Remodeling of Arteries in Response to Changes in their Mechanical Environment

Arteries are subjected to mechanical forces, which may vary in time. A long-lasting alteration in pressure and/or blood flow rate causes an adaptive response termed remodeling. At the macro-level remodeling is manifest as a change in arterial geometry and a change in mechanical properties of the arterial tissue. A review of the main experimental findings concerning pressure- and flow-induced remodeling of large arteries is presented. Theoretical models of volumetric and global growth based on a continuum mechanics approach are discussed. Some specific biomechanical problems of arterial remodeling associated with abnormal narrowing of the arterial lumen are considered.

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