]  A. Priori,et al.  Rhythm-specific pharmacological modulation of subthalamic activity in Parkinson's disease , 2004, Experimental Neurology.

[5]  Antonio Oliviero,et al.  Effects of stimulation of the subthalamic area on oscillatory pallidal activity in Parkinson's disease , 2004, Experimental Neurology.

[6]  Nicola J. Ray,et al.  Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation , 2008, Experimental Neurology.

[7]  Mandy Miller Koop,et al.  Intra-operative STN DBS attenuates the prominent beta rhythm in the STN in Parkinson's disease , 2006, Experimental Neurology.

[8]  P. Brown,et al.  Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease , 2006, The European journal of neuroscience.

[9]  Andrea A. Kühn,et al.  Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity , 2009, Experimental Neurology.

[10]  Jaimie M. Henderson,et al.  Bilateral symmetry and coherence of subthalamic nuclei beta band activity in Parkinson's disease , 2010, Experimental Neurology.

[11]  L. Defebvre,et al.  Modulation of dysarthropneumophonia by low‐frequency STN DBS in advanced Parkinson's disease , 2011, Movement disorders : official journal of the Movement Disorder Society.

[12]  Ritesh A. Ramdhani,et al.  Early Use of 60 Hz Frequency Subthalamic Stimulation in Parkinson's Disease: A Case Series and Review , 2015, Neuromodulation : journal of the International Neuromodulation Society.

[13]  Miles A. Whittington,et al.  Neurosystems: brain rhythms and cognitive processing , 2013, The European journal of neuroscience.

[14]  C. Moreau,et al.  STN-DBS frequency effects on freezing of gait in advanced Parkinson disease , 2008, Neurology.

[15]  Anca Velisar,et al.  Beta oscillations in freely moving Parkinson's subjects are attenuated during deep brain stimulation , 2015, Movement disorders : official journal of the Movement Disorder Society.

[16]  Vladimir Litvak,et al.  Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease , 2007, Experimental Neurology.

[17]  P. Brown,et al.  Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients , 2010, Journal of Neurology, Neurosurgery & Psychiatry.

[18]  P. Brown,et al.  Adaptive Deep Brain Stimulation In Advanced Parkinson Disease , 2013, Annals of neurology.

[19]  M. Stern,et al.  Deep brain stimulation in Parkinson disease: a metaanalysis of patient outcomes. , 2005, Journal of neurosurgery.

[20]  He Huang,et al.  Effects of deep brain stimulation frequency on bradykinesia of Parkinson's disease , 2014, Movement disorders : official journal of the Movement Disorder Society.

[21]  A. Benabid,et al.  Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. , 2003, The New England journal of medicine.

[22]  P. Welch.  The use of fast Fourier transform for the estimation of power spectra: A method based on time averaging over short, modified periodograms , 1967 .

[23]  Jorge Iriarte,et al.  Coupling between Beta and High-Frequency Activity in the Human Subthalamic Nucleus May Be a Pathophysiological Mechanism in Parkinson's Disease , 2010, The Journal of Neuroscience.

[24]  P. Krack,et al.  Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. , 2001, The New England journal of medicine.

[25]  H. Brontë-Stewart,et al.  Sixty Hertz Neurostimulation Amplifies Subthalamic Neural Synchrony in Parkinson’s Disease , 2015, PloS one.

[26]  Andrea A. Kühn,et al.  High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory β Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance , 2008, The Journal of Neuroscience.

[27]  T. Hastie,et al.  Quantitative measurements of alternating finger tapping in Parkinson's disease correlate with UPDRS motor disability and reveal the improvement in fine motor control from medication and deep brain stimulation , 2005, Movement disorders : official journal of the Movement Disorder Society.

[28]  G. E. Alexander,et al.  Functional architecture of basal ganglia circuits: neural substrates of parallel processing , 1990, Trends in Neurosciences.

[29]  J. Dostrovsky,et al.  Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease. , 2006, Journal of neurophysiology.

[30]  S. Haber,et al.  Closed-Loop Deep Brain Stimulation Is Superior in Ameliorating Parkinsonism , 2011, Neuron.

[31]  Vladimir Litvak,et al.  Deep brain stimulation modulates synchrony within spatially and spectrally distinct resting state networks in Parkinson’s disease , 2016, Brain : a journal of neurology.

[32]  P. Brown,et al.  Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease , 2005, Neuroscience Letters.

[33]  Annika Plate,et al.  Freezing of gait-related oscillatory activity in the human subthalamic nucleus , 2013 .

[34]  A. Priori,et al.  Dopamine‐dependent non‐linear correlation between subthalamic rhythms in Parkinson's disease , 2006, The Journal of physiology.

[35]  M. Rizzone,et al.  Transient effects of 80 Hz stimulation on gait in STN DBS treated PD patients: A 15 months follow-up study , 2012, Brain Stimulation.

[36]  Sara Marceglia,et al.  Adaptive deep brain stimulation in a freely moving parkinsonian patient , 2015, Movement disorders : official journal of the Movement Disorder Society.

[37]  David Garcia-Garcia,et al.  High beta activity in the subthalamic nucleus and freezing of gait in Parkinson's disease , 2014, Neurobiology of Disease.

[38]  S. Cerutti,et al.  Interaction Between Rhythms in the Human Basal Ganglia: Application of Bispectral Analysis to Local Field Potentials , 2007, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[39]  Jaimie M Henderson,et al.  Clinical Motor Outcome of Bilateral Subthalamic Nucleus Deep-Brain Stimulation for Parkinson's Disease Using Image-Guided Frameless Stereotaxy , 2010, Neurosurgery.

[40]  R. Folmer.  rTMS for Tinnitus , 2012, Front. Hum. Neurosci..

[41]  A. Oliviero,et al.  Dopamine Dependency of Oscillations between Subthalamic Nucleus and Pallidum in Parkinson's Disease , 2001, The Journal of Neuroscience.

[42]  J. Henderson,et al.  High frequency deep brain stimulation attenuates subthalamic and cortical rhythms in Parkinson's disease , 2012, Front. Hum. Neurosci..

[43]  Karl J. Friston,et al.  Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease. , 2011, Brain : a journal of neurology.

[44]  Hong Yu,et al.  Maximal subthalamic beta hypersynchrony of the local field potential in Parkinson's disease is located in the central region of the nucleus , 2011, Journal of Neurology, Neurosurgery & Psychiatry.

[45]  Jaimie M. Henderson,et al.  The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation , 2009, Experimental Neurology.

[46]  Hayriye Cagnan,et al.  Bilateral adaptive deep brain stimulation is effective in Parkinson's disease , 2015, Journal of Neurology, Neurosurgery & Psychiatry.

[47]  Markus Butz,et al.  Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease , 2011, NeuroImage.

[48]  P. Brown,et al.  Beta band stability over time correlates with Parkinsonian rigidity and bradykinesia , 2012, Experimental Neurology.

[49]  G. Deuschl,et al.  A randomized trial of deep-brain stimulation for Parkinson's disease. , 2006, The New England journal of medicine.