Evidence-Based Medicine: Pressure Sores

Learning Objectives: After studying this article, the participant should be able to: 1. Cite risk factors for pressure sore development. 2. Detail the pathophysiology of pressure sores. 3. List the types and classification of pressure sores. 4. Consider the various nonsurgical conservative wound management strategies. 5. Describe the appropriate surgical interventions for each pressure sore type. 6. Understand the causes of recurrent pressure sores and methods of avoiding recurrence. Summary: Pressure sores are the result of unrelieved pressure, usually over a bony prominence. With an estimated 2.5 million pressure ulcers treated annually in the United States at a cost of $11 billion, pressure sores represent a costly and labor-intensive challenge to the health care system. A comprehensive team approach can address both prevention and treatment of these recalcitrant wounds. Consideration must be given to the patient’s medical and socioeconomic condition, as these factors are significantly related to outcomes. Mechanical prophylaxis, nutritional optimization, treatment of underlying infection, and spasm control are essential in management. A variety of pressure sore patterns exist, with surgical approaches directed to maximize future coverage options. A comprehensive approach is detailed in this article to provide the reader with the range of treatment options available.

[1]  I. Weinbren SPONTANEOUS PERIODIC ŒDEMA: A New Syndrome , 1963 .

[2]  F W Pirruccello,et al.  Plastic and reconstructive surgery. , 1967, IMJ. Illinois medical journal.

[3]  R. Reynolds,et al.  THE EFFECT OF ORAL ZINC SULFATE THERAPY ON DECUBITUS ULCERS , 1971 .

[4]  T. Taylor,et al.  Ascorbic acid supplementation in the treatment of pressure-sores. , 1974, Lancet.

[5]  G. Sethi,et al.  Suppurative diseases of the lungs. Pleurae and pericardium. , 1977, Current problems in surgery.

[6]  S. Mathes,et al.  Bilateral Gluteus Maximus Myocutaneous Advancement Flaps: Sacral Coverage for Ambulatory Patients , 1982, Annals of plastic surgery.

[7]  T. G. Cooney,et al.  Pressure sores. , 1984, The Western journal of medicine.

[8]  R. K. Daniel,et al.  Pressure Sores and Paraplegia: An Experimental Model , 1985, Annals of plastic surgery.

[9]  T. V. D. van der Cammen,et al.  Prevention of pressure sores. A comparison of new and old pressure sore treatments , 1987, The British journal of clinical practice.

[10]  S. Takiguchi,et al.  Consistent wound care and nutritional support in treatment. , 1990, Decubitus.

[11]  P. Knipschild,et al.  Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers. , 1995, Journal of clinical epidemiology.

[12]  T. Farley,et al.  An exploratory study of pressure ulcers after spinal cord injury: relationship to protective behaviors and risk factors. , 2001, Archives of physical medicine and rehabilitation.

[13]  V. Pedone,et al.  Impact on pressure ulcer healing of an arginine-enriched nutritional solution in patients with severe cognitive impairment. , 2001, Archives of gerontology and geriatrics. Supplement.

[14]  D. Muir,et al.  Ratios of activated matrix metalloproteinase‐9 to tissue inhibitor of matrix metalloproteinase‐1 in wound fluids are inversely correlated with healing of pressure ulcers , 2002, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[15]  Cardiovascular Responses to Endotracheal Intubation in Patients with Acute and Chronic Spinal Cord Injuries , 2003, Anesthesia and analgesia.

[16]  G. Wells,et al.  Factors associated with pressure ulcers in adults in acute care hospitals. , 2004, Holistic nursing practice.

[17]  T. Crowe,et al.  Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial. , 2005, Clinical nutrition.

[18]  J. Torra i Bou,et al.  The effectiveness of a hyperoxygenated fatty acid compound in preventing pressure ulcers. , 2005, Journal of wound care.

[19]  P. Rochon,et al.  Preventing Pressure Ulcers: A Systematic Review , 2007 .

[20]  G. Rodeheaver,et al.  Guidelines for the treatment of pressure ulcers , 2006, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[21]  J. Martyn,et al.  Succinylcholine-induced Hyperkalemia in Acquired Pathologic States: Etiologic Factors and Molecular Mechanisms , 2006, Anesthesiology.

[22]  L. Phillips,et al.  MOC-PS(SM) CME Article: Pressure Sores , 2008, Plastic and reconstructive surgery.

[23]  Sunila R. Kalkar,et al.  Treatment of pressure ulcers: a systematic review. , 2008, JAMA.

[24]  W. Marston,et al.  Multiplexed analysis of matrix metalloproteinases in leg ulcer tissue of patients with chronic venous insufficiency before and after compression therapy , 2008, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[25]  E. Elster,et al.  Correlation of procalcitonin and cytokine expression with dehiscence of wartime extremity wounds. , 2008, The Journal of bone and joint surgery. American volume.

[26]  F. Gage,et al.  Metalloproteinase expression is associated with traumatic wound failure. , 2010, The Journal of surgical research.

[27]  J. Janis,et al.  A Practical Guide to Wound Healing , 2010, Plastic and reconstructive surgery.

[28]  D. Mathes,et al.  Multivariate Predictors of Failure after Flap Coverage of Pressure Ulcers , 2010, Plastic and reconstructive surgery.

[29]  D. Mozingo Biomarkers to Predict Wound Healing: The Future of Complex War Wound Management , 2011 .

[30]  R. Kirsner,et al.  State of the Art in Topical Wound-Healing Products , 2011, Plastic and reconstructive surgery.

[31]  V. Falanga,et al.  Bioengineered skin constructs , 2020, Principles of Tissue Engineering.